Objective To evaluate the feasibility, efficacy, and safety of high dose immunosuppressive therapy （HDIT） and autolognus hemopoietic stem cell transplantation （HSCT） with CD^34＋ cell selection in patients with se...Objective To evaluate the feasibility, efficacy, and safety of high dose immunosuppressive therapy （HDIT） and autolognus hemopoietic stem cell transplantation （HSCT） with CD^34＋ cell selection in patients with severe, refractory autoim mune diseases. Methods Twenty-six patients with persistent systemic lupus erythematosus （SLE）, rheumatoid arthritis （RA）, primary Sjogren＇s syndrome （pSS）, or systemic sclerosis （SSc） who had been treated unsuccessfully with conventional treatment were enrolled in the trial in Peking Union Medical College Hospital from September 1999 to June 2004. The patients received HDIT with 200 mg/kg cyclophosphamide followed by an infusion of autologous stem cells that were CD34 selected. Disease acti- vity, adverse effect, hemopoietic and immune reconstitution, and time to recurrence of disease were monitored. Overall treatment related mortality was 7.7% （2/26） with 1 patient died of cytomegalovirus infection and an other of severe pneumonia. Relapse occurred in 3 SLE patients （17.6%） in 37, 26, and 19 months posttransplantation respectively, and 1 RA patient in 15 months posttransplantation. SLE Disease Activity Index （SLEDAI） scores of SLE survivors decreased significantly （P 〈 0.01）. RA patients recorded a drop of Disease Activity Score 28 （DAS 28）. The pSS patient remained symptoms free up to now, more than 50 months aider the transplantation. Conclusion HSCT can be performed relative safely in patients with severe autoimmune disease. Short-term effect of HSCT is promising. However treatment related mortality and relapse were observed in a subset of patients.展开更多
Objective： To investigate the dynamics of vascular volume and the plasma dilution of lactated Ringer＇s solution in patients during the induction of general and epidural anesthesia. Methods： The hemodilution of i.v....Objective： To investigate the dynamics of vascular volume and the plasma dilution of lactated Ringer＇s solution in patients during the induction of general and epidural anesthesia. Methods： The hemodilution of i.v. infusion of 1000 ml of lactated Ringer＇s solution over 60 min was studied in patients undergoing general （n=31） and epidural （n= 22） anesthesia. Heart rate, arterial blood pressure and hemoglobin （Hb） concentration were measured every 5 rain during the study. Surgery was not started until the study period had been completed. Results： General anesthesia caused the greater decrease of mean arterial blood pressure （MAP） （mean 15% versus 9%; P〈0.01） and thereby followed by a more pronounced plasma dilution, blood volume expansion （VE） and blood volume expansion efficiency （VEE）. A strong linear correlation between hemodilution and the reduction in MAP （r=-0.50;P〈0.01） was found. At the end of infusion, patients undergoing general anesthesia retained 47% （SD 19%） of the infused fluid in the circulation, while epidural anesthesia retained 29% （SD 13%） （P〈0.001）. Correspondingly, a fewer urine output （mean 89 ml versus 156 ml; P〈0.05） and extravascular expansion （454 ml versus 551 ml; P〈0.05） were found during general anesthesia. Conclusion： We concluded that the induction of general anesthesia caused more hemodilution, volume expansion and volume expansion efficiency than epidural anesthesia, which was triggered only by the lower MAP.展开更多
Purpose： The present study investigated the effects of 16 weeks of small-volume, small-sided soccer training soccer group （SG, n = 13） and oscillating whole-body vibration training vibration group （VG, n = 17） on...Purpose： The present study investigated the effects of 16 weeks of small-volume, small-sided soccer training soccer group （SG, n = 13） and oscillating whole-body vibration training vibration group （VG, n = 17） on body composition, aerobic fitness, and muscle PCr kinetics in healthy inactive premenopausal women in comparison with an inactive control group （CO, n = 14）. Methods： Training for SG and VG consisted of twice-weekly 15-min sessions with average heart rates （HRs） of ～ 155 and 90 bpm respectively. Pre- and post-measurements of body composition （DXA）, phosphocreatine （PCr） on- and off-kinetics, and HR measurements during stand- ardised submaximal exercise were performed. Results： After 16 weeks of training in SG, fat percentage was lowered （p = 0.03） by 1.7%±2.4% from 37.5% ± 6.9% to 35.8% ± 6.2% and the PCr decrease in the quadriceps during knee-extension ramp exercise was attenuated （4% ± 8%, p = 0.04）, with no changes in VG or CO （time- group effect： p=0.03 and p = 0.03）. Submaximal exercise HR was also reduced in SG after 16 weeks of training （6%± 5% of HRmax, p = 0.01）. Conclusion： Short duration soccer training for 16 weeks appears to be sufficient to induce favourable changes in body composition and indicators of aerobic fitness and muscle oxidative capacity in untrained premenopausal women.展开更多
