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阿泰宁对牛结肠黏膜蛋白诱发大鼠免疫性溃疡性结肠炎的治疗作用 被引量:39
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作者 王文杰 王霖 +5 位作者 刘洋 彭珊瑛 张弗盈 李萍 万阜昌 崔云龙 《世界华人消化杂志》 CAS 北大核心 2008年第1期25-32,共8页
目的:观察阿泰宁对牛结肠黏膜蛋白(CCMP)诱发大鼠免疫性溃疡性结肠炎(UC)的治疗作用及机制.方法:将大鼠随机分为空白对照A组(n=8),模型B组(n=10),美沙拉秦(5-SAS)C组(n=10),阿泰宁大,小剂量D,E组(10^(11)CFU/L,10^(10)CFU/L),阿泰宁大剂... 目的:观察阿泰宁对牛结肠黏膜蛋白(CCMP)诱发大鼠免疫性溃疡性结肠炎(UC)的治疗作用及机制.方法:将大鼠随机分为空白对照A组(n=8),模型B组(n=10),美沙拉秦(5-SAS)C组(n=10),阿泰宁大,小剂量D,E组(10^(11)CFU/L,10^(10)CFU/L),阿泰宁大剂量+美沙拉秦F组(n=10),21 d后处死动物.肉眼观察结肠病变,分别测体质量、结肠湿质量、溃疡指数和结肠组织病理学变化.用MTT法测定各组肠系膜T/B淋巴细胞转化率,ELISA法测定大鼠血清中IL-8和TNF-α含量,单向免疫扩散法测定血清样品中IgG含量.结果:B,C,D,E组大鼠体质量均小于A组,但没有显著性差异.B组大多数大鼠排出的便呈白色.黏液且质软,治疗后排便均正常,结肠病变均减轻.C、D、E组大鼠的肠湿质量指数和溃疡指数得分以及D、E和F组的结肠中上段肠黏膜病变积分与B组均显著降低.与B组相比.C、D、E和F组的T淋巴细胞转化率显著增高(1.53±0.44,1.25±0.49,1.39±0.40,1.18±0.41 vs 0.59±0.20,P<0.05).而血清中IL-8含量均显著降低(47.7±16.9 ng/L,39.7±13.4 ng/L,57.0±8.6 ng/L,31.9±5.0 ng/L vs 81.0±10.9 ng/L,P<0.01),D、E,F组血清中TNF-α和D,F组IgG的含量均显著降低(TNF-α:31.7±11.2 ng/L,47.2±21.7 ng/L,30.3±17.1 ng/L vs 78.0±12.3 ng/L;IgG:9.6±1.8 g/L,7.5±0.2 g/L vs 11.9±0.4 g/L,P<0.05).结论:用CCMP可使大鼠结肠黏膜出现典型UC病变,并伴随IL-8、TNF-α、IgG致炎因子显著升高,T淋巴细胞转化率显著减低.用阿泰宁治疗后,IL-8、TNF-α及IgG的表达下调,T淋巴细胞转化升高,肠黏膜溃疡被修复.阿泰宁和美沙拉秦有协同作用. 展开更多
关键词 免疫性溃疡性结肠炎 阿泰宁 美沙拉秦 酪酸梭菌
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肠露灌肠剂治疗小鼠免疫性溃疡性结肠炎的实验研究 被引量:1
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作者 吴耀南 肖玉琴 +4 位作者 陈一斌 王文凡 涂志红 王瑞幸 黄自强 《中国中西医结合杂志》 CAS CSCD 北大核心 2007年第1期65-68,共4页
目的观察中药复方肠露灌肠剂对小鼠免疫性溃疡性结肠炎(ulcerative colitis,UC)模型的治疗作用。方法将实验小鼠随机分为正常组、模型组、肠露高剂量组(高剂组)、肠露低剂量组(低剂组)、柳氮磺吡啶(SASP)组。除正常组外,其余小鼠用兔结... 目的观察中药复方肠露灌肠剂对小鼠免疫性溃疡性结肠炎(ulcerative colitis,UC)模型的治疗作用。方法将实验小鼠随机分为正常组、模型组、肠露高剂量组(高剂组)、肠露低剂量组(低剂组)、柳氮磺吡啶(SASP)组。除正常组外,其余小鼠用兔结肠黏膜蛋白免疫法制作实验UC模型。给药治疗21天后,观察各组小鼠的疾病活动指数、体重变化,然后处死小鼠,取全段结肠,称结肠湿重,测肠重指数,比较各组小鼠的疾病活动指数、体重变化、结肠炎症反应及结肠组织病理学改变。结果肠露高、低剂量组,SASP组疾病活动指数明显减少,体重改善,结肠炎症反应减轻,与模型组比较差异有显著性(P<0.05或P<0.01);病理检查示:模型组小鼠结肠黏膜糜烂及溃疡形成、炎细胞浸润明显,肠壁充血伴出血,水肿明显;SASP组小鼠结肠黏膜未见明显糜烂及溃疡形成,但炎细胞浸润较明显,肠壁轻度充血,轻度水肿;肠露高刺组小鼠结肠黏膜无糜烂及溃疡形成,部分炎细胞浸润,肠壁轻度充血、无水肿。结论中药复方肠露灌肠剂对小鼠免疫性UC有明显的疗效。 展开更多
关键词 肠露灌肠剂 免疫性溃疡性结肠炎
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Two-sample Mendelian randomization analysis of causal relationship between eczema and autoimmune diseases
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作者 CHEN Chunli YAN Siyu +4 位作者 WAN Bangbei YU Yangyiyi ZENG Jinrong TAN Lina LU Jianyun 《中南大学学报(医学版)》 CAS CSCD 北大核心 2024年第6期932-942,共11页
Objective:The causal relationship between eczema and autoimmune diseases has not been previously reported.This study aims to evaluate the causal relationship between eczema and autoimmune diseases.Methods:The two‐sam... Objective:The causal relationship between eczema and autoimmune diseases has not been previously reported.This study aims to evaluate the causal relationship between eczema and autoimmune diseases.Methods:The two‐sample Mendelian randomization(MR)method was used to assess the causal effect of eczema on autoimmune diseases.Summary data from the Genome-Wide Association Study Catalog(GWAS)were obtained from the Integrative Epidemiology Unit(IEU)database.For eczema and autoimmune diseases,genetic instrument variants(GIVs)were identified according to the significant difference(P<5×10−8).Causal effect estimates were generated using the inverse‐variance weighted(IVW)method.MR Egger,maximum