一种免冲预孔的翻边模

对免冲预孔翻边模结构做了大胆尝试,摸索出了免冲预孔翻边模凸凹模的尺寸确定方法,为该类模具的设计提供了借鉴。

防逆流静脉留置针免冲封管的临床效果观察

目的探讨防逆流静脉留置针防逆流和免冲封管的，l各床应用效果。方法随机选取患者100例，分为两组，观察组和对照组各50例，两组均使用防逆流静脉留置针，其中观察组采用免冲封管，对照组采用常规的冲封管方法。结果两组实验组无一例发生血液回流，在临床应用中无差别。结论防逆流静脉留置针可以免冲封管，从而减轻护士的工作量和患者的心理压力。

脚踏式免冲厕所结构设计与流体仿真分析

提出了一种新型一体式脚踏生态免冲厕所的结构设计,无需冲水又可实现对肥料的发酵取用,安装方便可广泛应用。在结构上通过脚踏驱动装置、粪便搅拌装置、脚踏密封隔板设计,密封无污染;实现了脚踏驱动齿轮对搅拌箱体中的粪便和木屑充分发酵。并对搅拌粪便流场中非牛顿流体进行了多相流Fluent仿真分析,该结构设计可以对填充介质搅拌流场均匀混合。

生态型环保厕所应用与投资分析

介绍了生态厕所的几种类型和处理工艺 ,对循环水冲厕的处理工艺进行了重点介绍 ,同时从经济技术角度对环保型厕所及普通厕所进行了分析比较。

浅淡生态公厕环保建设的现状及对策

改变传统意识重视生态公厕发展建设,城市型免冲式生态环保的厕所(公厕)是微生物工程技术与环境控制技术的应用,为改善人民的生存环境,提高生活质量,发展循环经济,实现社会的可持续发展具有可操作性的指导意义,作者建议应纳入国家市政建设计划推广实施。

试论企业领导体制改革

在深化企业领导体制改革中,厂长和党委的关系成了企业的热门话题,社会上对这个问题议论也较多。对企业中厂长处于生产经营的中心地位和企业党组织处于核心地位的关系如何认识,关系到企业的两个文明建设。有人说:有了“中心”“何必又提个“核心”,这样两心磨擦、碰撞势必产生火星,刚刚理顺的体制又要乱了。又有人说:看来还是提“核心”科学,将来要取消“中心”,这几年企业出了不少问题,都是与“中心”有关。

液压剪切机的改进研究

针对唐山钢铁（集团）公司自行研制的600吨液压剪切机存在的某些性能缺陷进行了研究，提出了4条改进措施．

小议《窦娥冤》鬼魂形象的悲剧内涵

读关汉卿《窦娥冤》,人们击节叹赏的是那个敢于叱天骂地、个性恣肆、情感狂暴的刚烈女性,而对窦娥的鬼魂形象,则很少有人论及。学者一致认为,窦娥鬼魂形象的塑造,助成了一个较为圆满的结局,大快人心,而对其审美效果则众说纷纭。有的学者认为它是“喜剧式结尾”(刘世德《读关汉卿的〈窦娥冤〉》;有的学者认为“令人快意的结局使剧中的苦难有所消解”,“戏中原本异常强烈的悲剧色彩未免冲淡了”(章培垣、骆玉明《中国文学史》);而有的学者则认为“

把好进餐关

科学进餐,对于儿童健康和发育都至关重要。不过,科学进餐的“道道”不少,家长应注意帮孩子把好关。 进餐前 不要让孩子大量饮水,以免冲淡胃液,影响食物消化。不要让孩子吃零食,饭前吃了零食,吃饭时饭菜就不香了,影响食欲。饭前不可责骂孩子,不良情绪会使孩子胃口大减。

pH Stability of Defibrase_ in Aqueous Solution Determined by En-zyme-linked Immunosorbent Assay

Stability of Defibrase in various pH buffer solutions was investigated. Enzyme-linked immuno-sorbent assay (ELISA) and coagulating time method were used to assess antigenic stability and coagulating stability, respectively. The change of antigenic activities and coagulating activities of Defibrase in the same buffer solutions (pH 6, 7 and 8, with the exception of pH 3.6) showed similar tendency to decline with the time. Concentrated Defi-brase was relatively stable at neutral pH 6~7, more than 95% of its initial activities (100BUmL-1) was kept after a 10-day storage at 40 oC, whereas in pH 3.6 and pH 9 buffer solutions, diluted Defibrase was very labile. Addition of Triton X-100 or bovine serum albumin could effectively prevent loss of Defibrase by minimizing adsorption of De-fibrase to plastic surface (P<0.005). Concentration of Defibrase could also affect its stability in aqueous solutions.

