Gastric cancer is the second most common cancer worldwide and the second most common cause of cancer-related deaths. Despite complete resection of gastric cancer and lymph node dissection, as well as improvements in c...Gastric cancer is the second most common cancer worldwide and the second most common cause of cancer-related deaths. Despite complete resection of gastric cancer and lymph node dissection, as well as improvements in chemotherapy and radiotherapy, there are still 700 000 gastric cancer-related deaths per year worldwide and more than 80% of patients with advanced gastric cancer die of the disease or recurrent disease within 1 year after diagnosis. None of the treatment modalities we have been applying today can influence the overall survival rates:at present, the overall 5-year relative survival rate for gastric cancer is about 28%. Cellular metaplasia due to chronic inflammation, injury and repair are the most documented processes for neoplasia. It appears that chronic inflammation stimulates tumor development and plays a critical role in initiating, sustaining and advancing tumor growth. It is also evident that not all inflammation is tumorigenic. Additional mutations can be acquired, and this leads to the cancer cell gaining a further growth advantage and acquiring a more malignant phenotype. Intestinalization of gastric units, which is called "intestinal metaplasia"; phenotypic antralization of fundic units, which is called "spasmolytic polypeptide-expressing metaplasia"; and the development directly from the stem/progenitor cellzone are three pathways that have been described for gastric carcinogenesis. Also, an important factor for the development of gastrointestinal cancers is peritumoral stroma. However, the initiating cellular event in gastric metaplasia is still controversial. Understanding gastric carcinogenesis and its precursor lesions has been under intense investigation, and our paper attempts to highlight recent progress in this field of cancer research.展开更多
This study investigates the impact of global warming on drought/flood patterns in China at the end of the 21st century based on the simulations of 22 global climate models and a regional climate model(RegCM3) under th...This study investigates the impact of global warming on drought/flood patterns in China at the end of the 21st century based on the simulations of 22 global climate models and a regional climate model(RegCM3) under the SRES(Special Report on Emissions Scenarios) A1B scenario.The standardized precipitation index(SPI),which has well performance in monitoring the drought/flood characteristics(in terms of their intensity,duration,and spatial extent) in China,is used in this study.The projected results of 22 coupled models and the RegCM3 simulation are consistent.These models project a decrease in the frequency of droughts in most parts of northern China and a slight increase in the frequency in some parts of southern China.Considering China as a whole,the spatial extents of droughts are projected to be significantly reduced.In contrast,future flood events over most parts of China are projected to occur more frequently with stronger intensity and longer duration than those prevalent currently.Additionally,the spatial extents of flood events are projected to significantly increase.展开更多
A local and global context representation learning model for Chinese characters is designed and a Chinese word segmentation method based on character representations is proposed in this paper. First, the proposed Chin...A local and global context representation learning model for Chinese characters is designed and a Chinese word segmentation method based on character representations is proposed in this paper. First, the proposed Chinese character learning model uses the semanties of loeal context and global context to learn the representation of Chinese characters. Then, Chinese word segmentation model is built by a neural network, while the segmentation model is trained with the eharaeter representations as its input features. Finally, experimental results show that Chinese charaeter representations can effectively learn the semantic information. Characters with similar semantics cluster together in the visualize space. Moreover, the proposed Chinese word segmentation model also achieves a pretty good improvement on precision, recall and f-measure.展开更多
We discuss the relationship between the frequency and the growth of H-harmonic functions on the Heisenberg group.Precisely,we prove that an H-harmonic function must be a polynomial if its frequency is globally bounded...We discuss the relationship between the frequency and the growth of H-harmonic functions on the Heisenberg group.Precisely,we prove that an H-harmonic function must be a polynomial if its frequency is globally bounded.Moreover,we show that a class of H-harmonic functions are homogeneous polynomials provided that the frequency of such a function is equal to some constant.展开更多
The rate and distortion of Id-slice do not fit the globally linear relationship on a logarithmic scale. Lagrange multiplier selection methods based on the globally linear approximate relationship are neither efficient...The rate and distortion of Id-slice do not fit the globally linear relationship on a logarithmic scale. Lagrange multiplier selection methods based on the globally linear approximate relationship are neither efficient nor optimal for multi-view video coding (MVC). To improve the coding efficiency of MVC, a local curve fitting based Lagrange multiplier selection method is proposed in this paper, where Lagrange multipliers are selected according to the local slopes of the approximate curves. Experi-mental results showed that the proposed method improves the coding efficiency. Up to 2.5 dB gain was achieved at low bitrates.展开更多