likelihood,MR-PRESSO,and MR-RAPS methods were used for alternative analyses.Sensitivity tests,including heterogeneity,horizontal pleiotropy,and leave-one-out analyses,were performed.Finally,reverse causality was assessed.Results:Genetic susceptibility to eczema was associated with an increased risk of Crohn’s disease(OR=1.444,95%CI 1.199 to 1.738,P<0.001)and ulcerative colitis(OR=1.002,95%CI 1.001 to 1.003,P=0.002).However,no causal relationship was found for the other 6 autoimmune diseases,including systemic lupus erythematosus(SLE)(OR=0.932,P=0.401),bullous pemphigoid(BP)(OR=1.191,P=0.642),vitiligo(OR=1.000,P=0.327),multiple sclerosis(MS)(OR=1.000,P=0.965),ankylosing spondylitis(AS)(OR=1.001,P=0.121),rheumatoid arthritis(RA)(OR=1.000,P=0.460).Additionally,no reverse causal relationship was found between autoimmune diseases and eczema.Conclusion:Eczema is associated with an increased risk of Crohn’s disease and ulcerative colitis.No causal relationship is found between eczema and SLE,MS,AS,RA,BP,or vitiligo. 展开更多
关键词 ECZEMA atopic eczema autoimmune diseases Crohn’s disease ulcerative colitis Mendelian randomization
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Safety of anti-tumor necrosis factor therapy in inflammatory bowel disease 被引量:19
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作者 Frank Hoentjen Ad A van Bodegraven 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第17期2067-2073,共7页
Inflammatory bowel disease (IBD), in particular Crohn's disease refractory to conventional therapy, fistulizing Crohn's disease and chronic active ulcerative colitis, generally respond well to anti-tumor necro... Inflammatory bowel disease (IBD), in particular Crohn's disease refractory to conventional therapy, fistulizing Crohn's disease and chronic active ulcerative colitis, generally respond well to anti-tumor necrosis factor (TNF) therapy. However, serious side effects do occur, necessitating careful monitoring of therapy. Potential side effects of anti-TNF therapy include opportunistic infections, which show a higher incidence when concomitant immunosuppression is used. Furthermore, antibody formation against anti-TNF is associated with decreased efficacy and an increased frequency of infusion reactions. The hypothesis of a slightly increased risk of lymphomas in IBD patients treated with anti TNF-therapy is debatable, since most studies lack the specific design to properly address this issue. Alarmingly, the occurrence of hepatosplenic T-cell lymphomas coincides with combined immunosuppressive therapy. Despite the potential serious side effects, anti-TNF therapy is an effective and relatively safe treatment option for refractory IBD. Future research is needed to answer important questions, such as the long-term risk of malignancies, safety during pregnancy, when to discontinue and when to switch anti-TNF therapy, as well as to determine the balance between therapeutic and toxic effects. 展开更多
关键词 Anti-tumor necrosis factor BIOLOGICS Inflammatory bowel diseases Crohn's disease INFLIXIMAB
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Autoimmune pancreatitis:current concepts 被引量:5
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作者 WANG Qian ZHANG Xuan ZHANG FengChun 《Science China(Life Sciences)》 SCIE CAS 2013年第3期246-253,共8页
