儿肺清合剂联合抗生素治疗小儿支原体肺炎68例

支原体肺炎是儿科常见一种流行肺炎病之一。近年来发病率逐渐增加，特别是学龄儿童发病比较多见。支原体肺炎是一种地方性流行的呼吸道疾病，该病虽然全年均可见，但有一定的季节性和周期性。支原体感染一般在春秋季节容易流行，大约3～5年左右为1个周期，在周期大流行高峰时，其发病率可超过肺炎总发病率的70％～80％，而且西药如青霉素、先锋霉素、磺胺等对此病无效。笔者采用中西药结合治疗支原体感染肺炎患儿68例效果满意。现报告如下。

儿肺清口服液质量标准研究

采用薄层层析法鉴别儿肺清口服液中黄芪、白芍、麦冬；采用大孔吸附树脂-比色法测定人参总皂甙含量。方法简单，重复性好，可作为儿肺清口服液质量标准。

小儿肺清合剂制剂工艺

儿肺清合剂是我院儿科在生脉饮为基础上发展形成的经验处方,具有生津固肺、止咳敛汗之功效,适用于小儿急性支气管炎、支气管哮喘恢复期,以及体虚多汗等症。经临床验证取得较好疗效,现将该合剂的处方组成及制剂工艺介绍如下:

小儿清肺颗粒治疗小儿急性支气管炎痰热壅肺证的多中心、双盲、随机对照研究

目的评价小儿清肺颗粒治疗小儿急性支气管炎痰热壅肺证的有效性与安全性。方法采用区组随机、阳性药平行对照、双盲双模拟、非劣效检验、多中心临床研究的方法,共观察病例240例,分为治疗组和对照组各120例。治疗组给予口服小儿清肺颗粒以及急支糖浆模拟剂,对照组给予急支糖浆以及小儿清肺颗粒模拟剂。两组疗程均为5天。疗程结束后评价主要症状(咳嗽、咯痰)基本消失时间、止咳起效时间、疾病疗效、中医证候疗效、完全退热时间及安全性。结果两组主要症状(咳嗽、咯痰)基本消失时间、止咳起效时间、完全退热时间比较,差异均无统计学意义(P>0.05)。经非劣效性检验,治疗组疾病疗效不劣于对照组,两组疗效相当。治疗5天后,治疗组、对照组两组中医证候有效率分别达到98.33%及92.37%,全分析数据集(FAS)中两组间比较差异有统计学意义(PFAS=0.0285),提示治疗组在症状改善方面优于对照组。两组不良反应比较差异无统计学意义(P>0.05)。结论小儿清肺颗粒对小儿急性支气管炎痰热壅肺证具有良好的治疗效果,其总体疗效与急支糖浆一致,在中医证候改善方面,小儿清肺颗粒更优,且安全性较好。

Therapeutic observation on lung-clearing and spleen-strengthening tuina in children with exogenous cough

Objective:To observe the clinical efficacy of lung-clearing and spleen-strengthening tuina on exogenous cough in children.Methods:A total of 77 children with exogenous cough that met the inclusion criteria were randomly divided into a treatment group and a control group according to the random number table,with 39 cases in the treatment group and 38 cases in the control group.The routine lung-clearing manipulation was used in the two groups,while the spleen-strengthening manipulation was added in the treatment group.Both groups were treated once a day,5 times as a course of treatment.After one course of treatment,the symptom score and clinical efficacy were observed.Results:There were one dropout in the treatment group and 2 dropouts in the control group.Therefore,a total of 74 cases were finally included in the analysis,with 38 cases in the treatment group and 36 cases in the control group.After treatment,there was a statistically significant difference in cough score between the two groups(P<0.05).There was a statistically significant difference in the score of poor appetite between the two groups(P<0.05).After treatment,the total effective rate was 89.5%in the treatment group versus 75.0%in the control group,showing a statistically significant difference(P<0.05).Conclusion:The therapeutic efficacy of lung-clearing spleen-strengthening manipulation is better than that of lung-clearing tuina manipulation alone for children with exogenous cough;regulating spleen and stomach can improve the curative efficacy of exogenous cough in children.