不停生长的一位男性

不停生长的一位男性李洪，林木这位年轻人以２米高的身躯在人群中如鹤立鸡群。他的手足也都出奇的大。商店里找不到他那个尺码的鞋。这位男士的令人敬畏的尺码还不是他个人惊异的所在。真正令人吃惊的是，到了２８岁他还在生长。这位男士并没在意他的身高，而且在他看一位...

生脉心停搏液对体外循环开心手术病人的心肌保护作用

４０例体外循环开心手术病人，２０例采用改良Ｓｔ．Ｔｈｏｍａｓ晶血心停搏液作为对照组，２０例在对照组的心停搏液基础上加入生脉注射液作为观察组。结果示，生脉晶血心停搏液能增强对心肌的保护作用。

简讯 动态 信息

广州水泥厂去年改组为规范化的股份制企业,现称为“广州水泥股份有限公司”,该股份公司与香港越秀企业(集团)有限公司的全资附属企业——香港中孚企业有限公司于最近合资经营。首期投资总额一亿六千万人民币。

长期使用手机容易引发听神经瘤

瑞典卡罗琳医学院研究人员最近发布报告说,通过对北欧移动电话(NMT)手机用户的研究发现,人们使用NMT手机长达10年或更久,容易引发听神经瘤。听神经瘤是位于听神经上的良性肿瘤。如果不切除,它将会不停生长,终因瘤体过大压迫大脑而危及病人生命。

Effect of dynamic light at the coronary care unit on the length of hospital stay and development of delirium： a retrospective cohort study

Background Disturbed circadian rhythm is a potential cause of delirium and is linked to disorganisation of the circadian rhythmicity. Dynamic light （DL） could reset the circadian rhythm by activation of the suprachiasmatic nucleus to prevent delirium. Evidence regarding the effects of light therapy is predominantly focused on psychiatric disorders and circadian rhythm sleep disorders. In this study, we investi- gated the effect of DL on the total hospital length of stay （LOS） and occurrence of delirium in patients admitted to the Coronary Care Unit （CCU）. Methods This was a retrospective cohort study. Patients older than 18 years, who were hospitalized longer than 12 h at the CCU and had a total hospital LOS for at least 24 h, were included. Patients were assigned to a room with DL （n = 369） or regular lighting condi- tions （n = 379）. DL was administered at the CCU by two ceiling-mounted light panels delivering light with a colour temperature between 2700 and 6500 degrees Kelvin. Reported outcome data were： total hospital LOS, delirium incidence, consultation of a geriatrician and the amount of prescripted antipsychotics. Results Between May 2015 and May 2016, data from 748 patients were collected. Baseline charac- teristics, including risk factors provoking delirium, were equal in both groups. Median total hospital LOS in the DL group was 100.5 （70.8-186.0） and 101.0 （73.0-176.4） h in the control group （P = 0.935）. The incidence of delirium in the DL and control group was 5.4% （20/369） and 5.0% （19/379）, respectively （P = 0.802）. No significant differences between the DL and control group were observed in secon- dary endpoints. Subgroup analysis based on age and CCU LOS also showed no differences. Conclusion Our study suggests exposure to DL as an early single approach does not result in a reduction of total hospital LOS or reduced incidence of delirium. When delirium was diagnosed, it was associated with poor hospital outcome.

Activation-induced cell death in B lymphocytes

Upon encountering the antigen (Ag), the immune system can either develop a specific immune response or enter a specific state of unresponsiveness, tolerance. The response of B cells to their specific Ag can be activation and proliferation, leading to the immune response, or anergy and activation-induced cell death (AICD), leading to tolerance. AICD in B lymphocytes is a highly regulated event initiated by crosslinking of the B cell receptor (BCR). BCR engagement initiates several signaling events such as activation of PLCr, Ras, and PI3K, which generally speaking, lead to survival. However, in the absence of survival signals (CD40 or IL-4R engagement), BCR crosslinking can also promote apoptotic signal transduction pathways such as activation of effector caspases, expression of pro-apoptotic genes, and inhibition of pro-survival genes. The complex interplay between survival and death signals determines the B cell fate and, consequently, the immune response.

Numerical simulation of an algal bloom in Dianshan Lake

A hydrodynamic model and an aquatic ecology model of Dianshan Lake,Shanghai,were built using a hydrodynamic simulation module and the water quality simulation module of Delft3D,which is an integrated modelling suite offered by Deltares. The simulated water elevation,current velocity,and direction were validated with observed data to ensure the reliability of hydrodynamic model. The seasonal growth of different algae was analyzed with consideration of observed and historical data,as well as simulated results. In 2008,the dominant algae in Dianshan Lake was Bacillariophyta from February to March,while it was Chlorophyta from April to May,and Cyanophyta from July to August. In summer,the biomass of Cyanophyta grew quickly,reaching levels much higher than the peaks of Bacillariophyta and Chlorophyta. Algae blooms primarily occurred in the stagnation regions. This phenomenon indicates that water residence time can influence algal growth significantly. A longer water residence time was associated with higher algal growth. Two conclusions were drawn from several simulations: reducing the nutrients inflow had little effect on algal blooms in Dianshan Lake; however,increasing the discharge into Dianshan Lake could change the flow field characteristic and narrow the range of stagnation regions,resulting in inhibition of algal aggregation and propagation and a subsequent reduction in areas of high concentration algae.

