In this work, an industrial acetic acid dehydration system via heterogeneous azeotropic distillation is simulated by Aspen Plus software. Residue curves are used to analyze the distillating behavior, and appropriate o...In this work, an industrial acetic acid dehydration system via heterogeneous azeotropic distillation is simulated by Aspen Plus software. Residue curves are used to analyze the distillating behavior, and appropriate operating region of the system is determined. Based on steady states simulation, a sensitivity analysis is carried out to detect the output multiple steady states in the system. Different solution branches are observered when the flow rates of the feed stream and the organic reflux stream are selected as manipulated variables. The performance of the column under different steady states is different. A method is oroposed to achieve the desired steady state.展开更多
In this study, double-hydrophilic hydroxylpropyl cellulose (HPC) based copolymers with poly(N- isopropylacrylamide) (PNIPAM) and poly(acrylic acid) (PAA) as graft chains were synthesized and characterized. T...In this study, double-hydrophilic hydroxylpropyl cellulose (HPC) based copolymers with poly(N- isopropylacrylamide) (PNIPAM) and poly(acrylic acid) (PAA) as graft chains were synthesized and characterized. The release behavior of drug-loaded micelles was studied. The results show that the hydrophilicity of copolymers improves as the pH increases, whereas the hydrophobicity of copolymers enhances as the temperature increases, and all the phase behaviors are reversible. The diameter of micelles decreases and then increases with pH increase. It shows different micellizing behavior under acidic and basic conditions according to the temperature increase. In vitro release experiments, which used theophylline as a model drug, show that the micelles enhance pH sensitivity in the release process.展开更多
The pH-sensitive copolymer hydrogels were prepared with the monomers of acrylic acid and N-vinyl-2-pyrrolidone based on gamma radiation technique. The morphology of the hydrogels was monitored by using scanning electr...The pH-sensitive copolymer hydrogels were prepared with the monomers of acrylic acid and N-vinyl-2-pyrrolidone based on gamma radiation technique. The morphology of the hydrogels was monitored by using scanning electron microscope. The influence of absorbed dose, monomer composition and concentration on the swelling ratio (SR) of the hydrogels were investigated in detail. The effect of pH and temperature of the swelling medium on the swelling behavior of the hydrogels were also examined. The results show that the SR of the copolymer hydrogels decreases with the monomer concentration and absorbed dose increasing. The copolymer hydrogels show a better pH-sensitive behavior. In alkaline solution, the SR of the hydrogels is much higher than in acid solution.展开更多
1H NMR chemical shifts of binary aqueous mixtures of acylamide, alcohol, dimethyl sulphoxide (DMSO), and acetone are correlated by statistical associating fluid theory (SAFT) association model. The comparison between ...1H NMR chemical shifts of binary aqueous mixtures of acylamide, alcohol, dimethyl sulphoxide (DMSO), and acetone are correlated by statistical associating fluid theory (SAFT) association model. The comparison between SAPT association model and Wilson equation shows that the former is better for dealing with aqueous solutions. Finally, the specialties of both models are discussed.展开更多
To obtain the influence rules of the coating parameters of a long-period fiber grating(LPFG)with respect to temperature,strain and refractive index sensing properties,based on the mode coupling theory,a strict four-la...To obtain the influence rules of the coating parameters of a long-period fiber grating(LPFG)with respect to temperature,strain and refractive index sensing properties,based on the mode coupling theory,a strict four-layer theorietical model of a metal film coated LPFG is established,and these parameters that affect the spectral characteristics of the metal film coated LPFG are studied.The simulation results show that there is an optimal metal film thickness on the surface of the LPFG that will induce the surface-plasmon resonance(SP R)effect,which results in higher sensitivity to the environmental temperature and refractive index but has little influence on the strain There is theoretical evidence that when the silver thickness is between0.8and1.2nm,the refractive index sensitivity will reach the peak point of42.4026,at which the refractive index sensor sensitivity is increased by4.S%.The theoretical results of coating a long-period fiber grating provide a good theoretical basis and guidance for LPFG design and parameters optimization展开更多
