The calculation of earth pressure is a difficult problem in the pit foundation design. Aiming at the problem, the earth pressure calculation formulas considering the displacement are proposed. A method for determining...The calculation of earth pressure is a difficult problem in the pit foundation design. Aiming at the problem, the earth pressure calculation formulas considering the displacement are proposed. A method for determining the limit displacement is given and it is convenient for use. The result indicates that the earth pressure calculated by the formulas is between the earth pressure at rest and the Rankine earth pressure, the formulas can reflect the change rules of active and passive earth pressures along with the displacement. Moreover, the calculation result using the formulas is approximate to the monitoring result. It confirms the validity of the formula deduction and the rationality of the calculation results. As for the passive earth pressure, the calculation method is theoretically feasible.展开更多
Crustal deformation can provide constraints for studying earthquake rupture and shock wave transmission for the Mw9.0 eastern Japan great earthquake. Using the single- epoch precise point positioning (PPP) method an...Crustal deformation can provide constraints for studying earthquake rupture and shock wave transmission for the Mw9.0 eastern Japan great earthquake. Using the single- epoch precise point positioning (PPP) method and the appropriate positioning flow, we process GPS data from six IGS (International GNSS Service) sites (e.g., MIZU, TSK2, USUD, MTKA, AIRA and KSMV) located in Japan and obtain the positioning results with centimeter scale precision. The displacement time series of the six sites are analyzed using the least squares spectral analysis method to estimate deformations caused by the Mw9.0 mainshock and the Mw7.9 aftershock, and the cumulative displacements after 1 day. Mainshock displacements at station MIZU, the nearest site to the mainshock in the North (N), East (E), and Up (U) directions, are -1.202 m, 2.180 m and -0.104 m, respectively, and the cumulative deformations after 1 day are -1.117 m, 2.071 m and -0.072 m, respectively. The displacements at station KSMV, the nearest site to the Mw7.9 aftershock in the N, E and U directions, are -0.032 m, 0.742 m and -0.345 m, respectively. The other sites obviously experienced eastern movements and subsidence. The deformation vectors indicate that the horizontal displacements caused by the earthquake point to the epicenter and rupture. Elastic bounds evidently took place at all sites. The results indicate that the crustal movements and earthquake were part of a megathrust caused by the Pacific Plate sinking under the North American Plate to the northeast of Japan island arc.展开更多
In order to study the critical load position that causes cavities beneath the continuously reinforced concrete pavement( CRCP) slab under vehicle loading, the elliptical load is translated into the square load based...In order to study the critical load position that causes cavities beneath the continuously reinforced concrete pavement( CRCP) slab under vehicle loading, the elliptical load is translated into the square load based on the equivalence principle.The CRCP slab is analyzed to determine the cavity position beneath the slab under vehicle loading. The influences of cavity size on the CRCP slab's stress and vertical displacement are investigated. The study results showthat the formation of the cavity is unavoidable under traffic loading, and the cavity is located at the edge of the longitudinal crack and the slab corner.The cavity size exerts an obvious influence on the largest horizontal tensile stress and vertical displacement. The slab corner is the critical load position of the CRCP slab. The results can be used to assist the design of CRCP in avoiding cavities beneath slabs subject to vehicle loading.展开更多
A cellular automaton(CA) modeling of discontinuous dynamic recrystallization(DDRX) of a near-α Ti-6Al-2Zr-1Mo-1V(TA15) isothermally compressed in the β single phase field was presented.In the CA model,nucleati...A cellular automaton(CA) modeling of discontinuous dynamic recrystallization(DDRX) of a near-α Ti-6Al-2Zr-1Mo-1V(TA15) isothermally compressed in the β single phase field was presented.In the CA model,nucleation of the β-DDRX and the growth of recrystallized grains(re-grains) were considered and visibly simulated by the CA model.The driving force of re-grain growth was provided by dislocation density accumulating around the grain boundaries.To verify the CA model,the predicted flow stress by the CA model was compared with the experimental data.The comparison showed that the average relative errors were10.2%,10.1%and 6%,respectively,at 1.0,0.1 and 0.01 s^-1 of 1020 ℃,and were 10.2%,11.35%and 7.5%,respectively,at 1.0,0.1and 0.01 s^-1 of 1050 ℃.The CA model was further applied to predicting the average growth rate,average re-grain size and recrystallization kinetics.The simulated results showed that the average growth rate increases with the increasing strain rate or temperature,while the re-grain size increases with the decreasing strain rate;the volume fraction of recrystallization decreases with the increasing strain rate or decreasing temperature.展开更多
Let { E i∶i∈I } be a family of Archimedean Riesz algebras.The product of Riesz algebras is denoted by Π i∈I E i .The main result in this paper is the following conclusion:there ...Let { E i∶i∈I } be a family of Archimedean Riesz algebras.The product of Riesz algebras is denoted by Π i∈I E i .The main result in this paper is the following conclusion:there exists a completely regular Hausdorff space X such that Π i∈I E i is Riesz algebra isomorphic to C(X) if and only if for every i∈I there exists a completely regular Hausdorff space X i such that E i is Riesz algebra isomorphic to C(X i) .展开更多
In this article, we have given the definition of the relative double multiplier (quasi-multiplier) on a ternary algebra,and studied the isomorphic problem of the multiplier algebra M(A,e) of a ternary algerbra A.