To quantify the response to selection, heritability and genetic correlations between weight and size ofLitopenaeus vannamei, the body weight （BW）, total length （TL）, body length （BL）, first abdominal segment dep...To quantify the response to selection, heritability and genetic correlations between weight and size ofLitopenaeus vannamei, the body weight （BW）, total length （TL）, body length （BL）, first abdominal segment depth （FASD）, third abdominal segment depth （TASD）, first abdominal segment width （FASW）, and partial carapace length （PCL） of 5-month-old parents and of offspring were measured by calculating seven body measurings of offspring produced by a nested mating design. Seventeen half-sib families and 42 full-sib families ofL. vannamei were produced using artificial fertilization from 2-4 dams by each sire, and measured at around five months post-metamorphosis. The results show that heritabilities among various traits were high： 0.515±0.030 for body weight and 0.394±0.030 for total length. After one generation of selection, the selection response was 10.70% for offspring growth. In the 5th month, the realized heritability for weight was 0.296 for the offspring generation. Genetic correlations between body weight and body size were highly variable. The results indicate that external morphological parameters can be applied during breeder selection for enhancing the growth without sacrificing animals for determining the body size and breed ability; and selective breeding can be improved significantly, simultaneously with increased production.展开更多
The 124Sb in vivo exposed person is measured with whole-body counter. Thesolid point source method is applied to calibrate the counter. The minimum detectable activity of this system for 124Sb is 32 Bq.
In this paper, we conduct research on the reform and development of school sports education under the perspective of lifetime sports and nationwide fitness. School physical education is the foundation and the strategi...In this paper, we conduct research on the reform and development of school sports education under the perspective of lifetime sports and nationwide fitness. School physical education is the foundation and the strategic focus of the development of sports which is the foundation of the national fitness program which is also an important part of the whole education career. Our proposed approach and reform combines the advances of the state-of-the-art methodologies which will not only enhance the current model but set up for prospect and rnnrlifieatinn as well展开更多
With the nervousness degree of people＇s life pace accelerating and the increasing of work task, human health is increasingly being ignored. In order to improve the national physical health, the state advocates to sta...With the nervousness degree of people＇s life pace accelerating and the increasing of work task, human health is increasingly being ignored. In order to improve the national physical health, the state advocates to start national fitness activities. Under this background, each region begins to carry out the construction of the sport ground and conducts fruitful activities. Based on this, the paper has carried out the analysis and research on the construction and operation conditions of the sport ground under the national fitness background.展开更多
The operation of a complicated radiators structure creating a required field in a given area is disturbed often due to different external actions. As an example, the impact of metallic objects approaching off to an an...The operation of a complicated radiators structure creating a required field in a given area is disturbed often due to different external actions. As an example, the impact of metallic objects approaching off to an antenna system with minimal irradiation on user＇s body is analyzed. In this case, the zone itself, where the area of a weak field （a dark spot） is created, is generally not approachable for sensors installation. In order to counteract the disturbance of the system operation due to presence of different metallic objects in close proximity to the radiators, two methods based on two information sources are studied. These information sources are antennas driving currents and fields at a predetermined point outside the given area. As an example, the antenna system used in the compensation method for reducing human＇s body irradiation, to which a metal object approaches, is analyzed. The conditions of severe external actions are considered： a great metal body and a small distance from this body to the dark spot. It is shown that under these conditions of severe external actions the second method based on the field values measuring demonstrates a higher efficiency. A block scheme for structure of an automatic adjustment is suggested. The considered problem is a common one, and developers of radio circuits are faced with them constantly.展开更多
