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高龄老年患者共病综合治疗临床实践的哲学思考
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作者 胡燕红 夏曹柔 汪建飞 《医学与哲学》 北大核心 2024年第21期64-68,共5页
通过思考临床高龄老年患者共病综合治疗的临床实践,阐释在高龄老年患者共病综合治疗中应用哲学理论系统、辩证、全面地认识老年共病的客观性、相互联系性、复杂性与异质性,根据临床实践中的具体案例制定针对主要矛盾、提出重点更突出性... 通过思考临床高龄老年患者共病综合治疗的临床实践,阐释在高龄老年患者共病综合治疗中应用哲学理论系统、辩证、全面地认识老年共病的客观性、相互联系性、复杂性与异质性,根据临床实践中的具体案例制定针对主要矛盾、提出重点更突出性的个性化综合治疗方案,厘清综合治疗的思路,启迪创新的方向,为探索老年共病治疗的新路径奠定坚实基础,最大程度地发挥老年患者躯体功能、改善预后生活质量、维持生命的延续,促进健康老龄化,具有积极深远的意义。 展开更多
关键词 哲学思考 综合治疗 高龄老年患者
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中西医治疗轻度认知障碍与抑郁共病研究进展 被引量:1
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作者 李晓童 赵雷勇 +1 位作者 彭伟 胡志强 《现代中西医结合杂志》 CAS 2023年第6期871-876,共6页
轻度认知障碍(mild cognition impairment,MCI)是一种处于正常衰老与痴呆间的中间状态,具体表现为学习新信息或回忆、存储原有信息能力的减退,属于痴呆的早期阶段。国内一项大样本调查显示,1980-2020年,我国55岁及以上老年人MCI患病率为... 轻度认知障碍(mild cognition impairment,MCI)是一种处于正常衰老与痴呆间的中间状态,具体表现为学习新信息或回忆、存储原有信息能力的减退,属于痴呆的早期阶段。国内一项大样本调查显示,1980-2020年,我国55岁及以上老年人MCI患病率为15.4%,且呈逐年上升态势[1]。抑郁症与轻度认知障碍的关系复杂,而抑郁情绪也被认为是痴呆前期的重要表现之一,与MCI互为交叉,常相伴出现。从临床防治角度看,当前MCI与抑郁共病防治的最大问题是两类疾病的识别率低、就诊率低、系统治疗率低、疗效有限,所以对两者共病的早期干预治疗对延缓病情进展、降低痴呆风险有着尤为重要的意义。现对目前已知的MCI合并抑郁的发病机制与中西医治疗方法进行综述,以期为共病患者提供更及时、更有效、不良反应更少的治疗方法,并为后续两者共病研究提供参考。 展开更多
关键词 轻度认知障碍 抑郁 机制 共病治疗
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儿童注意缺陷多动障碍治疗进展 被引量:9
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作者 金星明 《中国儿童保健杂志》 CAS 2007年第2期111-112,114,共3页
儿童注意缺陷多动障碍(attention-deficit/hyperactivity disorder,ADHD)是儿童时期常见的行为障碍性疾病患。由于ADHD对儿童本人家庭、社会造成极大的危害,尽管病因仍未十分清楚,但及早诊断及早治疗是必需的。本文重点介绍了ADHD的治... 儿童注意缺陷多动障碍(attention-deficit/hyperactivity disorder,ADHD)是儿童时期常见的行为障碍性疾病患。由于ADHD对儿童本人家庭、社会造成极大的危害,尽管病因仍未十分清楚,但及早诊断及早治疗是必需的。本文重点介绍了ADHD的治疗原则;兴奋剂,特别是长效兴奋剂在治疗中的进展;ADHD综合治疗的意义及常见共患病的治疗,以供大家参考。 展开更多
关键词 ADHD 兴奋剂 综合治疗 共病治疗
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正念干预在孤独症患者中的临床应用(综述)
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作者 郝熙鸣 王崇颖 《中国健康心理学杂志》 2024年第12期1791-1799,共9页
近年来,孤独症谱系障碍的患病率已超过2.78%,同时有逾60%的孤独症患者共患抑郁或焦虑障碍。传统的认知、行为、教育和药物治疗等干预措施在针对上述共病的治疗效果方面仍有较大局限性,而将正念干预应用到孤独症患者的临床治疗中,可以弥... 近年来,孤独症谱系障碍的患病率已超过2.78%,同时有逾60%的孤独症患者共患抑郁或焦虑障碍。传统的认知、行为、教育和药物治疗等干预措施在针对上述共病的治疗效果方面仍有较大局限性,而将正念干预应用到孤独症患者的临床治疗中,可以弥补现有治疗手段的不足。本文对近10年来国内外有关正念干预在孤独症临床治疗当中应用的相关研究进行梳理,系统介绍并评述了其研究的实验设计、干预方式、被试人口学特征和干预效果,并针对其研究方法中的不足之处提供改进建议,以期为国内相关领域的研究和应用提供参考。 展开更多
关键词 正念 孤独症谱系障碍 临床治疗 共病治疗
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Hepatic echinococcosis:Clinical and therapeutic aspects 被引量:79
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作者 Giuseppe Nunnari Marilia R Pinzone +6 位作者 Salvatore Gruttadauria Benedetto M Celesia Giordano Madeddu Giulia Malaguarnera Piero Pavone Alessandro Cappellani Bruno Cacopardo 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第13期1448-1458,共11页
Echinococcosis or hydatid disease (HD) is a zoonosis caused by the larval stages of taeniid cestodes belong- ing to the genus Echinococcus. Hepatic echinococcosis is a life-threatening disease, mainly differentiated... Echinococcosis or hydatid disease (HD) is a zoonosis caused by the larval stages of taeniid cestodes belong- ing to the genus Echinococcus. Hepatic echinococcosis is a life-threatening disease, mainly differentiated into alveolar and cystic forms, associated with Echinoc- cus multilocularis (E. multi/ocular/s) and Echinococcus granulosus (E. granulosus) infection, respectively. Cys- tic echinococcosis (CE) has a worldwide distribution, while hepatic alveolar echinococcosis (AE) is endemic in the Northern hemisphere, including North America and several Asian and European countries, like France, Germany and Austria. E. granulosus young cysts are spherical, unilocular vesicles, consisting of an internal germinal layer and an outer acellular layer. Cyst expansion is associated with a host immune reaction and the subsequent development of a fibrous layer, called the per/cyst; old cysts typically present internal septa- tions and daughter cysts. E. multilocularis