The traditional algorithms for formation flying satellites treat the satellite position and attitude sepa- rately. A novel algorithm combining satellite attitude with position is proposed. The principal satellite traj...The traditional algorithms for formation flying satellites treat the satellite position and attitude sepa- rately. A novel algorithm combining satellite attitude with position is proposed. The principal satellite trajectory is obtained by dual quaternion interpolation, then the relative position and attitude of the deputy satellite are ob- tained by dual quaternion modeling on the principal satellite. Through above process, relative position and atti- tude are unified. Compared with the orbital parameter and the quaternion methods, the simulation result proves that the algorithm can unify position and attitude, and satisfy the precision requirement of formation flying satel- lites.展开更多
Based on the coded and non-coded targets, the targets are extracted from the images according to their size, shape and intensity etc., and thus an improved method to identify the unique identity(D) of every coded ta...Based on the coded and non-coded targets, the targets are extracted from the images according to their size, shape and intensity etc., and thus an improved method to identify the unique identity(D) of every coded target is put forward and the non-coded and coded targets are classified. Moreover, the gray scale centroid algorithm is applied to obtain the subpixel location of both uncoded and coded targets. The initial matching of the uncoded target correspondences between an image pair is established according to similarity and compatibility, which are based on the ID correspondences of the coded targets. The outliers in the initial matching of the uncoded target are eliminated according to three rules to finally obtain the uncoded target correspondences. Practical examples show that the algorithm is rapid, robust and is of high precision and matching ratio.展开更多
Accurate navigation is important for long-range rocket projectile's precise striking. To obtain stable and high-per- formance navigation result, a ultra-tight global positioning system/inertial navigation system (GP...Accurate navigation is important for long-range rocket projectile's precise striking. To obtain stable and high-per- formance navigation result, a ultra-tight global positioning system/inertial navigation system (GPS/INS) integration based nav- igation approach is proposed. The accurate short-time output of INS is used by GPS receiver to assist in acquisition of signal, and output information of INS and GPS is fused based on federated filter. Meanwhile, the improved cubature Kalman filter with strong tracking ability is chosen to serve as the local filter, and then the federated filter is enhanced based on vector sharing theory. Finally, simulation results show that the navigation accuracy with the proposed method is higher than that with traditional methods. It provides reference for long-range rocket projectile navigation.展开更多
To develop a new method of inducing mdrl multidrug resistance by establishinga nude mice model of orthotopic transplantation of liver carcinoma by sporadic abdominalchemotherapy at intervals. Methods: Hepatocellular c...To develop a new method of inducing mdrl multidrug resistance by establishinga nude mice model of orthotopic transplantation of liver carcinoma by sporadic abdominalchemotherapy at intervals. Methods: Hepatocellular carcinoma HepG2 cell was cultured and injectedsubcutaneously to form the tumor-supplying mice. The tumor bits from the tumor-supplying mice wereimplanted under the envelope of the mice liver and induced by abdominal chemotherapy withPharmorubicin. Physical examination, ultrasonography, spiral CT and operative inspection were usedto examine tumor progression. RT-PCR and immunohistochemistry were adopted to detect the expressionof mdr1-mRNA and its encoded protein P-gp protein (P-gp). Results: There was no operative dead, therate of implanting tumor successfully was 88% (22/25), the rate of implanting secondly successfullywas 100% (3/3), and the rate of inducing successfully was 80% (16/20). The expression of mdrl-mRNAand the P-gp in the inducing group was 23 folds and 13 folds in the control group respectively.Conclusion: We have established an in vivo model of mdr using nude mice transplanted with orthotopicliver neoplasm coupled to chemotherapy.展开更多
Let E be an Archimedean Riesz algebra possessing a weak unit element e and a maximal disjoint system {e,: i∈I} in which e, is a projection element for each i. The principal band generated by eiis denoted by B(ei). T...Let E be an Archimedean Riesz algebra possessing a weak unit element e and a maximal disjoint system {e,: i∈I} in which e, is a projection element for each i. The principal band generated by eiis denoted by B(ei). The main result in this paper says that if there exists a completely regular Hausdorff space X such that E is Riesz algebra isomorphic to C(X) then for every i ∈ I there exists a completely regular Hausdorff space X, such that B(ei) is Riesz algebra isomorphic to C(Xi). Under an additional condition the inverse holds.展开更多
