Aims: Chronotropic incompetence, an attenuated heart rate(HR) response to exer cise, is an independent predictor of cardiovascular mortality, but it is not kno wn whether chronotropic incompetence is related to caroti...Aims: Chronotropic incompetence, an attenuated heart rate(HR) response to exer cise, is an independent predictor of cardiovascular mortality, but it is not kno wn whether chronotropic incompetence is related to carotid atherosclerosis. The association between chronotropic incompetence and carotid atherosclerosis in 856 7(age 47.6±8.8 years) healthy men was examined. Methods and results: Chronotrop ic incompetence was defined as the failure to achieve 85%of the age-predicted maximal HR(APMHR),< 80%HR reserve(HRR), and chronotropic response index(CRI). C arotid atherosclerosis was defined, using B-mode ultrasonography, as stenosis > 25%and/or intima-media thickness(IMT) of >1.2 mm. In multivariable adjusted lo gistic regression models, the subjects who achieved less than 85%of APMHR exhib ited an odds ratio(OR) of 1.72[95%confidence intervals(CI): 1.32-2.22] for car otid atherosclerosis. Subjects with< 80%of HRR were 1.45(95%CI: 1.14-1.84) ti mes more likely to have carotid atherosclerosis after multivariate adjustment. A lso, the OR of carotid atherosclerosis across quartiles of CRI(highest to lowest ) was 1.51(95%CI: 1.10-2.09) after multivariate adjustment. Conclusion: These results suggest that the chronotropic response to exercise is associated with ca rotid atherosclerosis, independent of the established risk factors in healthy me n, which could contribute to high incidence of cardiovascular diseases in subjec ts with chronotropic incompetence.展开更多
目的探讨长期吸烟对健康中年男性血液炎性因子和动脉硬化的影响。方法纳入健康检查的中年男性吸烟组42人和非吸烟组42人,记录两组动脉硬化危险因子水平;同时检测白介素-6(IL-6)和高敏C蛋白(Hs-CRP);应用二维超声测量双侧颈动脉内膜中层...目的探讨长期吸烟对健康中年男性血液炎性因子和动脉硬化的影响。方法纳入健康检查的中年男性吸烟组42人和非吸烟组42人,记录两组动脉硬化危险因子水平;同时检测白介素-6(IL-6)和高敏C蛋白(Hs-CRP);应用二维超声测量双侧颈动脉内膜中层厚度(IMT)及斑块情况。结果两组间各动脉硬化危险因子差异均无统计学意义(P>0.05)。吸烟组的各项炎性因子水平与非吸烟组比较,IL-6(1.46±0.27 vs1.21±0.24)、Hs-CRP(6.57±2.47 vs 3.14±2.07)、白细胞(5.78±0.79 vs 5.25±0.64)和中性粒细胞(3.40±0.45 vs 2.87±0.42)均高于非吸烟组(P均<0.01);同时,吸烟组的颈动脉IMT比非吸烟组厚(1.01±0.18 vs 0.82±0.16,P<0.01),斑块检出率高于非吸烟组(73.81%vs 33.33%,P<0.01),颈动脉狭窄率也高于非吸烟组(19.00%vs 0.00%,P<0.01)。结论长期吸烟不仅导致健康中年男性体内炎性因子增高,而且加重其动脉粥样硬化程度。长期吸烟的健康中年男性是潜在的心血管疾病患者。展开更多
文摘Aims: Chronotropic incompetence, an attenuated heart rate(HR) response to exer cise, is an independent predictor of cardiovascular mortality, but it is not kno wn whether chronotropic incompetence is related to carotid atherosclerosis. The association between chronotropic incompetence and carotid atherosclerosis in 856 7(age 47.6±8.8 years) healthy men was examined. Methods and results: Chronotrop ic incompetence was defined as the failure to achieve 85%of the age-predicted maximal HR(APMHR),< 80%HR reserve(HRR), and chronotropic response index(CRI). C arotid atherosclerosis was defined, using B-mode ultrasonography, as stenosis > 25%and/or intima-media thickness(IMT) of >1.2 mm. In multivariable adjusted lo gistic regression models, the subjects who achieved less than 85%of APMHR exhib ited an odds ratio(OR) of 1.72[95%confidence intervals(CI): 1.32-2.22] for car otid atherosclerosis. Subjects with< 80%of HRR were 1.45(95%CI: 1.14-1.84) ti mes more likely to have carotid atherosclerosis after multivariate adjustment. A lso, the OR of carotid atherosclerosis across quartiles of CRI(highest to lowest ) was 1.51(95%CI: 1.10-2.09) after multivariate adjustment. Conclusion: These results suggest that the chronotropic response to exercise is associated with ca rotid atherosclerosis, independent of the established risk factors in healthy me n, which could contribute to high incidence of cardiovascular diseases in subjec ts with chronotropic incompetence.
文摘目的探讨长期吸烟对健康中年男性血液炎性因子和动脉硬化的影响。方法纳入健康检查的中年男性吸烟组42人和非吸烟组42人,记录两组动脉硬化危险因子水平;同时检测白介素-6(IL-6)和高敏C蛋白(Hs-CRP);应用二维超声测量双侧颈动脉内膜中层厚度(IMT)及斑块情况。结果两组间各动脉硬化危险因子差异均无统计学意义(P>0.05)。吸烟组的各项炎性因子水平与非吸烟组比较,IL-6(1.46±0.27 vs1.21±0.24)、Hs-CRP(6.57±2.47 vs 3.14±2.07)、白细胞(5.78±0.79 vs 5.25±0.64)和中性粒细胞(3.40±0.45 vs 2.87±0.42)均高于非吸烟组(P均<0.01);同时,吸烟组的颈动脉IMT比非吸烟组厚(1.01±0.18 vs 0.82±0.16,P<0.01),斑块检出率高于非吸烟组(73.81%vs 33.33%,P<0.01),颈动脉狭窄率也高于非吸烟组(19.00%vs 0.00%,P<0.01)。结论长期吸烟不仅导致健康中年男性体内炎性因子增高,而且加重其动脉粥样硬化程度。长期吸烟的健康中年男性是潜在的心血管疾病患者。
