Hydrogels constitute a group of polymeric materials which can hold a large amount of water in their three-dimensional networks due to their hydrophilic struc- tures. In the past few years, they have been researched fo...Hydrogels constitute a group of polymeric materials which can hold a large amount of water in their three-dimensional networks due to their hydrophilic struc- tures. In the past few years, they have been researched for various biomedical applications, such as drug/cell carriers, tissue engineering, and biosensors. Particularly, the hy- drogels used as drug delivery systems have shown distinct advantages in phototherapy. This review presents recent advancements of hydrogel＇s use in phototherapeutic applica- tions by focusing on three kinds of phototherapentic methods including photodynamic therapy （PDT）, photothermal therapy （PTT）, and phototherapy-containing combination therapy （PCCT）. The applications of these therapies in anti- cancer and antibacterial fields have also been summarized. We hope that this review will inspire researchers to further develop promising materials for phototherapy applications.展开更多
In recent years,the emerging two-dimensional(2 D)nanomaterials have shown great potential for a variety of applications such as electronics,catalysis,supercapacitors,and energy materials.In the biomedical arena,these ...In recent years,the emerging two-dimensional(2 D)nanomaterials have shown great potential for a variety of applications such as electronics,catalysis,supercapacitors,and energy materials.In the biomedical arena,these nanomaterials,especially 2 D-ultrathin nanomaterials,have also been regarded as promising nano-carriers and/or diagnostic agents for cancer diagnosis and treatment,owing to their remarkable mechanical,photothermal,and optical properties.In this review,we provide the recent development of the nanoplatforms based on near-infrared/ultrasound-sensitive 2 D-materials,representatively such as graphdiyne(GDY),black phosphorus,transition metal dichalcogenides(TMDs),and antimonene,for non-invasive cancer therapeutics including photothermal,photodynamic and sonodynamic approaches.The general properties of these 2 D nanomaterials linking to biomedical interests are first introduced,followed by the fabrication processes of diverse nano-platforms and related outcomes of cancer diagnosis and treatments.We also outline the current challenges and prospects of the 2 D materials for non-invasive approaches to cancer treatments in the future.展开更多
基金supported by the National Natural Science Foundation of China (21673037)Graduate Students’ Scientific Research Innovation Project of Jiangsu Province Ordinary University (SJLX16_0054)+2 种基金Fundamental Research Funds for the Central Universities (2242015R30016)Six Talents Peak Project in Jiangsu Province (2015-SWYY-003)Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
文摘Hydrogels constitute a group of polymeric materials which can hold a large amount of water in their three-dimensional networks due to their hydrophilic struc- tures. In the past few years, they have been researched for various biomedical applications, such as drug/cell carriers, tissue engineering, and biosensors. Particularly, the hy- drogels used as drug delivery systems have shown distinct advantages in phototherapy. This review presents recent advancements of hydrogel＇s use in phototherapeutic applica- tions by focusing on three kinds of phototherapentic methods including photodynamic therapy （PDT）, photothermal therapy （PTT）, and phototherapy-containing combination therapy （PCCT）. The applications of these therapies in anti- cancer and antibacterial fields have also been summarized. We hope that this review will inspire researchers to further develop promising materials for phototherapy applications.
基金supported by the State Key Research Development Program of China(2019YFB2203503)the National Natural Science Foundation of China(61875138,61435010,81972423 and 61961136001)+4 种基金Science and Technology Innovation Commission of Shenzhen(KQTD2015032416270385,JCYJ20170811093453105,JCYJ20180307164612205,JCYJ20170307144246792,GJHZ20180928160209731 and 202050345)the Clinical Research Startup Plan of Southern Medical University(LC2016YM018)Shenzhen Key Laboratory of Viral Oncology(ZDSYS201707311140430)the Grant of Sanming Medical Project(SM201702)the Instrumental Analysis Center of Shenzhen University(Xili Campus)。
文摘In recent years,the emerging two-dimensional(2 D)nanomaterials have shown great potential for a variety of applications such as electronics,catalysis,supercapacitors,and energy materials.In the biomedical arena,these nanomaterials,especially 2 D-ultrathin nanomaterials,have also been regarded as promising nano-carriers and/or diagnostic agents for cancer diagnosis and treatment,owing to their remarkable mechanical,photothermal,and optical properties.In this review,we provide the recent development of the nanoplatforms based on near-infrared/ultrasound-sensitive 2 D-materials,representatively such as graphdiyne(GDY),black phosphorus,transition metal dichalcogenides(TMDs),and antimonene,for non-invasive cancer therapeutics including photothermal,photodynamic and sonodynamic approaches.The general properties of these 2 D nanomaterials linking to biomedical interests are first introduced,followed by the fabrication processes of diverse nano-platforms and related outcomes of cancer diagnosis and treatments.We also outline the current challenges and prospects of the 2 D materials for non-invasive approaches to cancer treatments in the future.