Gene cloning and induced expression pattern of IRF4 and IRF10 in the Asian swamp eel(Monopterus albus)

The Asian swamp eel （Monopterus albus） is one of the most economically important freshwater fish in East Asia, but data on the immune genes of M. albus are scarce compared to other commercially important fish. A better understanding of the eel＇s immune responses may help in developing strategies for disease management, potentially improving yields and mitigating losses. In mammals, interferon regulatory factors （IRFs） play a vital role in both the innate and adaptive immune system; though among teleosts IRF4 and IRFIO have seldom been studied. In this study, we characterized IRF4 and IRFIO from M. albus （malRF4 and malRFlO） and found that malRF4 cDNA consists of 1 716 nucleotides encoding a 451 amino acid （aa） protein, while malRFlO consists of 1 744 nucleotides including an open reading frame （ORF） of 1 236 nt encoding 411 aa. The malRFlO gene was constitutively expressed at high levels in a variety of tissues, while malRF4 showed a very limited expression pattern. Expression of malRF4 and malRFlO in head kidney, and spleen tissues was significantly up-regulated from 12 h to 48 h post-stimulation with polyinosinic： polycytidylic acid （poly I：C）, lipopolysaccharide （LPS） and a common pathogenic bacteria Aeromonas hydrophila. These results suggest that IRF4 and IRF10 play roles in immune responses to both viral and bacterial infections in M. albus.

Multi-telerobot collaboration based on coordinated controller

A coordinated controller used for multi-telerobots collaboration was presented based on the strategy of shared control. First, it can overcome the effect of time delay. And, it combines the intelligence of the master side and the slave side, which cannot only increase the efficiency and the safety of the system but also relieve the burden and requirements of the operator. The controller can also cope with the collision between two telerobots. A simulation experiment was carried out to verify the validity of the controller for two slave robots.

Transmission Capacity Analysis for Linear VANET under Physical Model

In this study, the transmission capacity of VANETs in a highway scenario is analysed on the basis of a 1D line model and the carrier sense multiple access with collision avoidance(CSMA/CA) protocol. We describe the CSMA/CA protocol used in IEEE802.11 p from the perspective of the geometric relationship amongst simultaneous transmitters. The desired channel and interfering channels are assumed to experience the same amount of path-loss and Rayleigh fading. On the basis of the proposed model, we analyse the attempted transmission probability of each road segment and the maximum intensity of active transmitters, including their theoretical values. Then, we employ the physical model to obtain the outage probability and derive the upper bound of the transmission capacity of a VANET, which is defined as the average spatial density of successful transmissions in the network. Simulation results indicate that the theoretical value offers a good bound on network capacity.

Human Body Behavior as Response on Autonomous Maneuvers, Based on ATD and Human Model

In the near future, active safety systems will take more control over the vehicle driving, even up to introducing fully autonomous vehicles. Nowadays, it is expected that the active safety systems will aid avoiding collisions much more efficiently than human drivers. These systems can protect not only the passengers, but also other road users. To mitigate collision, certain maneuvers （e.g., sudden braking, lane change, etc.） need to be done in a reasonably quick time. However, this may lead to low-g energy pulses. The latter fact, may cause unexpected and, in some cases, unwanted occupant body motion resulting even in OOP （out of position） postures. New patterns of occupant reactions in such cases are, to some extent, confirmed experimentally [1-3]. This paper evaluates the limits of standard ATDs （anthropometric test devices） and chosen human models in well established maneuver scenarios. Obtained results are compared with experimental data available in the literature. Drawbacks identify new challenges for the near future simulation based safety engineering. One scenario with combined conditions of emergency braking during lane change has been used as an example of OOP posture after maneuver.

Glomerular chemokine expression and the effect of steroid and cyclophosphamide pulse therapy in human crescentic glomerulonephritis

