目的对比观察中西医结合药物治疗的基础上应用运动疗法治疗慢性充血性心力衰竭(CHF)的疗效。方法老年CHF患者60例随机分为治疗组和对照组;治疗组30例,在中西医结合药物治疗的基础上应用运动疗法;对照组30例,给予中西医结合药物治疗;两...目的对比观察中西医结合药物治疗的基础上应用运动疗法治疗慢性充血性心力衰竭(CHF)的疗效。方法老年CHF患者60例随机分为治疗组和对照组;治疗组30例,在中西医结合药物治疗的基础上应用运动疗法;对照组30例,给予中西医结合药物治疗;两组均治疗15 d。治疗前后以6 m in步行试验、超声心动图检测心功能各参数值以及血尿素氮(BUN)和血肌酐(C r)结果对两组患者的治疗效果进行比较。结果中西医结合药物治疗的基础上应用运动疗法治疗后,6 m in步行试验与对照组比较疗效显著(P<0.01);治疗组较对照组彩色超声心动图检测的心功能各参数治疗改善明显(P<0.05),生化指标检测与治疗前比较有显著性差异(P<0.05)。结论中西医结合药物治疗的基础上应用运动疗法治疗CHF能明显改善患者的心功能状态和临床症状。展开更多
Background: Little is known about the management of elderly patients with congstive heart failure(CHF) although they represent the majority of the CHF population. Therefore, the TIME-CHF study was set up(1) to evaluat...Background: Little is known about the management of elderly patients with congstive heart failure(CHF) although they represent the majority of the CHF population. Therefore, the TIME-CHF study was set up(1) to evaluate the medical management of very old patients(≥75 years) with CHF compared with younger patients(60-74 years),(2) to compare an intensified with a standard treatment approach, and(3) to differentiate between systolic and diastolic dysfunction(ejection fraction ≤45%vs >45%). Methods: In a prospective single-blinded multicenter trial, 824 symptomatic patients, CHF hospitalization within the last year and elevated NT-BNP, are randomized to an intensified versus a standard medical therapy. Treatment strategies follow the published guidelines with the aim to reduce symptoms to NYHA class ≤II(standard) or, additionally, NT-BNP levels below twice the upper limit of normal(intensified). The primary end points are 18-month hospitalization-free survival and quality of life. Results: By the end of 2004, 297 patients have been included, 147 randomized to intensified and 150 to standard therapy. Mean age in the older age group was 82±4 years(n=174) and 69±4 years in the younger group(n=123), respectively. Ejection fraction was >45%in 26%and 10%, respectively. Significant comorbidities were present in 93%of patients. Conclusion: TIME-CHF will be the first prospective randomized trial to comprehensively study the management of elderly patients with CHF. It will provide unique information comparing two treatment strategies in two age groups irrespective of ejection fraction regarding prognosis, quality of life, as well as resource utilization and costs.展开更多
文摘目的对比观察中西医结合药物治疗的基础上应用运动疗法治疗慢性充血性心力衰竭(CHF)的疗效。方法老年CHF患者60例随机分为治疗组和对照组;治疗组30例,在中西医结合药物治疗的基础上应用运动疗法;对照组30例,给予中西医结合药物治疗;两组均治疗15 d。治疗前后以6 m in步行试验、超声心动图检测心功能各参数值以及血尿素氮(BUN)和血肌酐(C r)结果对两组患者的治疗效果进行比较。结果中西医结合药物治疗的基础上应用运动疗法治疗后,6 m in步行试验与对照组比较疗效显著(P<0.01);治疗组较对照组彩色超声心动图检测的心功能各参数治疗改善明显(P<0.05),生化指标检测与治疗前比较有显著性差异(P<0.05)。结论中西医结合药物治疗的基础上应用运动疗法治疗CHF能明显改善患者的心功能状态和临床症状。
文摘Background: Little is known about the management of elderly patients with congstive heart failure(CHF) although they represent the majority of the CHF population. Therefore, the TIME-CHF study was set up(1) to evaluate the medical management of very old patients(≥75 years) with CHF compared with younger patients(60-74 years),(2) to compare an intensified with a standard treatment approach, and(3) to differentiate between systolic and diastolic dysfunction(ejection fraction ≤45%vs >45%). Methods: In a prospective single-blinded multicenter trial, 824 symptomatic patients, CHF hospitalization within the last year and elevated NT-BNP, are randomized to an intensified versus a standard medical therapy. Treatment strategies follow the published guidelines with the aim to reduce symptoms to NYHA class ≤II(standard) or, additionally, NT-BNP levels below twice the upper limit of normal(intensified). The primary end points are 18-month hospitalization-free survival and quality of life. Results: By the end of 2004, 297 patients have been included, 147 randomized to intensified and 150 to standard therapy. Mean age in the older age group was 82±4 years(n=174) and 69±4 years in the younger group(n=123), respectively. Ejection fraction was >45%in 26%and 10%, respectively. Significant comorbidities were present in 93%of patients. Conclusion: TIME-CHF will be the first prospective randomized trial to comprehensively study the management of elderly patients with CHF. It will provide unique information comparing two treatment strategies in two age groups irrespective of ejection fraction regarding prognosis, quality of life, as well as resource utilization and costs.