文摘Gastric cancer is the second most common cancer worldwide and the second most common cause of cancer-related deaths. Despite complete resection of gastric cancer and lymph node dissection, as well as improvements in chemotherapy and radiotherapy, there are still 700 000 gastric cancer-related deaths per year worldwide and more than 80% of patients with advanced gastric cancer die of the disease or recurrent disease within 1 year after diagnosis. None of the treatment modalities we have been applying today can influence the overall survival rates:at present, the overall 5-year relative survival rate for gastric cancer is about 28%. Cellular metaplasia due to chronic inflammation, injury and repair are the most documented processes for neoplasia. It appears that chronic inflammation stimulates tumor development and plays a critical role in initiating, sustaining and advancing tumor growth. It is also evident that not all inflammation is tumorigenic. Additional mutations can be acquired, and this leads to the cancer cell gaining a further growth advantage and acquiring a more malignant phenotype. Intestinalization of gastric units, which is called "intestinal metaplasia"; phenotypic antralization of fundic units, which is called "spasmolytic polypeptide-expressing metaplasia"; and the development directly from the stem/progenitor cellzone are three pathways that have been described for gastric carcinogenesis. Also, an important factor for the development of gastrointestinal cancers is peritumoral stroma. However, the initiating cellular event in gastric metaplasia is still controversial. Understanding gastric carcinogenesis and its precursor lesions has been under intense investigation, and our paper attempts to highlight recent progress in this field of cancer research.
基金supported by the National Basic Research Program of China (Grant No. 2012CB955401)the National Natural Science Foundation of China (Grant No. 41275078)supported by the "Strategic Priority Research Program-Climate Change:Carbon Budget and Relevant Issues" of the Chinese Academy of Sciences (Grant No. XDA05090306)
文摘This study investigates the impact of global warming on drought/flood patterns in China at the end of the 21st century based on the simulations of 22 global climate models and a regional climate model(RegCM3) under the SRES(Special Report on Emissions Scenarios) A1B scenario.The standardized precipitation index(SPI),which has well performance in monitoring the drought/flood characteristics(in terms of their intensity,duration,and spatial extent) in China,is used in this study.The projected results of 22 coupled models and the RegCM3 simulation are consistent.These models project a decrease in the frequency of droughts in most parts of northern China and a slight increase in the frequency in some parts of southern China.Considering China as a whole,the spatial extents of droughts are projected to be significantly reduced.In contrast,future flood events over most parts of China are projected to occur more frequently with stronger intensity and longer duration than those prevalent currently.Additionally,the spatial extents of flood events are projected to significantly increase.
基金Supported by the National Natural Science Foundation of China(No.61303179,U1135005,61175020)
文摘A local and global context representation learning model for Chinese characters is designed and a Chinese word segmentation method based on character representations is proposed in this paper. First, the proposed Chinese character learning model uses the semanties of loeal context and global context to learn the representation of Chinese characters. Then, Chinese word segmentation model is built by a neural network, while the segmentation model is trained with the eharaeter representations as its input features. Finally, experimental results show that Chinese charaeter representations can effectively learn the semantic information. Characters with similar semantics cluster together in the visualize space. Moreover, the proposed Chinese word segmentation model also achieves a pretty good improvement on precision, recall and f-measure.
基金supported by National Natural Science Foundation of China(Grant No.11071119)
文摘We discuss the relationship between the frequency and the growth of H-harmonic functions on the Heisenberg group.Precisely,we prove that an H-harmonic function must be a polynomial if its frequency is globally bounded.Moreover,we show that a class of H-harmonic functions are homogeneous polynomials provided that the frequency of such a function is equal to some constant.
基金Project (Nos. 60505017 and 60534070) supported by the National Natural Science Foundation of China
文摘The rate and distortion of Id-slice do not fit the globally linear relationship on a logarithmic scale. Lagrange multiplier selection methods based on the globally linear approximate relationship are neither efficient nor optimal for multi-view video coding (MVC). To improve the coding efficiency of MVC, a local curve fitting based Lagrange multiplier selection method is proposed in this paper, where Lagrange multipliers are selected according to the local slopes of the approximate curves. Experi-mental results showed that the proposed method improves the coding efficiency. Up to 2.5 dB gain was achieved at low bitrates.
