胃癌及癌前状态端粒酶活性的研究

为探讨端粒酶活性异常在胃癌发生及发展中的作用,采用TRAP银染法对胃粘膜端粒酶活性进行检测:结果端粒酶阳性率胃癌组织为100％(8/8),胃癌前状态组织为400％(4/10),浅表性胃炎为阴性(0/9)。胃癌组织阳性率最高(与其他组织比较,均P<0.05),而胃癌前状态与浅表性胃炎无显著性差异(P>0.05)。提示端粒酶激活参与胃癌的形成和发展,检测端粒酶活性可能有助于胃癌的早期诊断。

风湿性心瓣膜病血栓前状态的研究

目的：对风湿性心瓣膜病血栓前状态进行研究；方法：观察了20例超声心动图发现云雾状回声对比（SEC）与20例血栓形成的风心病患者血管内皮，血小板活性、凝血与抗凝、纤溶系统各种分子标志物的变化；结果：VWF：Ag、GMP－140、血小板聚集活性、AT-Ⅲ：C、t－PA、PA.Ⅰ、D－Dimer均与对照组差异有显著性（P＜0．01），患者两组之间差异亦有显著性；结论：风心病患者在TEE发现SEC时即已出现高凝状态。

输变电状态监测系统的分布式数据交换方法

分层分布式输变电设备状态监测系统中,状态接入控制器(CAC)与状态接入网关(CAG)之间的数据交换是实现状态信息纵向贯通的基础。通过对电力系统远程通信协议和分布式组件技术的分析,采用简单对象访问协议(SOAP)实现状态监测数据的分布式交换,给出基于Web服务描述语言(WSDL)的状态监测数据交换服务的建模方法和过程,以确保系统的可移植性和互操作性。采用上述方法和模型,设计实现了一个状态监测数据交换实验系统,并以变电CAC周期上传状态监测数据服务为例,对系统进行了性能和负载测试,验证了该方法的正确性和可行性。

CLINICAL APPLICATION OF NEIGUAN (内关 PC 6) IN THE TREATMENT OF DISORDERS OF THE DIGESTIVE SYSTEM——THE RELATED RESEARCH PROGRESS

In the present paper, the authors review recent situations of clinical application of Neiguan (PC 6内关), etc. in the treatment of disorders of the digestive system and its related research progresses. In clinical practice, Neiguan (PC 6) is usually selected as one of the main acupoints to treat gastrointestinal reactions induced by ① nausea and vomiting, ② hiccup, ③ gastrointestinal dyskinesia, ④ gastritis, and ⑤ intra-gastric examination, cesarean section, etc. Concerning experimental studies, the effects of Neiguan (PC 6), etc. on ① gastric electrical activities, ② gastrointestinal motion, ③ gastrointestinal hormone secretion, and ④ gastric mucosal structure were observed. Results indicated that Neiguan (PC 6) is an important and effective acupoint for treatment of gastrointestinal disorders in clinic. Stimulation of Neiguan (PC 6) induced favorable regulation of both the peripheral nervous system and central nervous system, and changes of the gastrointestinal hormone secretion may contribute to its effects in treating various disorders.

基于WAPI的电力物联网终端安全接入技术研究

为了提高电力物联网终端安全接入能力,提高数据网关信道容量和网关运行状态稳定性,设计了一个基于无线局域网鉴别和保密基础架构的电力物联网终端安全接入系统。通过加密无线网技术构建无线局域网鉴别和保密基础架构模块,实现电力终端数据的安全传输;利用物联技术构建电力终端接入物联网后的网关状态预测模型,利用最短寻优法对终端网关路由节点进行划分,设计信息信道传输模型;采用拉格朗日算法对传输信道容量的分析方案改进成多周期预测。从而实现对电力终端安全接入网关状态的准确预测。通过试验表明,系统技术核算的数据预测准确率在90%以上,实现了对电力终端安全接入网关状态的准确预测,为其他技术研究奠定基础。

DIGITAL PWM OF AC-AC MATRIX CONVERTER BASED ON OUTPUT-VOLTAGE ERROR FUNCTION

Based on the output-voltage error function, a novel time discrete modulation technique is proposed for matrix converters （MCs） and time-discrete difference equations of a MC circuit are derived. Switch states of MC are obtained when the output voltage error function is minimized, thus the optimum combination of switch states is derived for the closed-loop control of MC. Meanwhile, advantages of the least calculation workload, the simple process, and the convenient for implementation are brought while switch states are described as space vectors in the α-β coordination system. Simulation and experimental results demonstrate the validity of the time-discrete modulation technique and the feasibility of the control approach.

