原田病的光学相干断层扫描观察

目的 观察和探讨原田病 (Harada disease)的光学相干断层扫描 (optical coherence tomography,OCT)的图像特征。方法 对 2 3例 (4 6只眼 )原田病患者同时进行荧光素眼底血管造影 (fundus fluorescein angiog-raphy,FFA )和 OCT检查 ,并对所获得的图像进行分析。结果 原田病的 OCT表现为 :急性期 :(1) 2 6只眼表现为后极部多发性、多灶状视网膜神经上皮层脱离 ;(2 ) 12只眼表现为黄斑部神经上皮层间水肿 ,中心凹处神经上皮层脱离 ,中心凹隆起 ,结构不易辨认 ;(3 ) 8只眼表现为黄斑部大泡样视网膜神经上皮层脱离 ,其下方的色素上皮及脉络膜反光带显著变薄 ,呈波浪状 ;(4 ) 3 2只眼表现为视乳头周围视网膜水肿增厚。结论 OCT断层扫描能直观的、准确的呈现原田病的损害程度。对视网膜组织细微结构的改变及视网膜继发性损害的程度 ,提供了一个直观的二维断层扫描图像 ,对

Cause of Autoimmune Diseases： Anomalous Magnetic Fielads

The aim of this work is to prove the AMF （anomalous magnetic fields） from the environment cause of AID （autoimmune diseases）. The therapeutic possibilities of natural EMF （Earth＇s magnetic field） is pointed out and how to act to prevent AID is determined. Authors indicate in which magnetic fields the IS （immune system） defends the body. They also explain why, in medical literature, risk factors are mistakenly declared pathogens of AID. The magnetic fields intensity in 20 peoples＇ beds, suffering from Type 1 diabetes, was measured with proton magnetometer （accuracy of 100 nT）. The measurement results are presented on sketches, patients were transferred to the natural EMF, medical condition was monitored, and AID function IS ethiopathology was studied. The correlation between AMF and organ location where AID occurred was determined by measuring. The cells of an organism, formed in natural EMF, are in magnetic balance. When an intruder enters the body, magnetic balance disappears and leukocytes with its MF （magnetic forces） destroy intruders. In the AMF, cells get enlarged MF without magnetic balance, causing IS with its MF to attack own cells, resulting AID. When an intruder enters a tissue, tissue cells and cells of intruders gain enhanced MF. IS with its MF destroys intruders. In the literature （The China Study by T. Colin Campbell）, the food is presented as cause of number of diseases. It was found what led to such a misinterpretation. It has been proven that causes of mentioned diseases are only AMF, which can be located in any organ, and with Type 1 diabetes its spread to the whole body with strongest intensity on pancreas. AMF give tissue cells reinforced MF without magnetic balance causing IS to deplete own tissues, resulting AID. IS works perfectly without AMF and risk factors are only a consequence of AMF.

特发性骨髓纤维化发病机制的研究进展

特发性骨髓纤维化（IMF）属慢性骨髓增殖性疾病（CMPD）中的一种，以脾肿大，外周血中出现幼稚粒细胞、幼稚红细胞、泪滴形红细胞，骨髓纤维组织增生，髓外造血，骨髓微血管密度增加及持续动员造血干／祖细胞为特征。骨髓成纤维细胞的异常增殖是对造血细胞克隆性增生的继发性反应。目前多数学者认为这些反应是由异常巨核细胞和单核细胞克隆性增生及其释放的细胞因子所介导的。部分IMF合并免疫功能异常，故亦有学者认为此类IMF为一种与克隆性造血干细胞疾病无关的免疫异常性疾病——自身免疫性骨髓纤维化。随着JAK2V617F等基因突变发现于CMPD患者，对IMF发病机制的了解又深入了一步。

炎症性肠病与卫生假说的研究进展

IBD 是一种肠道慢性非特异性炎性反应性疾病，主要包括 UC 和 CD。随着人们生活水平和卫生条件的提高，无论在发展中国家还是发达国家，IBD 的发病率和患病率均逐年升高，已成为全球关注的健康问题。IBD 是遗传、环境、免疫等因素共同作用所致的免疫异常性疾病，但其具体的发病机制和病因尚无定论。研究表明，肠道微生物多态性的减少和微生物刺激的改变导致了机体免疫能力受损，肠道免疫调节紊乱。幼年期的卫生环境对机体免疫系统有重要影响，而卫生假说重点研究幼年期卫生环境因素对将来发生 IBD 的影响，为 IBD 的高发病率提供了很好的解释。现从寄生虫与微生物感染、家庭规模、生活环境和家庭卫生等方面就卫生假说与 IBD 的关系及其可能机制做一综述。