HPLC法测定元生胶囊中氧化苦参碱的含量

本试验以元生胶囊为研究对象,对制剂中氧化苦参碱的测定方法进行研究。结果表示高效液相色谱法含量测定中,氧化苦参碱的进样量在0.2～3.0μg范围内,线性关系良好。经方法学考察,改进了本品的质量标准,可用于本品的质量控制。

元生胶囊治疗直肠癌术后23例临床观察

目的:观察元生胶囊治疗直肠癌术后的临床疗效。方法:将45例直肠癌术后患者随机分为对照组22例和治疗组23例。对照组用FOLFOX4方案化疗,治疗组在单纯化疗的基础上加口服元生胶囊治疗,疗程为2个化疗周期。结果:治疗组显效率、总有效率分别为60.9%、91.3%,对照组分别为36.4%、72.8%,组间比较,差异有统计学意义(P<0.05)。与对照组比较,治疗组能抑制白细胞减少,减轻恶心、呕吐等化疗毒副作用,稳定KPS评分,差异均有统计学意义(P<0.01)。结论:元生胶囊能改善行FOLFOX4方案化疗的直肠癌患者的免疫功能,提高生活质量。

培元生金通窍汤辅助治疗对哮喘合并过敏性鼻炎患儿肺功能的影响

目的观察培元生金通窍汤辅助治疗对哮喘合并过敏性鼻炎患儿肺功能的影响。方法选取2016年8月至2018年8月丽水市中医院儿科住院部收治的哮喘合并过敏性鼻炎患儿66例,按随机数字表法分为对照组和治疗组,各33例。对照组给予布地奈德福莫特罗粉吸入剂、沙丁胺醇气雾剂治疗,治疗组在对照组治疗方法的基础上联合培元生金通窍汤治疗,2组均治疗3个月后比较临床疗效,治疗前后中医证候评分及肺功能指标[呼气峰流速值占预计值的百分比(PEF%)、第1秒用力呼气容积占预计值的百分比(FEV1%)]的变化情况。结果治疗组总有效率为93.94%,显著高于对照组的69.70%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组的鼻炎证候评分、喘息+咳嗽评分和中医证候总评分比较,差异无统计学意义(P>0.05),具有可比性;治疗后,2组的上述评分与同组治疗前比较均明显下降,且治疗组下降更显著,差异均有统计学意义(P<0.05)。治疗前,2组的PEF%、FEV1%比较,差异无统计学意义(P>0.05),具有可比性;治疗后,2组的PEF%、FEV1%与同组治疗前比较均明显上升,且治疗组上升更显著,差异均有统计学意义(P<0.05)。结论培元生金通窍汤辅助治疗哮喘合并过敏性鼻炎患儿临床疗效满意,可有效缓解临床症状,改善肺功能,值得临床推广应用。

Rapid detection and risk assessment of soil contamination at lead smelting site based on machine learning

A general prediction model for seven heavy metals was established using the heavy metal contents of 207soil samples measured by a portable X-ray fluorescence spectrometer(XRF)and six environmental factors as model correction coefficients.The eXtreme Gradient Boosting(XGBoost)model was used to fit the relationship between the content of heavy metals and environment characteristics to evaluate the soil ecological risk of the smelting site.The results demonstrated that the generalized prediction model developed for Pb,Cd,and As was highly accurate with fitted coefficients(R~2)values of 0.911,0.950,and 0.835,respectively.Topsoil presented the highest ecological risk,and there existed high potential ecological risk at some positions with different depths due to high mobility of Cd.Generally,the application of machine learning significantly increased the accuracy of pXRF measurements,and identified key environmental factors.The adapted potential ecological risk assessment emphasized the need to focus on Pb,Cd,and As in future site remediation efforts.

韦应物交游考

本文主要利用出土的唐代墓志,结合诗文等其他材料,考察了韦应物诗中涉及到的几个人物的生平中的一些事实,拟定了这几篇诗的写作时地。

Effects of Oestrogen on Ischemia-induced Neurogenesis in the Dentate Gyrus of Rats

To study the effects of oestrogcn on ischemia-induced neurogenesis in the hippocampal dentate gyms, thirty-two adult male rats were randomly divided into four groups： the control surgery group with eestrogen administration （SE）, the control surgery group with normal saline administration （SN）, the middle cerebral artery occlusion （MCAO） group with oestrogen administration （ME） and the MCAO group with normal saline administration （MN）. The MCAO rats were occluded for 90 rain by an intraluminal filament and then recirculated. After 1, 3, 12, 24 and 28 h of MCAO, the rats of the four groups were killed to investigate the infarct volume, apoptosis and neurogenesis. The cerebral infarct volume in the ME group was significantly smaller than that of the MN group （P 〈 0.05）. No significant cell loss was seen in the dentate gyms. Cerebral ischemia led to increased neurogenosis, which is independent of cell death in the ipsilateral dentate gyrus（P 〈 0.05）. BrdU-pesitive cells in the ipsilateral dentate gyms of the ME group were significantly increased when compared with those of the MN group（P 〈 0.05）. In the SE group, BrdU-positive cells in both the ipsilateral and contralateral dentate gyms, were increased when compared with those of the SN group （ P 〈 0.05 ）. We concluded that ocstregen plays an important role in neurogenesis, which is independent of ischemia-induced by MCAO in the hippocampal dentate gyms of rats.

