Recent advancements in the endoscopic imaging of Barrett's esophagus can be used to probe a wide range of optical properties that are altered with neoplastic progression.This review summarizes relevant changes in ...Recent advancements in the endoscopic imaging of Barrett's esophagus can be used to probe a wide range of optical properties that are altered with neoplastic progression.This review summarizes relevant changes in optical properties as well as imaging approaches that measures those changes.Wide-field imaging approaches include narrow-band imaging that measures changes in light scattering and absorption,and autofluorescence imaging that measure changes in endogenous fluorophores.High-resolution imaging approaches include optical coherence tomography,endocytoscopy,confocal microendoscopy,and high-resolution microendoscopy.These technologies,some coupled with an appropriate contrast agent,can measure differences in glandular morphology,nuclear morphology,or vascular alterations associated with neoplasia.Advances in targeted contrast agents are further discussed.Studies that have explored these technologies are highlighted;as are the advantages and limitations of each.展开更多
A new displacement measurement system is described in this paper according to the basic principles of traditional lasertriangulation method. The range of the traditional measuring method is enlarged by measuring in se...A new displacement measurement system is described in this paper according to the basic principles of traditional lasertriangulation method. The range of the traditional measuring method is enlarged by measuring in sections. Three independent CCDs, which are distributed uniformly along the optical axis, are used to achieve subsection measurement. The planemirror is regarded as a virtual detector. When imaging beam is reflected by the plane mirror, the beam is imaged on theCC D. The designed system is equivalent to add a CCD. The feasibility of the displacement measurement system is verifiedby the experiment.展开更多
基金Supported by The National Institute of Health Grants BRP CA103830 and RO1 EB007594
文摘Recent advancements in the endoscopic imaging of Barrett's esophagus can be used to probe a wide range of optical properties that are altered with neoplastic progression.This review summarizes relevant changes in optical properties as well as imaging approaches that measures those changes.Wide-field imaging approaches include narrow-band imaging that measures changes in light scattering and absorption,and autofluorescence imaging that measure changes in endogenous fluorophores.High-resolution imaging approaches include optical coherence tomography,endocytoscopy,confocal microendoscopy,and high-resolution microendoscopy.These technologies,some coupled with an appropriate contrast agent,can measure differences in glandular morphology,nuclear morphology,or vascular alterations associated with neoplasia.Advances in targeted contrast agents are further discussed.Studies that have explored these technologies are highlighted;as are the advantages and limitations of each.
基金supported by the Science and Technology Plan of Hebei Province, China (No. 10212149)
文摘A new displacement measurement system is described in this paper according to the basic principles of traditional lasertriangulation method. The range of the traditional measuring method is enlarged by measuring in sections. Three independent CCDs, which are distributed uniformly along the optical axis, are used to achieve subsection measurement. The planemirror is regarded as a virtual detector. When imaging beam is reflected by the plane mirror, the beam is imaged on theCC D. The designed system is equivalent to add a CCD. The feasibility of the displacement measurement system is verifiedby the experiment.
