为及时了解国内外对光动力杀菌的研究现状、热点和发展趋势,为相关研究领域的研究者提供参考,本文采用文献计量学方法对Web of Science核心数据库中收录的2002~2022年光动力杀菌相关研究文献进行统计分析。同时,结合可视化分析软件Cites...为及时了解国内外对光动力杀菌的研究现状、热点和发展趋势,为相关研究领域的研究者提供参考,本文采用文献计量学方法对Web of Science核心数据库中收录的2002~2022年光动力杀菌相关研究文献进行统计分析。同时,结合可视化分析软件Citespace对不同国家和地区、机构、作者等进行分析,并对光动力杀菌研究的关键词进行聚类分析和突现分析。通过分析可知,在食品领域,光动力灭菌技术的研究方向主要包括光敏剂的选择和改造、光源的选择和优化以及延长食品货架期等;此外,光动力联合其他冷灭菌技术增强灭菌效果也将成为未来光动力在食品领域的一个研究趋势。展开更多
The emergence of antibiotic resistance in bacteria is a major public-health issue.Synthesis of efficient antibiotic-free material is very important for fighting bacterial infection-related diseases.Herein,red-carbon d...The emergence of antibiotic resistance in bacteria is a major public-health issue.Synthesis of efficient antibiotic-free material is very important for fighting bacterial infection-related diseases.Herein,red-carbon dots(R-CDs)with a broad range of spectral absorption(350–700 nm)from organic bactericides or intermediates were synthesized through a solvothermal route.The prepared R-CDs not only had intrinsic antibacterial activities,but also could kill multidrug-resistant bacteria(multidrug-resistant Acinetobacter baumannii(MRAB)and multidrug-resistant Staphylococcus aureus(MRSA))effectively by generating reactive oxygen species.Furthermore,R-CDs could eliminate and inhibit the formation of MRAB biofilms,while conferring few side effects on normal cells.A unique property of R-CDs was demonstrated upon in vivo treatment of antibiotic-sensitive MRABinduced infected wounds.These data suggested that this novel R-CDs-based strategy might enable the design of nextgeneration agents to fight drug-resistant bacteria.展开更多
文摘为及时了解国内外对光动力杀菌的研究现状、热点和发展趋势,为相关研究领域的研究者提供参考,本文采用文献计量学方法对Web of Science核心数据库中收录的2002~2022年光动力杀菌相关研究文献进行统计分析。同时,结合可视化分析软件Citespace对不同国家和地区、机构、作者等进行分析,并对光动力杀菌研究的关键词进行聚类分析和突现分析。通过分析可知,在食品领域,光动力灭菌技术的研究方向主要包括光敏剂的选择和改造、光源的选择和优化以及延长食品货架期等;此外,光动力联合其他冷灭菌技术增强灭菌效果也将成为未来光动力在食品领域的一个研究趋势。
基金supported by the National Natural Science Foundation of China(NSFC,21925802,21878039,21808028,22022803 and 22078046)the NSFC-Liaoning United Fund(U1908202)the National Key Research and Development Plan(2018AAA0100301)。
文摘The emergence of antibiotic resistance in bacteria is a major public-health issue.Synthesis of efficient antibiotic-free material is very important for fighting bacterial infection-related diseases.Herein,red-carbon dots(R-CDs)with a broad range of spectral absorption(350–700 nm)from organic bactericides or intermediates were synthesized through a solvothermal route.The prepared R-CDs not only had intrinsic antibacterial activities,but also could kill multidrug-resistant bacteria(multidrug-resistant Acinetobacter baumannii(MRAB)and multidrug-resistant Staphylococcus aureus(MRSA))effectively by generating reactive oxygen species.Furthermore,R-CDs could eliminate and inhibit the formation of MRAB biofilms,while conferring few side effects on normal cells.A unique property of R-CDs was demonstrated upon in vivo treatment of antibiotic-sensitive MRABinduced infected wounds.These data suggested that this novel R-CDs-based strategy might enable the design of nextgeneration agents to fight drug-resistant bacteria.
