盐酸氨溴索与盐酸丙卡特罗联用对小儿肺炎患者的临床疗效评价

目的:评价盐酸氨溴索与盐酸丙卡特罗联用对小儿肺炎患者的临床疗效。方法:选取2012年8月—2015年8月诊治的小儿肺炎患者70例,将其随机分为对照组(30例)和治疗组(40例);对照组患者均给予常规综合疗法,治疗组在对照组治疗的基础上加用盐酸氨溴索与盐酸丙卡特罗治疗,比较两组患者治疗后临床总有效率、症状消失时间及不良反应的发生率。结果:治疗组患者治疗后的临床总有效率为92.50%高于对照组为76.67%(P<0.05);肺部啰音消失时间、退热时间和咳嗽消失时间均明显短于对照组(P<0.05);两组患者均发生轻微恶心、头痛等不良反应症状,但均在停药后缓解或消失。结论:盐酸氨溴索与盐酸丙卡特罗联用对小儿肺炎患者的临床疗效较确切,可快速改善患者症状,安全性较高。

磷酸肌酸钠治疗小儿肺炎合并心衰的疗效观察

目的观察磷酸肌酸钠治疗小儿肺炎合并心衰的疗效观察。方法肺炎合并心衰患儿65例,随机分为观察组和对照组,对照组应用综合疗法,包括吸氧、控制感染、强心利尿等;观察组在综合疗法基础上加用磷酸肌酸钠治疗。观察治疗前后患儿临床症状、体征和心肌酶改变情况。结果两组患儿临床症状、体征均得以改善,观察组改善明显优于对照组(P<0.05)。结论磷酸肌酸钠可减轻心肌损害,协助纠正心衰。

超声雾化吸入治疗小儿肺炎的疗效观察及护理

目的观察分析超声雾化吸入对小儿肺炎的临床治疗及护理方法。方法选择2014年12月至2015年11月在我院治疗的72例小儿肺炎患者为研究对象,按自愿原则将患儿分为观察组与对照组。两组患儿均采取一般性方法进行治疗,对照组患者采用常规护理,观察组患者采用超声雾化吸入进行辅助性治疗与护理。对比分析两组患儿治疗及护理效果。结果观察组患儿的胸部阴影改善情况、退热时间、肺啰音消失时间均优于对照组(P<0.05);观察组的治疗总有效率为94.59%,优于对照组的82.86%(P<0.05)。结论小儿肺炎采用超声雾化吸入治疗护理,可显著改善患儿的临床体征,并极大提高治疗效果,具有较高的治疗应用价值。

阿奇霉素与红霉素治疗小儿肺炎的临床效果对比

目的：探讨阿奇霉素与红霉素两组药物治疗小儿肺炎的临床效果。方法：选取在我院进行治疗的80倒小儿肺炎患者，在常规治疗基础上，分别采用红霉素和阿奇霉素注射治疗，观察疗效。结果：阿奇霉素组总有效率为95％，不良反应率为7．5％，红霉素组总有效率为77．5％，不良反应率为30％，阿奇霉素组的治疗效果更好。结论：利用阿奇霉素治疗小儿肺炎，是一种更安全有效的方法。

中西医结合治疗小儿支原体肺炎的临床效果

目的探讨中西医结合治疗小儿支原体肺炎的临床效果。方法选取2019年10月~2020年5月我院收治的120例小儿支原体肺炎患儿为研究对象,按随机数字表法分为对照组和观察组,各60例。对照组患儿给予阿奇霉素静滴治疗,观察组在对照组的基础上联合中药治疗,观察比较两组患儿的临床症状消失时间、临床疗效及不良反应发生情况。结果观察组患儿的发热、咳嗽消失时间均短于对照组(P<0.05);观察组临床总有效率为98.33%,显著高于对照组的86.67%(P<0.05);两组均未出现明显不良反应。结论中西医结合治疗小儿支原体肺炎效果显著,可缩短患儿的发热和咳嗽消失时间,安全性高,值得临床推广。

研究乳酸菌片联合复方胃蛋白酶散治疗小儿肺炎继发性腹泻疗效

目的:了解乳酸菌片联合复方胃蛋白酶散治疗小儿肺炎继发性腹泻疗效。方法:选择2017年1月至2018年1月我院收治的急性支气管肺炎患儿共200例,将患儿随机分为治疗组与对照组,两组患均按照儿童社区获得性肺炎管理指南对患儿使用抗生素以及相应的治疗,治疗组患儿在以上治疗的基础上加服复方胃蛋白酶散,对比两组患儿的治疗结果。结果:治疗组患儿治疗总有效率为91%,对照组患儿治疗总有效率为61%,治疗组患儿的治疗效果要明显好于对照组患儿,差异具有统计学意义(p<0.05)。结论:在小儿肺炎继发性腹泻中使用乳酸菌片联合复方胃蛋白酶散能够有效提高患儿的临床治疗效果,值得推广使用。

Effect of xiaoer feire kechuan oral solution on extrapulmonary injury induced by mycoplasma pneumoniae in infant wistar rats

