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新技术、新方法在病理学中的应用 被引量:5
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作者 王文勇 黄晓峰 +1 位作者 闫庆国 王伯沄 《临床与实验病理学杂志》 CAS CSCD 北大核心 2012年第8期909-911,共3页
随着科学技术的发展,新技术、新方法层出不穷,许多新的技术和方法已广泛应用于医学各领域,如用于肿瘤基因表达谱分析的基因芯片技术、分层表达扫描(layeredexpressionscanning,LES)分析技术等。本文简要介绍显色原位杂交和荧光原... 随着科学技术的发展,新技术、新方法层出不穷,许多新的技术和方法已广泛应用于医学各领域,如用于肿瘤基因表达谱分析的基因芯片技术、分层表达扫描(layeredexpressionscanning,LES)分析技术等。本文简要介绍显色原位杂交和荧光原位杂交技术、基因芯片技术、生物信息学技术、多光谱成像技术以及分子成像技术在病理学领域的应用。 展开更多
关键词 病理学 原位杂交 基因芯片 生物信息学 多光谱成 像分子成像
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Optical Molecular Imaging Frontiers in Oncology: The Pursuit of Accuracy and Sensitivity 被引量:1
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作者 Kun Wang Chongwei Chi +8 位作者 Zhenhua Hu Muhan Liu Hui Hui Wenting Shang Dong Peng Shuang Zhang Jiezuo Ye Haixiao Liu Jie Tian 《Engineering》 SCIE EI 2015年第3期309-323,共15页
Cutting-edge technologies in optical molecular imaging have ushered in new frontiers in cancer research, clinical translation, and medical practice, as evidenced by recent advances in optical multimodality imaging, Ce... Cutting-edge technologies in optical molecular imaging have ushered in new frontiers in cancer research, clinical translation, and medical practice, as evidenced by recent advances in optical multimodality imaging, Cerenkov luminescence imaging(CLI), and optical imageguided surgeries. New abilities allow in vivo cancer imaging with sensitivity and accuracy that are unprecedented in conventional imaging approaches. The visualization of cellular and molecular behaviors and events within tumors in living subjects is improving our deeper understanding of tumors at a systems level. These advances are being rapidly used to acquire tumor-to-tumor molecular heterogeneity, both dynamically and quantitatively, as well as to achieve more effective therapeutic interventions with the assistance of real-time imaging. In the era of molecular imaging, optical technologies hold great promise to facilitate the development of highly sensitive cancer diagnoses as well as personalized patient treatment—one of the ultimate goals of precision medicine. 展开更多
关键词 optical molecular imaging multimodality molecular imaging optical multimodality tomography Cerenkov luminescence imaging intraoperative image-guided surgery
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Optical molecular imaging for detection of Barrett's-associated neoplasia 被引量:3
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作者 Nadhi Thekkek Sharmila Anandasabapathy Rebecca Richards-Kortum 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第1期53-62,共10页
Recent advancements in the endoscopic imaging of Barrett's esophagus can be used to probe a wide range of optical properties that are altered with neoplastic progression.This review summarizes relevant changes in ... Recent advancements in the endoscopic imaging of Barrett's esophagus can be used to probe a wide range of optical properties that are altered with neoplastic progression.This review summarizes relevant changes in optical properties as well as imaging approaches that measures those changes.Wide-field imaging approaches include narrow-band imaging that measures changes in light scattering and absorption,and autofluorescence imaging that measure changes in endogenous fluorophores.High-resolution imaging approaches include optical coherence tomography,endocytoscopy,confocal microendoscopy,and high-resolution microendoscopy.These technologies,some coupled with an appropriate contrast agent,can measure differences in glandular morphology,nuclear morphology,or vascular alterations associated with neoplasia.Advances in targeted contrast agents are further discussed.Studies that have explored these technologies are highlighted;as are the advantages and limitations of each. 展开更多
关键词 Barrett's esophagus Barrett's metaplasia DYSPLASIA Esophageal adenocarcinoma ENDOSCOPY Imaging
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Historical Development in Soil Micromorphological Imaging 被引量:2
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作者 A.R.Mermut 《Journal of Mountain Science》 SCIE CSCD 2009年第2期107-112,共6页
The book "micropedolog" by Kubieana and a large number of publications has induced many people to practice soil micromorphology. Quantification of the soil fabric and its components was a major challenge. The use of... The book "micropedolog" by Kubieana and a large number of publications has induced many people to practice soil micromorphology. Quantification of the soil fabric and its components was a major challenge. The use of the image analyses in soil science was a breakthrough. Attempts to make soil thin sections go back to the beginning of the 2oth century. Microscopic techniques and recently high resolution electron microscope and use of computer assisted imaging techniques enabled the in vitro study of soils in three dimensional levels. It is now possible to store and process massive amounts of data. Micro- morphological concepts and techniques are applied in paleopedological, ecological, and archaeological studies. The aim of this work was to examine soil micromorphological imaging in historical perspective. 展开更多
关键词 Soil micromorphology quantification imaging techniques HISTORY
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A Three-Dimensional Velocity-Map Imaging Setup Designed for Crossed Ion-Molecule Scattering Studies
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作者 Guo-dong Zhang Li-chang Guan +2 位作者 Zi-feng Yan Min Cheng Hong Gao 《Chinese Journal of Chemical Physics》 SCIE CAS CSCD 2021年第1期71-80,I0011,共11页
