Large leisure activities usually use large sport facilities. There is often no serious problem with people gathering, but both incomplete facilities and negligence of people security manage may court injury or death. ...Large leisure activities usually use large sport facilities. There is often no serious problem with people gathering, but both incomplete facilities and negligence of people security manage may court injury or death. The purpose of this study is to analyze crowded nodes and to improve evacuation path use Simulex models. The fastest and safest way to achieve safe egress was then well planned. For turn locations, it was found that fixing the plane angle did not significantly raise the overall exiting efficiency. However, replacing the right angle or other angles with arc angle makes overall exiting moving line more fluent. For multito single-directional converging T-junction intersections, modification of turn angle increased the movement fluency, with the higher the modified angle, the higher in fluency. However, changing to round angle did not have as significant effect as expected while gate opening width must be increased to 1.0 m before more significant effects were produced. The results showed that modifying turn angles to 60° produces better improvements.展开更多
AIM： To evaluate the role of intestinal microflora in the effects of multi-herbal medicine on gene expression in the gut and liver. METHODS： The multi-herbal medicine Juzentaihoto （JTX） was administered to five ge...AIM： To evaluate the role of intestinal microflora in the effects of multi-herbal medicine on gene expression in the gut and liver. METHODS： The multi-herbal medicine Juzentaihoto （JTX） was administered to five germ-free mice and regular mice for 2 wk. Among the results of the comprehensive gene chip analysis of the intestine and liver, we featured heat shock proteins （HSPs） 70 and 105 because their gene expression changed only in the presence of microflora. Real-time RT-PCR was performed to confirm the expression levels of these HSP genes. To determine whether JTX acts directly on the HSP genes, sodium arsenite （SA） was used to induce the heat shock proteins directly. To examine the change of the intestinal microflora with administration of JTX, the terminal restriction fragment polymorphism （T-RFLP） method was used. To identify the changed bacteria, DNA sequencing was performed.documented by gene chip and real-time RT-PCR, changed with the administration of JTX in the regular mice but not in the germ-free mice. JTX did not suppress the direct induction of the HSPs by SA. T-RFLP suggested that JTX decreased unculturable bacteria and increased Lactobacillus johnsoni. These data suggested that JTX changed the intestinal microflora which, in turn, changed HSP gene expression.CONCLUSION： Intestinal microflora affects multi-herbal product JTX on the gene expression in the gut and liver.展开更多
Zhangjiakou is a northern Chinese city that hosted the Beijing 2022 Winter Olympic Games. As an important ice and snow tourist destination, it is essential to investigate Zhangjiakou’s rate of landscape pattern chang...Zhangjiakou is a northern Chinese city that hosted the Beijing 2022 Winter Olympic Games. As an important ice and snow tourist destination, it is essential to investigate Zhangjiakou’s rate of landscape pattern change,the landscape ecological security level, and ecosystem service value, particularly the tourism ecological service value during its construction. With land use data from 2000 to 2020, this study comprehensively analyzed the dynamic changes in Zhangjiakou, including land use dynamics, the land use transfer matrix, landscape vulnerability,landscape disturbance, ecosystem service value, tourism ecological service value, and other aspects. The results show that the landscape pattern in Zhangjiakou was greatly disturbed from 2015 to 2018, and the landscape ecological security was threatened in the process of landscape pattern adjustment. By 2020, after the landscape pattern was adjusted and stabilized, the landscape ecological security was restored, and the ecosystem service value was significantly improved, especially the tourism ecological service value. The results of this study will play an important role in promoting the optimization of Zhangjiakou’s ice and snow landscape pattern and the improvement of tourism ecological value. In addition, it provides important lessons for the development of other ice and snow tourist destinations.展开更多
文摘Large leisure activities usually use large sport facilities. There is often no serious problem with people gathering, but both incomplete facilities and negligence of people security manage may court injury or death. The purpose of this study is to analyze crowded nodes and to improve evacuation path use Simulex models. The fastest and safest way to achieve safe egress was then well planned. For turn locations, it was found that fixing the plane angle did not significantly raise the overall exiting efficiency. However, replacing the right angle or other angles with arc angle makes overall exiting moving line more fluent. For multito single-directional converging T-junction intersections, modification of turn angle increased the movement fluency, with the higher the modified angle, the higher in fluency. However, changing to round angle did not have as significant effect as expected while gate opening width must be increased to 1.0 m before more significant effects were produced. The results showed that modifying turn angles to 60° produces better improvements.
基金Supported by a Special Coordination Funds for Promoting Science and Technology by Ministry of Education, Culture, Sports, Science and Technology (MEXT)a Grant-in-Aid for Exploratory Research by MEXT
文摘AIM： To evaluate the role of intestinal microflora in the effects of multi-herbal medicine on gene expression in the gut and liver. METHODS： The multi-herbal medicine Juzentaihoto （JTX） was administered to five germ-free mice and regular mice for 2 wk. Among the results of the comprehensive gene chip analysis of the intestine and liver, we featured heat shock proteins （HSPs） 70 and 105 because their gene expression changed only in the presence of microflora. Real-time RT-PCR was performed to confirm the expression levels of these HSP genes. To determine whether JTX acts directly on the HSP genes, sodium arsenite （SA） was used to induce the heat shock proteins directly. To examine the change of the intestinal microflora with administration of JTX, the terminal restriction fragment polymorphism （T-RFLP） method was used. To identify the changed bacteria, DNA sequencing was performed.documented by gene chip and real-time RT-PCR, changed with the administration of JTX in the regular mice but not in the germ-free mice. JTX did not suppress the direct induction of the HSPs by SA. T-RFLP suggested that JTX decreased unculturable bacteria and increased Lactobacillus johnsoni. These data suggested that JTX changed the intestinal microflora which, in turn, changed HSP gene expression.CONCLUSION： Intestinal microflora affects multi-herbal product JTX on the gene expression in the gut and liver.
文摘Zhangjiakou is a northern Chinese city that hosted the Beijing 2022 Winter Olympic Games. As an important ice and snow tourist destination, it is essential to investigate Zhangjiakou’s rate of landscape pattern change,the landscape ecological security level, and ecosystem service value, particularly the tourism ecological service value during its construction. With land use data from 2000 to 2020, this study comprehensively analyzed the dynamic changes in Zhangjiakou, including land use dynamics, the land use transfer matrix, landscape vulnerability,landscape disturbance, ecosystem service value, tourism ecological service value, and other aspects. The results show that the landscape pattern in Zhangjiakou was greatly disturbed from 2015 to 2018, and the landscape ecological security was threatened in the process of landscape pattern adjustment. By 2020, after the landscape pattern was adjusted and stabilized, the landscape ecological security was restored, and the ecosystem service value was significantly improved, especially the tourism ecological service value. The results of this study will play an important role in promoting the optimization of Zhangjiakou’s ice and snow landscape pattern and the improvement of tourism ecological value. In addition, it provides important lessons for the development of other ice and snow tourist destinations.
