Objectives To investigate image characteristics and thickness of the retinal nerve fiber layer (RNFL) in normal and glaucomatous eyes using optical coherence tomography (OCT), and analyze the relationship between RNFL...Objectives To investigate image characteristics and thickness of the retinal nerve fiber layer (RNFL) in normal and glaucomatous eyes using optical coherence tomography (OCT), and analyze the relationship between RNFL thickness and visual field index.Methods Eighty-three normal persons (150 eyes) and 83 patients with primary open angle glaucoma (POAG, 149 eyes) underwent OCT examinations with 3.4 mm diameter circle scan to calculate the RNFL thickness. Statistical analysis was used to compare differences in RNFL thickness in quadrants and means between the normal and glaucomatous groups and the different stages of POAG. Linear correlation and regression analysis were used to show the correlation between RNFL thickness and visual field index of 115 eyes in glaucomatous patients. Reproducibility, sensitivity and specificity of RNFL measurements using OCT were evaluated.Results RNFL thickness measured by OCT in normal subjects was thicker in superior and inferior, less in temporal, and thinnest in nasal quadrants. The curve showed double peaks. RNFL of glaucomatous patients showed local thinning or defect, diffuse thinning, or both. The mean RNFL thicknesses of the normal group in the temporal, superior, nasal and infeior quadrants were 90.1 ± 10.8 lμm, 140.4 ± 10.5μm, 85.2 ± 14.0 μm, and 140.4 + 9.7 μm, respectively with a mean of 114.2 ± 6.0 μm. The numbers for the glaucomatous group were respectively 56.0 ± 31.0 μm, 81.0 ± 36.3 μm, 47.1 ± 27.5 μm, and 73.4 ±38.4 μm for the four quadrants, with a mean of 64.6 ± 28.8 μm. There was a significant difference in RNFL thickness between the normal and glaucomatous groups (P ＜ 0.000), and the three stages (early,developing and late) of glaucornatous groups (P ＜ 0.000). There was a close negative relationship between RNFL thickness and visual field index ( r = - 0.796, P ＜ 0.0001 ). The sensitivity and specificity of RNFL thickness in POAG measured using OCT were 93.3％ and 92.0％, respectively.Conclusions OCT can quantitatively measure RNFL thickness differences between normal persons and glaucomatous patients. RNFL thickness gradually decreases while visual field defect increases with the development of POAG.展开更多
Objectives： The study was done to evaluate the efficacy of optical coherence tomography （OCT）, to detect and analyze the microdamage occurring around the microimplant immediately following its placement, and to com...Objectives： The study was done to evaluate the efficacy of optical coherence tomography （OCT）, to detect and analyze the microdamage occurring around the microimplant immediately following its placement, and to compare the findings with micro-computed tomography （IJCT） images of the samples to validate the result of the present study. Methods： Microimplants were inserted into bovine bone samples. Images of the samples were obtained using OCT and μCT. Visual comparisons of the images were made to evaluate whether anatomical details and microdamage induced by microimplant insertion were accurately revealed by OCT. Results： The surface of the cortical bone with its anatomical variations is visualized on the OCT images. Microdamage occurring on the surface of the cortical bone around the microimplant can be appreciated in OCT images. The resulting OCT images were compared with the μCT images. A high correlation regarding the visualization of individual microcracks was observed. The depth penetration of OCT is limited when compared to μCT. Conclusions： OCT in the present study was able to generate high-resolution images of the microdamage occurring around the microimplant. Image quality at the surface of the cortical bone is above par when compared with μCT imaging, because of the inherent high contrast and high-resolution quality of OCT systems. Improvements in the imaging depth and development of intraoral sensors are vital for developing a real-time imaging system and integrating the system into orthodontic practice.展开更多
Objective： To assess the lower tear meniscus height（LTMH）, central tear film thickness（CTFT）, and central corneal epithelial thickness（CCET） after deep anterior lamellar keratoplasty（DALK）. Methods： This was...Objective： To assess the lower tear meniscus height（LTMH）, central tear film thickness（CTFT）, and central corneal epithelial thickness（CCET） after deep anterior lamellar keratoplasty（DALK）. Methods： This was a retrospective cross-sectional study of 20 patients who had DALK in one eye over a three-month period. LTMH, CTFT, and CCET of the operated eyes and the unoperated fellow eyes were measured using high-definition optical coherence tomography（HD-OCT）. Correlations between three OCT assessments and age, time following surgery, graft size, bed size, and the number of residual sutures were analyzed. Results： Compared to patients with keratoconus, patients with other corneal conditions had significantly higher CCET in the fellow