In this study,we report the design and simulation of an electrostatic ion lens system consisting of 22 round metal plates.The opening of the extractor plate is covered withmetal mesh,which is for shielding the interac... In this study,we report the design and simulation of an electrostatic ion lens system consisting of 22 round metal plates.The opening of the extractor plate is covered withmetal mesh,which is for shielding the interaction region of the lens system from the high DC voltages applied to all other plates than the repeller and extractor plates.The Simion simulation shows that both velocity-mapping and time focusing can be achieved simultaneously when appropriate voltages are applied to each of the plates.This makes the ion lens system be able to focus large ionic volumes in all three dimensions,which is an essential requirement for crossed ion-molecule scattering studies.A three-dimensional ion velocity measurement system with multi-hit and potential multi-mass capability is built,which consists of a microchannel plate(MCP),a P47 phosphor screen,a CMOS camera,a fast photomultiplier tube(PMT),and a high-speed digitizer.The two velocity components perpendicular to the flight axis are measured by the CMOS camera,and the time-of-flight,from which the velocity component along the flight axis can be deduced,is measured by the PMT.A Labview program is written to combine the two measurements for building the full three-dimensional ion velocity in real time on a frame-by-frame basis.The multi-hit capability comes from the fact that multiple ions from the camera and PMT in the same frame can be correlated with each other based on their various intensities.We demonstrate this by using the photodissociation of CH31 at 304 nm. 展开更多
关键词 Three-dimensional image Velocity-mapping Time-focusing Ion-molecule scattering PHOTODISSOCIATION
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AS1411 aptamer-conjugated Gd2O3:Eu nanoparticles for target-specific computed tomography/magnetic resonance/fluorescence molecular imaging 被引量:3
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作者 Tsungrong Kuo Weiyun Lai +5 位作者 Chenghung Li Yanjhan Wun Huancheng Chang Jinnshiun Chen Panchyr Yang Chiachun Chen 《Nano Research》 SCIE EI CAS CSCD 2014年第5期658-669,共12页
Europium-doped gadolinium oxide (Gd2O3:Eu) nanoparticles have been synthesized, and then their surfaces have been conjugated with nucleolin- targeted AS1411 aptamer to form functionalized target-specific Gd2OB:EU ... Europium-doped gadolinium oxide (Gd2O3:Eu) nanoparticles have been synthesized, and then their surfaces have been conjugated with nucleolin- targeted AS1411 aptamer to form functionalized target-specific Gd2OB:EU nanoparticles (A-GdO:Eu nanoparticles). The A-GdO:Eu nanoparticles present strong fluorescence in the visible range, high magnetic susceptibility, X-ray attenuation and good biocompatibility. The A-GdO:Eu nanoparticles have been applied to test molecular expression of nucleolin highly expressed CL1-5 lung cancer cells under a confocal microscope. Fluorescence imaging clearly reveals that the nanoparticles can be applied as fluorescent tags for cancer-targeting molecular imaging. Furthermore, taking together their excellent T1 contrast and strong computed tomography (CT) signal, the A-GdO:Eu nanoparticles demonstrate a great capability for use as a dual modality contrast agent for CT and magnetic resonance (MR) molecular imaging. Animal experiments also show that the A-GdO:Eu nanoparticles are able to contrast the tissues of BALB/c mice using CT modality. Moreover, the obvious red fluorescence of A-GdO:Eu nanoparticles can be visualized in a tumor by the naked eye. Overall, our results demonstrate that the A-GdO:Eu nanoparticles can not only serve as new medical contrast agents but also as intraoperative fluorescence imaging probes for guided surgery in the near future. 展开更多
关键词 APTAMER contrast agent Gd2O3 nanoparticles molecular imaging nanoparticles synthesis
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Dendrimer-based magnetic resonance imaging agents for brain cancer
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作者 Ling Ding Zhenbin Lyu +3 位作者 Dinesh Dhumal Chai-Lin Kao Monique Bernard Ling Peng 《Science China Materials》 SCIE EI CSCD 2018年第11期1420-1443,共24页
Brain cancer is one of the most lethal and difficult-to-treat cancers because of its physical location and biological barriers. The mainstay of brain cancer treatment is surgical resection, which demands precise imagi... Brain cancer is one of the most lethal and difficult-to-treat cancers because of its physical location and biological barriers. The mainstay of brain cancer treatment is surgical resection, which demands precise imaging for tumor localization and delineation. Thanks to advances in bioimaging, brain cancer can be detected earlier and resected more reliably. Magnetic resonance imaging(MRI) is the most common and preferred method to delineate brain cancer, and a contrast agent is often required to enhance imaging contrast.Dendrimers, a special family of synthetic macromolecules,constitute a particularly appealing platform for constructing MRI contrast agents by virtue of their well-defined three-dimensional structure, tunable nanosize and abundant surface terminals, which allow the accommodation of high payloads and numerous functionalities. Tuning the dendrimer size,branching and surface composition in conjunction with conjugation of MRI functionalities and targeting moieties can alter the relaxivity for MRI, overcome the blood-brain barrier and enhance tumor-specific targeting, hence improving the imaging quality and safety profile for precise and accurate imaging of brain tumors. This short review highlights the recent progress, opportunities and challenges in developing dendrimer-based MRI contrast agents for brain tumor imaging. 展开更多
关键词 DENDRIMER contrast agent blood-brain barrier tumor targeting magnetic resonance imaging
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