has a tumor-like, infiltrative behavior, which is responsible for tissue destruction and finally for liver failure. The liver is the main site of HD involvement, for both alveolar and cystic hydatidosis. HD is usually asymptomatic for a long period of time, because cyst growth is commonly slow; the most frequent symptoms are fatigue and abdominal pain. Patients may also present jaundice, hepatomegaly or anaphylaxis, due to cyst leakage or rupture. HD diagnosis is usually accomplished with the combined use of ultrasonography and immunodiagnosis; furthermore, the improvement of surgical techniques, the introduction of minimally invasive treatments [such as puncture, aspiration, injection, re-aspiration (PAIR)] and more effective drugs (such as benzoimidazoles) have deeply changed life expectancy and quality of life of patients with HD. The aim of this article is to provide an up-to-date review of biological, diagnostic, clinical and therapeutic aspects of hepatic echinococcosis. 展开更多
关键词 HYDATIDOSIS Cystic echinococcosis Alveolarechinococcosis Liver PAIR ALBENDAZOLE Treatment Diagnosis
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Current and future applications of magnetic resonance imaging and spectroscopy of the brain in hepatic encepha-lopathy 被引量:9
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作者 VP Bob Graver M Alex Dresner +5 位作者 Daniel M Forton Serena Counsell David J Larkman Nayna Patel Howard C Thomas Simon D Taylor-Robinson 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第19期2969-2978,共10页
Hepatic encephalopathy (HE) is a common neuropsychiatric abnormality, which complicates the course of patients with liver disease and results from hepatocellular failure and/or portosystemic shunting. The manifestat... Hepatic encephalopathy (HE) is a common neuropsychiatric abnormality, which complicates the course of patients with liver disease and results from hepatocellular failure and/or portosystemic shunting. The manifestations of HE are widely variable and involve a spectrum from mild subclinical disturbance to deep coma. Research interest has focused on the role of circulating gut-derived toxins, particularly ammonia, the development of brain swelling and changes in cerebral neurotransmitter systems that lead to global CNS depression and disordered function. Until recently the direct investigation of cerebral function has been difficult in man. However, new magnetic resonance imaging (MRI) techniques provide a non-invasive means of assessment of changes in brain volume (coregistered MRI) and impaired brain function (fMRI), while proton magnetic resonance spectroscopy (^1H MRS) detects changes in brain biochemistry, including direct measurement of cerebral osmolytes, such as myoinositol, glutamate and glutamine which govern processes intrinsic to cellular homeostasis, including the accumulation of intracellular water. The concentrations of these intracellular osmolytes alter with hyperammonaemia. MRS-detected metabolite abnormalities correlate with the severity of neuropsychiatric impairment and since MR spectra return towards normal after treatment, the technique may be of use in objective patient monitoring and in assessing the effectiveness of various treatment regimens. 展开更多
关键词 Hepatic encephalopathy Magnetic resonance imaging Magnetic resonance spectroscopy Diffusion weighted imaging Arterial spin labeling Functional MRI
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Current and future applications of in vitro magnetic resonance spectroscopy in hepatobiliary disease 被引量:10
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作者 I Jane Cox Amar Sharif +2 位作者 Jeremy FL Cobbold Howard C Thomas Simon D Taylor-Robinson 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第30期4773-4783,共11页
