目的:分析青光眼患者手术治疗后与健康相关的生活质量(health-related quality of life,HRQOL下降的相关因素。方法:收集苏州大学附属高邮医院2014年2月至2017年12月确诊为青光眼的患者86例,进行前瞻性队列研究。所有患者填写3份HRQOL...目的:分析青光眼患者手术治疗后与健康相关的生活质量(health-related quality of life,HRQOL下降的相关因素。方法:收集苏州大学附属高邮医院2014年2月至2017年12月确诊为青光眼的患者86例,进行前瞻性队列研究。所有患者填写3份HRQOL问卷调查:25项国家眼科研究所视觉功能问卷调查(25-item National Eye Institute Visual Function Questionnaire,NEI-VFQ25)、中国成人斜视生存质量评估量表(Chinses Adult Strabismus Questionnaire,CAS-20)和复视问卷(DiplopiaQ u est i o n na i re,D Q)调查。8 6例患者中37例接受了小梁切除术,其余4 9例接受药物治疗。多元回归分析与HRQOL相关的因素包括性别、年龄、治疗方式、视野、视力和复视等对HRQOL下降的影响。结果:86例患者中有51例女性,35例男性,女性占比59%;年龄(65±10)岁,视野的平均偏差(meandeviation,MD)是-13(10)d B。HRQOL的下降与严重的复视[DQ得分,部分r2的范围(rp2)为0. 2 0 7～0. 0 6 9]、最佳眼的M D降低(rp2范围为0.379～0.027)、最差眼的M D降低(rp2范围为0.242～0.046)、治疗方式(rp2范围为0.190～0.025)、最差眼的视力下降(rp2范围为0.063～0.025)、最佳眼的视力下降(rp2范围为0.032～0.017)以及较早的发病年龄(rp2范围为0.021～0.014)有关。在调整分析中,CA S-20量表的得分提示与药物治疗相比较,小梁切除术会导致更显著的HRQOL下降。结论:在青光眼患者中,无论是接受手术还是药物治疗,HRQOL的下降都很常见,其与更严重的复视、较低的视野平均偏差、双眼视力较差、治疗方式和较早的发病年龄有关。与药物治疗相比,小梁切除术与HRQOL的降低显著相关,在临床上选择手术方式时应该慎重考虑。展开更多
目的:探讨经尿道前列腺切除术(transurethral resection of prostate,TURP)治疗前列腺增生患者术后的健康相关生活质量(health-related quality of life,HRQoL)、心理健康状况和性功能,并确定这组患者HRQoL的预测因子。方法:采取横断面...目的:探讨经尿道前列腺切除术(transurethral resection of prostate,TURP)治疗前列腺增生患者术后的健康相关生活质量(health-related quality of life,HRQoL)、心理健康状况和性功能,并确定这组患者HRQoL的预测因子。方法:采取横断面研究、描述性研究和相关性研究。共纳入80例良性前列腺增生(benign prostatic hyperplasia,BPH)手术患者,来源于南通大学附属海安医院的泌尿外科。简明12项健康调查表(12 variables of the Health Survey,SF-12v2)、国际前列腺症状评分表(International Prostate Symptom Score,IPSS)、医院焦虑和抑郁量表(Hospital Anxiety and DepressionScale,HADS)、国际勃起功能5项指标(InternationalIndexofErectileFunction,IIEF-5)评分作为研究变量。结果:经SF-12v2评估,患者身体健康状况普遍较差,精神健康状况较好。实施TURP,超过1/4的患者出现中度下尿路症状(lower urinary tract symptoms,LUTS),13.8%的患者出现严重的勃起功能障碍。通过多元线性回归分析发现:LUTS(B=-0.51,P=0.02)和最大尿流率(B=-0.23,P=0.02)预测身体健康差,占方差的45.9%,而有焦虑(B=-1.07,P<0.01)和LUTS(B=-0.32,P=0.03)预测心理健康差,占57.2%的方差。结论:TURP患者身体健康状况不佳,多为中度LUTS,存在性功能障碍,临床医护人员应对那些有较低尿流率或有焦虑症症状的严重LUTS患者给予更多的关注,从而帮助患者维持和建立社会支持系统,改善不良的心理状态。展开更多
EORTC QLQ-OG 25(The Europe Organization for Research and Treatment of Cancer,Quality of Life Questionnaire-OG 25)结合了评估食道癌(QLQ-OG 18)和胃癌(QLQ-STO 22)患者的与健康相关的生活质量(health-related quality of life,H...EORTC QLQ-OG 25(The Europe Organization for Research and Treatment of Cancer,Quality of Life Questionnaire-OG 25)结合了评估食道癌(QLQ-OG 18)和胃癌(QLQ-STO 22)患者的与健康相关的生活质量(health-related quality of life,HRQL)量表,成为欧洲癌症治疗研究组织(EORTC)生活质量研究小组用于评估食道癌(EC)、食管胃交界癌(EGJC)和胃癌(GC)患者HRQL的有效工具。该量表已在欧美部分国家使用,被验证是可靠的、有效的、敏感的,而一部分非欧美国家和地区的医疗机构已经对其进行了本土化验证与运用,中国对于该量表的研究仍处于起步阶段,本文将对EORTC QLQ-OG 25的发展进行一个详细的阐述。展开更多
