Aiming at improving the sensitivity and accu- racy 9f diagnosis, the combination of magnetic resonance imaging （MRI） and X-ray computed tomography （CT） in a single probe is in urgent need. Here, we report the deve...Aiming at improving the sensitivity and accu- racy 9f diagnosis, the combination of magnetic resonance imaging （MRI） and X-ray computed tomography （CT） in a single probe is in urgent need. Here, we report the devel- opment of polyacrylic acid （PAA）-capped GdF3 nanoplates （NPs） as novel MRI and CT dual-mode contrast agents （CAs） with high longitudinal relaxivity （rl） and large X-ray attenuation coefficient. Uniform GdF3 rhombic NPs were fabricated by controlling reaction conditions and intro- ducing dopants. The average size of GdF3 NPs is （10.6 ：k 1.1） nm in long diagonal, （7.0 -t- 0.8） nm in short diagonal, and （4.2 -4- 1.2） nm in thickness. Ligand-exchange treat- ment was performed to render the NPs water-dispersible. The rl of PAA-capped GdF3 NPs （15.8 L/（mmol s）） is four times higher than that of clinically used Gd-DTPA. We suppose that the high r~ value originates from the con- struction of two-dimensional （2D） nanostructures, which endows nanocrystals with larger surface areas and longer rotational correlation time than those of sphere nanostruc- tures with the same volume. The CT contrast enhancement ability of PAA-capped GdF3 NPs was evaluated in com- parison with clinically used Iohexol. The above results suggest that the PAA-capped GdF3 NPs could serve as CAs for MRI and CT dual-mode imaging.展开更多
基金financially supported by grants from the National Natural Science Foundation of China (No. 51422301)Beijing Higher Education Young Elite Teacher Project (No. 29201493)the Fundamental Research Funds for the Central Universities(No.YWF-16-BJ-Y-68)
基金This work was supported by the National Natural Science Foundation of China （21425101, 21371011, 21331001） and the National Basic Research Program of China （2014CB643800）.
文摘Aiming at improving the sensitivity and accu- racy 9f diagnosis, the combination of magnetic resonance imaging （MRI） and X-ray computed tomography （CT） in a single probe is in urgent need. Here, we report the devel- opment of polyacrylic acid （PAA）-capped GdF3 nanoplates （NPs） as novel MRI and CT dual-mode contrast agents （CAs） with high longitudinal relaxivity （rl） and large X-ray attenuation coefficient. Uniform GdF3 rhombic NPs were fabricated by controlling reaction conditions and intro- ducing dopants. The average size of GdF3 NPs is （10.6 ：k 1.1） nm in long diagonal, （7.0 -t- 0.8） nm in short diagonal, and （4.2 -4- 1.2） nm in thickness. Ligand-exchange treat- ment was performed to render the NPs water-dispersible. The rl of PAA-capped GdF3 NPs （15.8 L/（mmol s）） is four times higher than that of clinically used Gd-DTPA. We suppose that the high r~ value originates from the con- struction of two-dimensional （2D） nanostructures, which endows nanocrystals with larger surface areas and longer rotational correlation time than those of sphere nanostruc- tures with the same volume. The CT contrast enhancement ability of PAA-capped GdF3 NPs was evaluated in com- parison with clinically used Iohexol. The above results suggest that the PAA-capped GdF3 NPs could serve as CAs for MRI and CT dual-mode imaging.
