目的探讨阿立哌唑和利培酮对于治疗女性精神分裂症患者的疗效。方法选取2022年7月—2023年7月福建省福州神经精神病防治院符合入组条件的85例女性精神分裂症住院患者。随机分为阿立哌唑组和利培酮组,阿立哌唑42例给予阿立哌唑治疗,利培...目的探讨阿立哌唑和利培酮对于治疗女性精神分裂症患者的疗效。方法选取2022年7月—2023年7月福建省福州神经精神病防治院符合入组条件的85例女性精神分裂症住院患者。随机分为阿立哌唑组和利培酮组,阿立哌唑42例给予阿立哌唑治疗,利培酮组43例给予利培酮治疗。比较2组在治疗前、治疗8周后阳性与阴性症状量表(positive and negative syndrome scale,PANSS)评分、P300成分、血清催乳素水平。结果治疗前,2组PANSS量表评分比较,差异无统计学意义(P>0.05);治疗后,2组PANSS量表评分比较,差异无统计学意义(P>0.05);治疗后,2组PANSS量表评分低于治疗前,差异有统计学意义(P<0.05)。治疗后,2组P300波幅均高于治疗前,差异有统计学意义(P<0.05);2组P300潜伏期与治疗前比较,差异无统计学意义(P>0.05)。治疗前,2组血清催乳素水平比较,差异无统计学意义(P>0.05);治疗后,利培酮组的血清催乳素水平为(37.785±6.068)ng/mL,高于阿立哌唑组的(28.433±5.288)ng/mL与治疗前的(25.522±5.200)ng/mL,差异有统计学意义(P<0.05)。结论阿立哌唑和利培酮作为疗效较好的临床抗精神病药物,能够有效且快速地控制临床精神症状(阴性症状和阳性症状),改善认知功能;阿立哌唑基本不引起血清催乳素水平升高,更适合推荐女性患者服用。展开更多
In 1970 a 20 year Mld woman presented with a pituitary chromophobe adenoma for which she underwent transfrontal pituitary surgery. In 1978 she had to be reope rated on because of local tumour recurrence, resulting in ...In 1970 a 20 year Mld woman presented with a pituitary chromophobe adenoma for which she underwent transfrontal pituitary surgery. In 1978 she had to be reope rated on because of local tumour recurrence, resulting in hypopituitarism. Bromo criptine (5 mg/day) was given for 15 years, but the plasma prolactin levels rema ined elevated. In 2000 the patient presented with signs and symptoms suggestive of a spinal cord lesion at the mid thoracic level. A magnetic resonance imaging (MRI) scan showed an extensive leptomeningeal mass extending from the brainstem to L5, with a thoracic syringomyelia at the T7 T8 level. The plasma prolactin level was very high (5114 μg/l). A biopsy showed the presence of a metastasised prolactinoma. On administration of high dose cabergoline, 0.5 mg twice a day or ally, the plasma prolactin levels decreased within one month and then normalised within 26 months. Tumour load reduced considerably but unfortunately, her signs and symptoms did not improve. This case illustrates that a high dose dopamine a gonist might be an important therapeutic option in patients with a metastasised prolactinoma.展开更多
9713921 在绝经后妇女饮酒、身高和肥胖与雄激素、催乳素水平的关系/Hankin-son S E//J Nat Cancer Inst.-1995,87(17).-1297～1302 重医图9713922 超声子宫造影术(SHG)检索子宫腔内病变的试探[日]/藤肋伸一郎//日产妇会志.-1995,47(4).
文摘目的探讨阿立哌唑和利培酮对于治疗女性精神分裂症患者的疗效。方法选取2022年7月—2023年7月福建省福州神经精神病防治院符合入组条件的85例女性精神分裂症住院患者。随机分为阿立哌唑组和利培酮组,阿立哌唑42例给予阿立哌唑治疗,利培酮组43例给予利培酮治疗。比较2组在治疗前、治疗8周后阳性与阴性症状量表(positive and negative syndrome scale,PANSS)评分、P300成分、血清催乳素水平。结果治疗前,2组PANSS量表评分比较,差异无统计学意义(P>0.05);治疗后,2组PANSS量表评分比较,差异无统计学意义(P>0.05);治疗后,2组PANSS量表评分低于治疗前,差异有统计学意义(P<0.05)。治疗后,2组P300波幅均高于治疗前,差异有统计学意义(P<0.05);2组P300潜伏期与治疗前比较,差异无统计学意义(P>0.05)。治疗前,2组血清催乳素水平比较,差异无统计学意义(P>0.05);治疗后,利培酮组的血清催乳素水平为(37.785±6.068)ng/mL,高于阿立哌唑组的(28.433±5.288)ng/mL与治疗前的(25.522±5.200)ng/mL,差异有统计学意义(P<0.05)。结论阿立哌唑和利培酮作为疗效较好的临床抗精神病药物,能够有效且快速地控制临床精神症状(阴性症状和阳性症状),改善认知功能;阿立哌唑基本不引起血清催乳素水平升高,更适合推荐女性患者服用。
文摘In 1970 a 20 year Mld woman presented with a pituitary chromophobe adenoma for which she underwent transfrontal pituitary surgery. In 1978 she had to be reope rated on because of local tumour recurrence, resulting in hypopituitarism. Bromo criptine (5 mg/day) was given for 15 years, but the plasma prolactin levels rema ined elevated. In 2000 the patient presented with signs and symptoms suggestive of a spinal cord lesion at the mid thoracic level. A magnetic resonance imaging (MRI) scan showed an extensive leptomeningeal mass extending from the brainstem to L5, with a thoracic syringomyelia at the T7 T8 level. The plasma prolactin level was very high (5114 μg/l). A biopsy showed the presence of a metastasised prolactinoma. On administration of high dose cabergoline, 0.5 mg twice a day or ally, the plasma prolactin levels decreased within one month and then normalised within 26 months. Tumour load reduced considerably but unfortunately, her signs and symptoms did not improve. This case illustrates that a high dose dopamine a gonist might be an important therapeutic option in patients with a metastasised prolactinoma.
文摘9713921 在绝经后妇女饮酒、身高和肥胖与雄激素、催乳素水平的关系/Hankin-son S E//J Nat Cancer Inst.-1995,87(17).-1297～1302 重医图9713922 超声子宫造影术(SHG)检索子宫腔内病变的试探[日]/藤肋伸一郎//日产妇会志.-1995,47(4).