AIM To assess the validity and reliability of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Colorectal Cancer 29 (EORTC QLQ-CR29) in Chinese patients with colorectal canc...AIM To assess the validity and reliability of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Colorectal Cancer 29 (EORTC QLQ-CR29) in Chinese patients with colorectal cancer (CRC). METHODS From March 2014 to January 2015, 356 patients with CRC from four different hospitals in China were enrolled in the study, and all patients self-administered the EORTC QLQ-CR29 and the quality of life core questionnaire (EORTC QLQ-C30). Evaluation of the scores was based on the Karnofsky Performance Scale (KPS). The reliability and validity of the questionnaires were assessed by Cronbach's proportional to coefficient, the Spearman correlation test and Wilcoxon rank sum test. RESULTS The EORTC QLQ-CR29 showed satisfactory reliability (proportional to > 0.7), although the urinary frequency and blood and mucus in stool dimensions had only moderate reliability (proportional to = 0.608). The multitrait scaling analyses showed good convergent (r > 0.4) and discriminant validity. Significant differences were obtained for each item in the different KPS subgroups (KPS <= 80; KPS > 80). Body image and most single- item dimensions showed statistically significant differences in patients with a stoma compared with the rest of the patients. CONCLUSION The EORTC QLQ-CR29 exhibits high validity and reliability in Chinese patients with CRC, and can therefore be recommended as a valuable tool for the assessment of quality of life in these patients.展开更多
AIMTo investigate the health-related quality of life (HRQoL) of patients suffering with idiopathic inflammatory bowel disease (IBD).METHODSThe Greek validated version of the Short Inflammatory Bowel Disease Questionna...AIMTo investigate the health-related quality of life (HRQoL) of patients suffering with idiopathic inflammatory bowel disease (IBD).METHODSThe Greek validated version of the Short Inflammatory Bowel Disease Questionnaire was used for evaluating the quality of life of IBD patients. The questionnaire was distributed to 100 consecutive patients suffering from IBD and presenting for a clinic appointment at the endoscopy unit of Larnaca General Hospital during the period from October to November 2012. The criteria for participating in this study were constituted by the documented diagnosis of either ulcerative colitis (UC) or Crohn’s disease (CD) after endoscopy and histologic examination at least 6 months before the study, adult patients (18 years old or older), the capability of verbal communication and the patient’s written consent for attending this study. The majority of the questionnaires were completed by a nurse practitioner who specializes in IBD patient care.RESULTSRegarding the physical dimension in patients with UC, males scored significantly higher than females (4.2 vs 3.4, P = 0.023). Higher scores were also observed in UC patients younger than 35 or older than 50 years (4.0 and 4.2 vs 3.2, respectively, P = 0.021). The psychological dimension revealed similar results in patients with UC, with males, and older ages scoring higher (5.0 vs 3.0, P = 0.01 and 4.7 vs 2.7, P < 0.5, respectively), whereas regarding CD higher scores were observed in married compared to unmarried (3.83 vs 2.33, P = 0.042). No statistical differences in any parameters in the social dimension were observed. Regarding the treatment of, patients with CD, overall higher scores were observed when treated with biological factors compared to standard therapy in all dimensions but with statistical significant difference in the social dimension (5.00 vs 3.25, P = 0.045).CONCLUSIONThe study reveals a negative impact of IBD on HRQoL. Increased risks are age and gender in patients with UC and family status in patients with CD.展开更多
