Background Although thyroid hormone （TH） has important effects on lipid metabolism, the relationship between TH and statin responsiveness has never been investigated. We hypothesize that TH plays an important role i...Background Although thyroid hormone （TH） has important effects on lipid metabolism, the relationship between TH and statin responsiveness has never been investigated. We hypothesize that TH plays an important role in statin responsiveness in patients with acute myocardial infarction （AMI）. Methods Consecutive 1091 hospitalized AMI patients in Fuwai hospital （Beijing, China） were enrolled into this current study. The study population was divided into three groups based on the intensity of statin treatment： low-intensity （n = 221）, moderate-intensity （n = 712） and high-intensity （n = 158）. Lipid levels were measured after statin therapy lasting for 10-14 days. The association between TH, lipid profile levels and achievement of low-density lipoprotein cholesterol （LDL-C） lowering goals was explored in patients with AMI on statin therapy. Results By general linear analysis, a significant linear trend between free triiodothyronine （FT3） and LDL-C level （linear coefficient r = -0.082, P = 0.001） and FT3 and total cholesterol （TC） level （r = -0.105, P = 0.031） was observed in the moderate-intensity statin group. A more apparent linear trend was detected in the high-intensity statin group （for LDL-C： r = -0.113, P = 0.005; for TC： r = -0.172, P = 0.029, respectively）. However, no significant correlation was observed in the low-intensity statin group. Compared with the low-FT3 group （defined as FT3 〈 1.79 pg/mL）, the OR （95% CI） for attaining a LDL-C 〈 3.0mmol/L was found to be 2.217 （1.001–4.839） in the higher FT3 group （〉 2.95 pg/mL）. The OR （95% CI） for attaining the more intensive goal （LDL-C 〈 1.8mmol/L） was 2.836 （1.014–5.182）. Conclusions Our study reveals that variation in FT3 levels is related to the cholesterol-lowering responsiveness of statins in AMI patients. These findings suggest that low FT3 may be a factor responsible for lack of LDL-C goal attainment and patients’ poor responsiveness to statin treatment.展开更多
Intercultures play an important role in localization of translation. They are the essential reference resources for those who are translators as well as writers in their literary translation or creation. Translators c...Intercultures play an important role in localization of translation. They are the essential reference resources for those who are translators as well as writers in their literary translation or creation. Translators contribute to the extension of source culture and in target culture by means ofintercultures to form new localized cultural paradigms. Bing Xin＇ s creation of the short free verse in the vernacular Chinese was influenced by Hu shih＇s new literature ideas and Zheng Zhenduo＇s translation of Stray Birds, a famous poetry anthology of Tagore. Through her translation, she borrowed new literary paradigms from foreign languages and successfully converted them into more acceptable ones in Chinese new literature. The paper, from the perspectives of Localization and Intercultures by Anthony Pym, explores the effects which Hu Shih and Zheng Zhenduo made upon Bing Xin＇s poetry translation and creation in the trend of poetry localization in the May Fourth Movement, and analyzes the interactions between Bing Xin＇s poetry creation and her poetry translation.展开更多
Alcohol ingestion causes alteration in several cellular mechanisms, and leads to inflammation, apoptosis, immunological response defects, and fibrosis. These phenomena are associated with significant changes in the ep...Alcohol ingestion causes alteration in several cellular mechanisms, and leads to inflammation, apoptosis, immunological response defects, and fibrosis. These phenomena are associated with significant changes in the epigenetic mechanisms, and subsequently, to liver cell memory. The ubiquitin-proteasome pathway is one of the vital pathways in the cell that becomes dysfunctionial as a result of chronic ethanol consumption. Inhibition of the proteasome activity in the nucleus causes changes in the turnover of transcriptional factors, histone modifying enzymes, and therefore, affects epigenetic mechanisms. Alcohol consumption has been associated with an increase in histone acetylation and a decrease in histone methylation, which leads to gene expression changes. DNA and histone modifications that result from ethanol-induced proteasome inhibition are key players in regulating gene expression, especially genes involved in the cell cycle, immunological responses, and metabolism of ethanol. The present review highlights the consequences of ethanol-induced proteasome inhibition in the nucleus of liver cells that are chronically exposed to ethanol.展开更多
An efficient and practical method is developed for the trifluoromethylation of enamides using Umemoto's reagent as the trifluoromethylating reagent. These reactions proceeded under visible light irradiation withou...An efficient and practical method is developed for the trifluoromethylation of enamides using Umemoto's reagent as the trifluoromethylating reagent. These reactions proceeded under visible light irradiation without any photocatalyst at room temperature in good chemical yields.展开更多
Under the high-speed vibration milling conditions,the solvent and catalyst-free azo-Michael addition of chalcone derivatives and amines was found to proceed efficiently in excellent yields at ambient temperature in sh...Under the high-speed vibration milling conditions,the solvent and catalyst-free azo-Michael addition of chalcone derivatives and amines was found to proceed efficiently in excellent yields at ambient temperature in short reaction time.In most cases,conventional side reactions were avoided and thus quantitative yields were achieved.The influences of the vibration frequency and reaction time on the azo-Michael addition were investigated.展开更多
基金We acknowledge the help from Wei LI, Yang WANG and Yan-Yan ZHAO （Medical Research ＆ Biometrics Center, Fuwai Hospital, National Center for Cardiovascular Disease, China） with the statistical analyses. This work was supported by the National Natural Science Foundation of China （No. 81470485）, Capital Clinical Featured Application Research Project （No. z151100004015175）, and CAMS Innovation Fund for Medical Sciences （CIFMS 2016-I2M- 1-009）. The authors have no potential conflict of interest to declare.
