Malignant glomus tumor (MGT) is a rare, recently described neoplasm that recapitulates the appearance of the modified smooth cells of the normal glomus body. We report a case of MGT of the hand of a 48-year-old woman....Malignant glomus tumor (MGT) is a rare, recently described neoplasm that recapitulates the appearance of the modified smooth cells of the normal glomus body. We report a case of MGT of the hand of a 48-year-old woman. Magnetic resonance imaging (MRI) showed a 2.8-cm, well circumscribed, enhancing mass on the volar aspect of the thenar region of the right hand in immediate continuity with the ulnar artery and nerve. Computed tomography scan (CT-Scan) of the chest was nor mal. Histologic evaluation revealed a multilobular lesion with prominent branchi ng capillary vasculature and perivascular arrangement of sheets of tumor cells. The tumor cells were round, relatively uniform in size with distinct cell border s and perinuclear cytoplasmic clearing. They were of intermediate to high nuclea r grade and showed significant mitotic activity. A wide local excision with nega tive margins was performed. Multiple lung metastases were evident at 8-month fo llow-up. To date, forty-five cases of MGT of skin and soft issue have been rep orted in the literature. Twelve of the forty-five cases developed metastasis. I n this report, we emphasize the differential diagnosis of MGT in the skin and de ep soft tissue.展开更多
淋巴上皮瘤样癌(lymphoepithelioma-like carcinoma,LELC)是一种低分化或未分化的恶性肿瘤,泌尿系统的LELC很少见,其中以膀胱淋巴上皮瘤样癌(lymphoepitheli-oma-like carcinoma of the bladder,LELCB)较多,少数发生于前列腺、肾盂、输...淋巴上皮瘤样癌(lymphoepithelioma-like carcinoma,LELC)是一种低分化或未分化的恶性肿瘤,泌尿系统的LELC很少见,其中以膀胱淋巴上皮瘤样癌(lymphoepitheli-oma-like carcinoma of the bladder,LELCB)较多,少数发生于前列腺、肾盂、输尿管或尿道。现将本院收治的2例泌尿系统LELC组织学形态及免疫组化特点进行报道。展开更多
Background: There are many reports of patients with a severe hydroa vacciniforme (HV)-like eruption in which cutaneous lesions occur in both sun-exposed and non-exposed areas, unlike in true HV. Several patients have ...Background: There are many reports of patients with a severe hydroa vacciniforme (HV)-like eruption in which cutaneous lesions occur in both sun-exposed and non-exposed areas, unlike in true HV. Several patients have died from a malignant haematological neoplasm. In most cases, a latent Epstein-Barr virus (EBV) infection has been detected in the skin lesions. Objectives: To describe the clinical and laboratory features of six additional patients with an EBV-associated HV-like eruption. Methods: The clinical, histological and immunohistochemical features were reviewed. T-cell receptor γgene rearrangements were studied using polymerase chain reaction (PCR) and hetero-duplex analysis. In-situ hybridization was performed to detect mRNA for EBV in skin biopsy specimens. PCR was performed to screen for EBV infection in the skin lesions of three patients and blood of two patients. Photoprovocation with repeated ultraviolet (UV) A exposure was performed in three patients. Results: The severity of the skin lesions and the clinical course varied among the patients. Skin lesions were induced by repeated UVA exposure in three patients and a latent EBV infection was demonstrated in the photoprovoked lesions. Conclusions: Three different clinical courses were found in six patients with an HV-like eruption associated with chronic EBV infection: (i) spontaneous remission; (ii) clearing after photoprotection; and (iii) continuous recurrence irrespective of sun exposure. It is possible that there are two patterns of HV-like eruption associated with chronic EBV infection. One is characterized by recurrent necrotic papulovesicles of the face and the other by nodules and facial swelling. It was demonstrated that the skin lesions could be triggered by repeated UVA exposure in the patients showing recurrent necrotic papulovesicles of the face.展开更多
文摘Malignant glomus tumor (MGT) is a rare, recently described neoplasm that recapitulates the appearance of the modified smooth cells of the normal glomus body. We report a case of MGT of the hand of a 48-year-old woman. Magnetic resonance imaging (MRI) showed a 2.8-cm, well circumscribed, enhancing mass on the volar aspect of the thenar region of the right hand in immediate continuity with the ulnar artery and nerve. Computed tomography scan (CT-Scan) of the chest was nor mal. Histologic evaluation revealed a multilobular lesion with prominent branchi ng capillary vasculature and perivascular arrangement of sheets of tumor cells. The tumor cells were round, relatively uniform in size with distinct cell border s and perinuclear cytoplasmic clearing. They were of intermediate to high nuclea r grade and showed significant mitotic activity. A wide local excision with nega tive margins was performed. Multiple lung metastases were evident at 8-month fo llow-up. To date, forty-five cases of MGT of skin and soft issue have been rep orted in the literature. Twelve of the forty-five cases developed metastasis. I n this report, we emphasize the differential diagnosis of MGT in the skin and de ep soft tissue.
文摘淋巴上皮瘤样癌(lymphoepithelioma-like carcinoma,LELC)是一种低分化或未分化的恶性肿瘤,泌尿系统的LELC很少见,其中以膀胱淋巴上皮瘤样癌(lymphoepitheli-oma-like carcinoma of the bladder,LELCB)较多,少数发生于前列腺、肾盂、输尿管或尿道。现将本院收治的2例泌尿系统LELC组织学形态及免疫组化特点进行报道。
文摘Background: There are many reports of patients with a severe hydroa vacciniforme (HV)-like eruption in which cutaneous lesions occur in both sun-exposed and non-exposed areas, unlike in true HV. Several patients have died from a malignant haematological neoplasm. In most cases, a latent Epstein-Barr virus (EBV) infection has been detected in the skin lesions. Objectives: To describe the clinical and laboratory features of six additional patients with an EBV-associated HV-like eruption. Methods: The clinical, histological and immunohistochemical features were reviewed. T-cell receptor γgene rearrangements were studied using polymerase chain reaction (PCR) and hetero-duplex analysis. In-situ hybridization was performed to detect mRNA for EBV in skin biopsy specimens. PCR was performed to screen for EBV infection in the skin lesions of three patients and blood of two patients. Photoprovocation with repeated ultraviolet (UV) A exposure was performed in three patients. Results: The severity of the skin lesions and the clinical course varied among the patients. Skin lesions were induced by repeated UVA exposure in three patients and a latent EBV infection was demonstrated in the photoprovoked lesions. Conclusions: Three different clinical courses were found in six patients with an HV-like eruption associated with chronic EBV infection: (i) spontaneous remission; (ii) clearing after photoprotection; and (iii) continuous recurrence irrespective of sun exposure. It is possible that there are two patterns of HV-like eruption associated with chronic EBV infection. One is characterized by recurrent necrotic papulovesicles of the face and the other by nodules and facial swelling. It was demonstrated that the skin lesions could be triggered by repeated UVA exposure in the patients showing recurrent necrotic papulovesicles of the face.
