Objective To evaluate the clinical efficacy and safety of Zhenzhu Qingyuan Granules through a clinical randomized controlled trial and to analyze the potential action targets and pathways of this formula using network...Objective To evaluate the clinical efficacy and safety of Zhenzhu Qingyuan Granules through a clinical randomized controlled trial and to analyze the potential action targets and pathways of this formula using network pharmacology.Methods Patients with gastroesophageal reflux disease(GERD)of liver–stomach stagnant heat pattern who met the inclusion and exclusion criteria were randomly divided into the control group and the observation group.The control group received oral rabeprazole,whereas the observation group were given Zhenzhu Qingyuan Granules in addition to the rabeprazole.The treatment duration was 8 weeks.Clinical efficacy was observed in both groups after 8 weeks.Network pharmacology was used to analyze the action targets of ZhenzhuQingyuanGranules and the genes related to GERD,and core targets were inferred.Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were conducted to explore the potential mechanisms of this formula.Results The clinical research results showed that the total effective rate in the treatment group was 92.68%,compared with 70.00%in the control group,with a statistically significant difference(p<0.05).After treatment,both Chinese medicine syndrome score and endoscopic score improved in both groups compared with before treatment(p<0.05),and the treatment group showed greater improvement than the control group(p<0.05).Network pharmacology identified effective components of Zhenzhu Qingyuan Granules for treating GERD,including quercetin,luteolin,andβ-sitosterol,with potential action targets such as tumor protein 53(TP53),protein kinase B(AKT1),and tumor necrosis factor.Conclusion Zhenzhu Qingyuan Granules can significantly improve clinical symptoms in patients with GERD of liver–stomach stagnated heat pattern,enhance clinical efficacy,and have high safety.This formula may exert therapeutic effects through multiple targets and pathways.展开更多
A binary eutectic mixture composed of tetradecanol(TD)and myristic acid(MA)was maximally absorbed into the microstructures of expanded perlite(EP)and expanded vermiculite(EVMT),respectively,through a self-made vacuum ...A binary eutectic mixture composed of tetradecanol(TD)and myristic acid(MA)was maximally absorbed into the microstructures of expanded perlite(EP)and expanded vermiculite(EVMT),respectively,through a self-made vacuum adsorption roller to prepare phase change material(PCM)particle(PCP).Then EP and EVMT-based composite PCM plates were respectively fabricated through a mold pressing method.The thermal property,chemical stability,microstructure and durability were characterized by differential scanning calorimeter(DSC),Fourier transform infrared spectroscope(FT-IR),scanning electron microscope(SEM)and thermal cycling tests,respectively.The results show that both PCPs have high latent heats with 110 J/g for EP-based PCP and more than 130 J/g for EVMT-based PCP,compact microstructure without PCM leakage,stable chemical property and good durability.The research results have proved the feasibility for the vacuum adsorption roller used in the composite PCM fabrication.Results of thermal storage performance experiment indicate that the fabricated PCM plates have better thermal inertia than common building materials,and the thermal storage performance of PCM plates has nonlinearly changed with outside air velocity and temperature increase.Therefore,PCM plates show a significant potential for the practical application of building thermal storage.展开更多
In this paper, the author shall deal with the Hungarian variants of dualistic world creation myths. The aim of this paper is to shed some light on the nature of the connection between the Central-East European Hungari...In this paper, the author shall deal with the Hungarian variants of dualistic world creation myths. The aim of this paper is to shed some light on the nature of the connection between the Central-East European Hungarian and South-East European Romanian and Bulgarian myth variants. The Hungarian pieces are the westernmost variants of the dualistic creation myth-group. Geographically, they stand close to the Romanian variants, but the serious motivational differences between the Romanian and Hungarian variants show that the descent of the two oral narrative groups are distinct, Both the Hungarian and the Romanian variants show similarities with the Bulgarian world creation myths, however, geographically they do not relate tightly. This is why a possible explanation of these correlations is, that the Hungarian and the Bulgarian myths have common Central Eurasian, South-Eastern Siberian origins, upon which starting from the sixth to the seventh centuries the super strata of various gnostic influences have settled.展开更多
基金National Administration of Traditional Chinese Medicine Evidence-Based Capacity Building Project(2019XZZXXH005)Special Project on Traditional Chinese Medicine Scientific Research of Health Commission of Henan Province(2022ZY2022)+1 种基金Henan Provincial Top Talents Cultivation Project in Traditional Chinese Medicine Discipline of Henan Provincial Traditional Chinese Medicine Inheritance and Innovation Talents Project(Zhongjing Project)(Henan Health TraditionalMedicine Letter[2021]No.15)Special Project on Traditional Chinese Medicine Scientific Research of Health Commission of Henan Province(2023ZY2062).
