Background: While elevation of antidiuretic horm one(ADH )(arginine vasopressin)levels in the serum has beenreported in severe atopic derm atitis (A D ),the cause is asyetunexplained.On the other hand,transepiderm alw...Background: While elevation of antidiuretic horm one(ADH )(arginine vasopressin)levels in the serum has beenreported in severe atopic derm atitis (A D ),the cause is asyetunexplained.On the other hand,transepiderm alwaterloss (TEW L)is known to increase in the dam aged skin dueto AD .O bjectives:A s A D H increases as a result of de-hydration of the body,this study exam ined whether thehigh A DH levelin severe A D is a reaction to the increasedwater loss through the entire body skin surface area.M ethods:Forty-eight patients of different ages and withvarious degrees of A D along with six age-and sex-m atchedcontrolpersons were the study subjects.Using a quick re-sponsive evaporim eter, an average total body TEW L(A TEW L)value was obtained for each subject.Laboratorytests including AD H ,serum lactate dehydrogenase (LD H )and peripheral blood eosinophil count (EOS)were alsoperform ed.Clinical severity grading was m ade globally.The relevancy ofthis grading was em pirically dem onstratedby its statistically significant relation to LDH and EO Swhich are com m only known as appropriate gauges for A Dseverity.Results:ATEW L was observed to be significantlygreater in patients with A D of at least m oderate severitythan in norm alcontrols,and ADH was significantly greaterin patients with severe and very severe A D.Both A TEW Land AD H showed a significant relation to AD severity.Finally,a significant correlation was found between A DHand ATEW L.Conclusions:It is possible that elevatedA DH is atleastin parta reaction to increased ATEW L.展开更多
文摘Background: While elevation of antidiuretic horm one(ADH )(arginine vasopressin)levels in the serum has beenreported in severe atopic derm atitis (A D ),the cause is asyetunexplained.On the other hand,transepiderm alwaterloss (TEW L)is known to increase in the dam aged skin dueto AD .O bjectives:A s A D H increases as a result of de-hydration of the body,this study exam ined whether thehigh A DH levelin severe A D is a reaction to the increasedwater loss through the entire body skin surface area.M ethods:Forty-eight patients of different ages and withvarious degrees of A D along with six age-and sex-m atchedcontrolpersons were the study subjects.Using a quick re-sponsive evaporim eter, an average total body TEW L(A TEW L)value was obtained for each subject.Laboratorytests including AD H ,serum lactate dehydrogenase (LD H )and peripheral blood eosinophil count (EOS)were alsoperform ed.Clinical severity grading was m ade globally.The relevancy ofthis grading was em pirically dem onstratedby its statistically significant relation to LDH and EO Swhich are com m only known as appropriate gauges for A Dseverity.Results:ATEW L was observed to be significantlygreater in patients with A D of at least m oderate severitythan in norm alcontrols,and ADH was significantly greaterin patients with severe and very severe A D.Both A TEW Land AD H showed a significant relation to AD severity.Finally,a significant correlation was found between A DHand ATEW L.Conclusions:It is possible that elevatedA DH is atleastin parta reaction to increased ATEW L.