Computational analysis of genetic loci required for amphid structure and functions and their possibly corresponding microRNAs in C. elegans

Objective To examine the important roles of microRNAs （miRNAs） in regulating amphid structure and function, we performed a computational analysis for the genetic loci required for the sensory perception and their possibly corresponding miRNAs in C. elegans. Methods Total 55 genetic loci required for the amphid structure and function were selected. Sequence alignment was combined with E value evaluation to investigate and identify the possible corresponding miRNAs. Results Total 30 genes among the 55 genetic loci selected have their possible corresponding regulatory miRNA（s）, and identified genes participate in the regulation of almost all aspects of amphid structure and function. In addition, our data suggest that both the amphid structure and the amphid functions might be regulated by a series of network signaling pathways. Moreover, the distribution of miRNAs along the 3＇ untranslated region （UTR） of these 30 genes exhibits different patterns. Conclusion We present the possible miRNA-mediated signaling pathways involved in the regulation of chemosensation and thermosensation by controlling the corresponding sensory neuron and interneuron functions. Our work will be useful for better understanding of the miRNA-mediated control of the chemotaxis and thermotaxis in C. elegans.

Regulation of axonal regeneration following the central nervous system injury in adult mammalian

It has been well established that the recovery ability of central nervous system （CNS） is very poor in adult mammals. As a result, CNS trauma generally leads to severe and persistent functional deficits. Thus, the investigation in this field becomes a ＂hot spot＂. Up to date, accumulating evidence supports the hypothesis that the failure of CNS neurons to regenerate is not due to their intrinsic inability to grow new axons, but due to their growth state and due to lack of a permissive growth environment. Therefore, any successful approaches to facilitate the regeneration of injured CNS axons will likely include multiple steps： keeping neurons alive in a certain growth-state, preventing the formation of a glial scar, overcoming inhibitory molecules present in the myelin debris, and giving direction to the growing axons. This brief review focused on the recent progress in the neuron regeneration of CNS in adult mammals.

Studies on a Traditional Chinese Medical Prescription Ma Xing Shi Gan Tang by Bio-coordination Chemistry

本文报道 pH 电位滴定法测出麻黄碱与生石膏中的 Cu^(2+)、Fe^(2+)、Zn^(2+)、Mn^(2+)离子形成的 ML 及 ML_2型络合物的稳定常数。滴定曲线显示甘草酸与上述四种金属离子也能分别形成不同稳定程度的络合物。用麻黄碱加甘草酸和上述四种金属离子配制成的模拟麻杏石甘汤和单纯生石膏煎剂与麻性石甘汤一样均有使家兔退热的效果,与对照组比较均有显著性差异(P<0.05);而用麻黄碱加甘草酸配制成的溶液无退热效果。作者认为应从生物—配位无机化学的多金属—多配体体系的观点去研究某些传统中医药方剂。

Changes of cell proliferation and differentiation in the developing brain of mouse

Objective To investigate the cell proliferation and differentiation in the developing brain of mouse. Methods C57/BL6 mice were divided into 3 groups at random. Bromodeoxyuridine （BrdU） was injected into the brains in different development periods once a day for 7 d. The brains were retrieved 4 weeks after the last BrdU injection. Immunohistochemical and immunofluorescent studies were carried out for detecting cell proliferation （BrdU） and cell differentiation （NeuN, APC, lbal, and S 100β）, respectively. Results The number of BrdU labeled cells decreased significantly with the development of the brain. Cell proliferation was prominent in the cortex and striatum. A small portion of BrdU and NeuN double labeled cells could be detected in the cortex at the early stage of development, and in the striatum and CA of the hippocampus in all groups. The majority of BrdU labeled cells were neuroglia, and the number of neuroglia cells decreased dramatically with brain maturation. Neurogenesis is the major cytogenesis in the dentate gyrus. Conclusion These results demonstrated that cell proliferation, differentiation and survival were age and brain region related.

