Conjugated, conductive polymers are a kind of important organic macromolecules, which has found appli- cations in a variety of areas. The application of conjugated polymers in developing fluorescent biosensors represe...Conjugated, conductive polymers are a kind of important organic macromolecules, which has found appli- cations in a variety of areas. The application of conjugated polymers in developing fluorescent biosensors represents the merge of polymer sciences and biological sciences. Conju- gated polymers are very good light harvesters as well as fluorescent polymers, and they are also “molecular wires”. Through elaborate designs, these important features, i.e. efficient light harvesting and electron/energy transfer, can be used as signal amplification in fluorescent biosensors. This might significantly improve the sensitivity of conjugated polymer-based biosensors. In this article, we reviewed the application of conjugated polymers, via either electron transfer or energy transfer, to detections of gene targets, an- tibodies or enzymes. We also reviewed recent efforts in con- jugated polymer-based solid-state sensor designs as well as chip-based multiple target detection. Possible directions in this conjugated polymer-based biosensor area are also dis- cussed.展开更多
文摘Conjugated, conductive polymers are a kind of important organic macromolecules, which has found appli- cations in a variety of areas. The application of conjugated polymers in developing fluorescent biosensors represents the merge of polymer sciences and biological sciences. Conju- gated polymers are very good light harvesters as well as fluorescent polymers, and they are also “molecular wires”. Through elaborate designs, these important features, i.e. efficient light harvesting and electron/energy transfer, can be used as signal amplification in fluorescent biosensors. This might significantly improve the sensitivity of conjugated polymer-based biosensors. In this article, we reviewed the application of conjugated polymers, via either electron transfer or energy transfer, to detections of gene targets, an- tibodies or enzymes. We also reviewed recent efforts in con- jugated polymer-based solid-state sensor designs as well as chip-based multiple target detection. Possible directions in this conjugated polymer-based biosensor area are also dis- cussed.