Traditional national sports are the representatives of traditional Chinese historic culture. With features like strong universality, nationality and involvement, they are deeply loved by the people. And after thousand...Traditional national sports are the representatives of traditional Chinese historic culture. With features like strong universality, nationality and involvement, they are deeply loved by the people. And after thousands of years of development, the constant evolution and precipitation, they have become not only the outstanding distinctive culture but also the spiritual wealth of Chinese nation. National fitness programs are mainly for improving the standards of people＇ s physical and mental health to serve for the enhancement of people＇ s overall quality. Traditional national sports are the fertile soil of the social culture and modem sports, as well as the inexhaustible material of popularizing the national fitness programs. With abundant life interest and great sport leisure, the people-oriented traditional national sports are in line with the national fitness programs.展开更多
In this context, we believe that the sun sports research now focuses on the meaning and value of sports sunshine, sunshine sports meaning and identity, how to develop the Sunshine Sports and other issues. These studie...In this context, we believe that the sun sports research now focuses on the meaning and value of sports sunshine, sunshine sports meaning and identity, how to develop the Sunshine Sports and other issues. These studies contributed to the development of sports sunshine, but there is also a lack of rigorous logical theory discussed, and the lack of institutional mechanisms for research, such as lack of a single research methods. Strengthening sunshine sports promotion model, the development of long-term mechanism research, both theoretical study sports sunshine depth development needs, but also a necessary requirement for the development of Sunshine Sports. In order to effectively promote the College “sunshine sports” to carry out and improve the physical health of college students, the use of literature, interviews, statistics and other research methods, sports curriculum University under the “sunshine sports” Perspectives issues the study. Sunshine Sports is a strong push forward by the Chinese government, the students physical health of government intervention measures. Activities three years, in all types of schools at all levels to actively carry out an hour a day exercise, teachers and students to participate in sports initiative, growing consciousness, awareness and physical exercise generally improved, exercise one hour a day has become common practice. But in some places there is still not know the place, lack of investment, lack of teachers and other issues, in order to make sustainable development the sun sports, will take in institution building, reform the examination and evaluation mechanisms, strengthening supervision and so do efforts.展开更多
基金Supported by Ministry of Health for ClinicalIntensiveSubjects(2001-2003 ).
文摘Objective To evaluate the feasibility, efficacy, and safety of high dose immunosuppressive therapy （HDIT） and autolognus hemopoietic stem cell transplantation （HSCT） with CD^34＋ cell selection in patients with severe, refractory autoim mune diseases. Methods Twenty-six patients with persistent systemic lupus erythematosus （SLE）, rheumatoid arthritis （RA）, primary Sjogren＇s syndrome （pSS）, or systemic sclerosis （SSc） who had been treated unsuccessfully with conventional treatment were enrolled in the trial in Peking Union Medical College Hospital from September 1999 to June 2004. The patients received HDIT with 200 mg/kg cyclophosphamide followed by an infusion of autologous stem cells that were CD34 selected. Disease acti- vity, adverse effect, hemopoietic and immune reconstitution, and time to recurrence of disease were monitored. Overall treatment related mortality was 7.7% （2/26） with 1 patient died of cytomegalovirus infection and an other of severe pneumonia. Relapse occurred in 3 SLE patients （17.6%） in 37, 26, and 19 months posttransplantation respectively, and 1 RA patient in 15 months posttransplantation. SLE Disease Activity Index （SLEDAI） scores of SLE survivors decreased significantly （P 〈 0.01）. RA patients recorded a drop of Disease Activity Score 28 （DAS 28）. The pSS patient remained symptoms free up to now, more than 50 months aider the transplantation. Conclusion HSCT can be performed relative safely in patients with severe autoimmune disease. Short-term effect of HSCT is promising. However treatment related mortality and relapse were observed in a subset of patients.
