元安颗粒对慢性心力衰竭大鼠心肌组织黏附分子表达的影响

目的探讨元安颗粒对慢性心力衰竭(CHF)大鼠心肌组织黏附分子表达的影响,研究其可能的作用机制。方法采用结扎WKY大鼠冠状动脉前降支法造成心肌梗死后形成CHF大鼠模型。观察心肌细胞病理变化。用ELISA法检测血清中心肌组织黏附分子表达情况。结果给药4周后,各组治疗前后比较,元安颗粒高、中、低剂量组与卡托普利组均能够降低血清中心肌组织黏附分子表达,差异有统计学意义,其中元安颗粒高剂量组疗效显著。结论元安颗粒是治疗CHF的有效方药。

元安浓缩丸治疗冠心病稳定型心绞痛瘀热互结证的临床研究

目的:探讨元安浓缩丸治疗稳定型心绞痛(瘀热互结证)患者的临床疗效及其治疗冠心病心绞痛的作用机制。方法:采用随机对照的临床研究方法,以复方丹参滴丸为对照组,观察服药前后心绞痛发作次数、持续时间、疼痛程度、中医证候疗效、心电图、血脂以及左室功能的情况。结果:治疗组较对照组能显著缓解心绞痛症状,改善中医证候,提高硝酸甘油减停率,改善心电图,降低血脂及改善左室功能(P<0.05)。结论:元安浓缩丸是治疗稳定型心绞痛瘀热互结证的有效方药。

对《丰碑》教学案例的再思考——与王元安老师和教材编者商榷

《小学教学设计》2010年第9期刊登了山东单县王元安老师的文章《对"文本解读个性化"的思考》。文中,王元安引用了《丰碑》一课的一则教学案例,转录如下:师:你们觉得军需处长是一个怎样的人?生:我觉得军需处长是一个毫不利己、专门利人的人,他是个关心集体的英雄。生:军需处长是一个把生的希望让给别人,把死的危险留给自己的好战士。

酸涩的苹果

放学了,我走出校门,高高兴兴地朝家走去。路过集市,我看到集市里的人还是熙熙攘攘的。远远望去,新鲜的水果应有尽有,真是诱人。我把书包往背后一甩,兴致勃勃地朝卖果品的地方走去。忽然,一筐红艳艳的苹果映入我的眼帘,满筐又大又水灵的苹果,让人看了就垂涎欲滴。我伏下身子。

安瑞祥 “雍容华贵”K金镶羊脂白玉手链

安瑞祥为中华老字号,安瑞祥创始于光绪年间,至今已有120周年,一直秉承至臻,独创,传承,典藏的文化理念,传统百年工艺结合现代独特审美,极品材质融合历史的艺术。这是一场繁华,一场积淀了历史的厚重与现代艺术碰撞的繁华,散发出让人寻找文化的美,不断探索艺术的迷的气息。

Discrete element approach for mine dump stability analysis

Mine overburden dumps have posed significant safety issues in the operations of various unit operations of open pit min-ing especially the external dumps. The external dumps are composed of a mixture of fragmented rocks and loose soil. Their charac-teristic is comparable to heavily discontinuous solid mass. The conventional approach of limit equilibrium methods provide safety factors for the slope but nothing about the stress-strain characteristics of the large dump mass. The designs of dump location and their respective geometry are integrated for the know-how of the stability characteristics of these dumps. The discrete element method uses a circular disk to represent the granular solid mass and their interactions are described by the Newton’s third law of motion. The displacement is described by the sliding of the circular disk. This work is focused on the modeling efficiency of the discrete element methods to represent the behaviour of mine dump masses with the specified joint plane for the limit equilibrium method. The advantage of the work lies on the ease of information retrieval at any point at the dump mass concerning the stress and strain histories, displacement, failures etc. which when integrated produces a better understanding of the stability of the dump masses.