Nuclear magnetic resonance spectroscopy allows the study of cellular biochemistry and metabolism, both in the whole body in vivo and at higher magnetic field strengths in vitro. Since the technique is non-invasive and... Nuclear magnetic resonance spectroscopy allows the study of cellular biochemistry and metabolism, both in the whole body in vivo and at higher magnetic field strengths in vitro. Since the technique is non-invasive and non-selective, magnetic resonance spectroscopy methodologies have been widely applied in biochemistry and medicine. In vitro magnetic resonance spectroscopy studies of cells, body fluids and tissues have been used in medical biochemistry to investigate pathophysiologi- cal processes and more recently, the technique has been used by physicians to determine disease abnormalities in vivo. This highlighted topic illustrates the potential of in vitro magnetic resonance spectroscopy in studying the hepatobiliary system. The role of in vitro proton and phosphorus magnetic resonance spectroscopy in the study of malignant and non-malignant liver disease and bile composition studies are discussed, particularly with reference to correlative in vivo whole-body magnetic resonance spectroscopy applications. In summary, magnetic resonance spectroscopy techniques can provide non-invasive biochemical information on disease severity and pointers to underlying pathophysiological processes. Magnetic resonance spectroscopy holds potential promise as a screening tool for disease biomarkers, as well as assessing therapeutic response. 展开更多
关键词 Magnetic resonance spectroscopy LIVER Hepatobiliary disease Membrane metabolism
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Coinfection of TT virus and response to interferon therapy in patients with chronic hepatitis B or C 被引量:4
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作者 Yung-ChihLai Ruey-TyngHu +1 位作者 Sien-SingYang Chi-HwaWu 《World Journal of Gastroenterology》 SCIE CAS CSCD 2002年第3期567-570,共4页
AIM: To investigate the serum positive percentage of TT virus (TTV) in patients with chronic hepatitis B or C and the response of the coinfected TTV to interferon (IFN) during IFN therapy for chronic hepatitis B and C... AIM: To investigate the serum positive percentage of TT virus (TTV) in patients with chronic hepatitis B or C and the response of the coinfected TTV to interferon (IFN) during IFN therapy for chronic hepatitis B and C. METHODS: We retrospectively studied the serum samples of 70 patients with chronic hepatitis who had received IFN-alpha therapy from January 1997 to June 2000, which included 40 cases of hepatitis B and 30 hepatitis C. All the patients had been followed up for at least 6 months after the end of IFN therapy. The serum TTV DNA was detected using the polymerase chain reaction (PCR) before and every month during the course of IFN treatment. RESULTS: TTV infection was detected in 15% (6/40) of the chronic hepatitis B group and 30% (9/30) of the chronic hepatitis C group. Loss of serum TTV DNA during IFN therapy occurred in 3 of 6 patients (50%) and 6 of 9 (67%) of hepatitis B and C groups, respectively. Seronegativity of TTV was found all during the first month of IFN therapy in the 9 patients. There was no correlation between the seroconversion of TTV and the biochemical changes of the patients. CONCLUSION: TTV is not infrequently coinfected in patients with chronic hepatitis B and C in Taiwan, and more than half of the TTV infections are IFN-sensitive. However, the loss of serum TTV DNA does not affect the clinical course of the patients with chronic hepatitis B or C. 展开更多
关键词 Torque teno virus ADULT DNA Virus Infections FEMALE Hepatitis B Chronic Hepatitis C Chronic Humans INTERFERON-ALPHA Male Middle Aged Retrospective Studies
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Controversies in the treatment of common anal problems
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作者 Ismail Sagap Feza H Remzi 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第20期3146-3154,共9页