Precipitates identification in R_2PdSi_3(R= Pr,Tb and Gd) single crystal growth

Floating zone method with optical radiation heating was applied to growing a class of R2PdSi3（R=Pr,Tb and Gd） single crystals due to its containerless melting and high stability of the floating zone.One serious problem during the single crystal growth,precipitates of secondary phases,was discussed from the following four parts：precipitates from the raw materials and preparation process,precipitates formed during the growing process,precipitates in the melts and precipitates in the grown crystals.Annealing treatment and composition shift can effectively reduce the precipitates which are not formed during the crystallization but precipitated on post-solidification cooling from the as-grown crystal matrix because of the retrograde solubility of Si.

关于中西科学会通的几点思考

关于中西科学的讨论 ,争论颇多 ,究其因 ,多在对历史的基本预设与对科学的基本界定不同。笔者以为 ,无论是西方的或中国的文化传统 ,都是在历史的长河中生成演化的 ,科学本是文化的不可分割的一部分。近年 ,笔者就中西科学问题 ,提出了一些自己的观点 ,简称为 :“两条路”———认为人类科学从发展的全过程 ,即整体看是统一的 ,但就发展的不同历史阶段看 ,则有两大方向 ,两大主流。“生成元”———试图以中国周易“乾坤并建”的思想为系统科学的发展确立不同于原子论的逻辑起点。“形而中”———揭示中国古典生成论模型———阴阳五行的基础是“有象无形”之“气” ,此与形而下的西方科学分属不同层面 ,是中西科学的根本差异之一。现将以上三观点集中归之于下 ,以冀同道批评。

Mesh Generation for Finite Element Analysis of Electric Machines

This paper describes two modified methods for triangular and quadrilateral meshing for finite element analysis of 2D electric machines. One is coupling the classic Delaunay method and advancing front method to generate optimal triangulation; the other is coupling the classic paving and Delaunay triangulation for optimal quadrilateral meshing. Various electric machine models are meshed successfully to demonstrate the robustness and effectiveness of the methods.

Multivariate Analysis of Community Structure Variation of Plankton and Zoobenthos in Municipal Polluted River

[Objective] The plankton and macrobenthos samples in municipal polluted river were analyzed by different methods, so as to explore the method suitable for biological data analysis in heavy polluted area. [Method] Shannon-Wiener diversity index, cluster analysis of multivariate statistical analysis and MDS （Non-matric Multi- dimentional Scaling）analysis were used to analyze biological data of phytoplankton, zooplankton and Zoobenthos collected from the representative municipal polluted river in Pearl River Delta. The sediment samples were also collected to determine. Pb, Cd, Hg, Cr, As, Cu, Ni, Zn, as well as CODe, and NH3-N of porewater. Hakanson potential ecological risk index method was used to evaluate the ecological risk. [Re- suit] Shannon-Wiener diversity index analysis results can not effectively reflect the difference of pollution status of various stations in heavy polluted area; despite the presence of some problems, multivariate analysis method is superior to the Shannon-Wiener diversity index method in biological monitoring of heavy polluted river in the city. [Conclusion] The paper provided theoretical basis for biological data analysis in heavy polluted area.

Effects of Ca2+concentrations on accumulations of mineral elements in the components of Pteroceltis tatarinowii

The bark of Pteroceltis tatarinowii is a raw material for manufacturing Xuan Paper. The effects of Ca2+ concentrations on the accumulation of mineral elements in the bark, leaf and root of Pteroceltis tatarinowii were studied under controlled condi-tions. The types of Hoagland nutrient solution with three Ca2+ concentrations levels (200, 400 and 600 靏g-1) and a control (without Ca2+) were designed to culture Pteroceltis tatarinowii. After 6 months, contents of seven mineral elements including Ca, K, Mg, Mn, Zn, Cu and Na in the root, leaf and bark were analyzed. The results indicated that Ca accumulations content in the root, leaf and bark had positively relation with Ca2+ concentrations (200, 400, 600 靏g-1), and the order of the Ca content in the three components was root】leaf】bark. Ca content in the root treated with 600 靏g-1 Ca2+ concentrations was 5.5 times as high as that of the control, and about 1.4 times as high as that of the root treated in 200 and 400 靏/g Ca2+ concentrations respectively. On the contrary, K and Mg contents in the root, leaf and bark were negatively related to Ca2+ concentrations, especially in the bark, and their accumulation trend followed the order of leaf】root】bark. K content in the bark treated with 600 靏g-1 Ca2+ con-centrations was 39.3% of that of the control, and was 79.0% and 91.8% of that of the bark treated with 200 靏g-1 and 400靏g-1 Ca2+ concentrations respectively; Mg content in the bark treated with 600 靏g-1 Ca2+ concentrations was 23.4% of that of the control, and was 27.1% and 35.4% of that of the bark treated with 200 and 400 靏g-1 Ca2+ concentrations respectively. Com-pared with the control, the general tendency of Mn, Zn and Cu content decreased with increasing of Ca2+ concentrations and their contents were in the order: root】leaf】bark. Based on the results of this study, the experiment has been useful for providing academic bases in improving the bark quality of Pteroceltis tatarinowii on non-limestone soil.