文摘Objective To evaluate the clinical efficacy and safety of Zhenzhu Qingyuan Granules through a clinical randomized controlled trial and to analyze the potential action targets and pathways of this formula using network pharmacology.Methods Patients with gastroesophageal reflux disease(GERD)of liver–stomach stagnant heat pattern who met the inclusion and exclusion criteria were randomly divided into the control group and the observation group.The control group received oral rabeprazole,whereas the observation group were given Zhenzhu Qingyuan Granules in addition to the rabeprazole.The treatment duration was 8 weeks.Clinical efficacy was observed in both groups after 8 weeks.Network pharmacology was used to analyze the action targets of ZhenzhuQingyuanGranules and the genes related to GERD,and core targets were inferred.Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were conducted to explore the potential mechanisms of this formula.Results The clinical research results showed that the total effective rate in the treatment group was 92.68%,compared with 70.00%in the control group,with a statistically significant difference(p<0.05).After treatment,both Chinese medicine syndrome score and endoscopic score improved in both groups compared with before treatment(p<0.05),and the treatment group showed greater improvement than the control group(p<0.05).Network pharmacology identified effective components of Zhenzhu Qingyuan Granules for treating GERD,including quercetin,luteolin,andβ-sitosterol,with potential action targets such as tumor protein 53(TP53),protein kinase B(AKT1),and tumor necrosis factor.Conclusion Zhenzhu Qingyuan Granules can significantly improve clinical symptoms in patients with GERD of liver–stomach stagnated heat pattern,enhance clinical efficacy,and have high safety.This formula may exert therapeutic effects through multiple targets and pathways.
基金Project(51408184)supported by the National Natural Science Foundation of ChinaProject(E2017202136)supported by the Natural Science Foundation of Hebei Province,China+1 种基金Project(BSBE2017-05)supported by Opening Funds of State Key Laboratory of Building Safety and Built Environment and National Engineering Research Center of Building Technology,ChinaProject(QG2018-3)supported by Hebei Provincial Department of Transportation,China
文摘A binary eutectic mixture composed of tetradecanol(TD)and myristic acid(MA)was maximally absorbed into the microstructures of expanded perlite(EP)and expanded vermiculite(EVMT),respectively,through a self-made vacuum adsorption roller to prepare phase change material(PCM)particle(PCP).Then EP and EVMT-based composite PCM plates were respectively fabricated through a mold pressing method.The thermal property,chemical stability,microstructure and durability were characterized by differential scanning calorimeter(DSC),Fourier transform infrared spectroscope(FT-IR),scanning electron microscope(SEM)and thermal cycling tests,respectively.The results show that both PCPs have high latent heats with 110 J/g for EP-based PCP and more than 130 J/g for EVMT-based PCP,compact microstructure without PCM leakage,stable chemical property and good durability.The research results have proved the feasibility for the vacuum adsorption roller used in the composite PCM fabrication.Results of thermal storage performance experiment indicate that the fabricated PCM plates have better thermal inertia than common building materials,and the thermal storage performance of PCM plates has nonlinearly changed with outside air velocity and temperature increase.Therefore,PCM plates show a significant potential for the practical application of building thermal storage.
文摘In this paper, the author shall deal with the Hungarian variants of dualistic world creation myths. The aim of this paper is to shed some light on the nature of the connection between the Central-East European Hungarian and South-East European Romanian and Bulgarian myth variants. The Hungarian pieces are the westernmost variants of the dualistic creation myth-group. Geographically, they stand close to the Romanian variants, but the serious motivational differences between the Romanian and Hungarian variants show that the descent of the two oral narrative groups are distinct, Both the Hungarian and the Romanian variants show similarities with the Bulgarian world creation myths, however, geographically they do not relate tightly. This is why a possible explanation of these correlations is, that the Hungarian and the Bulgarian myths have common Central Eurasian, South-Eastern Siberian origins, upon which starting from the sixth to the seventh centuries the super strata of various gnostic influences have settled.
