Dendritic Cells Algorithm （DCA） is a new development in Artificial Immune System （AIS）. It has various parameters, and as yet has not been ex- tensively tested. The general applicability of the al- gorithm to a va...Dendritic Cells Algorithm （DCA） is a new development in Artificial Immune System （AIS）. It has various parameters, and as yet has not been ex- tensively tested. The general applicability of the al- gorithm to a variety of problems is d. The aim of this work is to demonstrate the feas^ility and ro- bustness of the algorithm, and the sensitivity to the change of various parameters in a series of experi- ments for Nmap portscan detection by using DCA. Experiment results show that the algorithm per- forms well on the task of detecting a ping based Nmap portscan. Sensitivity analysis is also per- formed. True positive rate is higher for the detec- tion of anomaly processes and false positive rate is lower for the detection of normal orocesses.展开更多
Objective:The aim of this study was to investigate the relationship between expression of MEK1 protein in the mitogen-activated protein kinase (MAPK) signaling pathway and liver as well as lymph node metastasis in col...Objective:The aim of this study was to investigate the relationship between expression of MEK1 protein in the mitogen-activated protein kinase (MAPK) signaling pathway and liver as well as lymph node metastasis in colorectal cancer patients.Methods:Immunohistochemistry was performed to detect the expression of MEK1 protein in primary cancer,normal colonic mucosa,lymph nodes and liver metastatic foci from 86 colorectal cancer patients.Life table analysis was employed to evaluate the association between MEK1 expression and patients' survival.Results:The positive rate of MEK1 expression in the primary cancer,normal colonic mucosa,metastatic lymph nodes and liver metastatic foci was 52.3%,32.6%,71.4% and 78.3%,respectively.The positive rate of MEK1 expression in the primary cancer,metastatic lymph nodes and liver metastatic foci was significantly higher than that in the normal colonic mucosa (P < 0.01).Furthermore,the positive rate of MEK1 expression in stage III and IV colorectal cancer patients was dramatically higher than that in stage I and II colorectal cancer patients (P < 0.01).The positive rate of MEK1 expression in patients with poorly differentiated adenocarcinoma and mucinous adenocarcinoma was significantly higher than patients with well or moderately differentiated adenocarcinoma (P < 0.01).The 3-year disease-free survival rate was 41.3% in MEK1 positive patients and 73.1% in MEK1 negative patients.The survival rate of MEK1 positive patients was significantly lower than that of MEK1 negative patients (P < 0.05).Conclusion:The increased expression of MEK1 was associated with lymph node metastasis and liver metastasis of colorectal cancer.Therefore,detection of MEK1 expression may have important significance in the evaluation of patients' prognosis.展开更多
基金supported by the National Natural Science Foundation of China under Grants No.61100205,No.60873001the Project 2009RC0212 of the Fundamental Research Funds for the Central Universities
文摘Dendritic Cells Algorithm （DCA） is a new development in Artificial Immune System （AIS）. It has various parameters, and as yet has not been ex- tensively tested. The general applicability of the al- gorithm to a variety of problems is d. The aim of this work is to demonstrate the feas^ility and ro- bustness of the algorithm, and the sensitivity to the change of various parameters in a series of experi- ments for Nmap portscan detection by using DCA. Experiment results show that the algorithm per- forms well on the task of detecting a ping based Nmap portscan. Sensitivity analysis is also per- formed. True positive rate is higher for the detec- tion of anomaly processes and false positive rate is lower for the detection of normal orocesses.
基金Supported by agrant from the National Natural Science Foundation of China (No. 81101860)
文摘Objective:The aim of this study was to investigate the relationship between expression of MEK1 protein in the mitogen-activated protein kinase (MAPK) signaling pathway and liver as well as lymph node metastasis in colorectal cancer patients.Methods:Immunohistochemistry was performed to detect the expression of MEK1 protein in primary cancer,normal colonic mucosa,lymph nodes and liver metastatic foci from 86 colorectal cancer patients.Life table analysis was employed to evaluate the association between MEK1 expression and patients' survival.Results:The positive rate of MEK1 expression in the primary cancer,normal colonic mucosa,metastatic lymph nodes and liver metastatic foci was 52.3%,32.6%,71.4% and 78.3%,respectively.The positive rate of MEK1 expression in the primary cancer,metastatic lymph nodes and liver metastatic foci was significantly higher than that in the normal colonic mucosa (P < 0.01).Furthermore,the positive rate of MEK1 expression in stage III and IV colorectal cancer patients was dramatically higher than that in stage I and II colorectal cancer patients (P < 0.01).The positive rate of MEK1 expression in patients with poorly differentiated adenocarcinoma and mucinous adenocarcinoma was significantly higher than patients with well or moderately differentiated adenocarcinoma (P < 0.01).The 3-year disease-free survival rate was 41.3% in MEK1 positive patients and 73.1% in MEK1 negative patients.The survival rate of MEK1 positive patients was significantly lower than that of MEK1 negative patients (P < 0.05).Conclusion:The increased expression of MEK1 was associated with lymph node metastasis and liver metastasis of colorectal cancer.Therefore,detection of MEK1 expression may have important significance in the evaluation of patients' prognosis.
