Recently, the international campaign against terrorism has made great achievements, with Abu Bakr al-Baghdadi, the leader of the Islamic State(IS) killed, the last city Mosul the IS controlled in Iraq liberated and it...Recently, the international campaign against terrorism has made great achievements, with Abu Bakr al-Baghdadi, the leader of the Islamic State(IS) killed, the last city Mosul the IS controlled in Iraq liberated and its so-called capital Raqqa in Syria besieged. The visible"Caliphate"of the IS is breaking up with an obvious trend of declining, which will return to a normal terrorist group from a new-type and semi-militarized terrorist organization with an independent army, territories and administrative systems. Such a change will bring about new uncertainties to the IS itself and the environment of international terrorism. For some time to come in the future, how to cope with the impact brought about by such a change of the IS will become a major issue of the international community.展开更多
AIM： To investigate the efficacy and tolerability of H pylori eradication in an omeprazole-based triple therapy with high and low dose of clarithromycin and amoxicillin. METHODS： One hundred and sixty H pylori posi...AIM： To investigate the efficacy and tolerability of H pylori eradication in an omeprazole-based triple therapy with high and low dose of clarithromycin and amoxicillin. METHODS： One hundred and sixty H pylori positive patients were randomly assigned to two groups based on the following 2 wk investigation; （1） group A or low-dose regimen received omeprazole 20 mg b.i.d, clarithromycin 250 mg b.i.d and amoxicillin 500 mg b.i.d; and （2） group B or high-dose regimen received omeprazole 20 mg b.i.d, clarithromycin 500 mg b.i.d and amoxicillin 1000 mg b.i.d. During the study Hpylori status was assessed by histology and rapid urease test prior and by 13C-urea breath test 6 wk after the therapy. Standard questionnaires were administered to determine the compliance to treatment and possible adverse events of therapy. Data were subject to x^2 to compare the eradication rates in the two groups. The significant level of 95% （P ≤ 0.05） was considered statistically different. RESULTS： We found that the per-protocol eradication rate was 88% （68/77） in group A, and 89% （67/75） in group B. The intension-to-treat eradication rate was 85% （68/80） in group A and 83.75% （67180） in group B. Overall adverse events were 26% in group A and 31% in group B. The adverse events were generally mild in nature and tolerated well in both groups with a compliance of 98% in group A vs 96% in group B. CONCLUSION： The omeprazole-based low dose regimen of darithromycin and amoxicillin for two weeks in Hpylori eradication is as effective as high dose regimen in Iranian population.展开更多
The use of medicines for infants and children is presenting one unique set of challenges, because children are the most vulnerable population in any society. In this study, we set out to present the characteristics an...The use of medicines for infants and children is presenting one unique set of challenges, because children are the most vulnerable population in any society. In this study, we set out to present the characteristics and classification of antibiotics recommended for children according to WHO, EMA and EBM. Also, the aim of this study was to analyze the most prescribed pediatric antibiotics in 2013 in Republic of Macedonia compared with standard treatments. Presented data was collected according to the number of prescribed recipes of pediatric dosage forms covered by the Fund of Republic of Macedonia. The obtained results showed that the most prescribed pediatric antibiotic is amoxicillin with clavulanic acid （875mg ＋ 125mg） in form of tablet, with 280 863 prescribed recipes which corresponds to the recommendations of EBM.展开更多
A fully consistent relativistic continuum random phase approximation （RCRPA） is constructed in terms of the Green＇s function technique. In this method the contribution of the continuum spectrum to nuclear excitatio...A fully consistent relativistic continuum random phase approximation （RCRPA） is constructed in terms of the Green＇s function technique. In this method the contribution of the continuum spectrum to nuclear excitations is treated exactly by the single particle Green＇s function, which includes also the negative states in the Dirac sea in the no sea approximation. The theoretical formalism of RCRPA and numerical details are presented. The single particle Green＇s function is calculated numerically by a proper product of regular and irregular solutions of the Dirac equation. The numerical details and the formalism of RCRPA in the momentum representation are presented.展开更多
文摘Recently, the international campaign against terrorism has made great achievements, with Abu Bakr al-Baghdadi, the leader of the Islamic State(IS) killed, the last city Mosul the IS controlled in Iraq liberated and its so-called capital Raqqa in Syria besieged. The visible"Caliphate"of the IS is breaking up with an obvious trend of declining, which will return to a normal terrorist group from a new-type and semi-militarized terrorist organization with an independent army, territories and administrative systems. Such a change will bring about new uncertainties to the IS itself and the environment of international terrorism. For some time to come in the future, how to cope with the impact brought about by such a change of the IS will become a major issue of the international community.
文摘AIM： To investigate the efficacy and tolerability of H pylori eradication in an omeprazole-based triple therapy with high and low dose of clarithromycin and amoxicillin. METHODS： One hundred and sixty H pylori positive patients were randomly assigned to two groups based on the following 2 wk investigation; （1） group A or low-dose regimen received omeprazole 20 mg b.i.d, clarithromycin 250 mg b.i.d and amoxicillin 500 mg b.i.d; and （2） group B or high-dose regimen received omeprazole 20 mg b.i.d, clarithromycin 500 mg b.i.d and amoxicillin 1000 mg b.i.d. During the study Hpylori status was assessed by histology and rapid urease test prior and by 13C-urea breath test 6 wk after the therapy. Standard questionnaires were administered to determine the compliance to treatment and possible adverse events of therapy. Data were subject to x^2 to compare the eradication rates in the two groups. The significant level of 95% （P ≤ 0.05） was considered statistically different. RESULTS： We found that the per-protocol eradication rate was 88% （68/77） in group A, and 89% （67/75） in group B. The intension-to-treat eradication rate was 85% （68/80） in group A and 83.75% （67180） in group B. Overall adverse events were 26% in group A and 31% in group B. The adverse events were generally mild in nature and tolerated well in both groups with a compliance of 98% in group A vs 96% in group B. CONCLUSION： The omeprazole-based low dose regimen of darithromycin and amoxicillin for two weeks in Hpylori eradication is as effective as high dose regimen in Iranian population.
文摘The use of medicines for infants and children is presenting one unique set of challenges, because children are the most vulnerable population in any society. In this study, we set out to present the characteristics and classification of antibiotics recommended for children according to WHO, EMA and EBM. Also, the aim of this study was to analyze the most prescribed pediatric antibiotics in 2013 in Republic of Macedonia compared with standard treatments. Presented data was collected according to the number of prescribed recipes of pediatric dosage forms covered by the Fund of Republic of Macedonia. The obtained results showed that the most prescribed pediatric antibiotic is amoxicillin with clavulanic acid （875mg ＋ 125mg） in form of tablet, with 280 863 prescribed recipes which corresponds to the recommendations of EBM.
基金Supported by the National Natural Science Foundation of China under Grant Nos. 10875150, 10775183, 10535010Major State Basic Research Development Programme of China under Grant No. 2007CB815000
文摘A fully consistent relativistic continuum random phase approximation （RCRPA） is constructed in terms of the Green＇s function technique. In this method the contribution of the continuum spectrum to nuclear excitations is treated exactly by the single particle Green＇s function, which includes also the negative states in the Dirac sea in the no sea approximation. The theoretical formalism of RCRPA and numerical details are presented. The single particle Green＇s function is calculated numerically by a proper product of regular and irregular solutions of the Dirac equation. The numerical details and the formalism of RCRPA in the momentum representation are presented.