AIM To investigate the possible long-term psychological harm of participating in colorectal cancer(CRC)screening in Norway.METHODS In a prospective, randomized trial, 14294 participants(aged 50-74 years) were invited ...AIM To investigate the possible long-term psychological harm of participating in colorectal cancer(CRC)screening in Norway.METHODS In a prospective, randomized trial, 14294 participants(aged 50-74 years) were invited to either flexible sigmoidoscopy(FS) screening, or a faecal immunochemical test(FIT)(1:1). In total, 4422 screening participants(32%) completed the questionnaire, which consisted of the Hospital Anxiety and Depression Scale and the SF-12, a generic health-related quality of life(HRQOL) measurement, when invited to screening and one year after the invitation. A control group of 7650 individuals was invited to complete the questionnaire only, at baseline and one year after, and 1911(25%) completed the questionnaires.RESULTS Receiving a positive or negative screening result and participating in the two different screening modalities did not cause clinically relevant mean changes in anxiety, depression or HRQOL after one year. FS screening, but not FIT, was associated with an increased probability of being an anxiety case(score ≥ 8) at the one-year follow-up(5.6% of FS participants transitioned from being not anxious to anxious, while 3.0% experienced the reverse). This increase was moderately significantly different from the changes in the control group(in which the corresponding numbers were 4.8% and 4.5%, respectively), P = 0.06. CONCLUSION Most individuals do not experience psychological effects of CRC screening participation after one year, while FS participation is associated with increased anxiety for a smaller group.展开更多
文摘目的:分析青光眼患者手术治疗后与健康相关的生活质量(health-related quality of life,HRQOL下降的相关因素。方法:收集苏州大学附属高邮医院2014年2月至2017年12月确诊为青光眼的患者86例,进行前瞻性队列研究。所有患者填写3份HRQOL问卷调查:25项国家眼科研究所视觉功能问卷调查(25-item National Eye Institute Visual Function Questionnaire,NEI-VFQ25)、中国成人斜视生存质量评估量表(Chinses Adult Strabismus Questionnaire,CAS-20)和复视问卷(DiplopiaQ u est i o n na i re,D Q)调查。8 6例患者中37例接受了小梁切除术,其余4 9例接受药物治疗。多元回归分析与HRQOL相关的因素包括性别、年龄、治疗方式、视野、视力和复视等对HRQOL下降的影响。结果:86例患者中有51例女性,35例男性,女性占比59%;年龄(65±10)岁,视野的平均偏差(meandeviation,MD)是-13(10)d B。HRQOL的下降与严重的复视[DQ得分,部分r2的范围(rp2)为0. 2 0 7～0. 0 6 9]、最佳眼的M D降低(rp2范围为0.379～0.027)、最差眼的M D降低(rp2范围为0.242～0.046)、治疗方式(rp2范围为0.190～0.025)、最差眼的视力下降(rp2范围为0.063～0.025)、最佳眼的视力下降(rp2范围为0.032～0.017)以及较早的发病年龄(rp2范围为0.021～0.014)有关。在调整分析中,CA S-20量表的得分提示与药物治疗相比较,小梁切除术会导致更显著的HRQOL下降。结论:在青光眼患者中,无论是接受手术还是药物治疗,HRQOL的下降都很常见,其与更严重的复视、较低的视野平均偏差、双眼视力较差、治疗方式和较早的发病年龄有关。与药物治疗相比,小梁切除术与HRQOL的降低显著相关,在临床上选择手术方式时应该慎重考虑。