Based on an analysis of the relative shaft-to-hole position and attiude errors, as well as of the mechanics and Kinematics in the process of automatic assembly of industrial robots, the paper studies the principle of ...Based on an analysis of the relative shaft-to-hole position and attiude errors, as well as of the mechanics and Kinematics in the process of automatic assembly of industrial robots, the paper studies the principle of construction of dynamic wrists. Type I-3 and Ⅱ-6 dynamic compliant wrists have been designed and made. Prblems in the production of compliant elements and the connection between compliant elements and wrists were also solved. A study on the results of tests of the function of two kinds of dynamic compliant wrists shows that the dynamic compliant wrist's compliancy function can be improved by adding metallic materials having higher longitudinal and transverse rigidity into the softer elstomer. And the design Principle is proved to be feasible and practicable. It can be expected that the use of dynamic compliant wrist will greatly lower the technical requirements of the shaft-hole assembly and the requirements in the resetting accuracy.展开更多
AIM:To study the effect of aprotinin used in orthotopic liver transplantation (OLT) on the intraoperative requirement for blood products and on the incidence of laparotomy for bleeding, thrombotic events and mortality...AIM:To study the effect of aprotinin used in orthotopic liver transplantation (OLT) on the intraoperative requirement for blood products and on the incidence of laparotomy for bleeding, thrombotic events and mortality. METHODS: A systematic review of the literature in the electronic database Medline and the Clinic Trials Registry Database was performed. Literature that did not fit our study were excluded. Patients in the reviewed studies were divided into two groups; one group used aprotinin (aprotinin group) while the other did not (control group). The data in the literature that fit our requirements were recorded. Weighted mean differences (WMD) in the requirements for blood products between the aprotinin group and the control group were tested using a fixed effect model. A Z test was performed to examine their reliability; the Fleiss method of fixed effect model was used to analyze data on postoperative events, and odds ratios (ORs) were tested and merged. RESULTS: Seven citations were examined in our study. Among them, a requirement for blood products was reported in 4 studies including 321 patients, while postoperative events were reported in 5 studies including 477 patients. The requirement for red blood cells and fresh frozen plasma in the aprotinin group was statistically lower than that in the control group (WMD=-1.80 units, 95% CI,-3.38 to-0.22; WMD=-3.99 units, 95% CI,-6.47 to-1.50, respectively). However, no significant difference was indicated in the incidence of laparotomy for bleeding, thrombotic events and mortality between the two groups. Analysis on blood loss, anaphylactic reactions and renal function was not performed in this study due to a lack of sufficient information.CONCLUSION: Aprotinin can reduce the intraoperative requirement for blood products in OLT, and has no significant effect on the incidence of laparotomy for bleeding, thrombotic events and mortality.展开更多
In-situ LA-ICP-MS and S isotopes of pyrite from the Baoshan Cu polymetallic deposit were conducted to investigate the ore-forming process and the enrichment mechanism of elements.Three generations of pyrite (Py Ⅰ,Py ...In-situ LA-ICP-MS and S isotopes of pyrite from the Baoshan Cu polymetallic deposit were conducted to investigate the ore-forming process and the enrichment mechanism of elements.Three generations of pyrite (Py Ⅰ,Py Ⅱ,and Py Ⅲ) in the skarn-type ores and pyrite in the carbonate-hosted sulfide ores from central,western,and northern(C_Py,W_Py,and N_Py) mining districts are selected for comparison.Compared with Py Ⅰ and Py Ⅲ,the contents of most elements in Py Ⅱ are apparently higher.The As and Se contents are high within a wide range and are decoupled in the growth band of the C_Py.The highest As,Se,and Pb contents were found in W_Py and N_Py.These results indicate the drastic changes in the temperature and fluid mixing during the mineralization.The occurrence of fluctuation and change in temperature and f(O_(2)) was triggered by intermittent pulses of magmatic-hydrothermal fluids,mixing with meteoric water,and water-rock interactions.The sulfur isotopes of all species of pyrite indicated the magmatic source.The change in the f(O_(2)) conditions caused slight differences in the sulfur isotope compositions.Consequently,a metallogenic model was proposed to explain the ore-forming processes.展开更多
