非旋转对称光束的像散系数a_(ZF)

基于二阶矩定义,综合考虑像散光束的非旋转对称性,提出采用M^4参数来描述光束的像散特性。推导出了在指定方位角上像散基模高斯光束、像散厄米高斯光束传输和像散光束的束腰、发散角的解析表达式,提出采用像散系数a_(ZF)表示光束的像散特性,最终给出了用像散系数a_(ZF)表达的M^4参数(M_(xx)~4、M_(yy)~4、M_(xy)~4和M_r^4)的解析表达式。另外,根据实测光束的M4参数反过来也可以求出光束的像散系数a_(ZF)及光束在主方向上的M^4参数等。光束经过无像差旋转对称光学系统传输时,其传输不变量为a_(ZF)、J_(ZF1)和J_(ZF2)。本文所得结果对实际工作中激光器的设计、制造和应用有重要的参考价值。

H-C-G光束通过光阑-像散透镜的焦开关现象

研究了H-C-G光束通过光阑-像散透镜分离系统的焦开关现象,尤其研究了透镜的像散对焦开关的影响,结果表明:当系统参数和光束参数满足一定的条件时,H-C-G光束通过光阑-像散透镜分离系统后,可能出现两个焦开关现象,甚至可能有三个焦开关的出现。

像散透镜对双曲余弦高斯光束的影响

据广义Huygens -Fresnel衍射积分公式 ,推导了新型光束———双曲余弦高斯光束通过简单像散透镜后的光场分布特点 ,并通过数值计算 ,说明了像散系数对焦移、光强分布的影响。

线偏振相位涡旋光束的像散特性

提出采用像散系数表征涡旋光束的像散特性。利用螺旋相位板产生了线偏振相位涡旋光束,并对其光束质量及像散特性进行了实际测量。数值模拟了不同拓扑荷数的涡旋光束的传输特性及光束质量,分析了像散系数随拓扑荷数变化的规律,结果表明:当拓扑荷数为整数时,光束无像散,像散系数为零;当拓扑荷数为半奇数时,光束的像散特性明显,像散系数达到极大值;随着拓扑荷数整数部分的增加,像散系数的极大值减小。

Strategy to differentiate autoimmune pancreatitis from pancreas cancer

Autoimmune pancreatitis (AIP) is a newly described entity of pancreatitis in which the pathogenesis appears to involve autoimmune mechanisms. Based on histological and immunohistochemical examinations of various organs of AIP patients, AIP appears to be a pancreatic lesion reflecting a systemic "IgG4-related sclerosing disease". Clinically, AIP patients and patients with pancreatic cancer share many features, such as preponderance of elderly males, frequent initial symptom of painless jaundice, development of new-onset diabetes mellitus, and elevated levels of serum tumor markers. It is of uppermost importance not to misdiagnose AIP as pancreatic cancer. Since there is currently no diagnostic serological marker for AIP, and approach to the pancreas for histological examination is generally difficult, AIP is diagnosed using a combination of clinical, serological, morphological, and histopathological features. Findings suggesting AIP rather than pancreatic cancer include:fluctuating obstructive jaundice; elevated serum IgG4 levels; diffuse enlargement of the pancreas; delayed en- hancement of the enlarged pancreas and presence of a capsule-like rim on dynamic computed tomography; low apparent diffusion coefficient values on diffusion-weighted magnetic resonance image; irregular narrowing of the main pancreatic duct on endoscopic retrograde cholangiopancreatography; less upstream dilatation of the main pancreatic duct on magnetic resonance cholangiopancreatography, presence of other organ involvement such as bilateral salivary gland swelling, retroperitoneal fibrosis and hilar or intrahepatic sclerosing cholangitis; negative work-up for malignancy including endoscopic ultrasound-guided fine needle aspiration; and steroid responsiveness. Since AIP responds dramatically to steroid therapy, accurate diagnosis of AIP can avoid unnecessary laparotomy or pancreatic resection.

Magnetic resonance-based total liver volume and magnetic resonance-diffusion weighted imaging for staging liver fibrosis in mini-pigs

AIM:To determine whether and how magnetic resonance imaging(MRI)-based total liver volume(TLV) and diffusion weighted imaging(DWI) could predict liver fibrosis.METHODS:Sixteen experimental mature mini-pigs(6 males,10 females),weighing between 20.0 and 24.0 kg were prospectively used to model liver fibrosis induced by intraperitoneal injection of 40% CCl4 dissolved in fat emulsion twice a week for 16 wk,and by feeding 40% CCl4 mixed with maize flour twice daily for the subsequent 5 wk.All the survival animals underwent percutaneous liver biopsy and DWI using b = 300,500 and 800 s/mm2 followed by abdominal gadolinium-enhanced MRI at the 0,5th,9th,16th and 21st weekend after beginning of the modeling.TLV was obtained on enhanced MRI,and apparent diffusion coefficient(ADC) was obtained on DWI.Hepatic tissue specimens were stained with hematoxylin and Masson' s trichrome staining for staging liver fibrosis.Pathological specimens were scored using the human METAVIR classification system.Statistical analyses were performed to determine whether and how the TLV and ADC could be used to predict the stage of liver fibrosis.RESULTS:TLV increased from stage 0 to 2 and decreased from stage 3(r = 0.211;P < 0.001).There was a difference in TLV between stage 0-1 and 2-4(P = 0.03) whereas no difference between stage 0-2 and 3-4(P = 0.71).TLV could predict stage ≥ 2 [area under receiver operating characteristic curve(AUC) = 0.682].There was a decrease in ADC values with increasing stage of fibrosis for b = 300,500 and 800 s/mm2(r =-0.418,-0.535 and-0.622,respectively;all P < 0.001).Differences were found between stage 0-1 and 2-4 in ADC values for b = 300,500 and 800 s/mm2,and between stage 0-2 and 3-4 for b = 500 or 800 s/mm2(all P < 0.05).For predicting stage ≥ 2 and ≥ 3,AUC was 0.803 and 0.847 for b = 500 s/mm2,and 0.848 and 0.887 for b = 800 s/mm2,respectively.CONCLUSION:ADC for b = 500 or 800 s/mm2 could be better than TLV and ADC for b = 300 s/mm2 to pre-dict fibrosis stage ≥ 2 or ≥ 3.