Although microscopy still remains the gold standard for the diagnosis of malaria, rapid diagnostic tests (RDTs) and PCR assays have been shown to be sensitive and specific. Very few comparative studies have been rep...Although microscopy still remains the gold standard for the diagnosis of malaria, rapid diagnostic tests (RDTs) and PCR assays have been shown to be sensitive and specific. Very few comparative studies have been reported of the three diagnostic methods on the same samples in vulnerable groups. Microscopy, RDTs and PCR assays were used for detection and speciation of Plasmodium falciparum (P)'), Plasmodium malariae (Pm) and Plasmodium ovale (Po) in patients in a rice culture savanna ecotype. Fifty four children and 16 pregnant women presenting with a fever were recruited. Bloods collected was used for thin and thick smears, perform RDTs and spotted blood on filter paper for DNA extraction and performance of a PCR. Mean parasitaemia was 37,619.06 (+ 33,599.04) p/pL and 7,512.5 (+ 12,446.11) p/μL for children and pregnant women, respectively. A total of 87.14% were positive by microscopy, 85.71% by RDTs and 90% by PCR. Distribution of Plasmodium species as identified by PCR was 72.86% Pf/Pm, 11.43% Pf/Pm/Po and 5.43% Pm while 10% were negative. Cohen's Kappa value for PCR and RDTs was K = 0.75 (CI = 0.28-1.22) while PCR and microscopy was K = 0.64 (CI = 0.18-1.10). Malaria infection in Bangolan was mostly due to mix infection predominantly P. falciparum/P, malariae.展开更多
In this paper,by utilizing the angle of arrivals(AOAs) and imprecise positions of the sensors,a novel modified Levenberg-Marquardt algorithm to solve the source localization problem is proposed.Conventional source loc...In this paper,by utilizing the angle of arrivals(AOAs) and imprecise positions of the sensors,a novel modified Levenberg-Marquardt algorithm to solve the source localization problem is proposed.Conventional source localization algorithms,like Gauss-Newton algorithm and Conjugate gradient algorithm are subjected to the problems of local minima and good initial guess.This paper presents a new optimization technique to find the descent directions to avoid divergence,and a trust region method is introduced to accelerate the convergence rate.Compared with conventional methods,the new algorithm offers increased stability and is more robust,allowing for stronger non-linearity and wider convergence field to be identified.Simulation results demonstrate that the proposed algorithm improves the typical methods in both speed and robustness,and is able to avoid local minima.展开更多
The optical characteristics of a simple, planar, single layer, dielectric Mg-based guided mode resonance filter (GMRF) were investigated by means of rigorous-coupled wave analysis (RCWA). This filter has great pot...The optical characteristics of a simple, planar, single layer, dielectric Mg-based guided mode resonance filter (GMRF) were investigated by means of rigorous-coupled wave analysis (RCWA). This filter has great potential for real-life applications, especially as bio- and environmental sensors. The structure of the proposed sensor is compact, and all of its layers can be grown in a single process. In this paper, we present results on the design of a water pollution sensor in the violet region of the visible spectrum. The spectral and angular sensitivities of the sensor for both the transverse electric (TE) and transverse magnetic (TM) polarization modes were estimated and compared for various regions in the violet spectrum. A spectral response characterized with a narrow bandwidth and low reflection side bands was realized by carrying out extensive parameter search and optimization. Optimal spectral and angular sensitivities were found for the sensor with a grating thickness of 100nm in the TM polarized mode where we found them to be 100nm and 40 degrees, per index refraction unit, respectively.展开更多
High entropy alloys(HEAs)have attracted extensive attention due to their excellent properties in harsh environments.Here,we introduced the HEA NbMoTaW into the laminated structure to synthesize the Cu/HEA nanolaminate...High entropy alloys(HEAs)have attracted extensive attention due to their excellent properties in harsh environments.Here,we introduced the HEA NbMoTaW into the laminated structure to synthesize the Cu/HEA nanolaminates(NLs)with equal layer thickness h spanning from 5 to 100 nm,and comparatively investigated the size dependent mechanical properties and plastic deformation.The experimental results demonstrated that the hardness of Cu/HEA NLs increased with decreasing h,and reached a plateau at h≤50 nm,while the strain rate sensitivity m unexpectedly went through a maximum with reducing h.The emergence of maximum m results from a transition from the synergetic effect of crystalline constituents to the competitive effect between crystalline Cu and amorphous-like NbMoTaW.Microstructural examinations revealed that shear banding caused by the incoherent Cu/HEA interfaces occurred under severe deformation,and the soft Cu layers dominated plastic deformation of Cu/HEA NLs with large h.展开更多