Treating common benign anal diseases has evolved towards more outpatient procedures with better outcome. However, minimizing post-procedure morbidities such as pain and the avoidance incontinence remain the most signi... Treating common benign anal diseases has evolved towards more outpatient procedures with better outcome. However, minimizing post-procedure morbidities such as pain and the avoidance incontinence remain the most significant concerns. We introduce some controversies and highlight the developments in current surgical practice for the treatment of common anal problems. 展开更多
关键词 Anal problems TREATMENT
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PERITUMORAL CYSTIC MENINGIOMA:REPORT OF SIX CASES AND REVIEW OF LITERATURES
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作者 孙青芳 卞留贯 +2 位作者 赵卫国 沈建康 张天锡 《Journal of Shanghai Second Medical University(Foreign Language Edition)》 2006年第2期109-112,共4页
Objective Cystic meningiomas are quite rare. There is a great controversy concerning the management of the cystic wall. We reported six peritumoral cystic meningiomas and reviewed the literature to discuss the managem... Objective Cystic meningiomas are quite rare. There is a great controversy concerning the management of the cystic wall. We reported six peritumoral cystic meningiomas and reviewed the literature to discuss the management of the cystic wall. Methods Six cases of peritumoral cystic meningiomas were retrospectively analyzed. Results Gadolinium-enhanced Tl-weighted magnetic resonance imaging scans disclosed the solid tumor enhancement in 3 cases, the cystic wall enhancement in 2 cases. One case only showed the cystic lesion. All the tumors were totally removed ( including the involved dura and partial cystic wall). Histopathological examination showed 3 meningiotheliomatous meningiomas, 2 microcystic meningiomas, 1 mucoid degeneration. After operation, all the patients recovered well and demonstrated no neurological deficit. During the follow-up time, no tumor was recurrence. Conclusion Magnetic resonance imaging with contrast enhancement can provide information regarding whether surgical removal of the cystic wall is indicated. Peripheral enhancement of the cystic wall strongly indicates the presence of tumor infiltration. The removal of the entire cystic wall should be performed, excessive damage to brain be prevented. 展开更多
关键词 cystic meningioma cystic wall magnetic resonance imaging
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Homeopathy--A Regulation Therapy Healing Hypo- or Hyper-functions of Pathological Pathways by Magnetic Photons according to the Resonance Principle
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作者 Lenger Karin 《Journal of Life Sciences》 2017年第2期53-64,共12页
Since Lenger's detection of magnetic photons in homeopathic remedies by magnetic resonance the mystery of homeopathy comes to a solution. Homeopathy is a regulation therapy curing hypo- and hyper-functions of patholo... Since Lenger's detection of magnetic photons in homeopathic remedies by magnetic resonance the mystery of homeopathy comes to a solution. Homeopathy is a regulation therapy curing hypo- and hyper-functions of pathological pathways. It reacts according to the principle of resonance. The fundamental principles of homeopathy as proving, symptom picture, curing according to the Law of Similars and the production of homeopathic remedies over the Avogadro number by repeated dilution and succussion are explained to have the same frequencies so that the resonance principle can work. Pathological pathways are cured by using their highly potentized substrates, inhibitors and enzymes, given daily or each second day. This is in contradiction to the normal applied homeopathy. The efficacy of homeopathy now has a scientific base and is completely explained by applying biochemical and biophysical laws. 展开更多
关键词 Magnetic photons resonance principle magnetic frequencies homeopathic remedies homeopathic healing.