文摘Background Although thyroid hormone （TH） has important effects on lipid metabolism, the relationship between TH and statin responsiveness has never been investigated. We hypothesize that TH plays an important role in statin responsiveness in patients with acute myocardial infarction （AMI）. Methods Consecutive 1091 hospitalized AMI patients in Fuwai hospital （Beijing, China） were enrolled into this current study. The study population was divided into three groups based on the intensity of statin treatment： low-intensity （n = 221）, moderate-intensity （n = 712） and high-intensity （n = 158）. Lipid levels were measured after statin therapy lasting for 10-14 days. The association between TH, lipid profile levels and achievement of low-density lipoprotein cholesterol （LDL-C） lowering goals was explored in patients with AMI on statin therapy. Results By general linear analysis, a significant linear trend between free triiodothyronine （FT3） and LDL-C level （linear coefficient r = -0.082, P = 0.001） and FT3 and total cholesterol （TC） level （r = -0.105, P = 0.031） was observed in the moderate-intensity statin group. A more apparent linear trend was detected in the high-intensity statin group （for LDL-C： r = -0.113, P = 0.005; for TC： r = -0.172, P = 0.029, respectively）. However, no significant correlation was observed in the low-intensity statin group. Compared with the low-FT3 group （defined as FT3 〈 1.79 pg/mL）, the OR （95% CI） for attaining a LDL-C 〈 3.0mmol/L was found to be 2.217 （1.001–4.839） in the higher FT3 group （〉 2.95 pg/mL）. The OR （95% CI） for attaining the more intensive goal （LDL-C 〈 1.8mmol/L） was 2.836 （1.014–5.182）. Conclusions Our study reveals that variation in FT3 levels is related to the cholesterol-lowering responsiveness of statins in AMI patients. These findings suggest that low FT3 may be a factor responsible for lack of LDL-C goal attainment and patients’ poor responsiveness to statin treatment.
文摘Intercultures play an important role in localization of translation. They are the essential reference resources for those who are translators as well as writers in their literary translation or creation. Translators contribute to the extension of source culture and in target culture by means ofintercultures to form new localized cultural paradigms. Bing Xin＇ s creation of the short free verse in the vernacular Chinese was influenced by Hu shih＇s new literature ideas and Zheng Zhenduo＇s translation of Stray Birds, a famous poetry anthology of Tagore. Through her translation, she borrowed new literary paradigms from foreign languages and successfully converted them into more acceptable ones in Chinese new literature. The paper, from the perspectives of Localization and Intercultures by Anthony Pym, explores the effects which Hu Shih and Zheng Zhenduo made upon Bing Xin＇s poetry translation and creation in the trend of poetry localization in the May Fourth Movement, and analyzes the interactions between Bing Xin＇s poetry creation and her poetry translation.
文摘Alcohol ingestion causes alteration in several cellular mechanisms, and leads to inflammation, apoptosis, immunological response defects, and fibrosis. These phenomena are associated with significant changes in the epigenetic mechanisms, and subsequently, to liver cell memory. The ubiquitin-proteasome pathway is one of the vital pathways in the cell that becomes dysfunctionial as a result of chronic ethanol consumption. Inhibition of the proteasome activity in the nucleus causes changes in the turnover of transcriptional factors, histone modifying enzymes, and therefore, affects epigenetic mechanisms. Alcohol consumption has been associated with an increase in histone acetylation and a decrease in histone methylation, which leads to gene expression changes. DNA and histone modifications that result from ethanol-induced proteasome inhibition are key players in regulating gene expression, especially genes involved in the cell cycle, immunological responses, and metabolism of ethanol. The present review highlights the consequences of ethanol-induced proteasome inhibition in the nucleus of liver cells that are chronically exposed to ethanol.
基金supported by the National Natural Science Foundation of China(2147208481421091)+2 种基金the Qing Lan Project of Jiangsu Province and State Key Laboratory of Bioorganic & Natural Products ChemistryShanghai Institute of Organic ChemistryChinese Academy of Sciences
文摘An efficient and practical method is developed for the trifluoromethylation of enamides using Umemoto's reagent as the trifluoromethylating reagent. These reactions proceeded under visible light irradiation without any photocatalyst at room temperature in good chemical yields.
基金supported by the National Natural Science Foundation of China (20876148)the Natural Science Foundation of Zhejiang (Y407306)
文摘Under the high-speed vibration milling conditions,the solvent and catalyst-free azo-Michael addition of chalcone derivatives and amines was found to proceed efficiently in excellent yields at ambient temperature in short reaction time.In most cases,conventional side reactions were avoided and thus quantitative yields were achieved.The influences of the vibration frequency and reaction time on the azo-Michael addition were investigated.
