目的评价2002年以后,中华人民共和国卫生部(MInistry Of Health Of the People’s Republic of China,MOH)/全球疫苗和免疫联盟(Global Alliance for Vaccine and Immunization,GAVI)合作项目乙型肝炎(乙肝)疫苗(Hepatitis B Vaccine,He...目的评价2002年以后,中华人民共和国卫生部(MInistry Of Health Of the People’s Republic of China,MOH)/全球疫苗和免疫联盟(Global Alliance for Vaccine and Immunization,GAVI)合作项目乙型肝炎(乙肝)疫苗(Hepatitis B Vaccine,HepB)纳入免疫规划的效果。方法在全国68个项目县(区、市),采用多阶段随机抽样方法,抽取2002～2005年出生的儿童作为调查对象。通过调查问卷收集基本情况、HepB接种史等信息,同时采集血清标本2～4ml,现场分离血清后,用酶联免疫吸附试验检测乙肝病毒表面抗原(Hepatitis B Surfance Antigen,HBsAg)、抗乙肝病毒表面抗原抗体、抗乙肝病毒核心抗原抗体。结果MOH/GAVI合作项目地区2002～2005年出生的儿童,HepB3剂全程免疫接种率为80.02%,HepB首剂及时接种率为60.06%;出生越晚,接种率越高,农村接种率低于城市;在家出生儿童接种率低于在医院出生儿童。项目地区2002～2005年出生儿童HBsAg携带率<2%。结论MOH/GAVI合作项目实施后,加快了HepB纳入免疫规划进程,HepB接种率显著提高,起到了良好的预防作用。展开更多
Objective To evaluate the effects of supplementation of glutamine （GLN） on maintaining glu- tathione （GSH） level, immune system function, liver function, and clinical outcome of patients receiving abdominal operat...Objective To evaluate the effects of supplementation of glutamine （GLN） on maintaining glu- tathione （GSH） level, immune system function, liver function, and clinical outcome of patients receiving abdominal operation. Methods Forty patients undergoing elective abdominal surgical treatment were randomly divided into 2 groups： study group （n=20） and control group （n=20）. All patients received total parenteral nutrition （TPN） for up to 7 days during perioperative period. The study group received TPN supplemented with GLN dipeptide while the control group received TPN without GLN dipeptide. Patients in both groups received equivalent nitrogen and caloric intake. Blood sample was taken on preoperative day, and the 1st, 3rd, 6th postoperative day to measure GSH level, immune indexes, and liver function indexes. Results The decrease of GSH level in plasma and red blood cell （RBC） in study group was less than that in control group during postoperative period. Ratio of GSH/glutathione disulfide （GSSG） in plasma in study grouP was higher than that in control group on the 3rd postoperative day （52.53±11.46 vs. 31.43±7.27, P = 0.001）. Albumin level in study group was higher than that in control group on the 3rd postoperative day （37.7±3.8 g/L vs. 33.8±4.2 g/L, P = 0.02）. There was no significant difference in the levels of immunoglobin （IgG, IgM, IgA） or T lymphocyte subgroup （CD4, CD8, CD4/CD8） in both groups during postoperative period. There was one case with infectious complication in control group, while none in study group. A trend of shortened hospital stay was observed in study group compared with control group （22.3±2.1 d vs. 24.9±1.7 d,P= 0.32）. Conclusions Supplementation of GLN-enriched TPN has beneficial effects on maintaining GSH levels in plasma and RBC, sustaining GSH/GSSG ratio and albumin level, and keeping antioxidant abilities during postoperative period in patients with abdominal operation, with the trends of decreasing incidence of infectious complication and shortening hospital stay.展开更多
文摘目的评价2002年以后,中华人民共和国卫生部(MInistry Of Health Of the People’s Republic of China,MOH)/全球疫苗和免疫联盟(Global Alliance for Vaccine and Immunization,GAVI)合作项目乙型肝炎(乙肝)疫苗(Hepatitis B Vaccine,HepB)纳入免疫规划的效果。方法在全国68个项目县(区、市),采用多阶段随机抽样方法,抽取2002～2005年出生的儿童作为调查对象。通过调查问卷收集基本情况、HepB接种史等信息,同时采集血清标本2～4ml,现场分离血清后,用酶联免疫吸附试验检测乙肝病毒表面抗原(Hepatitis B Surfance Antigen,HBsAg)、抗乙肝病毒表面抗原抗体、抗乙肝病毒核心抗原抗体。结果MOH/GAVI合作项目地区2002～2005年出生的儿童,HepB3剂全程免疫接种率为80.02%,HepB首剂及时接种率为60.06%;出生越晚,接种率越高,农村接种率低于城市;在家出生儿童接种率低于在医院出生儿童。项目地区2002～2005年出生儿童HBsAg携带率<2%。结论MOH/GAVI合作项目实施后,加快了HepB纳入免疫规划进程,HepB接种率显著提高,起到了良好的预防作用。
文摘Objective To evaluate the effects of supplementation of glutamine （GLN） on maintaining glu- tathione （GSH） level, immune system function, liver function, and clinical outcome of patients receiving abdominal operation. Methods Forty patients undergoing elective abdominal surgical treatment were randomly divided into 2 groups： study group （n=20） and control group （n=20）. All patients received total parenteral nutrition （TPN） for up to 7 days during perioperative period. The study group received TPN supplemented with GLN dipeptide while the control group received TPN without GLN dipeptide. Patients in both groups received equivalent nitrogen and caloric intake. Blood sample was taken on preoperative day, and the 1st, 3rd, 6th postoperative day to measure GSH level, immune indexes, and liver function indexes. Results The decrease of GSH level in plasma and red blood cell （RBC） in study group was less than that in control group during postoperative period. Ratio of GSH/glutathione disulfide （GSSG） in plasma in study grouP was higher than that in control group on the 3rd postoperative day （52.53±11.46 vs. 31.43±7.27, P = 0.001）. Albumin level in study group was higher than that in control group on the 3rd postoperative day （37.7±3.8 g/L vs. 33.8±4.2 g/L, P = 0.02）. There was no significant difference in the levels of immunoglobin （IgG, IgM, IgA） or T lymphocyte subgroup （CD4, CD8, CD4/CD8） in both groups during postoperative period. There was one case with infectious complication in control group, while none in study group. A trend of shortened hospital stay was observed in study group compared with control group （22.3±2.1 d vs. 24.9±1.7 d,P= 0.32）. Conclusions Supplementation of GLN-enriched TPN has beneficial effects on maintaining GSH levels in plasma and RBC, sustaining GSH/GSSG ratio and albumin level, and keeping antioxidant abilities during postoperative period in patients with abdominal operation, with the trends of decreasing incidence of infectious complication and shortening hospital stay.