eye（P=0.024）. For all patients, CCET in the operated eye was significantly negatively correlated with the number of residual sutures（R=-0.579, P=0.008）, and was significantly positively correlated with time following surgery（R=0.636, P=0.003）. In the fellow eye, a significant positive correlation was found between age and CCET（R=0.551, P=0.012）, and a significant negative correlation between age and CTFT（R=-0.491, P=0.028）. LTMH was found to be significantly correlated between operated and fellow eyes（R=0.554, P=0.011）. There was no significant correlation between LTMH and age, bed/graft size, time following surgery, or residual sutures（all possible correlations, P0.05）. Conclusions： Patients with keratoconus tend to have a thinner central corneal epithelium. Corneal epithelium keeps regenerating over time after DALK. DALK did not induce a significant change in tear volume compared with the fellow eye. Postoperative tear function might depend on an individual＇s general condition, rather than on age, gender, bed/graft size, time following surgery, or residual sutures.展开更多
Objective:To investigate the value of optic disc retinal nerve fiber layer(RNFL)thickness in the diagnosis of diabetic peripheral neuropathy(DPN).Methods:Ninety patients with type 2 diabetes,including 60 patients with...Objective:To investigate the value of optic disc retinal nerve fiber layer(RNFL)thickness in the diagnosis of diabetic peripheral neuropathy(DPN).Methods:Ninety patients with type 2 diabetes,including 60 patients without DPN(NDPN group)and 30 patients with DPN(DPN group),and 30 healthy participants(normal group)were enrolled.Optical coherence tomography(OCT)was used to measure the four quadrants and the overall average RNFL thickness of the optic disc.The receiver operator characteristic curve was drawn and the area under the curve(AUC)was calculated to evaluate the diagnostic value of RNFL thickness in the optic disc area for DPN.Results:The RNFL thickness of the DPN group was thinner than those of the normal and NDPN groups in the overall average((101.07±12.40)μm vs.(111.07±6.99)μm and(109.25±6.90)μm),superior quadrant((123.00±19.04)μm vs.(138.93±14.16)μm and(134.47±14.34)μm),and inferior quadrant((129.37±17.50)μm vs.(143.60±12.22)μm and(144.48±14.10)μm),and the differences were statistically significant.The diagnostic efficiencies of the overall average,superior quadrant,and inferior quadrant RNFL thicknesses,and a combined index of superior and inferior quadrant RNFL thicknesses were similar,and the AUCs were 0.739(95%confidence interval(CI)0.635–0.826),0.683(95%CI 0.576–0.778),0.755(95%CI 0.652–0.840),and 0.773(95%CI 0.672–0.854),respectively.The diagnostic sensitivity of RNFL thickness in the superior quadrant reached 93.33%.Conclusions:The thickness of the RNFL in the optic disc can be used as a diagnostic method for DPN.展开更多
基金agrantfromtheGuangdongProvincialMainItemFoundation (No 49)
文摘Objectives To investigate image characteristics and thickness of the retinal nerve fiber layer (RNFL) in normal and glaucomatous eyes using optical coherence tomography (OCT), and analyze the relationship between RNFL thickness and visual field index.Methods Eighty-three normal persons (150 eyes) and 83 patients with primary open angle glaucoma (POAG, 149 eyes) underwent OCT examinations with 3.4 mm diameter circle scan to calculate the RNFL thickness. Statistical analysis was used to compare differences in RNFL thickness in quadrants and means between the normal and glaucomatous groups and the different stages of POAG. Linear correlation and regression analysis were used to show the correlation between RNFL thickness and visual field index of 115 eyes in glaucomatous patients. Reproducibility, sensitivity and specificity of RNFL measurements using OCT were evaluated.Results RNFL thickness measured by OCT in normal subjects was thicker in superior and inferior, less in temporal, and thinnest in nasal quadrants. The curve showed double peaks. RNFL of glaucomatous patients showed local thinning or defect, diffuse thinning, or both. The mean RNFL thicknesses of the normal group in the temporal, superior, nasal and infeior quadrants were 90.1 ± 10.8 lμm, 140.4 ± 10.5μm, 85.2 ± 14.0 μm, and 140.4 + 9.7 μm, respectively with a mean of 114.2 ± 6.0 μm. The numbers for the glaucomatous group were respectively 56.0 ± 31.0 μm, 81.0 ± 36.3 μm, 47.1 ± 27.5 μm, and 73.4 ±38.4 μm for the four quadrants, with a mean of 64.6 ± 28.8 μm. There was a significant difference in RNFL thickness between the normal and glaucomatous groups (P ＜ 0.000), and the three stages (early,developing and late) of glaucornatous groups (P ＜ 0.000). There was a close negative relationship between RNFL thickness and visual field index ( r = - 0.796, P ＜ 0.0001 ). The sensitivity and specificity of RNFL thickness in POAG measured using OCT were 93.3％ and 92.0％, respectively.Conclusions OCT can quantitatively measure RNFL thickness differences between normal persons and glaucomatous patients. RNFL thickness gradually decreases while visual field defect increases with the development of POAG.
