Two inner salt carbocyanines were filmed chemically on the Si surface through Si-O-C bond. The structures were characterized by SERS and XPS. And the spectral response and surface photovoltage spectrum were measured. ...Two inner salt carbocyanines were filmed chemically on the Si surface through Si-O-C bond. The structures were characterized by SERS and XPS. And the spectral response and surface photovoltage spectrum were measured. These results show that the Si wafer can be sensitized by dyes, and the filmed Si wafers have photovoltage effect.展开更多
Mesoporous silica nanoparticles （MSNs） have attracted tremendous attention in recent years as drug delivery carriers due to their large surface areas, tunable sizes, facile modification and considerable biocompatibi...Mesoporous silica nanoparticles （MSNs） have attracted tremendous attention in recent years as drug delivery carriers due to their large surface areas, tunable sizes, facile modification and considerable biocompatibility. In this work, we fabricate an interesting type of MSNs which are intrinsically doped with photosensitizing molecules, chlorin e6 （Ce6）. By increasing the amount of Ce6 doped inside the silica matrix, it is found that the morphology of MSNs changes from spheres to rod-like shapes. The obtained Ce6-doped mesoporous silica nanorods （CMSNRs） are not only able to produce singlet oxygen for photodynamic therapy, but can also serve as a drug delivery platform with high drug loading capacity by utilizing their mesoporous structure. Compared to spherical nano- particles, it is found that CMSNRs with a larger aspect ratio show much faster uptake by cancer cells. With doxorubicin （DOX） employed as a model drug, the combined photodynamic and chemotherapy is carried out, achieving synergistic anti-tumor effects both in vitro and in vivo. Our study presents a new design of an MSN-based drug delivery platform, which intrinsically is fluorescent and able to serve as a photodynamic agent, promising for future imaging-guided combination therapy of cancer.展开更多
The enhanced sensitivity of a guided mode biosensor is analyzed by employing double-layered porous silicon grating structures. The grating-coupled waveguide structure consists of two porous silicon grating layers with...The enhanced sensitivity of a guided mode biosensor is analyzed by employing double-layered porous silicon grating structures. The grating-coupled waveguide structure consists of two porous silicon grating layers with different refractive indices. simulations are carried out by changing the refractive index, which is due to the binding of biological molecules on the porous silicon pore can increase the refractive index of porous silicon. The numerical results show that this novel guided mode biosensor with a double-layered grating can provide not only a very high sensitivity but also a better reflectivity characteristic.展开更多
文摘Two inner salt carbocyanines were filmed chemically on the Si surface through Si-O-C bond. The structures were characterized by SERS and XPS. And the spectral response and surface photovoltage spectrum were measured. These results show that the Si wafer can be sensitized by dyes, and the filmed Si wafers have photovoltage effect.
基金This work was partially supported by the National Basic Research Programs of China （973 Program） （Nos. 2012CB932600 and 2011CB911002）, the National Natural Science Foundation of China （Nos. 51222203 and 51132006）, Jiangsu Key Laboratory for Carbon- Based Functional Materials and Devices, a Jiangsu Natural Science Fund for Distinguished Young Scholars, and a Project Funded by the Priority Academic Program Development （PAPD） of Jiangsu Higher Education Institutions.
文摘Mesoporous silica nanoparticles （MSNs） have attracted tremendous attention in recent years as drug delivery carriers due to their large surface areas, tunable sizes, facile modification and considerable biocompatibility. In this work, we fabricate an interesting type of MSNs which are intrinsically doped with photosensitizing molecules, chlorin e6 （Ce6）. By increasing the amount of Ce6 doped inside the silica matrix, it is found that the morphology of MSNs changes from spheres to rod-like shapes. The obtained Ce6-doped mesoporous silica nanorods （CMSNRs） are not only able to produce singlet oxygen for photodynamic therapy, but can also serve as a drug delivery platform with high drug loading capacity by utilizing their mesoporous structure. Compared to spherical nano- particles, it is found that CMSNRs with a larger aspect ratio show much faster uptake by cancer cells. With doxorubicin （DOX） employed as a model drug, the combined photodynamic and chemotherapy is carried out, achieving synergistic anti-tumor effects both in vitro and in vivo. Our study presents a new design of an MSN-based drug delivery platform, which intrinsically is fluorescent and able to serve as a photodynamic agent, promising for future imaging-guided combination therapy of cancer.
基金supported by the National Natural Science Foundation of China (No.60968002)the China Postdoctoral Science Foundation (No.2011M501501)
文摘The enhanced sensitivity of a guided mode biosensor is analyzed by employing double-layered porous silicon grating structures. The grating-coupled waveguide structure consists of two porous silicon grating layers with different refractive indices. simulations are carried out by changing the refractive index, which is due to the binding of biological molecules on the porous silicon pore can increase the refractive index of porous silicon. The numerical results show that this novel guided mode biosensor with a double-layered grating can provide not only a very high sensitivity but also a better reflectivity characteristic.
