儿泻散治疗小儿非感染性腹泻209例临床观察

目的 观察儿泻散治疗小儿非感染性腹泻临床疗效。方法 2 77例非感染性腹泻患儿随机分为 2组 ,治疗组 2 0 9例予中药儿泻散治疗 ,对照组 6 8例予西药思密达治疗。急性腹泻治疗 3日 ,迁延性、慢性腹泻治疗 7～ 10日后观察比较 2组临床疗效及主要症状、体征改善情况和痊愈病例疗程 ,并检查 2组治疗前后大便常规及 2组治疗后小肠功能D -木糖吸收排泄情况。结果 治疗组临床痊愈率 6 5 .5 5 % ,与对照组 (4 4 .12 % )比较有显著性差异 (P <0 .0 1) ;2组治疗后主要症状、体征 (恶心、呕吐、腹痛、食欲下降、体重下降 )改善情况及痊愈病例疗程比较均有显著性差异 (P <0 .0 1,P <0 .0 5 ) ;实验室检查 2组治疗后大便常规指标 (大便性状、脂肪滴、白细胞数 )改善情况治疗组明显优于对照组 (P <0 .0 1) ;治疗后小肠功能D -木糖 5h尿内排出量治疗组 (1.2± 0 .175 )g ,明显优于对照组 (1.0± 0 .18)g(P <0 .0 1)。结论 儿泻散治疗小儿非感染性腹泻疗程短 ,起效快 ,是理想的中草药肠黏膜保护剂。

Clinical study on Tuina plus Shen Ling Bai Zhu San in treating children with diarrhea due to spleen deficiency

Objective:To observe the clinical efficacy of Tuina(Chinese therapeutic massage)plus Shen Ling Bai Zhu San for pediatric diarrhea due to spleen deficiency.Methods:A total of 105 children with diarrhea due to spleen deficiency were selected and randomized into two groups by the random number table method.Fifty-two cases in the control group were treated with oral Shen Ling Bai Zhu San,and 53 cases in the observation group were treated with additional Tuina treatment.The clinical efficacy was evaluated after treatment,and the changes of traditional Chinese medicine(TCM)symptom scores were observed.Results:During the trial,there were three dropouts in the observation group,and two in the control group.After the treatment,the total effective rate was 100.0%in the observation group,and 90.0%in the control group.The difference between the two groups was statistically significant(P<0.05).The scores of primary and secondary symptoms,and the total scores of TCM symptoms in both groups were significantly lower than those before treatment(P<0.05).And the scores of primary and secondary symptoms,and the total score of TCM symptoms in the observation group after treatment were lower than those in the control group(P<0.05).There were no obvious adverse reactions in either group during the treatment.Conclusion:Tuina plus Shen Ling Bai Zhu San has a better therapeutic effect in treating pediatric diarrhea due to spleen deficiency than Shen Ling Bai Zhu San alone.