AIM:To evaluate the association of human leukocyte antigen(HLA)-DQB1 alleles with hepatocellular carcinoma(HCC) through meta-analysis of published data.METHODS:Case-control studies on HLA-DQB1 allele association with ...AIM:To evaluate the association of human leukocyte antigen(HLA)-DQB1 alleles with hepatocellular carcinoma(HCC) through meta-analysis of published data.METHODS:Case-control studies on HLA-DQB1 allele association with HCC published up to January 2010 were included in the analyses.The odds ratios(ORs) of HLADQB1 allele distributions in HCC patients were analyzed and compared with healthy controls.The meta-analysis software REVMAN 5.0 was applied for investigating heterogeneity among individual studies and for summarizing all the studies.A meta-analysis was performed using fixed-effect or random-effect methods,depending on the absence or presence of significant heterogeneity.Seven case-control studies containing 398 cases and 594 controls were included in the final analysis.RESULTS:Among the five family alleles,two(DQB1*02 and DQB1*03) were found to be significantly associated with the risk of HCC.The combined OR for the association of DQB1*02 and DQB1*03 allele with the risk for HCC was 1.78(95% CI:1.05-3.03,P = 0.03) and 0.65(95% CI:0.48-0.89,P = 0.007),respectively.Among the 13 specific alleles,two(DQB1*0502 and DQB1*0602) were significantly associated with risk of HCC.The combined OR for the association of DQB1*0502 and DQB1*0602 allele with the risk for HCC was 1.82(95% CI:1.14-2.92,P = 0.01) and 0.58(95% CI:0.36-0.95,P = 0.03),respectively.No significant association was established for other HLA-DQB1 family alleles and specific alleles.CONCLUSION:Our results support the hypothesis that specific HLA-DQB1 allele families and alleles might influence the susceptibility or resistance to HCC,although it needs further investigations.展开更多
A three-dimensional finite element simulation was carried out to investigate the effects of tunnel construction on nearby pile foundation.The displacement controlled model (DCM) was used to simulate the tunneling-indu...A three-dimensional finite element simulation was carried out to investigate the effects of tunnel construction on nearby pile foundation.The displacement controlled model (DCM) was used to simulate the tunneling-induced volume loss effects.The numerical model was verified based on the results of a centrifuge test and a set of parametric studies was implemented based on this model.There is good agreement between the trend of the results of the centrifuge test and the present model.The results of parametric studies show that the tunnelling-induced pile internal force and deformation depend mainly on the pile?tunnel distance,the pile length to tunnel depth ratio and the volume loss.Two different zones are separated by a 45° line projected from the tunnel springline.Within the zone of influence,the pile is subjected to tensile force and large settlement;whereas outside the zone of influence,dragload and small settlement are induced.It is also established that the impact of tunnelling on a pile group is substantially smaller as compared with a single pile in the same location with the rear pile in a group,demonstrating a positive pile group effect.展开更多
In this work, we successfully synthesized bicrystalline anatase/TiO2(B) nanofibre and used it as active substrate for surface-enhanced Raman scattering (SERS) applications. The bicrystalline structured TiO2 substr...In this work, we successfully synthesized bicrystalline anatase/TiO2(B) nanofibre and used it as active substrate for surface-enhanced Raman scattering (SERS) applications. The bicrystalline structured TiO2 substrates provide additional charge transfer across the anatase-TiO2(B) interface and thus enhanced activity compared to the pure single crystalline phase. With an effort to further increase the sensitivity of SERS, nitrogen element was doped into bicrystalline anatase/TiO2(B) nanofibres (N-TiO2) and higher SERS enhancement was achieved. The nitrogen content was controlled by tuning the calcination temperature of titanate precursor at 500, 600 and 700℃, respectively. The sample calcined at 600℃ (NT600) acquires the highest percentage of nitrogen element due to its open pore structure that facilitates the diffusion of nitrogen during calcination. Raman intensity depends on the amount of nitrogen doping, thus NT600 exhibited the best SERS activity. The doped nitrogen in TiO2 facilitates the charge transfer between TiO2 and probing molecules and thus suppresses the electron-hole recombination. This work provides a new perspective on the design of efficient TiO2 SERS active substrate and is expected to be valuable for adsorbate detection on semiconductor surface.展开更多
基金Supported by the Natural Foundation of Jiangsu Province(BK2004427)~~
文摘The calculation of earth pressure is a difficult problem in the pit foundation design. Aiming at the problem, the earth pressure calculation formulas considering the displacement are proposed. A method for determining the limit displacement is given and it is convenient for use. The result indicates that the earth pressure calculated by the formulas is between the earth pressure at rest and the Rankine earth pressure, the formulas can reflect the change rules of active and passive earth pressures along with the displacement. Moreover, the calculation result using the formulas is approximate to the monitoring result. It confirms the validity of the formula deduction and the rationality of the calculation results. As for the passive earth pressure, the calculation method is theoretically feasible.