基金Project (No. 20051899) supported by Office of Education of Zheji-ang Province, China
文摘Objective： To investigate the dynamics of vascular volume and the plasma dilution of lactated Ringer＇s solution in patients during the induction of general and epidural anesthesia. Methods： The hemodilution of i.v. infusion of 1000 ml of lactated Ringer＇s solution over 60 min was studied in patients undergoing general （n=31） and epidural （n= 22） anesthesia. Heart rate, arterial blood pressure and hemoglobin （Hb） concentration were measured every 5 rain during the study. Surgery was not started until the study period had been completed. Results： General anesthesia caused the greater decrease of mean arterial blood pressure （MAP） （mean 15% versus 9%; P〈0.01） and thereby followed by a more pronounced plasma dilution, blood volume expansion （VE） and blood volume expansion efficiency （VEE）. A strong linear correlation between hemodilution and the reduction in MAP （r=-0.50;P〈0.01） was found. At the end of infusion, patients undergoing general anesthesia retained 47% （SD 19%） of the infused fluid in the circulation, while epidural anesthesia retained 29% （SD 13%） （P〈0.001）. Correspondingly, a fewer urine output （mean 89 ml versus 156 ml; P〈0.05） and extravascular expansion （454 ml versus 551 ml; P〈0.05） were found during general anesthesia. Conclusion： We concluded that the induction of general anesthesia caused more hemodilution, volume expansion and volume expansion efficiency than epidural anesthesia, which was triggered only by the lower MAP.
基金FIFA-Medical Assessments and Research Centre(F-MARC) and Nordea-fonden supported the study(No.1-ST-P-$$$-$$$-036-JZ-F1-05858)
文摘Purpose： The present study investigated the effects of 16 weeks of small-volume, small-sided soccer training soccer group （SG, n = 13） and oscillating whole-body vibration training vibration group （VG, n = 17） on body composition, aerobic fitness, and muscle PCr kinetics in healthy inactive premenopausal women in comparison with an inactive control group （CO, n = 14）. Methods： Training for SG and VG consisted of twice-weekly 15-min sessions with average heart rates （HRs） of ～ 155 and 90 bpm respectively. Pre- and post-measurements of body composition （DXA）, phosphocreatine （PCr） on- and off-kinetics, and HR measurements during stand- ardised submaximal exercise were performed. Results： After 16 weeks of training in SG, fat percentage was lowered （p = 0.03） by 1.7%±2.4% from 37.5% ± 6.9% to 35.8% ± 6.2% and the PCr decrease in the quadriceps during knee-extension ramp exercise was attenuated （4% ± 8%, p = 0.04）, with no changes in VG or CO （time- group effect： p=0.03 and p = 0.03）. Submaximal exercise HR was also reduced in SG after 16 weeks of training （6%± 5% of HRmax, p = 0.01）. Conclusion： Short duration soccer training for 16 weeks appears to be sufficient to induce favourable changes in body composition and indicators of aerobic fitness and muscle oxidative capacity in untrained premenopausal women.
基金Supported by National Higb Technology Research and Development Program of China (863 Program) (No. 2006AA10A406)the Key Laboratory of Marine Biology,Instihite of Oceanology,Chinese Academy of Sciences (No. IaF201002)
文摘To quantify the response to selection, heritability and genetic correlations between weight and size ofLitopenaeus vannamei, the body weight （BW）, total length （TL）, body length （BL）, first abdominal segment depth （FASD）, third abdominal segment depth （TASD）, first abdominal segment width （FASW）, and partial carapace length （PCL） of 5-month-old parents and of offspring were measured by calculating seven body measurings of offspring produced by a nested mating design. Seventeen half-sib families and 42 full-sib families ofL. vannamei were produced using artificial fertilization from 2-4 dams by each sire, and measured at around five months post-metamorphosis. The results show that heritabilities among various traits were high： 0.515±0.030 for body weight and 0.394±0.030 for total length. After one generation of selection, the selection response was 10.70% for offspring growth. In the 5th month, the realized heritability for weight was 0.296 for the offspring generation. Genetic correlations between body weight and body size were highly variable. The results indicate that external morphological parameters can be applied during breeder selection for enhancing the growth without sacrificing animals for determining the body size and breed ability; and selective breeding can be improved significantly, simultaneously with increased production.
