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乙酰半胱氨酸对半乳糖胺致小鼠引起免疫性肝衰竭的治疗作用 被引量:2
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作者 王佩 张萍萍 吴锡铭 《中国新药与临床杂志》 CAS CSCD 北大核心 2003年第1期16-18,共3页
目的 :观察乙酰半胱氨酸 (NAC)治疗小鼠免疫性肝衰竭的疗效。方法 :ICR小鼠随机分成 6组 :正常对照组、模型对照组、阳性对照组 ,乙酰半胱氨酸 2 5 ,5 0 ,10 0mg·kg- 1剂量组 ,每组 30只。除正常对照组外 ,每组腹腔注射半乳糖胺 (D... 目的 :观察乙酰半胱氨酸 (NAC)治疗小鼠免疫性肝衰竭的疗效。方法 :ICR小鼠随机分成 6组 :正常对照组、模型对照组、阳性对照组 ,乙酰半胱氨酸 2 5 ,5 0 ,10 0mg·kg- 1剂量组 ,每组 30只。除正常对照组外 ,每组腹腔注射半乳糖胺 (D galac tosamine ,Gal) 80 0mg·kg- 1,并同时腹腔注射脂多糖 (lipopolysacharides ,LPS) 10 μg·kg- 1,正常对照组、模型对照组、阳性对照组、给药组于注入Gal/LPS前、后 2h分别静脉注射生理盐水 ,生理盐水 ,促肝细胞生长素 (pHGF) 6 0mg·kg- 1,NAC 2 5 ,5 0 ,10 0mg·kg- 1。结果 :乙酰半胱氨酸能明显阻止Gal/LPS攻击 6h后引起小鼠血清转氨酶活力增高 ,改善凝血功能 ,使肝组织腐胺水平下降 ,肝组织损害减轻 ,降低小鼠死亡率 ,显示剂量依赖。结论 展开更多
关键词 乙酰半胱氨酸 动物实验 免疫 胺类 免疫肝衰竭 治疗
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免疫抑制诱导性暴发性肝衰竭/纤维淤胆性肝炎1例
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作者 钟忠辉 夏向南 +1 位作者 陈学香 张丹凤 《中华老年多器官疾病杂志》 2006年第1期63-63,共1页
免疫抑制诱导性暴发性肝衰竭/纤维淤胆性肝炎(fibrosing cholestatic hepatits,FCH)不仅可出现于乙型肝炎病毒(HBV)相关性严重慢性肝病而接受原位肝移植的患者,也可出现原先慢性无症状HBV携带者或仅有轻度慢性乙型肝炎的患者,... 免疫抑制诱导性暴发性肝衰竭/纤维淤胆性肝炎(fibrosing cholestatic hepatits,FCH)不仅可出现于乙型肝炎病毒(HBV)相关性严重慢性肝病而接受原位肝移植的患者,也可出现原先慢性无症状HBV携带者或仅有轻度慢性乙型肝炎的患者,在接受肝外器官移植如肾移植、骨髓移植并进行免疫抑制治疗后。本文报道一例“大三阳”老年患者,肾移植3年后长期口服免疫抑制剂出现暴发性肝衰竭/纤维淤胆性肝炎。 展开更多
关键词 免疫抑制诱导性暴发性衰竭 纤维淤胆性 乙型炎病毒(HBV) 无症状HBV携带者 慢性乙型 老年患者 慢性 原位移植 免疫抑制剂 器官移植
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免疫抑制诱导性暴发性肝衰竭 被引量:2
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作者 于乐成 顾长海 《中华内科杂志》 CAS CSCD 北大核心 2001年第7期496-498,共3页
关键词 免疫抑制诱导性暴发性衰竭 FHF 诊断 治疗 病因
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Clinical heterogeneity in autoimmune acute liver failure 被引量:1
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作者 Norberto C Chavez-Tapia Julio Martinez-Salgado +2 位作者 Julio Granados Misael Uribe Felix I Tellez-Avila 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第12期1824-1827,共4页
AIM: To describe the outcome and prognosis in a cohort of patients with acute liver failure due to autoimmune hepatitis without liver transplantation. METHODS: A retrospective trial was conducted in 11 patients with a... AIM: To describe the outcome and prognosis in a cohort of patients with acute liver failure due to autoimmune hepatitis without liver transplantation. METHODS: A retrospective trial was conducted in 11 patients with acute liver failure due to autoimmune hepatitis who attended the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran. Demographic, biochemical and severity indexes, and treatment and outcome were assessed. RESULTS: Among the 11 patients, with a median age of 31 years, 72% had inflammatory response syndrome, and six patients received corticosteroids. The mortality rate within four weeks was 56%, and the one-year survival was 27%. In the survivors, severity indexes were lower and 83% received corticosteroids. CONCLUSION: We observed a relatively high survival rate in patients with acute liver failure due to autoimmune hepatitis. This survival rate could be influenced by severity of the disease and/or use of corticosteroids. 展开更多
关键词 Autoimmune hepatitis Acute liver failure CORTICOSTEROIDS
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Optimizing management in autoimmune hepatitis with liver failure at initial presentation 被引量:3
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作者 Jonathan R Potts Sumita Verma 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第16期2070-2075,共6页
Autoimmune hepatitis (AIH) is a disease of unknown etiology,its hallmark being ongoing hepatic inflammation.By its very nature,it is a chronic condition,although increasingly,we are becoming aware of patients with acu... Autoimmune hepatitis (AIH) is a disease of unknown etiology,its hallmark being ongoing hepatic inflammation.By its very nature,it is a chronic condition,although increasingly,we are becoming aware of patients with acute presentations,some of whom may have liver failure.There are very limited published data on patients with AIH with liver failure at initial diagnosis,which consist mostly of small retrospective studies.As a consequence,the clinical features and optimal management of this cohort remain poorly defined.A subset of patients with AIH who present with liver failure do respond to corticosteroids,but for the vast majority,an urgent liver transplantation may offer the only hope of long-term survival.At present,there is uncertainty on how best to stratify such a cohort into responders and non-responders to corticosteroids as soon as possible after hospitalization,thus optimizing their management.This editorial attempts to answer some of the unresolved issues relating to management of patients with AIH with liver failure at initial presentation.However,it must be emphasized that,at present,this editorial is based mostly on small retrospective studies,and it is an understatement that multicenter prospective studies are urgently needed to address this important clinical issue. 展开更多
关键词 Autoimmune hepatitis Liver failure Liver transplantation CORTICOSTEROIDS
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