Autoimmune pancreatitis (AIP) is a distinct type of chronic pancreatitis with unique clinical, pathological, serological, and imaging features. AIP usually presents with obstructive jaundice. Imaging studies often r... Autoimmune pancreatitis (AIP) is a distinct type of chronic pancreatitis with unique clinical, pathological, serological, and imaging features. AIP usually presents with obstructive jaundice. Imaging studies often reveal enlargement of the pancreas with a pancreatic mass and strictures of the main pancreatic duct. Two subtypes of AIP have recently been identified. Type 1 AIP is more prevalent in elderly Asian males and is characterized by lymphoplasmacytic sclerosing pancreatitis, obliterative phlebitis, and infiltration of large numbers of IgG4-positive plasma cells. Type II AIP is more prevalent in Caucasians and is characterized by granulocyte epithelial lesions. Most patients with type I AIP have a significantly elevated serum IgG4 con- centration, which is an important feature for diagnosis and for differentiating between AIP and other conditions such as pan- creatic cancer. Extrapancreatic complications are common, such as sclerosing cholangitis, sclerosing sialadenitis, retroperito- neal fibrosis in type I AIP, and ulcerative colitis in type II AIP. A rapid response to glucocorticoids treatment is suggestive of AlP, but the relapse rate is high, warranting the use of immunosuppressant treatment. B-cell depletion with rituximab may be a promising therapy. The prognosis of AIP is generally benign if treated promptly, and spontaneous remission occurs in a pro- portion of patients. 展开更多
关键词 autoimmune pancreatitis IGG4 pancreatic cancer GLUCOCORTICOIDS
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Case Report:Takayasu's arteritis associated with Crohn's disease
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作者 You-shi LIU You-hong FANG +3 位作者 Ling-xiang RUAN You-ming LI Lin LI Ling-ling JIANG 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2009年第8期631-634,共4页
Takayasu's arteritis(TA),also known as the "pulseless disease," is a chronic vasculitis of the aorta and aortic branches.TA with Crohn's disease is rare and has not been documented in China before.In... Takayasu's arteritis(TA),also known as the "pulseless disease," is a chronic vasculitis of the aorta and aortic branches.TA with Crohn's disease is rare and has not been documented in China before.In this paper we report on a case of Takayasu's arteritis associated with concurrent Crohn's disease.A 17-year-old Chinese male developed upper limb sourness and a sensation of fatigue,and his upper limb pulses were absent.He was diagnosed with TA and underwent an axillary artery bypass with autologous great saphenous vein on the left subclavian artery.After the surgery,he regained the normal blood pressure.This patient also had years of diarrhea and developed an anal canal ulcer,and was diagnosed with inflammatory bowel disease and ulcerative colitis before.Five months after the TA surgery,he was hospitalized for severe stomachache and diarrhea and was finally diagnosed with Crohn's disease.The possible pathophysiological mechanisms responsible for concurrent existence of TA and Crohn's disease may be associated with immune disorders,especially autoimmunity. 展开更多
关键词 Takayasu's arteritis Crohn's disease Inflammatory bowel disease Immune disorders
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