Study on effect of segments erection tolerance and wedge-shaped segment on segment ring in shield tunnel

Deformation and dislocations of segments of shield tunnel in construction stage have apparent effect on tunnel structure stress and even cause local cracks and breakage in tunnel. 3D finite element method was used to analyze two segment ring models under uniform injected pressure: (1) segment ring without wedge-shaped segment, which has 16 types of preinstall erection tolerance; (2) segment ring with wedge-shaped segment, which has no preinstall erection tolerance. The analysis results indicate that different erection tolerances can cause irregular deformation in segment ring under uniform injected pressure, and that the tolerance values are enlarged further. Wedge-shaped segment apparently affects the overall deformation of segment ring without erection tolerances. The uniform injected pressure can cause deformation of ring with wedge-shaped segment irregular, and dislocations also appear in this situation. The stress of segment with erection tolerances is much larger than that of segment without erection tolerances. Enlarging the central angle of wedge-shaped segment can make the irregular deformation and dis- locations of segments smaller. The analysis results also provide basis for erection tolerance control and improvement of segment constitution.

Rare earth element geochemistry of groundwater from a deep seated sandstone aquifer,northern Anhui province,China

Deep coal mines in northern Anhui province, China, provide opportunities for tracing the distribution and fractionation of rare earth elements CREEs） in deep seated environments. Major ions, as well as REE concentrations were measured in groundwater from a sandstone aquifer located between -400 and -280 m. Our results indicate that this groundwater consists of CI.HCOH-Na or CI.CO3-Na water types with warm temperature （30.1-31.4~C）, circumneutral pH （7.27-8.61） and high levels of total dissolved solids （TDS ~ 1306--2165 mg/L）. Concentrations of REEs in groundwater are high as expressed by their Nd con- centrations （0.0086-0.018μg/L）. Except for weak heavy REEs （HREE） enrichment relative to light REEs （LREE）, the similarity of REE distribution patterns between groundwater and aquifer rock indicate that enrichment of REEs is considered to be controlled by aquifer rock, as well as by their minerals, whereas the fractionation of REEs is controlled by HREE enriched minerals and, to a lesser extent, by inorganic REE complexes. Ce anomalies normalized to Post Archean Average Shale （PAAS） and aquifer rock are weak, which probably reflect the contribution of reduced conditions in combination with pH, rather than a sig- nature of aouifer rock.

A fault injection model-oriented testing strategy for component security

A fault injection model-oriented testing strategy was proposed for detecting component vulnerabilities.A fault injection model was defined,and the faults were injected into the tested component based on the fault injection model to trigger security exceptions.The testing process could be recorded by the monitoring mechanism of the strategy,and the monitoring information was written into the security log.The component vulnerabilities could be detected by the detecting algorithm through analyzing the security log.Lastly,some experiments were done in an integration testing platform to verify the applicability of the strategy.The experimental results show that the strategy is effective and operable.The detecting rate is more than 90%for vulnerability components.

Assessment of compliance-relevant indispensable knowledge to cope with epilepsy in epileptic patients in Xi'an

Objective: To investigate the knowledge level related to compliance in patients with epilepsy. Methods: Eighty-seven patients with epilepsy were tested in the city of Xi’an with a knowledge questionnaire containing 21 questions related to compliance. Results: Over 39.5% of patients did not know that epilepsy is the result of abnormal firing of neurons, while 29.9% were uncertain or did not realize that epilepsy attacks can bring up accidents such as traffic accidents, drowning and trauma. A total of 36.6% of responders thought that the best therapy for epilepsy could be found in Traditional Chinese Medicine. As many as 36.8% of tested patients were uncertain or did not know that frequent epilepsy attacks can affect their intelligence. Up to 36% were unaware of the possible consequence of sudden withdrawal of anti-epileptic drugs (AED). Among responders, 39.1% did not know the right treatment method of epilepsy. That AED can control seizure attacks were doubted in 57.5% of epileptic patients. Furthermore, 32.2% did not know whether the disease could be cured. Conclusion: In this group of epileptic patients, generally they do not have enough indispensable knowledge to cope with epilepsy. They urgently need for proper health education besides effective AED to control seizure attacks and improve their quality of life.

Secure Big Data Storage and Sharing Scheme for Cloud Tenants

The Cloud is increasingly being used to store and process big data for its tenants and classical security mechanisms using encryption are neither sufficiently efficient nor suited to the task of protecting big data in the Cloud.In this paper,we present an alternative approach which divides big data into sequenced parts and stores them among multiple Cloud storage service providers.Instead of protecting the big data itself,the proposed scheme protects the mapping of the various data elements to each provider using a trapdoor function.Analysis,comparison and simulation prove that the proposed scheme is efficient and secure for the big data of Cloud tenants.

