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利用组织中的光子迁移使异物成像
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作者 东初 《光电子技术与信息》 1997年第4期35-36,共2页
关键词 光子迁移 光学异物 人体组织 肿瘤诊断
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Pharmacokinetics and Biodegradation of Chitosan in Rats 被引量:3
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作者 LI Hui JIANG Zhiwen +3 位作者 HAN Baoqin NIU Shuyi DONG Wen LIU Wanshun 《Journal of Ocean University of China》 SCIE CAS 2015年第5期897-904,共8页
Chitosan, an excellent biomedical material, has received a widespread in vivo application. In contrast, its metabolism and distribution once being implanted were less documented. In this study, the pharmacokinetics an... Chitosan, an excellent biomedical material, has received a widespread in vivo application. In contrast, its metabolism and distribution once being implanted were less documented. In this study, the pharmacokinetics and biodegradation of fluorescein isothiocyanate(FITC) labeled and muscle implantation administrated chitosan in rats were investigated with fluorescence spectrophotometry, histological assay and gel chromatography. After implantation, chitosan was degraded gradually during its distribution to diverse organs. Among the tested organs, liver and kidney were found to be the first two highest in chitosan content, which was followed by heart, brain and spleen. Urinary excretion was believed to be the major pathway of chitosan elimination, yet 80% of chitosan administered to rats was not trackable in their urine. This indicated that the majority of chitosan was degraded in tissues. In average, the molecular weight of the degradation products of chitosan in diverse organs and urine was found to be <65 k Da. This further confirmed the in vivo degradation of chitosan. Our findings provided new evidences for the intensive and safe application of chitosan as a biomedical material. 展开更多
关键词 CHITOSAN fluorescein isothiocyanate PHARMACOKINETICS BIODEGRADATION fluorescence spectrophotometry muscle implantation
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