The purpose of this study is to develop an integrated framework for capacity analysis to address the influence of systematic hazardous factors on the haulage fleet nominal capacity.The proposed model was made to captu...The purpose of this study is to develop an integrated framework for capacity analysis to address the influence of systematic hazardous factors on the haulage fleet nominal capacity.The proposed model was made to capture unexpected risks for mining equipment based upon data-driven method considering different scenarios.Probabilistic risk assessment(PRA)was employed to quantify the loss of production capacity by focusing on severity of failure incidents and maintainability measurements.Discrete-event simulation was configured to characterize the nominal capacity for mining operation.Accordingly,the system capacity was analyzed through the comparison of nominal and actual capacity.A case study was completed to validate the research methodology.The past operation and maintenance field data were collected for shovel operation.The discrete-event simulation was developed to estimate the rate of shovel nominal capacity.Then,the effects of undesirable scenarios were assessed by developing the PRA approach.The research results provide significant insights into how to enhance the production capacity in mines.The analyst gets a well judgment for the crucial elements dealing with high risk levels.A holistic maintenance plan can be developed to mitigate and control the losses.展开更多
A study was conducted on high-density young plantations of three native trees （Albizia lebbeck, Albizia. procera and Tectona grandis） and one native woody grass species （Dendrocalamus strictus） to examine their in...A study was conducted on high-density young plantations of three native trees （Albizia lebbeck, Albizia. procera and Tectona grandis） and one native woody grass species （Dendrocalamus strictus） to examine their influence on total nutrient concentrations of coal mine spoil during early phase of plantation establishment. Soil samples were analyzed for total organic carbon （SOC）, Kjeldahl nitrogen （TKN） and phosphorus （TP） at spoil depths of 0-10 and 10-20 cm under 4- and 5-year-old plantations of all species. A significant effect on concentrations of total SOC, TKN and TP were observed due to plantation age, species and soil depth. However, corresponding con- centrations （SOC, TKN and TP） were substantially lower at spoil profile of 10-20 cm. In comparison, plantation ofA. lebbeck showed greater SOC and nutrient concentrations followed by D. strictus, A. procera and T. grandis, respectively. Therefore, present study clearly indicates attributing qualities of plantation towards improving redeveloping soil of mine spoil varied with species.展开更多
As Busan New Port has been developed with a total scale of 30 berths in 2020, the chronic problem of Busan port, a lack of port facilities, is being addressed, and there is a growing interest in regard to port develop...As Busan New Port has been developed with a total scale of 30 berths in 2020, the chronic problem of Busan port, a lack of port facilities, is being addressed, and there is a growing interest in regard to port development with an optimal scale. The Korean container port development under the master plan for national port development reveals a severe problem of excess supply of port facility in some ports. This paper, the authors analysed the second and the third master plan for national port development implemented in 2001 and 2011, and a revised plan in 2006, along with the amended predictions for container throughput. Furthermore, the effectiveness of the implementation of the initial plan, and the current situation of South Korea＇s main container ports of Busan, Gwangyang, Incheon, and Pyeongtaek ＆ Dangjin was examined. Through the analysis of port vitalizations, we have examined the actual problems for the prediction of container throughput. Also, this research analysed the functional difference of each port and organized the function of each one discriminatively. Therefore, identifies the problems, which arise with making the container throughput forecasts, which is a fimdamental aspect of existing port development policy, and suggest a direction for future port development by synthesizing the results of analysis.展开更多
Recent evidence of research has been proposed that the phosphoinositide 3-kinase(PI3K) pathway is noticeable target for searching novel anticancer agents. The phosphoinositide 3-kinase(PI3K) is accountable for harmoni...Recent evidence of research has been proposed that the phosphoinositide 3-kinase(PI3K) pathway is noticeable target for searching novel anticancer agents. The phosphoinositide 3-kinase(PI3K) is accountable for harmonizing a diverse range of cell functions, such as transcription, proliferation, cell survival, cell growth, degranulation, vesicular trafficking and cell migration, which are mostly involved in carcinogenesis. Particularly, PI3K-mediated signaling molecules and its effects on gene expression contribute to tumorigenesis. PI3Ks generally are grouped into three distinct classes: Ⅰ, Ⅱ and Ⅲ according to their structure and function. The class IA of PI3K includes an alpha, beta or delta p110 catalytic subunit(p110α, p110β, or p110γ), which are associated with the activation of RTKs. Mutations in PIK3CA, the gene encoding the p110α catalytic subunit of PI3K, have just been recognized as novel mechanisms of inducing oncogenic PI3K signaling. Therefore, the class IA PI3K is the only one of most evidently implicated in cancer. The PI3K pathway is mostly mutated in more cancer patients compared with normal person, making it an eyecatching molecular target for analyses based on inhibitor molecule. In this article, we highlighted the signaling effects and regulation pathway of PI3K involved in the development and survival of tumor cells. The consequence and intricacy of PI3K pathway made it an essential beneficial target for cancer treatment.展开更多
Abstract： In the present study, we developed a simple approach for the structural modifications ofkaempferol （1）. A new compound, 3,5-dihydroxy-2-（4-hydroxyphenyl）-6,8,8-tris（3-methylbut-2-en-1-yl）-4H-chromene-...Abstract： In the present study, we developed a simple approach for the structural modifications ofkaempferol （1）. A new compound, 3,5-dihydroxy-2-（4-hydroxyphenyl）-6,8,8-tris（3-methylbut-2-en-1-yl）-4H-chromene-4,7（SH）-dione （5） together with three known compounds, 8-prenylkaempferol （Z）, 6-prenylkaempferol （3） and 6,8-diprenylkaempferol （4）, were synthesized under different reaction conditions. All of derivatives were synthesized in a structural modification way for the first time. Their structures were primarily elucidated by NMR and MS analyses. Compounds 2, 3 and 5 exhibited prominent cytotoxic activity against MDA-231 （IC50 values were 9.45±0.20 μM, 7.15±0.37 μM and 6.92±0.30 μM, respectively） and MCF-7 （ICso values were 10.08±0.57 0M, 10.04±0.23 μM and 2.15±0.20 μM, respectively） breast cancer cells.展开更多
文摘The purpose of this study is to develop an integrated framework for capacity analysis to address the influence of systematic hazardous factors on the haulage fleet nominal capacity.The proposed model was made to capture unexpected risks for mining equipment based upon data-driven method considering different scenarios.Probabilistic risk assessment(PRA)was employed to quantify the loss of production capacity by focusing on severity of failure incidents and maintainability measurements.Discrete-event simulation was configured to characterize the nominal capacity for mining operation.Accordingly,the system capacity was analyzed through the comparison of nominal and actual capacity.A case study was completed to validate the research methodology.The past operation and maintenance field data were collected for shovel operation.The discrete-event simulation was developed to estimate the rate of shovel nominal capacity.Then,the effects of undesirable scenarios were assessed by developing the PRA approach.The research results provide significant insights into how to enhance the production capacity in mines.The analyst gets a well judgment for the crucial elements dealing with high risk levels.A holistic maintenance plan can be developed to mitigate and control the losses.
