《Frontiers in Immunology》8月2日在线发表了华中农业大学赵书红教授所在猪遗传育种团队的学术论文，该论文揭示了miR～155基因的功能性SNP（单核苷酸多态性）位点的免疫调控机理，对动物抗病育种及临床上研究与miR—155突变位点相关...《Frontiers in Immunology》8月2日在线发表了华中农业大学赵书红教授所在猪遗传育种团队的学术论文，该论文揭示了miR～155基因的功能性SNP（单核苷酸多态性）位点的免疫调控机理，对动物抗病育种及临床上研究与miR—155突变位点相关的疾病具有重要指导意义。与宿主抗性相关的基因和关键SNP的鉴定一直是动物抗病育种的热点和难点。展开更多
Cholangiopathies are a group of diseases primarily or secondarily affecting bile duct cells, and result in cholangiocyte proliferation, regression, and/or transformation. Their etiopathogenesis may be associated with ...Cholangiopathies are a group of diseases primarily or secondarily affecting bile duct cells, and result in cholangiocyte proliferation, regression, and/or transformation. Their etiopathogenesis may be associated with a broad variety of causes of different nature, which includes genetic, neoplastic, immune-associated, infectious, vascular, and drug-induced alterations, or being idiopathic. miRNAs, small non-coding endogenous RNAs that post-transcriptionally regulate gene expres sion, have been associated with pathophysiological processes in different organs and cell types, and are postulated as potential targets for diagnosis and therapy. In the current manuscript, knowledge regarding the role of miRNAs in the development and/or progression of cholangiopathies has been reviewed and the most relevant findings in this promising field of hepatology have been highlighted.展开更多
文摘《Frontiers in Immunology》8月2日在线发表了华中农业大学赵书红教授所在猪遗传育种团队的学术论文，该论文揭示了miR～155基因的功能性SNP（单核苷酸多态性）位点的免疫调控机理，对动物抗病育种及临床上研究与miR—155突变位点相关的疾病具有重要指导意义。与宿主抗性相关的基因和关键SNP的鉴定一直是动物抗病育种的热点和难点。
文摘Cholangiopathies are a group of diseases primarily or secondarily affecting bile duct cells, and result in cholangiocyte proliferation, regression, and/or transformation. Their etiopathogenesis may be associated with a broad variety of causes of different nature, which includes genetic, neoplastic, immune-associated, infectious, vascular, and drug-induced alterations, or being idiopathic. miRNAs, small non-coding endogenous RNAs that post-transcriptionally regulate gene expres sion, have been associated with pathophysiological processes in different organs and cell types, and are postulated as potential targets for diagnosis and therapy. In the current manuscript, knowledge regarding the role of miRNAs in the development and/or progression of cholangiopathies has been reviewed and the most relevant findings in this promising field of hepatology have been highlighted.