Optimization and Application of SRAM in 90nm CMOS Technology

This paper presents an optimized SRAM that is repairable and dissipates less power. To improve the yield of SRAMs per wafer,redundancy logic and an E-FUSE box are added to the SRAM and an SR SRAM is set up. In order to reduce power dissipation,power on/off states and isolation logic are introduced into the SR SRAM and an LPSR SRAM is constructed. The optimized LPSR SRAM64K × 32 is used in SoC and the testing method of the LPSR SRAM64K × 32 is also discussed. The SoC design is successfully implemented in the Chartered 90nm CMOS process. The SoC chip occupies 5. 6mm× 5. 6ram of die area and the power dissipation is 1997mW. The test results indicate that LPSR SRAM64K ×32 obtains 17. 301% power savings and the yield of the LPSR SRAM64K × 32s per wafer is improved by 13. 255%.

Analysis on the Essential Characters and Biological Yield Change of Purple-fleshed Sweetpotato Xuzishu 3

Objective] This study was performed to investigate the trait changes and their correlations as wel as the dynamic changes of biological yield of Xuzishu 3, which wil help to enhance the yield and anthocyanin content of sweetpotato by cul-tivation. [Method] We systematical y measured the agronomic traits, qualitative char-acters and biological yield of Xuzishu 3 during six growing periods to investigate the dynamic changes of its essential characters and yield accumulation. [Result] The characters of Xuzishu 3 appeared most prosperous after the 90th d except for an-thocyanin content. Extremely significant positive correlations were found between ev-ery two of the dry matter rates of above-ground parts （including leaf petioles, leaves and stems）, reducing sugar content and potato weight per plant. Assimilated product distributed more in stems and leaves than in storage roots before the 90th d in growing period. Photosynthetic capacity and net assimilation rate gradual y de-creased after the 90th d, but the assimilated product distributing to storage roots in-creased quickly and maximized in the 135th d. [Conclusion] Xuzishu 3 is a late ma-turing variety requiring more fertilizer, and the accumulation of anthocyanin fluctuates during the growth period of Xuzishu 3. So yield of Xuzishu 3 can be increased by applying more fertilizer and extending the growth period reasonably, meanwhile the anthocyanin content can be increased by means of control ing temperature, light, water and phytohormone within 60 d after planting.

Canonical Correlation Analysis of Agronomic Characters of Brassica juncea in Western China

[Objective] The study aimed at exploring the relationship among the agronomic characters of B. juncea in western China, in order to provide scientific basis for the breeding of B. juncea in western China. [Method] 39 B. juncea materials from western China were used for the canonical correlation analysis, and canonical correlations between each pair of the four ecological character （containing 18 variables） were verified, including yield characters （5 variables）, caulis characters （6 variables）, branch characters （3 variables） and pod characters （3 variables）. [Result] Yield per plant of B. juncea in western China suffered a tremendous influence from effective pod number per plant while was not significantly affected by the total pod number per plant, seed number per pod and 1 000-seed weight; the most important character related with the yield character of B. juncea in western China was caulis character, followed by the branch character and pod character; yield characters, caulis characters, branch characters and pod characters of B. juncea in western China were closely correlated. [Conclusion] In order to improve the yield characters of B. juncea in western China, caulis characters should be focused on, followed by branch characters and pod characters; rapeseed varieties with high performance in total pod number per plant and effective pod number per plant should be chosen through the perspectives of effective branch number, plant height, pod number of main inflorescence, fruit stalk number of main inflorescence and other traits, while rapeseed varieties with high performance in seed number per pod and 1 000-seed weight should be chosen through the perspectives of beak length and other traits.

An Improved Markov Chain Model Based on Autocorrelation and Entropy Techniques and Its Application to State Prediction of Water Resources

According to the relationships among state transition probability matrixes with different step lengths, an improved Markov chain model based on autocorrelation and entropy techniques was introduced. In the improved Markov chain model, the state transition probability matrixes can be adjusted. The steps of the historical state of the event, which was significantly related to the future state of the event, were determined by the autocorrelation technique, and the impact weights of the event historical state on the event future state were determined by the entropy technique. The presented model was applied to predicting annual precipitation and annual runoff states, showing that the improved model is of higher precision than those existing Markov chain models, and the determination of the state transition probability matrixes and the weights is more reasonable. The physical concepts of the improved model are distinct, and its computation process is simple and direct, thus, the presented model is sufficiently general to be applicable to the prediction problems in hydrology and water resources.

