Simple synthesis of multifunctional electrocatalysts with plentiful active sites from earth-abundant materials is especially fascinating. Here, N-doped defective carbon with trace Co （1.5 wt%） was prepared via a sca...Simple synthesis of multifunctional electrocatalysts with plentiful active sites from earth-abundant materials is especially fascinating. Here, N-doped defective carbon with trace Co （1.5 wt%） was prepared via a scalable one pot solid pyrolysis process. The sample exhibits efficient bifunctional OER/ORR activiW in alkaline, mainly ascribed to the unique micro-mesoporous structure （1-3 nm）, high population of graphitic-N doping （up to 49.0%）, abundant defects and the encapsulated Co nanoparticles with graphitized carbon. The according rechargeahle liquid Zn-air batteries showed excellent performance （maximum power density of 154.0 mWcm-2： energy density of 773Wh kg -1 at 5 mAcm 2 and charging-discharging cycling stability over 100 cycles）. As a proof-of-concept, the flexible, rechargeable all-solid-state Zn-air batteries were constructed, and displayed a maximum power density as high as 45.9 mW cm 2 among the top level of those reported previously.展开更多
This study aimed at determining the effects of Angelica sinensis(AS) on urinary metabolites in blood deficiency mice and exploring its replenishing blood mechanism. Gas chromatography–mass spectrometry(GC-MS) was app...This study aimed at determining the effects of Angelica sinensis(AS) on urinary metabolites in blood deficiency mice and exploring its replenishing blood mechanism. Gas chromatography–mass spectrometry(GC-MS) was applied to detect metabolites in the urine samples in different collection periods. Principal component analysis(PCA) and orthogonal partial least squares discriminant analysis(OPLS-DA) were used to investigate the differences in metabolic profiles among control group(CG), blood deficiency model group(MG), AS groups, and Colla Corii Asini group(CCAG). The potential biomarkers were identified based on the variable importance in the projection(VIP), T-test, and National Institute of Standards and Technology(NIST) and mass spectra library. The metabolites were analyzed using metabolomics pathway analysis(Met PA) to build the metabolic pathways. Our results indicated that, on the seventh day, the levels of glucose, lactic acid, pyruvic acid, alanine, acetoacetic acid, and citric acid changed significantly in blood deficiency mice. However, these metabolic deviations came to closer to normal levels after AS intervention. The reversing blood-deficiency mechanism of AS might involve regulating synthesis and degradation of ketone bodies, Pyruvate metabolism, TCA cycle, and Glycolysis / Gluconeogenesis. In conclusion, metabonomics is a robust and promising means for the identification of biomarkers and elucidation of the mechanisms of a disease, thereby highlighting its importance in drug discovery.展开更多
基金support from the Research Project of National University of Defense Technology(ZK16-03-32)National University Student Innovation Programthe support form Research Foundation of Education Bureau of Hunan Province(16K102)
文摘Simple synthesis of multifunctional electrocatalysts with plentiful active sites from earth-abundant materials is especially fascinating. Here, N-doped defective carbon with trace Co （1.5 wt%） was prepared via a scalable one pot solid pyrolysis process. The sample exhibits efficient bifunctional OER/ORR activiW in alkaline, mainly ascribed to the unique micro-mesoporous structure （1-3 nm）, high population of graphitic-N doping （up to 49.0%）, abundant defects and the encapsulated Co nanoparticles with graphitized carbon. The according rechargeahle liquid Zn-air batteries showed excellent performance （maximum power density of 154.0 mWcm-2： energy density of 773Wh kg -1 at 5 mAcm 2 and charging-discharging cycling stability over 100 cycles）. As a proof-of-concept, the flexible, rechargeable all-solid-state Zn-air batteries were constructed, and displayed a maximum power density as high as 45.9 mW cm 2 among the top level of those reported previously.
基金financially supported by the Natural Science Foundation of China(No.31272600)
文摘This study aimed at determining the effects of Angelica sinensis(AS) on urinary metabolites in blood deficiency mice and exploring its replenishing blood mechanism. Gas chromatography–mass spectrometry(GC-MS) was applied to detect metabolites in the urine samples in different collection periods. Principal component analysis(PCA) and orthogonal partial least squares discriminant analysis(OPLS-DA) were used to investigate the differences in metabolic profiles among control group(CG), blood deficiency model group(MG), AS groups, and Colla Corii Asini group(CCAG). The potential biomarkers were identified based on the variable importance in the projection(VIP), T-test, and National Institute of Standards and Technology(NIST) and mass spectra library. The metabolites were analyzed using metabolomics pathway analysis(Met PA) to build the metabolic pathways. Our results indicated that, on the seventh day, the levels of glucose, lactic acid, pyruvic acid, alanine, acetoacetic acid, and citric acid changed significantly in blood deficiency mice. However, these metabolic deviations came to closer to normal levels after AS intervention. The reversing blood-deficiency mechanism of AS might involve regulating synthesis and degradation of ketone bodies, Pyruvate metabolism, TCA cycle, and Glycolysis / Gluconeogenesis. In conclusion, metabonomics is a robust and promising means for the identification of biomarkers and elucidation of the mechanisms of a disease, thereby highlighting its importance in drug discovery.