基金supported partially by the National Natural Science Foundation of China(No.40974004 and 40974016)the Key Laboratory of Surveying and Mapping Technology on Island and Reef of NASMG,China(No.2011A01)the Key Laboratory of Advanced Surveying Engineering of NASMG,China(No.TJES1101)
文摘Crustal deformation can provide constraints for studying earthquake rupture and shock wave transmission for the Mw9.0 eastern Japan great earthquake. Using the single- epoch precise point positioning (PPP) method and the appropriate positioning flow, we process GPS data from six IGS (International GNSS Service) sites (e.g., MIZU, TSK2, USUD, MTKA, AIRA and KSMV) located in Japan and obtain the positioning results with centimeter scale precision. The displacement time series of the six sites are analyzed using the least squares spectral analysis method to estimate deformations caused by the Mw9.0 mainshock and the Mw7.9 aftershock, and the cumulative displacements after 1 day. Mainshock displacements at station MIZU, the nearest site to the mainshock in the North (N), East (E), and Up (U) directions, are -1.202 m, 2.180 m and -0.104 m, respectively, and the cumulative deformations after 1 day are -1.117 m, 2.071 m and -0.072 m, respectively. The displacements at station KSMV, the nearest site to the Mw7.9 aftershock in the N, E and U directions, are -0.032 m, 0.742 m and -0.345 m, respectively. The other sites obviously experienced eastern movements and subsidence. The deformation vectors indicate that the horizontal displacements caused by the earthquake point to the epicenter and rupture. Elastic bounds evidently took place at all sites. The results indicate that the crustal movements and earthquake were part of a megathrust caused by the Pacific Plate sinking under the North American Plate to the northeast of Japan island arc.
基金The Science Foundation of Ministry of Transport of the People's Republic of China(No.200731822301-7)
文摘In order to study the critical load position that causes cavities beneath the continuously reinforced concrete pavement( CRCP) slab under vehicle loading, the elliptical load is translated into the square load based on the equivalence principle.The CRCP slab is analyzed to determine the cavity position beneath the slab under vehicle loading. The influences of cavity size on the CRCP slab's stress and vertical displacement are investigated. The study results showthat the formation of the cavity is unavoidable under traffic loading, and the cavity is located at the edge of the longitudinal crack and the slab corner.The cavity size exerts an obvious influence on the largest horizontal tensile stress and vertical displacement. The slab corner is the critical load position of the CRCP slab. The results can be used to assist the design of CRCP in avoiding cavities beneath slabs subject to vehicle loading.
