目的对医院新引进的瓦里安Trilogy直线加速器按照国际原子能机构(IAEA)TRS277号报告进行光子束和电子束吸收剂量的测量和标定,将吸收剂量在参考条件下标定为1 MU=1 c Gy,确保输出剂量准确,以便后期的投入临床使用。方法采用德国PTW公司...目的对医院新引进的瓦里安Trilogy直线加速器按照国际原子能机构(IAEA)TRS277号报告进行光子束和电子束吸收剂量的测量和标定,将吸收剂量在参考条件下标定为1 MU=1 c Gy,确保输出剂量准确,以便后期的投入临床使用。方法采用德国PTW公司的UNDOS E型静电计和TW30013 0.6cc指形电离室和普通三维水箱现场测量Trilogy直线加速器光子束和电子束的吸收剂量,然后通过调节加速器上剂量监测系统的电位器,使得机器输出1 MU=1 c Gy。结果经过测量和标定后,测得光子束和电子束的吸收剂量结果误差<1%。结论经过对Trilogy直线加速器光子束和电子束吸收剂量的测量和标定后,其输出剂量符合国家要求。展开更多
Objective: The aim of our study was to assess and compare the potential dosimetric advantages and drawbacks of photon beams and electron beams as a boost for the tumor bed in superficial and deep seated early-stage br...Objective: The aim of our study was to assess and compare the potential dosimetric advantages and drawbacks of photon beams and electron beams as a boost for the tumor bed in superficial and deep seated early-stage breast cancer. Methods: We planned CTs of 10 women with early breast cancer underwent breast conservative surgery were selected. Tumor bed was defined as superficial and deep with a cut of point 4 cm, those with less than 4 cm were defined as superficial tumors representing 4 patients and those with depth of 4 cm or more were classified as deep tumors representing 6 patients. The clinical target volume (CTV) was defined as the area of architectural distortion surrounded by surgical clips. The planning target volume (PTV) was the CTV plus margin 1 cm. A dose of 10 Gy in 2 Gy fractions was given concurrently at the last week of treatment. Organs at risk (OARs) were heart, lungs, contra-lateral breast and a 5 mm thick skin segment of the breast surface. Dose volume histograms were defined to quantify the quality of concurrent treatment plans assessing target coverage and sparing OARs. The following treatment techniques were assessed: photon beam with 3D-conformal technique and a single electron beam. Results: For superficial tumors better coverage for CTV and PTV with good homogeneity with better CI was found for the 3D conformal radiotherapy (3DCRT) but with no significant planning objectives over electron beam. For deep tumors, the 3DCRT met the planning objectives for CTV, PTV with better coverage and fewer hot spots with better homogeneity and CI. For superficial tumors, OARs were spared by both techniques with better sparing for the electron beam where as for deep tumors also OARs were well spared by both techniques. Conclusion: Boosting the tumor bed in early-stage breast cancer with optimized photon may be preferred to electron beam for both superficial and deep tumors. The OARs dose sparing effect may allow for a potential long-term toxicity risk reduction and better cosmesis.展开更多
文摘目的对医院新引进的瓦里安Trilogy直线加速器按照国际原子能机构(IAEA)TRS277号报告进行光子束和电子束吸收剂量的测量和标定,将吸收剂量在参考条件下标定为1 MU=1 c Gy,确保输出剂量准确,以便后期的投入临床使用。方法采用德国PTW公司的UNDOS E型静电计和TW30013 0.6cc指形电离室和普通三维水箱现场测量Trilogy直线加速器光子束和电子束的吸收剂量,然后通过调节加速器上剂量监测系统的电位器,使得机器输出1 MU=1 c Gy。结果经过测量和标定后,测得光子束和电子束的吸收剂量结果误差<1%。结论经过对Trilogy直线加速器光子束和电子束吸收剂量的测量和标定后,其输出剂量符合国家要求。
文摘Objective: The aim of our study was to assess and compare the potential dosimetric advantages and drawbacks of photon beams and electron beams as a boost for the tumor bed in superficial and deep seated early-stage breast cancer. Methods: We planned CTs of 10 women with early breast cancer underwent breast conservative surgery were selected. Tumor bed was defined as superficial and deep with a cut of point 4 cm, those with less than 4 cm were defined as superficial tumors representing 4 patients and those with depth of 4 cm or more were classified as deep tumors representing 6 patients. The clinical target volume (CTV) was defined as the area of architectural distortion surrounded by surgical clips. The planning target volume (PTV) was the CTV plus margin 1 cm. A dose of 10 Gy in 2 Gy fractions was given concurrently at the last week of treatment. Organs at risk (OARs) were heart, lungs, contra-lateral breast and a 5 mm thick skin segment of the breast surface. Dose volume histograms were defined to quantify the quality of concurrent treatment plans assessing target coverage and sparing OARs. The following treatment techniques were assessed: photon beam with 3D-conformal technique and a single electron beam. Results: For superficial tumors better coverage for CTV and PTV with good homogeneity with better CI was found for the 3D conformal radiotherapy (3DCRT) but with no significant planning objectives over electron beam. For deep tumors, the 3DCRT met the planning objectives for CTV, PTV with better coverage and fewer hot spots with better homogeneity and CI. For superficial tumors, OARs were spared by both techniques with better sparing for the electron beam where as for deep tumors also OARs were well spared by both techniques. Conclusion: Boosting the tumor bed in early-stage breast cancer with optimized photon may be preferred to electron beam for both superficial and deep tumors. The OARs dose sparing effect may allow for a potential long-term toxicity risk reduction and better cosmesis.
