MicroRNAs(miRNAs) are small,non-coding single-stranded RNAs that can modulate target gene expression at posttranscriptional level and participate in cell proliferation,differentiation,and apoptosis.T cells have import...MicroRNAs(miRNAs) are small,non-coding single-stranded RNAs that can modulate target gene expression at posttranscriptional level and participate in cell proliferation,differentiation,and apoptosis.T cells have important functions in acquired immune response;miRNAs regulate this immune response by targeting the mRNAs of genes involved in T cell development,proliferation,differentiation,and function.For instance,miR-181 family members function in progression by targeting Bcl2 and CD69,among others.MiR-17 to miR-92 clusters function by binding to CREB1,PTEN,and Bim.Considering that the suppression of T cell-mediated immune responses against tumor cells is involved in cancer progression,we should investigate the mechanism by which miRNA regulates T cells to develop new approaches for cancer treatment.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.81171653 and 30972703)Natural Science Foundation of Jiangsu Province(Grant Nos.BK2011246 and BK2011247)Jiangsu Provincial Innovation Award BC2012093 by the Bureau of Science and Technology of Jiangsu Province
文摘MicroRNAs(miRNAs) are small,non-coding single-stranded RNAs that can modulate target gene expression at posttranscriptional level and participate in cell proliferation,differentiation,and apoptosis.T cells have important functions in acquired immune response;miRNAs regulate this immune response by targeting the mRNAs of genes involved in T cell development,proliferation,differentiation,and function.For instance,miR-181 family members function in progression by targeting Bcl2 and CD69,among others.MiR-17 to miR-92 clusters function by binding to CREB1,PTEN,and Bim.Considering that the suppression of T cell-mediated immune responses against tumor cells is involved in cancer progression,we should investigate the mechanism by which miRNA regulates T cells to develop new approaches for cancer treatment.