基金Projects (50935007,51175428) supported by the National Natural Science Foundation of ChinaProject (2010CB731701) supported by the National Basic Research Program of China+2 种基金Project (NPU-FFR-JC20100229) supported by the Foundation for Fundamental Research of Northwestern Polytechnical University in ChinaProject (27-TZ-2010) supported by the Research Fund of the State Key Laboratory of Solidification Processing,ChinaProject (B08040) supported by the Program of Introducing Talents of Discipline to University,China
文摘A cellular automaton(CA) modeling of discontinuous dynamic recrystallization(DDRX) of a near-α Ti-6Al-2Zr-1Mo-1V(TA15) isothermally compressed in the β single phase field was presented.In the CA model,nucleation of the β-DDRX and the growth of recrystallized grains(re-grains) were considered and visibly simulated by the CA model.The driving force of re-grain growth was provided by dislocation density accumulating around the grain boundaries.To verify the CA model,the predicted flow stress by the CA model was compared with the experimental data.The comparison showed that the average relative errors were10.2%,10.1%and 6%,respectively,at 1.0,0.1 and 0.01 s^-1 of 1020 ℃,and were 10.2%,11.35%and 7.5%,respectively,at 1.0,0.1and 0.01 s^-1 of 1050 ℃.The CA model was further applied to predicting the average growth rate,average re-grain size and recrystallization kinetics.The simulated results showed that the average growth rate increases with the increasing strain rate or temperature,while the re-grain size increases with the decreasing strain rate;the volume fraction of recrystallization decreases with the increasing strain rate or decreasing temperature.
文摘Let { E i∶i∈I } be a family of Archimedean Riesz algebras.The product of Riesz algebras is denoted by Π i∈I E i .The main result in this paper is the following conclusion:there exists a completely regular Hausdorff space X such that Π i∈I E i is Riesz algebra isomorphic to C(X) if and only if for every i∈I there exists a completely regular Hausdorff space X i such that E i is Riesz algebra isomorphic to C(X i) .
文摘In this article, we have given the definition of the relative double multiplier (quasi-multiplier) on a ternary algebra,and studied the isomorphic problem of the multiplier algebra M(A,e) of a ternary algerbra A.
基金Supported by the National Natural Science Foundation of China(60974107)the Research Foundation of Nanjing University of Aeronautics and Astronautics(2010219)~~
文摘The traditional algorithms for formation flying satellites treat the satellite position and attitude sepa- rately. A novel algorithm combining satellite attitude with position is proposed. The principal satellite trajectory is obtained by dual quaternion interpolation, then the relative position and attitude of the deputy satellite are ob- tained by dual quaternion modeling on the principal satellite. Through above process, relative position and atti- tude are unified. Compared with the orbital parameter and the quaternion methods, the simulation result proves that the algorithm can unify position and attitude, and satisfy the precision requirement of formation flying satel- lites.
基金The National Natural Science Foundation of China(No50475041)
文摘Based on the coded and non-coded targets, the targets are extracted from the images according to their size, shape and intensity etc., and thus an improved method to identify the unique identity(D) of every coded target is put forward and the non-coded and coded targets are classified. Moreover, the gray scale centroid algorithm is applied to obtain the subpixel location of both uncoded and coded targets. The initial matching of the uncoded target correspondences between an image pair is established according to similarity and compatibility, which are based on the ID correspondences of the coded targets. The outliers in the initial matching of the uncoded target are eliminated according to three rules to finally obtain the uncoded target correspondences. Practical examples show that the algorithm is rapid, robust and is of high precision and matching ratio.
基金Project Funded by Chongqing Changjiang Electrical Appliances Industries Group Co.,Ltd
文摘Accurate navigation is important for long-range rocket projectile's precise striking. To obtain stable and high-per- formance navigation result, a ultra-tight global positioning system/inertial navigation system (GPS/INS) integration based nav- igation approach is proposed. The accurate short-time output of INS is used by GPS receiver to assist in acquisition of signal, and output information of INS and GPS is fused based on federated filter. Meanwhile, the improved cubature Kalman filter with strong tracking ability is chosen to serve as the local filter, and then the federated filter is enhanced based on vector sharing theory. Finally, simulation results show that the navigation accuracy with the proposed method is higher than that with traditional methods. It provides reference for long-range rocket projectile navigation.
基金This project was supported by a grant from the Medical Science and Technique Foundation of Ministry of Health of China(No. Wkz-2000-1-15).
文摘To develop a new method of inducing mdrl multidrug resistance by establishinga nude mice model of orthotopic transplantation of liver carcinoma by sporadic abdominalchemotherapy at intervals. Methods: Hepatocellular carcinoma HepG2 cell was cultured and injectedsubcutaneously to form the tumor-supplying mice. The tumor bits from the tumor-supplying mice wereimplanted under the envelope of the mice liver and induced by abdominal chemotherapy withPharmorubicin. Physical examination, ultrasonography, spiral CT and operative inspection were usedto examine tumor progression. RT-PCR and immunohistochemistry were adopted to detect the expressionof mdr1-mRNA and its encoded protein P-gp protein (P-gp). Results: There was no operative dead, therate of implanting tumor successfully was 88% (22/25), the rate of implanting secondly successfullywas 100% (3/3), and the rate of inducing successfully was 80% (16/20). The expression of mdrl-mRNAand the P-gp in the inducing group was 23 folds and 13 folds in the control group respectively.Conclusion: We have established an in vivo model of mdr using nude mice transplanted with orthotopicliver neoplasm coupled to chemotherapy.