LINEAR FILTERING FOR VASICEK TERM STRUCTURE MODEL WITH SEQUENTIALLY CORRELATED NOISE

When Kalman filter is used in the estimation of Vasicek term structure of interest rates,it is usual to assume that the measurement noise is uncorrelated.Study results are more favorable to the assumption of correlated measurement noise.An augmented state Kalman filter form for Vasicek model is proposed to optimally estimate the unobservable state variable with the assumption of correlated measurement noise.Empirical results indicate that the model with sequentially correlated measurement noise can more accurately describe the dynamics of the term structure of interest rates.

Correspondence between the ENSO-like state and glacial- interglacial condition during the past 360 kyr

In the warming world, tropical Pacific sea surface temperature （SST） variation has received considerable attention because of its enormous influence on global climate change, particularly the El Nino-Southern Oscillation process. Here, we provide new high-resolution proxy records of the magnesium/ calcium ratio and the oxygen isotope in foraminifera from a core on the Ontong-Java Plateau to reconstruct the SST and hydrological variation in the center of the Western Pacific Warm Pool （WPWP） over the last 360 000 years. In comparison with other Mg/Ca-derived SST and δ18O records, the results suggested that in a relatively stable condition, e.g., the last glacial maximum （LGM） and other glacial periods, the tropical Pacific would adopt a La Nifia-like state, and the Walker and Hadley cycles would be synchronously enhanced. Conversely, El Nino-like conditions could have occurred in the tropical Pacific during fast- changing periods, e.g., the termination and rapidly cooling stages of interglacial periods. In the light of the sensitivity of the Eastern Pacific Cold Tongue （EPCT） and the inertia of the WPWP, we hypothesize an inter-restricted relationship between the WPWP and EPCT, which could control the zonal gradient variation of SST and affect climate change.

Molecular mechanisms of ＂off-on switch＂ of activities of human IDH1 by tumor-associated mutation R132H

Human cytosolic NADP-1DH （IDH1） has recently been found to be involved in tumorigenesis. Notably, the tumorderived IDH1 mutations identified so far mainly occur at Arg132, and mutation R132H is the most prevalent one. This mutation impairs the oxidative IDH activity of the enzyme, but renders a new reduction function of converting a-ketoglutarate （aKG） to 2-hydroxyglutarate. Here, we report the structures of the R132H mutant IDH1 with and without isocitrate OCT） bound. The structural data together with mutagenesis and biochemical data reveal a previ- ously undefined initial ICT-binding state and demonstrate that IDH activity requires a conformational change to a closed pre-transition state. Arg132 plays multiple functional roles in the catalytic reaction; in particular, the R132H mutation hinders the conformational changes from the initial ICT-binding state to the pre-transition state, leading to the impairment of the IDH activity. Our results describe for the first time that there is an intermediate conformation that corresponds to an initial ICT-binding state and that the R132H mutation can trap the enzyme in this conforma- tion, therefore shedding fight on the molecular mechanism of the ＂off switch＂ of the potentially tumor-suppressive IDH activity. Furthermore, we proved the necessity of Tyr139 for the gained aKG reduction activity and propose that Tyr139 may play a vital role by compensating the increased negative charge on the C2 atom of aKG during the trans- fer of a hydride anion from NADPH to aKG, which provides new insights into the mechanism of the ＂on switch＂ of the hypothetically oncogenic reduction activity of IDH1 by this mutation.

Fermion Coherent State Studies of One-Dimensional Hubbard Model

We present a comparative study of the ground state of the one-dimensional Hubbard model. We first use a new fermion coherent state method in the framework of Fermi liquid theory by introducing a hole operator and considering the interactions of two pairs electrons and holes. We construct the ground state of the Hubbard model as ｜〉=[f＋∑^tφk1σ1hk2σ2ck3σ3hk4σ4 ∏exp（ρck1σ1 hk2σ2）]｜〉0,where φ and ρ are the coupling constants. Our results are then compared to those of varlational methods, density functional theory based on the exact solvable Bethe ansatz solutions, variational Monto-Carlo method （VMC） as well as to the exact result of the infinite system. We find satisfactory agreement between the fermion coherent state scheme and the VMC data, and provide a new picture to deal with the strongly correlated system.