文摘目的:探讨经尿道前列腺切除术(transurethral resection of prostate,TURP)治疗前列腺增生患者术后的健康相关生活质量(health-related quality of life,HRQoL)、心理健康状况和性功能,并确定这组患者HRQoL的预测因子。方法:采取横断面研究、描述性研究和相关性研究。共纳入80例良性前列腺增生(benign prostatic hyperplasia,BPH)手术患者,来源于南通大学附属海安医院的泌尿外科。简明12项健康调查表(12 variables of the Health Survey,SF-12v2)、国际前列腺症状评分表(International Prostate Symptom Score,IPSS)、医院焦虑和抑郁量表(Hospital Anxiety and DepressionScale,HADS)、国际勃起功能5项指标(InternationalIndexofErectileFunction,IIEF-5)评分作为研究变量。结果:经SF-12v2评估,患者身体健康状况普遍较差,精神健康状况较好。实施TURP,超过1/4的患者出现中度下尿路症状(lower urinary tract symptoms,LUTS),13.8%的患者出现严重的勃起功能障碍。通过多元线性回归分析发现:LUTS(B=-0.51,P=0.02)和最大尿流率(B=-0.23,P=0.02)预测身体健康差,占方差的45.9%,而有焦虑(B=-1.07,P<0.01)和LUTS(B=-0.32,P=0.03)预测心理健康差,占57.2%的方差。结论:TURP患者身体健康状况不佳,多为中度LUTS,存在性功能障碍,临床医护人员应对那些有较低尿流率或有焦虑症症状的严重LUTS患者给予更多的关注,从而帮助患者维持和建立社会支持系统,改善不良的心理状态。
文摘EORTC QLQ-OG 25(The Europe Organization for Research and Treatment of Cancer,Quality of Life Questionnaire-OG 25)结合了评估食道癌(QLQ-OG 18)和胃癌(QLQ-STO 22)患者的与健康相关的生活质量(health-related quality of life,HRQL)量表,成为欧洲癌症治疗研究组织(EORTC)生活质量研究小组用于评估食道癌(EC)、食管胃交界癌(EGJC)和胃癌(GC)患者HRQL的有效工具。该量表已在欧美部分国家使用,被验证是可靠的、有效的、敏感的,而一部分非欧美国家和地区的医疗机构已经对其进行了本土化验证与运用,中国对于该量表的研究仍处于起步阶段,本文将对EORTC QLQ-OG 25的发展进行一个详细的阐述。
基金Supported by Science&Technology Innovation Commission of Shenzhen(to Lin JB)No.201404113000346 and No.JCYJ20140411150916744+1 种基金the Science &Technology Project of Shenzhen Longgang District,No.201406063001007 and No.YLWS20140606101914846the Science &Technology Project of Shenzhen Longgang District,No.20160607153104624(to Zhang YF)
文摘AIM To assess the validity and reliability of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Colorectal Cancer 29 (EORTC QLQ-CR29) in Chinese patients with colorectal cancer (CRC). METHODS From March 2014 to January 2015, 356 patients with CRC from four different hospitals in China were enrolled in the study, and all patients self-administered the EORTC QLQ-CR29 and the quality of life core questionnaire (EORTC QLQ-C30). Evaluation of the scores was based on the Karnofsky Performance Scale (KPS). The reliability and validity of the questionnaires were assessed by Cronbach's proportional to coefficient, the Spearman correlation test and Wilcoxon rank sum test. RESULTS The EORTC QLQ-CR29 showed satisfactory reliability (proportional to > 0.7), although the urinary frequency and blood and mucus in stool dimensions had only moderate reliability (proportional to = 0.608). The multitrait scaling analyses showed good convergent (r > 0.4) and discriminant validity. Significant differences were obtained for each item in the different KPS subgroups (KPS <= 80; KPS > 80). Body image and most single- item dimensions showed statistically significant differences in patients with a stoma compared with the rest of the patients. CONCLUSION The EORTC QLQ-CR29 exhibits high validity and reliability in Chinese patients with CRC, and can therefore be recommended as a valuable tool for the assessment of quality of life in these patients.