文摘Let E be an Archimedean Riesz algebra possessing a weak unit element e and a maximal disjoint system {e,: i∈I} in which e, is a projection element for each i. The principal band generated by eiis denoted by B(ei). The main result in this paper says that if there exists a completely regular Hausdorff space X such that E is Riesz algebra isomorphic to C(X) then for every i ∈ I there exists a completely regular Hausdorff space X, such that B(ei) is Riesz algebra isomorphic to C(Xi). Under an additional condition the inverse holds.
文摘Based on an analysis of the relative shaft-to-hole position and attiude errors, as well as of the mechanics and Kinematics in the process of automatic assembly of industrial robots, the paper studies the principle of construction of dynamic wrists. Type I-3 and Ⅱ-6 dynamic compliant wrists have been designed and made. Prblems in the production of compliant elements and the connection between compliant elements and wrists were also solved. A study on the results of tests of the function of two kinds of dynamic compliant wrists shows that the dynamic compliant wrist's compliancy function can be improved by adding metallic materials having higher longitudinal and transverse rigidity into the softer elstomer. And the design Principle is proved to be feasible and practicable. It can be expected that the use of dynamic compliant wrist will greatly lower the technical requirements of the shaft-hole assembly and the requirements in the resetting accuracy.
基金Grant 02KJD320015 from the Education Committee of Jiangsu Province, China
文摘AIM:To study the effect of aprotinin used in orthotopic liver transplantation (OLT) on the intraoperative requirement for blood products and on the incidence of laparotomy for bleeding, thrombotic events and mortality. METHODS: A systematic review of the literature in the electronic database Medline and the Clinic Trials Registry Database was performed. Literature that did not fit our study were excluded. Patients in the reviewed studies were divided into two groups; one group used aprotinin (aprotinin group) while the other did not (control group). The data in the literature that fit our requirements were recorded. Weighted mean differences (WMD) in the requirements for blood products between the aprotinin group and the control group were tested using a fixed effect model. A Z test was performed to examine their reliability; the Fleiss method of fixed effect model was used to analyze data on postoperative events, and odds ratios (ORs) were tested and merged. RESULTS: Seven citations were examined in our study. Among them, a requirement for blood products was reported in 4 studies including 321 patients, while postoperative events were reported in 5 studies including 477 patients. The requirement for red blood cells and fresh frozen plasma in the aprotinin group was statistically lower than that in the control group (WMD=-1.80 units, 95% CI,-3.38 to-0.22; WMD=-3.99 units, 95% CI,-6.47 to-1.50, respectively). However, no significant difference was indicated in the incidence of laparotomy for bleeding, thrombotic events and mortality between the two groups. Analysis on blood loss, anaphylactic reactions and renal function was not performed in this study due to a lack of sufficient information.CONCLUSION: Aprotinin can reduce the intraoperative requirement for blood products in OLT, and has no significant effect on the incidence of laparotomy for bleeding, thrombotic events and mortality.
基金funded by the National Key Research and Development Program of China (Nos. 2018YFC0603904, 2018YFC0603901)。
文摘In-situ LA-ICP-MS and S isotopes of pyrite from the Baoshan Cu polymetallic deposit were conducted to investigate the ore-forming process and the enrichment mechanism of elements.Three generations of pyrite (Py Ⅰ,Py Ⅱ,and Py Ⅲ) in the skarn-type ores and pyrite in the carbonate-hosted sulfide ores from central,western,and northern(C_Py,W_Py,and N_Py) mining districts are selected for comparison.Compared with Py Ⅰ and Py Ⅲ,the contents of most elements in Py Ⅱ are apparently higher.The As and Se contents are high within a wide range and are decoupled in the growth band of the C_Py.The highest As,Se,and Pb contents were found in W_Py and N_Py.These results indicate the drastic changes in the temperature and fluid mixing during the mineralization.The occurrence of fluctuation and change in temperature and f(O_(2)) was triggered by intermittent pulses of magmatic-hydrothermal fluids,mixing with meteoric water,and water-rock interactions.The sulfur isotopes of all species of pyrite indicated the magmatic source.The change in the f(O_(2)) conditions caused slight differences in the sulfur isotope compositions.Consequently,a metallogenic model was proposed to explain the ore-forming processes.