Objective To observe the effect of Xiaoer Feire Kechuan oral solution on the extrapulmonary injury induced by Mycoplasma pneumoniae in infant Wistar rats. Methods Infant Wistar rats were infected intranasally with M. pneumoniae once a day for four days. In the treatment groups, Xiaoer Feire Kechuan oral solution was administered daily for four days beginning from the day of infection. On day 5, blood of the rats was collected, and blood routine and biochemistry indexes were measured. All rats were sacrificed, and the weight of brain, heart, liver, and kidney was measured to calculate the organ indexes. The GM1 and GALC-Ab content in brain tissue was determined by ELISA. Pathological changes in the brain, heart, liver, kidney, and cerebellum were observed by HE staining. Results Blood routine indexes fluctuated within the normal range in the infection control group and in three of the Xiaoer Feire Kechuan oral solution groups. The serum LDH, CK, and CRE in all three Xiaoer Feire Kechuan oral solution groups were distinctly lower than those in the infection control group (P < 0.01, P < 0.05). Rat brain index and GALC-Ab content in the brain tissue showed an increase in infection control group. In the Xiaoer Feire Kechuan oral solution groups, the GALC-Ab content in brain tissue was decreased significantly. The heart, liver, and kidney tissues showed mild pathological changes in the infection group, which were reversed by Xiaoer Feire Kechuan oral solution treatment. Conclusions The extrapulmonary injury induced by M. pneumoniae in infant Wistar rats was significantly inhibited by Xiaoer Feire Kechuan oral solution.

Progression of anti-mycoplasma drug therapy in children with refractory mycoplasma pneumonia

The incidence of refractory mycoplasma pneumoniae pneumonia(RMPP)in children is increasing year by year,and the disease is progressing rapidly.It is accompanied by serious complications and legacy effects,seriously affecting the quality of life of children.The selection,dosage,and course of anti-MP drugs in children with RMPP have brought a lot of troubles to pediatric hospitals.In the present study,the characteristics,usage and dosage,drug resistance mechanism,and treatment progress of anti-MP drugs for the treatment of RMPP in children were reviewed.Collectively,our findings provided ideas for the treatment of children with RMPP using anti-MP drugs.

Potassium dehydroandrographolide succinate injection for treatment of infantile pneumonia:a systematic review and Meta-analysis

OBJECTIVE:To evaluate systematically the clinical efficacy and safety of potassium dehydroandrographolide succinate injection(PDS) in treatment of infantile pneumonia.METHODS:Randomized controlled trials(RCTs) of infantile pneumonia treated by PDS were searched in China National Knowledge Infrastructure Database,China Science and Technology Journal Database,Wanfang Database,Chinese Biomedical Literature Database,PubMed,and Cochrane Library,from January 1979 to July 2013.Two reviewers independently retrieved the RCTs and extracted the information.The quality of included studies was assessed by the Cochrane risk of bias,and a Meta-analysis was conducted with Review Manager 5.2 software.RESULTS:A total of 9 studies with 1056 participants were included.The quality of the studies was generally no high,only one study mentioned the random method.The Meta-analysis indicated that PDS was significantly superior to the conventional therapy in the total effective rate[relative risk(RR)=1.21,95%CI(1.14,1.27),P<0.000 01],the time of temperature recovery[mean difference(MD)=-1.43,95%CI(-1.75,-1.11),P<0.000 01],rale disappeared and cough relieving[MD=-1.44,95%CI(-1.93,-0.90),P<0.000 01].Six adverse drug reactions from five studies mainly represented rash and diarrhea,and no serious ADRs were reported.CONCLUSION:Based on this systematic review,PDS was proved effective and relatively safe in treatment of infantile pneumonia.However the articles enrolled in the study were not high in quality,studies with higher quality should be conducted for assessment of efficacy and safety of PDS in treatment of infantile pneumonia.

Preventative effect of massage on gastric volvulus in infants with gastroesophageal reflux-induced pneumonia

OBJECTIVE:To study the preventative effects of massage on gastric volvulus(GV) in infants with gastroesophageal reflux(GER)-induced pneumonia.METHODS:One-hundred and eighty GV with GER-induced pneumonia inpatients were divided randomly into four groups:basic treatment 1(n =60),basic treatment 2(n = 30),massage treatment1(n = 60) and massage treatment 2(n = 30).Clinical examinations selected between groups 1 and 2were different.Radiography of the upper gastrointestinal tract using iodine-containing contrast was assessed in group 1 before and after treatment,whereas 24-h pH monitoring of the distal esophagus was assessed in group 2 before and after treatment.Symptom scores and chest radiography were assessed in all groups upon hospital admission and after procedures.Clinical effects were estimated after procedures in all groups.The prevalence of severe pneumonia among the four groups was compared.RESULTS:Massage treatment groups showed a significantly higher percentage of cure and total effect(P<0.05,P<0.01) and a lower prevalence of recurrence(but with no statistic difference,P>0.05)than basic treatment groups.Furthermore,massage treatment groups had remarkably lower scores for symptoms and signs(P<0.05,P<0.01),especially for choking on milk,than basic treatment groups.There was significant attenuation of chest inflammation(P<0.05,P<0.01),GV(P<0.05,P<0.01) and GER(P<0.05,P<0.01) in massage treatment groups compared with those in basic treatment groups.Finally,massage treatment groups demonstrated a lower prevalence of severe pneumonia than basic treatment groups(P<0.05).CONCLUSION:Massage treatment can prevent GV with GER-induced pneumonia in infants by timely correction of stomach rotation and subsequent attenuation of GER.