DIFFERENTIABILITY OF C_0-SEMIGROUPS WITH APPLICATION

This paper considers the differentiability of C 0 semigroups with respect to (w.r.t.) parameters contained in their infinitesimal generators.It is proved that the generalized continuity and strong differentiability of their infinitesimal generators w.r.t.parameters imply the differentiability of the C 0 semigroups.The results are applied to the differentiability of the solution of a linear delay differential equation w.r.t.its delays.

Effects of Substrate Complexing Light Rare Earth on Growth,Cd Absorption and Organ Distribution of Sweet Pepper(Capsicum annuum var.annuum)

[Objective] The aim was to research effects of substrate complexing light rare earth on growth, Cd absorption and organ distribution of sweet pepper to pro- vide references for development of rhizosphere regulation products in farmland seri- ously polluted. [Method] In the test, effects of substrate cakes （at the same size） and light rare earth （in different doses） on growth, Cd absorption and distribution of green peppers under stress from Cd were explored with a pot experiment. [Result] When 40 mg/kg of rare earth was added into a substrate cake, plant height of pep- per seedlings and the dry weight increased by 21.52% and 11.11%, compared with control group; when Cd was at 5.19 mg/kg （a highly graded pollution）, the shoot biomass, olant biomass and dry weight of fruits all enhanced significantly, but root system changed little in the groups where substrate cakes were saved, compared with the group where the substrate cake was washed away. No matter RE was added into substrate cakes or not, root system was significantly inhibited by Cd stress （5.19 mg/kg）, but RE at proper dose improved growth of green pepper and had little effect on fruit yielding. In addition, RE had little inhibition on Cd content in roots. RE at 10 mg/kg promoted Cd contents in stems and leaves, but reduced the content in fruits substantially. The regressive equation of Cd content and rare dose in leaves was as follows： y=4E-05x%0.009 6x＋0.655 6, FF=0.542 6; the regression equations of Cd content in root, stem and fruit did not make sense. [Conclusion] The experiment lays foundation for further research on heavy metals rhizosphere complexing controlling.

葛藤托起合川农民绿色的希望

合川是重庆的农业大县,是重庆首批农业产业化产品出口基地县(市),自然资源丰富,农业基础条件较好,气候特点适宜农作物生长。曾是全国有名的粮食、生猪、蚕桑、柑桔大县,全市常年粮食产量75万吨、肥猪出栏110余万头、水果产量6万吨,合川农业和农村经济在国民经济发展中占有十分重要的地位。近年来,合川大力发展农业产业化。

The Gaoyuzhuang Palaeobiology

Black bedded, nodular, and lenticular chert and silicified parts of stromatolites from the approximately 1 400 - 1 600 million year-old Gaoyuzhuang Formation, North China, contain remark-ably well prep served microflora composed of diverse prokaryotic and possible eukaryotic microbes. Macroscopic algae have also been found. This Formation provides important paleobiological information from which to assess status of Mesoproterozoic life, and to evaluate paleoenvironmental conditions and pre-Phanerozoic biostratigraphy. The Gaoyuzhuang Formation has yielded over 100 taxa described by over 10 investigators. Most of the microbial taxa can be divided into three different assemblages according to their paleobiological and paleoenvironmental characteristics. I. The oscillatoriacean/chroococcacean assemblage which occurs in the first member of the Formation and this is interpreted to represent an assemblage from shallow water mat-building and mat-dwelling taxa with some possible planktonic taxa; 2. the nostocacean assemblage found only in the second member, and includes benthic mat-building or mat-dwelling taxa; and 3. the chroococcacean assemblage of the fourth member, which represents intertidal to supratidal mat-building and allochthonous taxa. Proterozoic microfossils found in chert, especially cyanobacteria, are possibly more valuable as paleoenvironmental indicators than as chronostratigraphic tools because of their morphological conservation, although trends in diversity appear to exist for cyanobacteria in the Proterozoic. The general characteristics of Gaoyuzhuang microfossils, and the fact that most nostocacean chains occur and are. preserved with the chain perpendicular to bedding indicate that: (1) the individual size of Gaoyuzhuang microfossils are part of a general trend of increase with time; (2) Gaoyuzhuang deposits are possibly in a fresh water environment and the rate of sedimentation might be equal to or less than the microbial growth rate; (3) the sedimentary model of Gaoyuzhuang might be from intertidal to subtidal or deep sea, and then to intertidal or supratidal; and (4) the eukaryotic organisms had densely occurred when Gaoyuzhuang Formation deposited.