Effect of behavior training on learning and memory of young rats with fetal growth restriction

Objective: To investigate the effect of behavior training on the learning and memory of young rats with fetal growth restriction (FGR). Methods: The model of FGR was established by passive smoking method to pregnant rats. The new-born rats were divided into FGR group and normal group, and then randomly subdivided into trained and untrained group respectively. Morris water maze behavior training was performed on postnatal months 2 and 4, then learning and memory abilities of young rats were measured by dark-avoidance testing and step-down testing. Results: In the dark-avoidance and step-down testing, the young rats’ performance of FGR group was worse than that of control group, and the trained group was better than the untrained group significantly. Conclusion: FGR young rats have descended learning and memory abilities. Behavior training could improve the young rats’ learning and memory abilities, especially for the FGR young rats.

Effect of Sludge Retention Time on Nitrite Accumulation in Real-time Control Biological Nitrogen Removal Sequencing Batch Reactor

In this study,four sequencing batch reactors(SBR),with the sludge retention time(SRT)of 5,10,20 and 40 d,were used to treat domestic wastewater,and the effect of SRT on nitrite accumulation in the biological nitrogen removal SBR was investigated.The real-time control strategy based on online parameters,such as pH,dissolved oxygen(DO)and oxidation reduction potential(ORP),was used to regulate the nitrite accumulation in SBR. The model-based simulation and experimental results showed that with the increase of SRT,longer time was needed to achieve high level of nitritation.In addition,the nitrite accumulation rate(NAR)was higher when the SRT was relatively shorter during a 112-day operation.When the SRT was 5 d,the system was unstable with the mixed liquor suspended solids(MLSS)decreased day after day.When the SRT was 40 d,the nitrification process was significantly inhibited.SRT of 10 to 20 d was more suitable in this study.The real-time control strategy combined with SRT control in SBR is an effective method for biological nitrogen removal via nitrite from wastewater.

Effect of Solid Retention and Hydraulic Retention Times on Membrane Fouling in Membrane Bioreactor

In this bench scale submerged membrane bioreactor, effect of solid retention time and hydraulic retention time on membrane fouling propensity has been studied. This experiment is carried out at different solid retention time of 5, 10, 30, 70 and 98 days; and fouling behavior of membrane bioreactor is investigated. Average effluent quality is found to be 88.14%-94.38%. The experiment with different hydraulic retention is carried for 3 to 4 days and fouling behavior has been investigated. The effluent quality at different hydraulic retention time of 1, 2, 3, 5, 10 and 24 hours has been investigated. This paper aims to search optimal values of solid and hydraulic retention times at which lower fouling and higher organic removal efficiency can be obtained. This study has been mainly focused on operating parameters rather than microbial structure, effect and analysis of activated sludge to membrane fouling.

Dark Fermentative H2 Production from Wastes： Effect of Operating Conditions

Hydrogen （H2） appears as one of the most promising alternative forms of energy supply, as it is non-pollutant and has a high heating value. The production of H2 by non-conventional ways, such as fermentative production, depends on economic factors and the H2 yield achieved in the process. Therefore, this review summarizes the basic aspects of hydrogen production, specifically focusing on the role of the dark fermentation process, as a way to produce this gas by biological means. The different parameters affecting the production of H2 are also discussed. The existence of different hydrogen producing microorganisms with different enzymes causes the necessity to investigate the effect of the conditions under which the process is carried out. Thus, the factors influencing the fermentative process, such as pH, temperature, inoculum pretreatment, hydraulic retention time, hydrogen partial pressure and substrate composition （metal ions, nitrogen source, etc.） are summarized.

Conflict Within the Boundary of Nature Reserve： The Case of Crocker Range Park in Sabah, Malaysia

For the formation of nature reserves can directly affect the livelihood of indigenous people living in the area, negotiation between the authority and the community is crucial to the management of the natural resources. Crocker Range Park is the largest state park in Sabah state, Malaysia. Since there is a village community living within the boundary of the nature reserve, the state government and the villagers have had a conflict over the land rights. Until the government and the village delegation reached an agreement on the park＇s management plan in 2015, three actors intervened in the conflict： PACOS Trust, Japan International Cooperation Agency （JICA）, and Japan Overseas Cooperation Volunteers （JOCV）. In this study, these interventions by different actors were analyzed with the Tripartite Conflict Management （TCM} model. The results indicate that JOCV was the sole actor that was able to communicate with both the state government and the villagers. To support the result, a preliminary research was conducted, and the villagers＇ perception was investigated through a questionnaire survey. This paper concludes that JOCV was perceived as an actor that can be trusted more than JICA and the state government. This conclusion supports the result of the analysis of TCM model.

Novel berberine derivatives:Design,synthesis,antimicrobial effects,and molecular docking studies

A series of berberine derivatives were synthesized by introducing substituted benzyl groups at C-9.All these synthesized compounds（4a–4m）were screened for their in vitro antibacterial activity against four Gram-positive bacteria and four Gram-negative bacteria and evaluated for their antifungal activity against three pathogenic fungal strains.All these compounds displayed good antibacterial and antifungal activities,compared to reference drugs including Ciprofloxacin and Fluconazole;Compounds 4f,4g,and 4l showed the highest antibacterial and antifungal activities.Moreover,all the synthesized compounds were docked into topoisomerase Ⅱ-DNA complex,which is a crucial drug target for the treatment of microbial infections.Docking results showed that H-bond,π-πstacked,π-cationic,andπ-anionic interactions were responsible for the strong binding of the compounds with the target protein-DNA complex.