Origin of Quaternary Red Clay of Southern Anhui Province

The particle size distribution, heavy mineral constituents and rare earth elements (REE) characteristics of the Quaternary red clay of southern Anhui Province were studied to explore the origin of the clay. The results showed that the clay had some properties of areolian deposits, which could be compared with those of the loess in North China; and its chondrite normalized curves of REE were similar to those of the Xiashu loess, implying that they shared the same origin. It was concluded in combination with the results reported by other researchers that the Quaternary red clay of southern Anhui Province originated from aeolian deposits, and this could reveal the cycles of warm and cold climates in the area during the Quaternary period.

Thermodynamic properties of metamizol monohydrate in pure and binary solvents at temperatures from(283.15 to 313.15) K

The thermodynamic properties of metamizol monohydrate in pure solvents(methanol,ethanol,n-propanol and isopropanol) and two binary mixed solvent systems including(methanol+ethanol) and(methanol+isopropanol) were measured from 283.15 K to 313.15 K by gravimetric method under atmospheric pressure thought as 0.1 MPa.The modi fied Apelblat equation,the CNIBS/R-K equation,the Hybrid model and the NRTL model were used to correlate the solubility of metamizol monohydrate,respectively.The results show that the solubility of metamizol monohydrate in all the tested solvents increases with the rising temperature which means that it has temperature dependence.What's more,the effects of solvent components of the binary solvent mixtures on solubility were discussed,it illustrates that the increasing of the molar fraction of methanol gives the system a greater dissolving power.Furthermore,according to the NRTL model,the enthalpy,the Gibbs energy and the entropy of the mixing process were also obtained and discussed.

Electrochemical Study of Trinuclear Metal Complexes ［M_3O_2（O_2CCH_3）_6（H_2O）_3］^（2＋）（M_3＝Mo_3，MoW_2，W_3）

In this paper detailed studies of the cyclic voltammetry(CV) of trinuclear metal cluster compounds [M_3O_2(O_2CCH_3,)6(H,O),j z+ (M,=Mo3,MoW2,W3) are reported.The result of CV shows that they are similar to each other.There are a reversible redox peak near-0. 48 V and an irreversible reduced peak near-1.10 V in the scan range of + l.0 V to l. 5 V.It implies that the M_3O_2,clusters might gain one electron to be further reduced.But the two-electron-reduced product of M_3O_2 clusters are instable.The theoretical calculations(EHMO) agree well with the result of the CV experiment.

Effect of stiffeners on crashworthiness of square aluminium columns considering damage evolution

Combining the optimization and FEM technology,crashworthiness of aluminum extrusions was studied for an automobile safety plan.The effects of longitudinal stiffeners on the crushing of stiffened square columns were studied considering the damage evolution.The numerical analysis was carried out by ABAQUS software.Subsequently,the collapse behavior of aluminum extrusion damage was validated by comparing against solution published in literature.Finally,in order to find more efficient and lighter crush absorber and achieving minimum peak crushing force,response surface methodology(RSM) has been applied for optimizing the aluminum extrusion tube.

Origin of the regional stress field along the Liquine-Ofqui Fault Zone(LOFZ),Southern Chilean Andes by means of FE Simulation

The Liquine-Ofqui Fault Zone(LOFZ) of southern Chilean Andes is one of the largest active strike-slip fault zones.There is an ongoing debate regarding the origin of the stress field along the LOFZ due to its complex geometry.This paper represents a study of the origins of the LOFZ regional stress field.Stress fields are calculated by finite element(FE) analysis.The two possible stress origins, i.e., oblique plate convergence and ridge collision/indenter tectonics of Chile ridge against Peru-Chile trench, have been emphasized in the present study.Three types of boundary conditions for the three particular models have been applied to calculate stress fields.Models are assumed to be elastic and plane stress condition.Modeling results are presented in terms of four parameters, i.e., orientation of maximum horizontal stress(σ H max ), displacement vector, s train distribution, and maximum shear stress(τmax ) contour line within the model.The results of the first model with oblique plate convergence show inconsistency between the geometric shape of the LOFZ and the distribution of the four parameters.Although more realistic results are obtained from the second model with normal ridge collision, there are few coincident in the LOFZ geometry and regional stress field.The third model with normal and oblique ridge collision is reasonable in understanding the origin of stress field and geometrical condition in the lithosphere of the LOFZ.

