治疗药物监测（therapeutic drug monitoring,TDM）是在药物动力学原理指导下,通过运用各种灵敏的现代分析测试手段,定量分析生物样品中药物及其代谢产物的浓度,以探讨患者体内血药浓度与疗效及毒性反应的关系,从而确定有效及毒性血药...治疗药物监测（therapeutic drug monitoring,TDM）是在药物动力学原理指导下,通过运用各种灵敏的现代分析测试手段,定量分析生物样品中药物及其代谢产物的浓度,以探讨患者体内血药浓度与疗效及毒性反应的关系,从而确定有效及毒性血药浓度范围.TDM是临床药学工作的一个重要方面,也是药物治疗学的重要内容.展开更多
In this letter, a new method is proposed for unsupervised classification of terrain types and man-made objects using POLarimetric Synthetic Aperture Radar (POLSAR) data. This technique is a combi-nation of the usage o...In this letter, a new method is proposed for unsupervised classification of terrain types and man-made objects using POLarimetric Synthetic Aperture Radar (POLSAR) data. This technique is a combi-nation of the usage of polarimetric information of SAR images and the unsupervised classification method based on fuzzy set theory. Image quantization and image enhancement are used to preprocess the POLSAR data. Then the polarimetric information and Fuzzy C-Means (FCM) clustering algorithm are used to classify the preprocessed images. The advantages of this algorithm are the automated classification, its high classifica-tion accuracy, fast convergence and high stability. The effectiveness of this algorithm is demonstrated by ex-periments using SIR-C/X-SAR (Spaceborne Imaging Radar-C/X-band Synthetic Aperture Radar) data.展开更多
Objective: This study aimed to establish chemiluminescent immunoassay (CLIA) for quantitative determination of theophylline levels in human serum. Methods: To measure the concentration of theophylline (n=122) and eval...Objective: This study aimed to establish chemiluminescent immunoassay (CLIA) for quantitative determination of theophylline levels in human serum. Methods: To measure the concentration of theophylline (n=122) and evaluate the assay.Results: The linear range of the CLIA method was 0.51～40 mg/L (Y=1.02X+0.44, r=0.995). The intra and inter CV (coefficient variance) of CLIA were 3.20% and 3.57%, respectively. The average recovery rate was 102.3%. This method was free from interference by brilirubin (＜200 μmol/L), hemoglobin (＜10 g/L), and triglycerides (＜15 mmol/L). Conclusion: This method is simple, convenient and precise for clinical pharmacokinetics study oftheophylline.展开更多
文摘治疗药物监测（therapeutic drug monitoring,TDM）是在药物动力学原理指导下,通过运用各种灵敏的现代分析测试手段,定量分析生物样品中药物及其代谢产物的浓度,以探讨患者体内血药浓度与疗效及毒性反应的关系,从而确定有效及毒性血药浓度范围.TDM是临床药学工作的一个重要方面,也是药物治疗学的重要内容.
基金Supported by the University Doctorate Special Research Fund (No. 20030614001) and the Youth Scholarship Leader Fund of Univ. of Electro. Sci. and Tech. of China.
文摘In this letter, a new method is proposed for unsupervised classification of terrain types and man-made objects using POLarimetric Synthetic Aperture Radar (POLSAR) data. This technique is a combi-nation of the usage of polarimetric information of SAR images and the unsupervised classification method based on fuzzy set theory. Image quantization and image enhancement are used to preprocess the POLSAR data. Then the polarimetric information and Fuzzy C-Means (FCM) clustering algorithm are used to classify the preprocessed images. The advantages of this algorithm are the automated classification, its high classifica-tion accuracy, fast convergence and high stability. The effectiveness of this algorithm is demonstrated by ex-periments using SIR-C/X-SAR (Spaceborne Imaging Radar-C/X-band Synthetic Aperture Radar) data.
文摘Objective: This study aimed to establish chemiluminescent immunoassay (CLIA) for quantitative determination of theophylline levels in human serum. Methods: To measure the concentration of theophylline (n=122) and evaluate the assay.Results: The linear range of the CLIA method was 0.51～40 mg/L (Y=1.02X+0.44, r=0.995). The intra and inter CV (coefficient variance) of CLIA were 3.20% and 3.57%, respectively. The average recovery rate was 102.3%. This method was free from interference by brilirubin (＜200 μmol/L), hemoglobin (＜10 g/L), and triglycerides (＜15 mmol/L). Conclusion: This method is simple, convenient and precise for clinical pharmacokinetics study oftheophylline.