基金Project supported by the BK21 Plus Project Funded by the Ministry of Education,Korea(No.21A20131600011)the Industrial Infrastructure Program of Laser Industry Support Funded by the Ministry of Trade,Industry & Energy,Korea(No.N0000598)
文摘Objectives： The study was done to evaluate the efficacy of optical coherence tomography （OCT）, to detect and analyze the microdamage occurring around the microimplant immediately following its placement, and to compare the findings with micro-computed tomography （IJCT） images of the samples to validate the result of the present study. Methods： Microimplants were inserted into bovine bone samples. Images of the samples were obtained using OCT and μCT. Visual comparisons of the images were made to evaluate whether anatomical details and microdamage induced by microimplant insertion were accurately revealed by OCT. Results： The surface of the cortical bone with its anatomical variations is visualized on the OCT images. Microdamage occurring on the surface of the cortical bone around the microimplant can be appreciated in OCT images. The resulting OCT images were compared with the μCT images. A high correlation regarding the visualization of individual microcracks was observed. The depth penetration of OCT is limited when compared to μCT. Conclusions： OCT in the present study was able to generate high-resolution images of the microdamage occurring around the microimplant. Image quality at the surface of the cortical bone is above par when compared with μCT imaging, because of the inherent high contrast and high-resolution quality of OCT systems. Improvements in the imaging depth and development of intraoral sensors are vital for developing a real-time imaging system and integrating the system into orthodontic practice.
基金Project supported by the Zhejiang Provincial Natural Science Foundation of China(No.LQ16H120002)
文摘Objective： To assess the lower tear meniscus height（LTMH）, central tear film thickness（CTFT）, and central corneal epithelial thickness（CCET） after deep anterior lamellar keratoplasty（DALK）. Methods： This was a retrospective cross-sectional study of 20 patients who had DALK in one eye over a three-month period. LTMH, CTFT, and CCET of the operated eyes and the unoperated fellow eyes were measured using high-definition optical coherence tomography（HD-OCT）. Correlations between three OCT assessments and age, time following surgery, graft size, bed size, and the number of residual sutures were analyzed. Results： Compared to patients with keratoconus, patients with other corneal conditions had significantly higher CCET in the fellow eye（P=0.024）. For all patients, CCET in the operated eye was significantly negatively correlated with the number of residual sutures（R=-0.579, P=0.008）, and was significantly positively correlated with time following surgery（R=0.636, P=0.003）. In the fellow eye, a significant positive correlation was found between age and CCET（R=0.551, P=0.012）, and a significant negative correlation between age and CTFT（R=-0.491, P=0.028）. LTMH was found to be significantly correlated between operated and fellow eyes（R=0.554, P=0.011）. There was no significant correlation between LTMH and age, bed/graft size, time following surgery, or residual sutures（all possible correlations, P0.05）. Conclusions： Patients with keratoconus tend to have a thinner central corneal epithelium. Corneal epithelium keeps regenerating over time after DALK. DALK did not induce a significant change in tear volume compared with the fellow eye. Postoperative tear function might depend on an individual＇s general condition, rather than on age, gender, bed/graft size, time following surgery, or residual sutures.
基金the Science and Technology Plan Project of Quanzhou(Nos.2018Z114,2018Z115,and 2019N104S)the Qihang Fund of Fujian Medical University(No.2016QH072)the Health Research Talent Training Project of Fujian(No.2019-ZQN-66),China。
文摘Objective:To investigate the value of optic disc retinal nerve fiber layer(RNFL)thickness in the diagnosis of diabetic peripheral neuropathy(DPN).Methods:Ninety patients with type 2 diabetes,including 60 patients without DPN(NDPN group)and 30 patients with DPN(DPN group),and 30 healthy participants(normal group)were enrolled.Optical coherence tomography(OCT)was used to measure the four quadrants and the overall average RNFL thickness of the optic disc.The receiver operator characteristic curve was drawn and the area under the curve(AUC)was calculated to evaluate the diagnostic value of RNFL thickness in the optic disc area for DPN.Results:The RNFL thickness of the DPN group was thinner than those of the normal and NDPN groups in the overall average((101.07±12.40)μm vs.(111.07±6.99)μm and(109.25±6.90)μm),superior quadrant((123.00±19.04)μm vs.(138.93±14.16)μm and(134.47±14.34)μm),and inferior quadrant((129.37±17.50)μm vs.(143.60±12.22)μm and(144.48±14.10)μm),and the differences were statistically significant.The diagnostic efficiencies of the overall average,superior quadrant,and inferior quadrant RNFL thicknesses,and a combined index of superior and inferior quadrant RNFL thicknesses were similar,and the AUCs were 0.739(95%confidence interval(CI)0.635–0.826),0.683(95%CI 0.576–0.778),0.755(95%CI 0.652–0.840),and 0.773(95%CI 0.672–0.854),respectively.The diagnostic sensitivity of RNFL thickness in the superior quadrant reached 93.33%.Conclusions:The thickness of the RNFL in the optic disc can be used as a diagnostic method for DPN.