文摘A study was conducted on high-density young plantations of three native trees （Albizia lebbeck, Albizia. procera and Tectona grandis） and one native woody grass species （Dendrocalamus strictus） to examine their influence on total nutrient concentrations of coal mine spoil during early phase of plantation establishment. Soil samples were analyzed for total organic carbon （SOC）, Kjeldahl nitrogen （TKN） and phosphorus （TP） at spoil depths of 0-10 and 10-20 cm under 4- and 5-year-old plantations of all species. A significant effect on concentrations of total SOC, TKN and TP were observed due to plantation age, species and soil depth. However, corresponding con- centrations （SOC, TKN and TP） were substantially lower at spoil profile of 10-20 cm. In comparison, plantation ofA. lebbeck showed greater SOC and nutrient concentrations followed by D. strictus, A. procera and T. grandis, respectively. Therefore, present study clearly indicates attributing qualities of plantation towards improving redeveloping soil of mine spoil varied with species.
文摘As Busan New Port has been developed with a total scale of 30 berths in 2020, the chronic problem of Busan port, a lack of port facilities, is being addressed, and there is a growing interest in regard to port development with an optimal scale. The Korean container port development under the master plan for national port development reveals a severe problem of excess supply of port facility in some ports. This paper, the authors analysed the second and the third master plan for national port development implemented in 2001 and 2011, and a revised plan in 2006, along with the amended predictions for container throughput. Furthermore, the effectiveness of the implementation of the initial plan, and the current situation of South Korea＇s main container ports of Busan, Gwangyang, Incheon, and Pyeongtaek ＆ Dangjin was examined. Through the analysis of port vitalizations, we have examined the actual problems for the prediction of container throughput. Also, this research analysed the functional difference of each port and organized the function of each one discriminatively. Therefore, identifies the problems, which arise with making the container throughput forecasts, which is a fimdamental aspect of existing port development policy, and suggest a direction for future port development by synthesizing the results of analysis.
文摘Recent evidence of research has been proposed that the phosphoinositide 3-kinase(PI3K) pathway is noticeable target for searching novel anticancer agents. The phosphoinositide 3-kinase(PI3K) is accountable for harmonizing a diverse range of cell functions, such as transcription, proliferation, cell survival, cell growth, degranulation, vesicular trafficking and cell migration, which are mostly involved in carcinogenesis. Particularly, PI3K-mediated signaling molecules and its effects on gene expression contribute to tumorigenesis. PI3Ks generally are grouped into three distinct classes: Ⅰ, Ⅱ and Ⅲ according to their structure and function. The class IA of PI3K includes an alpha, beta or delta p110 catalytic subunit(p110α, p110β, or p110γ), which are associated with the activation of RTKs. Mutations in PIK3CA, the gene encoding the p110α catalytic subunit of PI3K, have just been recognized as novel mechanisms of inducing oncogenic PI3K signaling. Therefore, the class IA PI3K is the only one of most evidently implicated in cancer. The PI3K pathway is mostly mutated in more cancer patients compared with normal person, making it an eyecatching molecular target for analyses based on inhibitor molecule. In this article, we highlighted the signaling effects and regulation pathway of PI3K involved in the development and survival of tumor cells. The consequence and intricacy of PI3K pathway made it an essential beneficial target for cancer treatment.
基金National Key Technology R&D Program“New Drug Innovation”of China(Grant No.2013ZX09103002-006)National Natural Science Foundation of China(Grant No.81673590)
文摘Abstract： In the present study, we developed a simple approach for the structural modifications ofkaempferol （1）. A new compound, 3,5-dihydroxy-2-（4-hydroxyphenyl）-6,8,8-tris（3-methylbut-2-en-1-yl）-4H-chromene-4,7（SH）-dione （5） together with three known compounds, 8-prenylkaempferol （Z）, 6-prenylkaempferol （3） and 6,8-diprenylkaempferol （4）, were synthesized under different reaction conditions. All of derivatives were synthesized in a structural modification way for the first time. Their structures were primarily elucidated by NMR and MS analyses. Compounds 2, 3 and 5 exhibited prominent cytotoxic activity against MDA-231 （IC50 values were 9.45±0.20 μM, 7.15±0.37 μM and 6.92±0.30 μM, respectively） and MCF-7 （ICso values were 10.08±0.57 0M, 10.04±0.23 μM and 2.15±0.20 μM, respectively） breast cancer cells.
