胡桃醌衍生物的合成

用对苯二酚与马来酸酐在高温下进行傅-克反应合成了5,8-二羟基-1,4-萘醌(Ⅰ).从核磁共振谱确定了它的分子结构是一个十分对称的共振杂化体.在同样的反应条件下,合成了5-羟基-8-甲基-1,4-萘醌(Ⅱ).用α-溴代-2′,3′,4′,6′-四-O-乙酰吡喃葡萄糖与5,8-二羟基-1,4-萘醌反应,合成了8-(5-羟基-1,4-萘醌基)-2′,3′,4′,6′-四-O-乙酰基-β-D-吡喃葡萄糖苷(Ⅲ),(Ⅲ)是新化合物.以上化合物通过IR、~1H-NMR、^(13)C-NMR、MS谱确定了它们的结构.

6-溴-1-乙酰芘的合成研究

以1-溴芘为原料,经傅瑞德尔-克拉夫茨(Friedel-Crafts)酰基化反应,以无水三氯化铝为催化剂,乙酰氯为酰基化试剂,合成了6-溴-1-乙酰芘.讨论了温度、催化剂用量、原料与试剂比等诸因素对反应的影响,并经元素分析、IR、1HNMR对其结构进行了表征.

Enantioselective synthesis of quaternary α-aminophosphonates by organocatalytic Friedel–Crafts reactions of indoles with cyclicα-ketiminophosphonates

An efficient asymmetric Friedel-Crafts reaction has been developed for the synthesis of optically active quaternaryα‐aminophosphonates with up to98%ee.The synthesis involves the reaction of cyclicα‐ketiminophosphonates with indoles using an H8‐BINOL‐derived chiral phosphoric acid(CPA)catalyst that bears electron‐withdrawing3,5‐ditrifluoromethylphenyl substituents on its3‐and3′‐positions.This Friedel-Crafts reaction of cyclicα‐ketiminophosphonates was also successful with pyrrole.