Constructing high strength pH sensitive supramolecular polymer hydrogel remains very challenging due to the unavoidable network swelling caused by ionization of acid or basic groups at a specified pH.In this work,we p...Constructing high strength pH sensitive supramolecular polymer hydrogel remains very challenging due to the unavoidable network swelling caused by ionization of acid or basic groups at a specified pH.In this work,we proposed a simple and very convenient approach to fabricate high strength pH responsive supramolecular polymer(SP) hydrogels by one-pot copolymerization of N-acryloyl glycinamide(NAGA) and 2-vinyl-4,6-diamino-1,3,5-triazine(VDT),two feature hydrogen bonding monomers.In these PNAGA-PVDT SP hydrogels obtained,the hydrogen bonding of NAGA was shown to play a dominant role in reinforcing strength,while the hydrogen bonding of diaminotriazine served as a pH sensitive moiety.At pH 3,the mechanical properties of PNAGA-PVDT hydrogels decreased to a different extent due to the breakup of hydrogen bonding;in contrast,the hydrogel resumed the original strength while pH was raised to 7.4 because of reconstruction of hydrogen bonding.Over the selected pH range,the PNAGA-PVDT hydrogels exhibited up to 1.25 MPa tensile strength,845% breaking strain,69 kPa Young's modulus and 21 MPa compressive strength.This novel high strength pH-responsive SP hydrogels may find applications in biomedical and industrial fields.展开更多
Infectious conjunctivitis is no longer a common eye disease in cities and developed areas, but in remote mountainous regions of China where living conditions are relatively under-developed, the occurrence of infectiou...Infectious conjunctivitis is no longer a common eye disease in cities and developed areas, but in remote mountainous regions of China where living conditions are relatively under-developed, the occurrence of infectious conjunctivitis remains a public health issue. Here, we evaluate the ratio of infectious conjunctivitis among primary school students in the rural areas of Xunhua, Huangyuan, and Huzhu Counties in the Qinghai province of China, and report the microorganisms involved in causing infection. Of the 765 eligible primary school students, 694 participated to this study(a response rateof 90.7%), 381 boys and 313 girls, with a mean age of 7.52 years(range 7–9 years). A clinical diagnosis of infectious conjunctivitis was returned for 238 of the 694 children examined. The ratio of infectious conjunctivitis in Xunhua County(46.64%) was higher compared to that in Huangyuan(26.67%; P=0.03) and Huzhu Counties(23.61%; P=0.02). The leading cause of conjunctivitis was bacterial, followed by chlamydial and viral. Our results show that there is a high ratio of infectious conjunctivitis among rural primary school students in Qinghai province.展开更多
基金Supported by the National Natural Science Foundation of China (20976048) and Shanghai Leading Academic Discipline Project (B504).
文摘In this work, an industrial acetic acid dehydration system via heterogeneous azeotropic distillation is simulated by Aspen Plus software. Residue curves are used to analyze the distillating behavior, and appropriate operating region of the system is determined. Based on steady states simulation, a sensitivity analysis is carried out to detect the output multiple steady states in the system. Different solution branches are observered when the flow rates of the feed stream and the organic reflux stream are selected as manipulated variables. The performance of the column under different steady states is different. A method is oroposed to achieve the desired steady state.
文摘In this study, double-hydrophilic hydroxylpropyl cellulose (HPC) based copolymers with poly(N- isopropylacrylamide) (PNIPAM) and poly(acrylic acid) (PAA) as graft chains were synthesized and characterized. The release behavior of drug-loaded micelles was studied. The results show that the hydrophilicity of copolymers improves as the pH increases, whereas the hydrophobicity of copolymers enhances as the temperature increases, and all the phase behaviors are reversible. The diameter of micelles decreases and then increases with pH increase. It shows different micellizing behavior under acidic and basic conditions according to the temperature increase. In vitro release experiments, which used theophylline as a model drug, show that the micelles enhance pH sensitivity in the release process.
基金Natural Science Foundation of Henan Province (0611023900)
文摘The pH-sensitive copolymer hydrogels were prepared with the monomers of acrylic acid and N-vinyl-2-pyrrolidone based on gamma radiation technique. The morphology of the hydrogels was monitored by using scanning electron microscope. The influence of absorbed dose, monomer composition and concentration on the swelling ratio (SR) of the hydrogels were investigated in detail. The effect of pH and temperature of the swelling medium on the swelling behavior of the hydrogels were also examined. The results show that the SR of the copolymer hydrogels decreases with the monomer concentration and absorbed dose increasing. The copolymer hydrogels show a better pH-sensitive behavior. In alkaline solution, the SR of the hydrogels is much higher than in acid solution.
