Two new sesquiterpenes, named tussilagonone (1) and neotussilagolactone (2), together with two known sesquiterpenes (3) and (4) and two phthalic acid derivatives (5) and (6), were isolated from the flower buds of Tu...Two new sesquiterpenes, named tussilagonone (1) and neotussilagolactone (2), together with two known sesquiterpenes (3) and (4) and two phthalic acid derivatives (5) and (6), were isolated from the flower buds of Tussilago farfara . The structures of (1) and (2) were determined on the basis of spectroscopic analyses. Compounds (1) and (2) exhibited activities against platelet aggregation caused by platelet activating factor.展开更多
A chemical investigation of the aerial parts ofArtemisia vestita Wall. led to the isolation of 12 known sesquiterpenes, including 2 furan-containing sesquiterpenoids and 10 eudesmane sesquiterpene lactones. Their stru...A chemical investigation of the aerial parts ofArtemisia vestita Wall. led to the isolation of 12 known sesquiterpenes, including 2 furan-containing sesquiterpenoids and 10 eudesmane sesquiterpene lactones. Their structures were identified as negunfurol （1）, schensianol A （2）, artemine （3）, erivanin （4）, 1,5-diepi-artemin （5）, acetylartemin （6）, naphtho[1,2-b]furan-2（3H）-one, 6-（acetyloxy） decahydro-9a-hydroxy-3,Sa-dimethyl-9-methylene-（3S,3aS,5aS,6S,9aS, ghS） （7）, naphtho[1,2-b]furan-2（3H）-one, 6-（acetyloxy）- 3a,4,5,5a,6,7,8,9b-octahydro-8-hydroxy-3,Sa,9-trimethyl- （3S,3aS, SaR,6S, SS,9bS） （8）, isoerivanin （9）, harrelierin （10）, （11S）-1- oxoeudesm-4（14）-eno-13,6a-lactone （11）, 1-epi-dehydroisoeranin （12）, respectively. All of these compounds were isolated from Artemisia vestita for the first time, and compounds 1 and 2 were isolated from the genus Artemisia for the first time.展开更多
In the 1970 s, artemisinin(‘‘qinghaosu'' in Chinese), a sesquiterpene lactone with an unusual peroxide bridge, was isolated from Artemisia annua L. It showed promising antimalarial activity, particularly by ...In the 1970 s, artemisinin(‘‘qinghaosu'' in Chinese), a sesquiterpene lactone with an unusual peroxide bridge, was isolated from Artemisia annua L. It showed promising antimalarial activity, particularly by eliminating parasites resistant to chloroquine. For more than 30 years,artemisinin has contributed to worldwide health as a new type of antimalarial drug. Artemisinin and its analogs, such as dihydroartemisinin, artemether, artesunate, artemiside,artemisone, and arteether, possess not only potent antimalarial activity but also anti-viral, antifungal, anticancer,and anti-inflammatory properties. In this review, we discuss the current understanding of how artemisinin and its analogs affect the immune system and immune-related diseases.展开更多
Artemisinin, also known as qinghaosu, a sesquiterpene endoperoxide lactone isolated from the Chinese medicinal plant Artemisia annua L., is the most effective antimalarial drug which has saved millions of lives.Due to...Artemisinin, also known as qinghaosu, a sesquiterpene endoperoxide lactone isolated from the Chinese medicinal plant Artemisia annua L., is the most effective antimalarial drug which has saved millions of lives.Due to its great antimalarial activity and low content in wild A. annua plants, researches focused on enhancing the artemisin yield in plants became a hotspot. Several families of transcription factors have been reported to participate in regulating the biosynthesis and accumulation of artemisinin.In this review, we summarize recent investigations in these fields, with emphasis on newly identified transcription factors and their functions in artemisinin biosynthesis regulation, and provide new insight for further research.展开更多
文摘Two new sesquiterpenes, named tussilagonone (1) and neotussilagolactone (2), together with two known sesquiterpenes (3) and (4) and two phthalic acid derivatives (5) and (6), were isolated from the flower buds of Tussilago farfara . The structures of (1) and (2) were determined on the basis of spectroscopic analyses. Compounds (1) and (2) exhibited activities against platelet aggregation caused by platelet activating factor.
基金National Natural Science Foundation of China(Grant No.30973629)National Key Technology R&D Program "New Drug Innovation" of China(Grant No.2012ZX09301002-002-002,2012ZX09304-005)
文摘A chemical investigation of the aerial parts ofArtemisia vestita Wall. led to the isolation of 12 known sesquiterpenes, including 2 furan-containing sesquiterpenoids and 10 eudesmane sesquiterpene lactones. Their structures were identified as negunfurol （1）, schensianol A （2）, artemine （3）, erivanin （4）, 1,5-diepi-artemin （5）, acetylartemin （6）, naphtho[1,2-b]furan-2（3H）-one, 6-（acetyloxy） decahydro-9a-hydroxy-3,Sa-dimethyl-9-methylene-（3S,3aS,5aS,6S,9aS, ghS） （7）, naphtho[1,2-b]furan-2（3H）-one, 6-（acetyloxy）- 3a,4,5,5a,6,7,8,9b-octahydro-8-hydroxy-3,Sa,9-trimethyl- （3S,3aS, SaR,6S, SS,9bS） （8）, isoerivanin （9）, harrelierin （10）, （11S）-1- oxoeudesm-4（14）-eno-13,6a-lactone （11）, 1-epi-dehydroisoeranin （12）, respectively. All of these compounds were isolated from Artemisia vestita for the first time, and compounds 1 and 2 were isolated from the genus Artemisia for the first time.
基金supported by the National Natural Science Foundation of China (91529305, 81427805, 81302507, 81302809, 31401611, 81573161, and 81502122)the Ministry of Science and Technology of China (2014AA020524)+2 种基金the CAS/ SAFEA International Partnership Program for Creative Research Teams of the Chinese Academy of Sciencesthe Science and Technology Commission of Shanghai Municipality (14391901800)the Key Laboratory of Food Safety Research of INS, SIBS, CAS
文摘In the 1970 s, artemisinin(‘‘qinghaosu'' in Chinese), a sesquiterpene lactone with an unusual peroxide bridge, was isolated from Artemisia annua L. It showed promising antimalarial activity, particularly by eliminating parasites resistant to chloroquine. For more than 30 years,artemisinin has contributed to worldwide health as a new type of antimalarial drug. Artemisinin and its analogs, such as dihydroartemisinin, artemether, artesunate, artemiside,artemisone, and arteether, possess not only potent antimalarial activity but also anti-viral, antifungal, anticancer,and anti-inflammatory properties. In this review, we discuss the current understanding of how artemisinin and its analogs affect the immune system and immune-related diseases.
基金supported by National High Technology Research and Development Program(2011AA100605)Shanghai Key Discipline Cultivation and Construction Project(Horticulture+1 种基金ZXDF150005)Shanghai Jiao Tong University Agri-Engineering Program(AF1500028)
文摘Artemisinin, also known as qinghaosu, a sesquiterpene endoperoxide lactone isolated from the Chinese medicinal plant Artemisia annua L., is the most effective antimalarial drug which has saved millions of lives.Due to its great antimalarial activity and low content in wild A. annua plants, researches focused on enhancing the artemisin yield in plants became a hotspot. Several families of transcription factors have been reported to participate in regulating the biosynthesis and accumulation of artemisinin.In this review, we summarize recent investigations in these fields, with emphasis on newly identified transcription factors and their functions in artemisinin biosynthesis regulation, and provide new insight for further research.
