目的:评价老年患者认知障碍及相关铁代谢的关系.方法:选择全身麻醉下行保胆取石术老年患者120例,性别不限,年龄60-75岁,体质量45-75 kg,美国麻醉师协会(American Society of Anesthesiologists,ASA)分级Ⅱ或Ⅲ级,受教育年限≥6年.术前1 ...目的:评价老年患者认知障碍及相关铁代谢的关系.方法:选择全身麻醉下行保胆取石术老年患者120例,性别不限,年龄60-75岁,体质量45-75 kg,美国麻醉师协会(American Society of Anesthesiologists,ASA)分级Ⅱ或Ⅲ级,受教育年限≥6年.术前1 d和术后1、3、7 d进行简易智力状态检查(mini-mental state examination,MMSE)评分,麻醉诱导前30min和术后1、3、7 d采取外周静脉血,检测血清铁蛋白(serum ferritin,SF)、血清转铁蛋白(serum transferrin,TF)、转铁蛋白饱和度(transferrin saturation,TS).结果:MMSE评分结果统计可得出,术后出现认知障碍患者有31例,术后认知障碍发生率为25.8%,与术前1 d相比较,认知障碍组术后1、3 d MMSE评分、SF含量和TS测定降低,TF含量升高(P<0.05);术后7 dMMS E评分、SF、T F含量和T S测定差异无统计学意义(P>0.05);非认知障碍组术后1、3和7 d MMSE评分、SF、TF含量和T S测定差异无统计学意义(P>0.05).与非认知障碍组相比较,认知障碍组术后1、3d MMSE评分、SF含量和TS测定降低、TF含量升高(P<0.05);术后7 d MMSE评分、S F、T F含量和T S测定差异无统计学意义(P>0.05).血清转铁蛋白、转铁蛋白饱和度与术后认知障碍患者MMSE评分呈正相关(P=0.321,P=0.0287).结论:全麻老年患者术后认知障碍与铁代谢异常相关.展开更多
A 46-year-old male sustained severe pe- netrating injury by a sharp instrument to his right upper sternoclavicular junction. The wound tract was from su- prasternal notch to mediastinum. Exploratory operation via medi...A 46-year-old male sustained severe pe- netrating injury by a sharp instrument to his right upper sternoclavicular junction. The wound tract was from su- prasternal notch to mediastinum. Exploratory operation via median sternotomy under general anesthesia found a large mediastinal septum hematoncus, as well as brachiocephalic trunk and left brachiocephalic vein injuries. The perforating vascular wounds were repaired with 5-0 prolene suture. He was recovered uneventfully and discharged 9 days after operation. There was no sequel found during 7 years fol- low-up.展开更多
基金the Medical Science and Technology Project of Health Department of Hebei ProvinceNo.ZD20140451
文摘目的:评价老年患者认知障碍及相关铁代谢的关系.方法:选择全身麻醉下行保胆取石术老年患者120例,性别不限,年龄60-75岁,体质量45-75 kg,美国麻醉师协会(American Society of Anesthesiologists,ASA)分级Ⅱ或Ⅲ级,受教育年限≥6年.术前1 d和术后1、3、7 d进行简易智力状态检查(mini-mental state examination,MMSE)评分,麻醉诱导前30min和术后1、3、7 d采取外周静脉血,检测血清铁蛋白(serum ferritin,SF)、血清转铁蛋白(serum transferrin,TF)、转铁蛋白饱和度(transferrin saturation,TS).结果:MMSE评分结果统计可得出,术后出现认知障碍患者有31例,术后认知障碍发生率为25.8%,与术前1 d相比较,认知障碍组术后1、3 d MMSE评分、SF含量和TS测定降低,TF含量升高(P<0.05);术后7 dMMS E评分、SF、T F含量和T S测定差异无统计学意义(P>0.05);非认知障碍组术后1、3和7 d MMSE评分、SF、TF含量和T S测定差异无统计学意义(P>0.05).与非认知障碍组相比较,认知障碍组术后1、3d MMSE评分、SF含量和TS测定降低、TF含量升高(P<0.05);术后7 d MMSE评分、S F、T F含量和T S测定差异无统计学意义(P>0.05).血清转铁蛋白、转铁蛋白饱和度与术后认知障碍患者MMSE评分呈正相关(P=0.321,P=0.0287).结论:全麻老年患者术后认知障碍与铁代谢异常相关.
文摘A 46-year-old male sustained severe pe- netrating injury by a sharp instrument to his right upper sternoclavicular junction. The wound tract was from su- prasternal notch to mediastinum. Exploratory operation via median sternotomy under general anesthesia found a large mediastinal septum hematoncus, as well as brachiocephalic trunk and left brachiocephalic vein injuries. The perforating vascular wounds were repaired with 5-0 prolene suture. He was recovered uneventfully and discharged 9 days after operation. There was no sequel found during 7 years fol- low-up.