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Heart failure research in China: current status and future direction 被引量:3
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作者 Yuangui Zhu Ruijuan Sun Erdan Dong 《Science Bulletin》 SCIE EI CAS CSCD 2016年第23期1793-1801,共9页
Heart failure is a major public health problem worldwide. Despite advances in the therapy and care of heart failure, morbidity and mortality remain persistently high. Recent years have witnessed major breakthroughs in... Heart failure is a major public health problem worldwide. Despite advances in the therapy and care of heart failure, morbidity and mortality remain persistently high. Recent years have witnessed major breakthroughs in the investigations of pathogenesis, prevention, and treatment of heart failure in China. It is noteworthy that the continuing and growing support from funding agencies in China including the National Natural Science Foundation of China has yielded substantial effects on the basic and clinical research in heart failure in the last decade. In this review, we provide an update on the current status of heart failure research, both basic and translational/clinical, in China, including funding and publications. We also discuss the future challenges and possible strategies in improving our understanding and management of heart failure in China. 展开更多
关键词 Heart failure Basic research Translational research Clinical research China
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A novel and effective hyperthermia method for Schistosomiasis japonica prevention and treatment
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作者 Huixia Yang Tao Tang +15 位作者 Pei He Youren Zhang Le Xie Guangqi Liu Li Li Weichao Kong Jingdingsha Li Ruiting Liu Yukun Li Junjian Hu Xiaowen Wang Liya Li Guanghong Xiang Geoffrey Gobert Yuesheng Li Jintian Tang 《Science Bulletin》 SCIE EI CAS CSCD 2015年第16期1461-1464,共4页
The emerging resistance to schistosoma has been paid much attention and is in urgent need for a novel strategy to control the prevalent parasitic zoonosis. In this study, the efficiency of hyperthermia therapy was inv... The emerging resistance to schistosoma has been paid much attention and is in urgent need for a novel strategy to control the prevalent parasitic zoonosis. In this study, the efficiency of hyperthermia therapy was investigated by the skin hyperthermia device. The survival rate of cercariae decreased from 68.15 % (37 ℃, 5 min) to 0 (49℃, 10 min) with the thermal dosages increased, which proved the preventing effect of hyperthermia therapy (P 〈 0.05). Therapeutic effects were assessed in Schistosoma japonicum-infected BALB/c mice. When the cercarial contact region of the skin was treated at 45-49℃ for 5 min within 8 h of infection, worm reduction rate (WRR) reached 74 %-83 % (P 〈 0.01). The sensitivity of adult schistosoma to heat was also investigated using microwave intraperitoneal hyperthermia (thermal dosages 42-43℃, 20 min). The WRR, hepatic shift rates and egg reduction rates were 23.7 %, 40 % and 30 %, respectively, comparing with 80.2 %, 59.6 % and 53.9 % of praziquantel (PZQ)-treated group. Encouraging results have been obtained that hyperthermia can effectively kill schistosomula, especially with the appearance of cercarial dermatitis, while PZQ lacks efficacy against the cercariae. Thus, hyperthermia therapy would show significant benefit in preventing and treatment of schistosoma, especially in the early stage. 展开更多
关键词 HYPERTHERMIA Schistosomiasis japonica Praziquantel (PZQ) CERCARIAE
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Clenched fist injury complicated by septic arthritis and osteomyelitis treated with negative pressure wound therapy: One case report
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作者 Miroslav Kilian 《Chinese Journal of Traumatology》 CAS CSCD 2016年第3期176-178,共3页
We reported a 30 years old man who suffered a bite wound of the right hand in a fight. Two days after the injury, he was admitted in emergency because of stab wound above the head of the third metacarpal bone. He pres... We reported a 30 years old man who suffered a bite wound of the right hand in a fight. Two days after the injury, he was admitted in emergency because of stab wound above the head of the third metacarpal bone. He presented the swelling, redness, pain and fever. Primary revision confirmed only partial lesion of the extensor apparatus. During the following days, we recorded a deterioration of local findings and magnetic resonance imaging revealed osteomyelitis and septic arthritis of the third metacarpophalangeal joint. The wound was then revised several times using negative pressure wound therapy in combination with intravenous antibiotics. After resolution of clinical and laboratory findings, the wound was finally closed by delayed primary suture. Clenched fist injury is a medical emergency that requires immediate surgical revision. We treated clenched fist injury with the development of septic arthritis and osteo- myelitis with negative pressure wound therapy and obtained good outcomes. 展开更多
关键词 Clenched fist injuwNegative pressure wound therapyArthritisOsteomyelitis
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