Creation of Coherent Superposition States in Multilevel Systems

A powerful approach to generate multilevel superposition state in A-type manifold of levels is proposed. In the analysis, we introduce a group of rotations to transform the coupled system to a simpler form, which involves one coupled and several decoupled, dark states in the ground state manifold. Then an arbitrary superposition state of initial and final states can be created. In particular, when the Rabi frequencies of the Stokes pulses have equal magnitudes, a superposition state （equal population of the （n - 2） superposition states） will be generated. A numerical simulation of coherence generation is given. It is shown that a small transient population in metastable state decreases as the intensity of Stokes pulses increases. Experimental implementation in Neon atom is given.

Correlation and path analysis of morphological and weight traits in marine gastropod Glossaulax reiniana

Using correlation and path analysis, the genetic correlation between weight traits and morphological traits was determined in the marine gastropod Glossaulax reiniana. A total of 100 G. reiniana individuals from a wild population were used. Shell width （X1）, shell height （X2）, umbo-callus height （X3）, body width （X4）, operculum length （X5）, operculum width （X6）, body weight （Y1） and soft-tissue weight （Y2） were measured, and the correlation coefficient matrix calculated. Morphological traits were used as independent variables and weight traits as dependent variables for path coefficient analysis. Path coefficients, correlation indices and determination coefficients were also determined. Results indicate that the correlation coefficients associated with each morphological and weight trait were all highly significant （P〈0.01）. After deleting redundant independent variables, the following optimum multiple regression equations were obtained using stepwise multiple regression analysis： Y1=-29.317＋0.362X2＋0.349X4＋ 1.190）（5 for body weight; and Y2=-17.292＋0.166X1＋0.171X2＋0.703X5, for soft-tissue weight. Operculum height had the highest positive direct correlation with both body weight and soft-tissue weight, which was in accordance with the test results obtained from determinate coefficient analysis. The indication of high genetic correlations between weight traits and morphological traits will provide valuable information for G. reiniana breeding programs.

Separability of Pure States and Mixed States of the Quantum Network of Two Nodes

This article discusses the separability of the pure states and mixed states of the quantum network of two nodes by means of the criterion of no entanglement in terms of the covariance correlation tensor in quantum network theory, i.e. for a composite system consisting of two nodes. The covariance correlation tensor is equal to zero for all possible and .

Modeling p VT Properties and Vapor-Liquid Equilibrium of Ionic Liquids Using Cubic-plus-association Equation of State

Combining Peng-Robinson （PR） equation of state （EoS） with an association model derived from shield-sticky method （SSM） by Liu et al., a new cubic-plus-association （CPA） EoS is proposed to describe the ther-modynamic properties of pure ionic liquids （ILs） and their mixtures. The new molecular parameters for 25 ILs are obtained by fitting the experimental density data over a wide temperature and pressure range, and the overall aver-age deviation is 0.22%. The model parameter b for homologous ILs shows a good linear relationship with their mo-lecular mass, so the number of model parameters is reduced effectively. Using one temperature-independent binary adjustable parameter kij, satisfactory correlations of vapor-liquid equilibria （VLE） for binary mixtures of ILs ＋ non-associating solvents and ＋ associating solvents are obtained with the overall average deviation of vapor pressure 2.91% and 7.01%, respectively. In addition, VLE results for ILs ＋ non-associating mixtures from CPA, lattice-fluid （LF） and square-well chain fluids with variable range （SWCF-VR） EoSs are compared.

Free State Constructions

This paper attempts to investigate Free State （FS） in Hijazi Arabic. This structure is not used in Modem Standard Arabic. It was introduced into the Arabic dialects later on as a competing structure to the Construct State （CS）. First, we discuss the characteristics of this structure in comparison to its counterpart： the CS. we show that semantically FS can express only three semantic relations out of the five semantic relations CS can convey. Furthermore, the paper shows that the FS genitive exponent in HA ＂hagg＂ agrees with the head noun of the matrix DP in phi-features. The discussion then shifts to the origin of the genitive exponent hagg. The paper argues that it is originally a noun that has acquired a new meaning： an anaphor that means something like ＂one of＂. Hence, we gloss hagg as ANAPH. Contrary to previous analyses for the FS genitive exponent, the paper proposes that hagg, the noun, heads its own CS and it is linked to the preceding DP by a binding relationship, which involves feature agreement in gender and number. Consequently, we propose that hagg-headed CS has the same structure of the nominal CS. Finally, we investigate the occurrence of both FS and CS structures in HA and show when one structure is preferred to the other.