Forming Proterozoic basement within eastern Central Asian Orogenic Belt:Evidence from zircon U-Pb-Hf-O isotopes

As part of the mosaic of micro-continents within the Central Asian Orogenic Belt(CAOB), the Xing’anAirgin Sum Block(XAB) features increasingly-recognized Meso-Neoproterozoic geological records. However, the origin, temporal-spatial distribution of ancient materials, and their roles in crust evolution remain to debate. This paper presents an integrated study of zircon U-Pb ages and Hf-O isotopes for Mesoproterozoic and Paleozoic granites from the Erenhot region of central Inner Mongolia, along eastern CAOB. The intrusion of 1450 Ma syenogranite denotes that the Precambrian basement of XAB extends from Sonid Zuoqi westward to Erenhot. The 384 and 281 Ma monzogranites containing Mesoproterozoic xenocrystic zircons possess Proterozoic-dominant two-stage Hf model ages, further suggesting the wide existence of Proterozoic crust beneath western XAB. Cyclic Proterozoic crustal growth and reworking seem to show close linkages with the orogenesis during relevant supercontinent cycles. 1450-1360 Ma juvenile crustal growth at Erenhot and synchronous ancient crust reworking at Sonid Zuoqi and Abagaqi were likely resulted from retreating subduction involved in Columbia breakup, while 1.2-1.0 Ga reworking and 0.9-0.7 Ga growth events within the Erenhot basement might respond to assembly and breakup of Rodinia, respectively. Besides, our work confirms that reworking of Neoproterozoic crust played important roles during Paleozoic multi-stage accretion of CAOB.

Research on the stability analysis and design of soil tunnel surrounding rock

The paper first analyzes the failure mechanism and mode of tunnel according to model experiments and mechanical calculation and then discusses the deficiency of taking the limit value of displacement around the tunnel and the size of the plastic zone of surrounding rock as the criterion of stability. So the writers put forward the idea that the safety factor of surrounding rock calculated through strength reduction FEM(finit element method) should be regarded as the criterion of stability,which has strict mechanical basis and unified standard and would not be influenced by other factors. The paper also studies the safety factors of tunnel surrounding rock (safety factors of shear and tension failure) and lining and some methods of designing and calculating tunnels. At last,the writers take the loess tunnel for instance and show the design and calculation results of two-lane railway tunnel.

Metamodeling Transfer Capability of Manitoba-Ontario Electrical Interconnections

The electric power transfer capability on the Manitoba-Ontario interconnection depends on various system operating conditions such as area generation patterns and ambient temperatures. This work models the power network as a black-box function, which is evaluated with the system reliability analysis techniques to determine the maximum transfer capability under a given operating condition. A metamodel or an approximation model of the maximized power transfer capability is built based on the sampled system responses and optimized with respect to the corresponding operating conditions. An optimal metamodel is implemented as a prototype software tool, PTCanalyzer, and applied to Manitoba-Ontario interconnection power transfer calculations. This optimized metamodel technique provides an in-depth understanding of the dependency of the power transfer capability on system operating conditions and proves to be an effective tool in optimizing the operation planning of the interconnection for a given power system configuration. The PTCanalyzer has the potential to be used for optimization of other power network interconnections.

Dionysos and Apollo： Remediating Said＇s Orientalism with Metacritical Perspective

Geography is a kind of differential calculus in the sense that the three-dimensional, that is, the act of tangentially accessing things, is mapped on to the two-dimensional or the concrete. It is why we can say that the East-West or Occidental versus Oriental dichotomy is so limited in its binary dualism. We could easily criticize not only Said＇s Orientalism, but also in turn, a critical self-defense by turning itself upon its own head. It can indeed be said that the cross or cardinal directions run four different ways and not two. ＂The East＂ is not just Far Eastern, that is, the so-called ＂Asian,＂ but extends to the Far West or to California. Parts of Europe and the Dionysian are not simply limited to Central Europe and Southeastern Asia. We can see in Asia, that is, Eurasia and in North Africa, that 1-2% of non-Sub-saharan human DNA is genotypically Neanderthal in addition to being Homo Sapiens in DNA. 1 The task, it might be said, is to continually remediate binary directions and to reweave Apollo and Dionysos in Friedrich Nietzsche. We can see the limitations of Continentalism in categorizing the human.