Diffusion-weighted imaging of biliopancreatic disorders:Correlation with conventional magnetic resonance imaging

Diffusion-weighted magnetic resonance imaging(DWI)is a well established method for the evaluation of intracranial diseases,such as acute stroke.DWI for extracranial application is more difficult due to physiological motion artifacts and the heterogeneous composition of the organs.However,thanks to the newer technical development of DWI,DWI has become increasingly used over the past few years in extracranial organs including the abdomen and pelvis.Most previous studies of DWI have been limited to the evaluation of diffuse parenchymal abnormalities and focal lesions in abdominal organs,whereas there are few studies about DWI for the evaluation of the biliopancreatic tract.Although further studies are needed to determine its performance in evaluating bile duct,gallbladder and pancreas diseases,DWI has potential in the assessment of the functional information on the biliopancreatic tract concerning the status of tissue cellularity,because increased cellularity is associated with impeded diffusion,as indicated by a reduction in the apparent diffusion coefficient.The detection of malignant lesions and their differentiation from benign tumor-like lesions in the biliopancreatic tract could be improved using DWI in conjunction with findings obtained with conventional magnetic resonance cholagiopancreatography.Additionally,DWI can be useful for the assessment of the biliopancreatic tract in patients with renal impairment because contrast-enhanced computed tomography or magnetic resonance scans should be avoided in these patients.

Detecting Shifted Double JPEG Compression Tampering Utilizing Both Intra-Block and Inter-Block Correlations

Copy-paste forgery is a very common type of forgery in JPEG images.The tampered patch has always suffered from JPEG compression twice with inconsistent block segmentation.This phenomenon in JPEG image forgeries is called the shifted double JPEG(SDJPEG) compression.Detection of SDJPEG compressed image patches can make crucial contribution to detect and locate the tampered region.However,the existing SDJPEG compression tampering detection methods cannot achieve satisfactory results especially when the tampered region is small.In this paper,an effective SDJPEG compression tampering detection method utilizing both intra-block and inter-block correlations is proposed.Statistical artifacts are left by the SDJPEG compression among the magnitudes of JPEG quantized discrete cosine transform(DCT) coefficients.Firstly,difference 2D arrays,which describe the differences between the magnitudes of neighboring JPEG quantized DCT coefficients on the intrablock and inter-block,are used to enhance the SDJPEG compression artifacts.Then,the thresholding technique is used to deal with these difference 2D arrays for reducing computational cost.After that,co-occurrence matrix is used to model these difference 2D arrays so as to take advantage of second-order statistics.All elements of these co-occurrence matrices are served as features for SDJPEG compression tampering detection.Finally,support vector machine(SVM) classifier is employed to distinguish the SDJPEG compressed image patches from the single JPEG compressed image patches using the developed feature set.Experimental results demonstrate the efficiency of the proposed method.

Diffusion curves with diffusion coefficients

Diffusion curves can be used to generate vector graphics images with smooth variation by solving Poisson equations. However, using the classical diffusion curve model, it is difficult to ensure that the generated diffusion image satisfies desired constraints. In this paper, we develop a model for producing a diffusion image by solving a diffusion equation with diffusion coefficients, in which color layers and coefficient layers are introduced to facilitate the generation of the diffusion image. Doing so allows us to impose various constraints on the diffusion image, such as diffusion strength, diffusion direction,diffusion points, etc., in a unified computational framework. Various examples are presented in this paper to illustrate the capabilities of our model.

Early changes in apparent diffusion coefficient as an indicator of response to sorafenib in hepatocellular carcinoma

Objective： The relationship between apparent diffusion coefficient （ADC） and chemotherapy has been established. However, whether ADC could be considered as a measure for monitoring response to sorafenib in hepatocellular carcinoma （HCC） has not been demonstrated. This study was to investigate the ADC changes of ad- vanced HCC under sorafenib treatment. Methods： Athymic mice with HepG2 xenografts were allocated to two groups： control and sorafenib （40 mg/kg, bid）. T2 and diffusion images were acquired at each time point （0, 10, 14, and 18 d post-therapy）. Tumor volume and changes in ADC were calculated. Results： Tumor volumes on Days 10, 14, and 18 after treatment showed significant decreases in the sorafenib-treated group compared with the control. Pretreatment ADC values were not significantly different between the control and treated groups. A slow increase in ADC in the peripheral zone of tumors appeared in the treated group, which was significantly higher compared with the control group on Days 10, 14, and 18. In the central part of tumors on Day 10 after treatment, an increase in ADC appeared in the treated and control groups, the ADC of the control group being significantly lower compared with the treated tumors From Day 10 to Day 14, the ADC map showed a progressive decrease in the central region of tumors in the treated and control groups. However, this change is more significant in the treated groups. Conclusions： Early changes in mean ADC correlated with sorafenib treatment in HCC, which are promising indicators for predicting sorafenib response in this carcinoma.