基金Supported by the National Natural Science Foundation of China (No. 29976035)the Natural Science Foundation of Zhejiang Provincial (No. RC01051).
文摘1H NMR chemical shifts of binary aqueous mixtures of acylamide, alcohol, dimethyl sulphoxide (DMSO), and acetone are correlated by statistical associating fluid theory (SAFT) association model. The comparison between SAPT association model and Wilson equation shows that the former is better for dealing with aqueous solutions. Finally, the specialties of both models are discussed.
基金National Natural Science Foundation of China(No.51309001)Scientific Research Key Project of Anhui Province(No.KJ2017A041)
文摘To obtain the influence rules of the coating parameters of a long-period fiber grating(LPFG)with respect to temperature,strain and refractive index sensing properties,based on the mode coupling theory,a strict four-layer theorietical model of a metal film coated LPFG is established,and these parameters that affect the spectral characteristics of the metal film coated LPFG are studied.The simulation results show that there is an optimal metal film thickness on the surface of the LPFG that will induce the surface-plasmon resonance(SP R)effect,which results in higher sensitivity to the environmental temperature and refractive index but has little influence on the strain There is theoretical evidence that when the silver thickness is between0.8and1.2nm,the refractive index sensitivity will reach the peak point of42.4026,at which the refractive index sensor sensitivity is increased by4.S%.The theoretical results of coating a long-period fiber grating provide a good theoretical basis and guidance for LPFG design and parameters optimization
文摘Although microscopy still remains the gold standard for the diagnosis of malaria, rapid diagnostic tests (RDTs) and PCR assays have been shown to be sensitive and specific. Very few comparative studies have been reported of the three diagnostic methods on the same samples in vulnerable groups. Microscopy, RDTs and PCR assays were used for detection and speciation of Plasmodium falciparum (P)'), Plasmodium malariae (Pm) and Plasmodium ovale (Po) in patients in a rice culture savanna ecotype. Fifty four children and 16 pregnant women presenting with a fever were recruited. Bloods collected was used for thin and thick smears, perform RDTs and spotted blood on filter paper for DNA extraction and performance of a PCR. Mean parasitaemia was 37,619.06 (+ 33,599.04) p/pL and 7,512.5 (+ 12,446.11) p/μL for children and pregnant women, respectively. A total of 87.14% were positive by microscopy, 85.71% by RDTs and 90% by PCR. Distribution of Plasmodium species as identified by PCR was 72.86% Pf/Pm, 11.43% Pf/Pm/Po and 5.43% Pm while 10% were negative. Cohen's Kappa value for PCR and RDTs was K = 0.75 (CI = 0.28-1.22) while PCR and microscopy was K = 0.64 (CI = 0.18-1.10). Malaria infection in Bangolan was mostly due to mix infection predominantly P. falciparum/P, malariae.
基金Supported by the National High Technology Research and Development Programme of China(No.2011AA7014061)
文摘In this paper,by utilizing the angle of arrivals(AOAs) and imprecise positions of the sensors,a novel modified Levenberg-Marquardt algorithm to solve the source localization problem is proposed.Conventional source localization algorithms,like Gauss-Newton algorithm and Conjugate gradient algorithm are subjected to the problems of local minima and good initial guess.This paper presents a new optimization technique to find the descent directions to avoid divergence,and a trust region method is introduced to accelerate the convergence rate.Compared with conventional methods,the new algorithm offers increased stability and is more robust,allowing for stronger non-linearity and wider convergence field to be identified.Simulation results demonstrate that the proposed algorithm improves the typical methods in both speed and robustness,and is able to avoid local minima.
文摘The optical characteristics of a simple, planar, single layer, dielectric Mg-based guided mode resonance filter (GMRF) were investigated by means of rigorous-coupled wave analysis (RCWA). This filter has great potential for real-life applications, especially as bio- and environmental sensors. The structure of the proposed sensor is compact, and all of its layers can be grown in a single process. In this paper, we present results on the design of a water pollution sensor in the violet region of the visible spectrum. The spectral and angular sensitivities of the sensor for both the transverse electric (TE) and transverse magnetic (TM) polarization modes were estimated and compared for various regions in the violet spectrum. A spectral response characterized with a narrow bandwidth and low reflection side bands was realized by carrying out extensive parameter search and optimization. Optimal spectral and angular sensitivities were found for the sensor with a grating thickness of 100nm in the TM polarized mode where we found them to be 100nm and 40 degrees, per index refraction unit, respectively.