OBJECTIVE: To study glomerular expression of C-C chemokines, monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-1alpha and beta (MIP-1alpha, MIP-1beta) and the effect of steroid and cyclophosphamide (CTX) intermittent intravenous pulse therapy on expression in patients with crescentic glomerulonephritis (CGN) to further investigate the underlying mechanism of the treatment. METHODS: Twelve patients with initial biopsy-proven CGN(2), 6 with lupus nephritis (lupus-CGN, LN-CGN) and 6 with vasculitis, (vasculitis-CGN, V-CGN) were enrolled in this study. They underwent an initial biopsy before steroid and CTX intermittent intravenous pulse therapy and were biopsied again one to three months later. Expression of MCP-1, MIP-1alpha, MIP-1beta, and CD68 in glomeruli with cellular and fibrocellular crescents were examined by immunohistochemical analysis in serial sections of renal biopsies. The effect of the pulse therapy on histopathological changes was also observed. RESULTS: Although steroid and CTX intermittent intravenous pulse therapy markedly reduced the degree of glomerular crescent formation both in LN-CGN and V-CGN, the effect of the therapy on glomerular chemokine expression was significantly different between LN-CGN and V-CGN. It was found that steroid and CTX intermittent intravenous pulse therapy reduced the expression of CD68, MCP-1, and MIP-1alpha, but had no effect on MIP-1beta in glomeruli with cellular crescents of patients with LN-CGN. In patients with V-CGN, the therapy also reduced the expression of CD68, but had no effect on MCP-1, MIP-1alpha, and MIP-1beta in glomeruli with cellular crescents. It was noted that the degree of glomerulosclerosis and tubular interstitial fibrosis increased more significantly at the second biopsy in V-CGN as compared to LN-CGN. CONCLUSIONS: The efficacy of steroid and CTX intermittent intravenous pulse therapy in CGN might be affected by reduction of glomerular chemokine expression. The different changes in glomerular expression of MCP-1 and MIP-1alpha in patients with LN-CGN and V-CGN after pulse therapy may correlate to different responses to treatment and prognosis.

“双创”实现梦想

走进六师创新创业示范基地,工作室、商务中心、会议室、茶歇区等一应俱全,为创业者提供了良好的工作环境。网站的成功转型＂这里是圆梦之处,是释放激情之所。＂近日,＂五家渠在线＂微信公众号负责人罗璇说,她加入创新创业示范基地的＂创客＂团队已有3年时间了。通过2年多的线上运营,＂五家渠在线＂微信公众号已经拥有一批固定的粉丝群体和联盟商家。2013年10月,罗璇加入刚刚建立不久的五家渠市＂青湖在线＂网站,

Systematic review and meta-analysis of the efficacy and safety of immunosuppressive pulse therapy in the treatment of paraquat poisoning

Paraquat(PQ),a highly effective herbicide,is widely used worldwide.PQ poisoning can cause multiple organ failure,in which the lung is the primary target organ.After PQ poisoning,the patient mortality rate is as high as 90%,and there is currently no specific antidote.The main clinical treatment is the use of glucocorticoids and cyclophosphamide for pulse therapy,but its effectiveness and safety are still uncertain.We investigated the effectiveness and safety of immunosuppressive pulse therapy with glucocorticoids and cyclophosphamide to evaluate the treatment value in patients with acute PQ poisoning.This meta-analysis,combined with seven trials that enrolled a total of 426 patients,showed that immunosuppressive pulse therapy with glucocorticoids and cyclophosphamide for PQ poisoning significantly reduced mortality of the study group(59.3%,134/226) compared with the control group(81.0%,162/200).There was no significant difference of hepatitis or renal failure between the control and study groups,indicating that immunosuppressive pulse therapy was relatively safe.Several patients were reported to have leukopenia and returned to normal after 1-2 weeks without any abnormalities.Two cases of non-fatal sepsis were reported and considered to be a side effect of the immunosuppressive pulse therapy.Thus,immunosuppressive pulse therapy can efficiently reduce the mortality of PQ poisoning and it is relatively safe.

Dynamics on tumor immunotherapy model with periodic impulsive infusion

A periodic pulse differential equation model of tumor immunotherapy is established by considering the periodic and transient behavior of infusing immune cells. Using comparison theorem and Floquet multiplier theory of the impulsive differential equation, the boundedness of the model solution, the existence and stability of the free-tumor periodic solution are given. Furthermore, the persistence of the system is analyzed. Numerical simulations are carried to confirm the main theorems.

The effect of vaccination to dendritic cell and immune cell interaction in HIV disease progression

In this research paper, our main objective is to find out the meticulous role of activated dendritic cells （DCs） during the human immunodeficiency virus （HIV） infection process. DCs play a dual role by enhancing both HIV infection progression, as well as antiviral immune response. To explore the implications of these dual roles, we have formulated our mathematical model and analyzed the model by both analytical and numerical approaches. By using an impulsive differential equation, we have studied the effect of DC-based vaccination. Analytically we have determined the threshold value of drug dosage and dosing interval for optimum levels of injection. We have also investigated the effect of perfect adherence of drug dose on the immune cell count in extreme cases and observed that, systematic drug dose of the immune cells leads to its maximum level.