基金Supported by Shandong Provincial Natural Science Foundation,China,No. ZR2009CQ031
文摘AIM:To evaluate the association of human leukocyte antigen(HLA)-DQB1 alleles with hepatocellular carcinoma(HCC) through meta-analysis of published data.METHODS:Case-control studies on HLA-DQB1 allele association with HCC published up to January 2010 were included in the analyses.The odds ratios(ORs) of HLADQB1 allele distributions in HCC patients were analyzed and compared with healthy controls.The meta-analysis software REVMAN 5.0 was applied for investigating heterogeneity among individual studies and for summarizing all the studies.A meta-analysis was performed using fixed-effect or random-effect methods,depending on the absence or presence of significant heterogeneity.Seven case-control studies containing 398 cases and 594 controls were included in the final analysis.RESULTS:Among the five family alleles,two(DQB1*02 and DQB1*03) were found to be significantly associated with the risk of HCC.The combined OR for the association of DQB1*02 and DQB1*03 allele with the risk for HCC was 1.78(95% CI:1.05-3.03,P = 0.03) and 0.65(95% CI:0.48-0.89,P = 0.007),respectively.Among the 13 specific alleles,two(DQB1*0502 and DQB1*0602) were significantly associated with risk of HCC.The combined OR for the association of DQB1*0502 and DQB1*0602 allele with the risk for HCC was 1.82(95% CI:1.14-2.92,P = 0.01) and 0.58(95% CI:0.36-0.95,P = 0.03),respectively.No significant association was established for other HLA-DQB1 family alleles and specific alleles.CONCLUSION:Our results support the hypothesis that specific HLA-DQB1 allele families and alleles might influence the susceptibility or resistance to HCC,although it needs further investigations.
文摘A three-dimensional finite element simulation was carried out to investigate the effects of tunnel construction on nearby pile foundation.The displacement controlled model (DCM) was used to simulate the tunneling-induced volume loss effects.The numerical model was verified based on the results of a centrifuge test and a set of parametric studies was implemented based on this model.There is good agreement between the trend of the results of the centrifuge test and the present model.The results of parametric studies show that the tunnelling-induced pile internal force and deformation depend mainly on the pile?tunnel distance,the pile length to tunnel depth ratio and the volume loss.Two different zones are separated by a 45° line projected from the tunnel springline.Within the zone of influence,the pile is subjected to tensile force and large settlement;whereas outside the zone of influence,dragload and small settlement are induced.It is also established that the impact of tunnelling on a pile group is substantially smaller as compared with a single pile in the same location with the rear pile in a group,demonstrating a positive pile group effect.
基金Supported by Chinese MOST 973 project(2013CB733501)the National Natural Science Foundation of China1(21136004,21476106,21606131)+1 种基金the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)the Fundamental Research Funds for the Central Universities(30916011351)at Nanjing University of Science&Technology
文摘In this work, we successfully synthesized bicrystalline anatase/TiO2(B) nanofibre and used it as active substrate for surface-enhanced Raman scattering (SERS) applications. The bicrystalline structured TiO2 substrates provide additional charge transfer across the anatase-TiO2(B) interface and thus enhanced activity compared to the pure single crystalline phase. With an effort to further increase the sensitivity of SERS, nitrogen element was doped into bicrystalline anatase/TiO2(B) nanofibres (N-TiO2) and higher SERS enhancement was achieved. The nitrogen content was controlled by tuning the calcination temperature of titanate precursor at 500, 600 and 700℃, respectively. The sample calcined at 600℃ (NT600) acquires the highest percentage of nitrogen element due to its open pore structure that facilitates the diffusion of nitrogen during calcination. Raman intensity depends on the amount of nitrogen doping, thus NT600 exhibited the best SERS activity. The doped nitrogen in TiO2 facilitates the charge transfer between TiO2 and probing molecules and thus suppresses the electron-hole recombination. This work provides a new perspective on the design of efficient TiO2 SERS active substrate and is expected to be valuable for adsorbate detection on semiconductor surface.