目的:探讨静脉注射免疫球蛋白(IVIG)治疗儿童心肌炎的有效性。方法:计算机检索PubMed,EMBASE,Cochrane Central Register of Controlled Trials,MEDLINE,CBM,CNKI。全面收集IVIG治疗儿童心肌炎的临床研究,用Review manager 5.0软件进行M...目的:探讨静脉注射免疫球蛋白(IVIG)治疗儿童心肌炎的有效性。方法:计算机检索PubMed,EMBASE,Cochrane Central Register of Controlled Trials,MEDLINE,CBM,CNKI。全面收集IVIG治疗儿童心肌炎的临床研究,用Review manager 5.0软件进行Meta分析。结果:纳入5项回顾性临床研究,共223例患者。Meta分析结果表明:IVIG可提高心肌炎患儿的左心室射血分数(LVEF)[MD=18.91%,95%CI(11.74~26.08),P<0.00001],还可降低儿童心肌炎患者的病死率和心脏移植率[OR=0.31,95%CI(0.12~0.75),P=0.01]。结论:IVIG可提高儿童心肌炎患者的左心室射血分数,降低患者的死亡率和心脏移植率。展开更多
Objective: To describe the treatment and long term outcome after immunosuppres sive treatment of children with myocarditis. Methods and results: 114 patients w ith newly diagnosed dilated cardiomyopathy were divided i...Objective: To describe the treatment and long term outcome after immunosuppres sive treatment of children with myocarditis. Methods and results: 114 patients w ith newly diagnosed dilated cardiomyopathy were divided into three groups, accor ding to the histological pattern: group A, acute myocarditis; group B, borderlin e myocarditis; and group C, non inflammatory cardiomyopathy. Groups A and B wer e treated with cyclosporine and prednisone in addition to conventional treatment . Survivors of the whole cohort were analysed for 13 year transplant free survi val and assessed for left ventricular function. Event free survival at 13 years was 97 (3)%for group A, 70 (8)%for group B, and 32 (7)%for group C (p< 0.000 1). It was 96 (4)%at one year and 83(5)%at 13 years for the cumulatedmyocardit is group (A and B). Cardiac function recovered completely in 79%of survivors in group A, 64%in group B, and 36%in group C. The rate of complete recovery in t he cumulated group(A and B) was 70%. Conclusions: The high long term survival r ate of this cohort of children with myocarditis is probably due to the effect of short term immunosuppression. This result differs from previously published ser ies of conventionally treated children, whose survival probability at one yearwa s about 60%.展开更多
文摘目的:探讨静脉注射免疫球蛋白(IVIG)治疗儿童心肌炎的有效性。方法:计算机检索PubMed,EMBASE,Cochrane Central Register of Controlled Trials,MEDLINE,CBM,CNKI。全面收集IVIG治疗儿童心肌炎的临床研究,用Review manager 5.0软件进行Meta分析。结果:纳入5项回顾性临床研究,共223例患者。Meta分析结果表明:IVIG可提高心肌炎患儿的左心室射血分数(LVEF)[MD=18.91%,95%CI(11.74~26.08),P<0.00001],还可降低儿童心肌炎患者的病死率和心脏移植率[OR=0.31,95%CI(0.12~0.75),P=0.01]。结论:IVIG可提高儿童心肌炎患者的左心室射血分数,降低患者的死亡率和心脏移植率。
文摘Objective: To describe the treatment and long term outcome after immunosuppres sive treatment of children with myocarditis. Methods and results: 114 patients w ith newly diagnosed dilated cardiomyopathy were divided into three groups, accor ding to the histological pattern: group A, acute myocarditis; group B, borderlin e myocarditis; and group C, non inflammatory cardiomyopathy. Groups A and B wer e treated with cyclosporine and prednisone in addition to conventional treatment . Survivors of the whole cohort were analysed for 13 year transplant free survi val and assessed for left ventricular function. Event free survival at 13 years was 97 (3)%for group A, 70 (8)%for group B, and 32 (7)%for group C (p< 0.000 1). It was 96 (4)%at one year and 83(5)%at 13 years for the cumulatedmyocardit is group (A and B). Cardiac function recovered completely in 79%of survivors in group A, 64%in group B, and 36%in group C. The rate of complete recovery in t he cumulated group(A and B) was 70%. Conclusions: The high long term survival r ate of this cohort of children with myocarditis is probably due to the effect of short term immunosuppression. This result differs from previously published ser ies of conventionally treated children, whose survival probability at one yearwa s about 60%.