基金supported by the National Natural Science Foundation of China (51621063, 51722104, 51625103, 51790482, 51761135031 and 51571157)the National Key Research and Development Program of China (2017YFA0700701 and 2017YFB0702301)+6 种基金the 111 Project 2.0 of China (BP2018008)the International Joint Laboratory for Micro/Nano Manufacturing and Measurement Technologiesthe Fundamental Research Funds for the Central Universities (xzy022019071)the Fok Ying-Tong Education Foundation (161096)China Postdoctoral Science Foundation (2017T100744)Shaanxi Province innovative talents promotion Projects (2018KJXX-004)the support from China Postdoctoral Science Foundation (2016M602811)
文摘High entropy alloys(HEAs)have attracted extensive attention due to their excellent properties in harsh environments.Here,we introduced the HEA NbMoTaW into the laminated structure to synthesize the Cu/HEA nanolaminates(NLs)with equal layer thickness h spanning from 5 to 100 nm,and comparatively investigated the size dependent mechanical properties and plastic deformation.The experimental results demonstrated that the hardness of Cu/HEA NLs increased with decreasing h,and reached a plateau at h≤50 nm,while the strain rate sensitivity m unexpectedly went through a maximum with reducing h.The emergence of maximum m results from a transition from the synergetic effect of crystalline constituents to the competitive effect between crystalline Cu and amorphous-like NbMoTaW.Microstructural examinations revealed that shear banding caused by the incoherent Cu/HEA interfaces occurred under severe deformation,and the soft Cu layers dominated plastic deformation of Cu/HEA NLs with large h.
基金supported by the National Natural Science Foundation of China(Grant No.51325305)National Key Research and Development Program(GrantNo.2016YFC1101301)Tianjin Municipal Natural Science Foundation(Grant Nos.13ZCZDSY00900,15JCZDJC38000)
文摘Constructing high strength pH sensitive supramolecular polymer hydrogel remains very challenging due to the unavoidable network swelling caused by ionization of acid or basic groups at a specified pH.In this work,we proposed a simple and very convenient approach to fabricate high strength pH responsive supramolecular polymer(SP) hydrogels by one-pot copolymerization of N-acryloyl glycinamide(NAGA) and 2-vinyl-4,6-diamino-1,3,5-triazine(VDT),two feature hydrogen bonding monomers.In these PNAGA-PVDT SP hydrogels obtained,the hydrogen bonding of NAGA was shown to play a dominant role in reinforcing strength,while the hydrogen bonding of diaminotriazine served as a pH sensitive moiety.At pH 3,the mechanical properties of PNAGA-PVDT hydrogels decreased to a different extent due to the breakup of hydrogen bonding;in contrast,the hydrogel resumed the original strength while pH was raised to 7.4 because of reconstruction of hydrogen bonding.Over the selected pH range,the PNAGA-PVDT hydrogels exhibited up to 1.25 MPa tensile strength,845% breaking strain,69 kPa Young's modulus and 21 MPa compressive strength.This novel high strength pH-responsive SP hydrogels may find applications in biomedical and industrial fields.
基金supported by National Natural Science Foundation of China (81470607)
文摘Infectious conjunctivitis is no longer a common eye disease in cities and developed areas, but in remote mountainous regions of China where living conditions are relatively under-developed, the occurrence of infectious conjunctivitis remains a public health issue. Here, we evaluate the ratio of infectious conjunctivitis among primary school students in the rural areas of Xunhua, Huangyuan, and Huzhu Counties in the Qinghai province of China, and report the microorganisms involved in causing infection. Of the 765 eligible primary school students, 694 participated to this study(a response rateof 90.7%), 381 boys and 313 girls, with a mean age of 7.52 years(range 7–9 years). A clinical diagnosis of infectious conjunctivitis was returned for 238 of the 694 children examined. The ratio of infectious conjunctivitis in Xunhua County(46.64%) was higher compared to that in Huangyuan(26.67%; P=0.03) and Huzhu Counties(23.61%; P=0.02). The leading cause of conjunctivitis was bacterial, followed by chlamydial and viral. Our results show that there is a high ratio of infectious conjunctivitis among rural primary school students in Qinghai province.