文摘The 124Sb in vivo exposed person is measured with whole-body counter. Thesolid point source method is applied to calibrate the counter. The minimum detectable activity of this system for 124Sb is 32 Bq.
文摘In this paper, we conduct research on the reform and development of school sports education under the perspective of lifetime sports and nationwide fitness. School physical education is the foundation and the strategic focus of the development of sports which is the foundation of the national fitness program which is also an important part of the whole education career. Our proposed approach and reform combines the advances of the state-of-the-art methodologies which will not only enhance the current model but set up for prospect and rnnrlifieatinn as well
文摘With the nervousness degree of people＇s life pace accelerating and the increasing of work task, human health is increasingly being ignored. In order to improve the national physical health, the state advocates to start national fitness activities. Under this background, each region begins to carry out the construction of the sport ground and conducts fruitful activities. Based on this, the paper has carried out the analysis and research on the construction and operation conditions of the sport ground under the national fitness background.
文摘The operation of a complicated radiators structure creating a required field in a given area is disturbed often due to different external actions. As an example, the impact of metallic objects approaching off to an antenna system with minimal irradiation on user＇s body is analyzed. In this case, the zone itself, where the area of a weak field （a dark spot） is created, is generally not approachable for sensors installation. In order to counteract the disturbance of the system operation due to presence of different metallic objects in close proximity to the radiators, two methods based on two information sources are studied. These information sources are antennas driving currents and fields at a predetermined point outside the given area. As an example, the antenna system used in the compensation method for reducing human＇s body irradiation, to which a metal object approaches, is analyzed. The conditions of severe external actions are considered： a great metal body and a small distance from this body to the dark spot. It is shown that under these conditions of severe external actions the second method based on the field values measuring demonstrates a higher efficiency. A block scheme for structure of an automatic adjustment is suggested. The considered problem is a common one, and developers of radio circuits are faced with them constantly.
文摘Traditional national sports are the representatives of traditional Chinese historic culture. With features like strong universality, nationality and involvement, they are deeply loved by the people. And after thousands of years of development, the constant evolution and precipitation, they have become not only the outstanding distinctive culture but also the spiritual wealth of Chinese nation. National fitness programs are mainly for improving the standards of people＇ s physical and mental health to serve for the enhancement of people＇ s overall quality. Traditional national sports are the fertile soil of the social culture and modem sports, as well as the inexhaustible material of popularizing the national fitness programs. With abundant life interest and great sport leisure, the people-oriented traditional national sports are in line with the national fitness programs.
文摘In this context, we believe that the sun sports research now focuses on the meaning and value of sports sunshine, sunshine sports meaning and identity, how to develop the Sunshine Sports and other issues. These studies contributed to the development of sports sunshine, but there is also a lack of rigorous logical theory discussed, and the lack of institutional mechanisms for research, such as lack of a single research methods. Strengthening sunshine sports promotion model, the development of long-term mechanism research, both theoretical study sports sunshine depth development needs, but also a necessary requirement for the development of Sunshine Sports. In order to effectively promote the College “sunshine sports” to carry out and improve the physical health of college students, the use of literature, interviews, statistics and other research methods, sports curriculum University under the “sunshine sports” Perspectives issues the study. Sunshine Sports is a strong push forward by the Chinese government, the students physical health of government intervention measures. Activities three years, in all types of schools at all levels to actively carry out an hour a day exercise, teachers and students to participate in sports initiative, growing consciousness, awareness and physical exercise generally improved, exercise one hour a day has become common practice. But in some places there is still not know the place, lack of investment, lack of teachers and other issues, in order to make sustainable development the sun sports, will take in institution building, reform the examination and evaluation mechanisms, strengthening supervision and so do efforts.