文摘AIMTo investigate the health-related quality of life (HRQoL) of patients suffering with idiopathic inflammatory bowel disease (IBD).METHODSThe Greek validated version of the Short Inflammatory Bowel Disease Questionnaire was used for evaluating the quality of life of IBD patients. The questionnaire was distributed to 100 consecutive patients suffering from IBD and presenting for a clinic appointment at the endoscopy unit of Larnaca General Hospital during the period from October to November 2012. The criteria for participating in this study were constituted by the documented diagnosis of either ulcerative colitis (UC) or Crohn’s disease (CD) after endoscopy and histologic examination at least 6 months before the study, adult patients (18 years old or older), the capability of verbal communication and the patient’s written consent for attending this study. The majority of the questionnaires were completed by a nurse practitioner who specializes in IBD patient care.RESULTSRegarding the physical dimension in patients with UC, males scored significantly higher than females (4.2 vs 3.4, P = 0.023). Higher scores were also observed in UC patients younger than 35 or older than 50 years (4.0 and 4.2 vs 3.2, respectively, P = 0.021). The psychological dimension revealed similar results in patients with UC, with males, and older ages scoring higher (5.0 vs 3.0, P = 0.01 and 4.7 vs 2.7, P < 0.5, respectively), whereas regarding CD higher scores were observed in married compared to unmarried (3.83 vs 2.33, P = 0.042). No statistical differences in any parameters in the social dimension were observed. Regarding the treatment of, patients with CD, overall higher scores were observed when treated with biological factors compared to standard therapy in all dimensions but with statistical significant difference in the social dimension (5.00 vs 3.25, P = 0.045).CONCLUSIONThe study reveals a negative impact of IBD on HRQoL. Increased risks are age and gender in patients with UC and family status in patients with CD.
基金Supported by the Ministry of Health and Care Services in Norway
文摘AIM To investigate the possible long-term psychological harm of participating in colorectal cancer(CRC)screening in Norway.METHODS In a prospective, randomized trial, 14294 participants(aged 50-74 years) were invited to either flexible sigmoidoscopy(FS) screening, or a faecal immunochemical test(FIT)(1:1). In total, 4422 screening participants(32%) completed the questionnaire, which consisted of the Hospital Anxiety and Depression Scale and the SF-12, a generic health-related quality of life(HRQOL) measurement, when invited to screening and one year after the invitation. A control group of 7650 individuals was invited to complete the questionnaire only, at baseline and one year after, and 1911(25%) completed the questionnaires.RESULTS Receiving a positive or negative screening result and participating in the two different screening modalities did not cause clinically relevant mean changes in anxiety, depression or HRQOL after one year. FS screening, but not FIT, was associated with an increased probability of being an anxiety case(score ≥ 8) at the one-year follow-up(5.6% of FS participants transitioned from being not anxious to anxious, while 3.0% experienced the reverse). This increase was moderately significantly different from the changes in the control group(in which the corresponding numbers were 4.8% and 4.5%, respectively), P = 0.06. CONCLUSION Most individuals do not experience psychological effects of CRC screening participation after one year, while FS participation is associated with increased anxiety for a smaller group.
