破中有立 水到渠成──评林则徐《钱票无甚关碍宜重禁吃烟以杜弊源片》的写作特色

鸦片战争间的重要文献林则徐《钱票无甚关碍宜重禁吃烟以杜弊源片》是一篇很有写作特色的文章。它将钱票影响银钱比价之论作为论改进行驳斥，在驳论中引出影响银钱比价失衡的真正原因是白银外流的论点，顺势提出了为解决该问题而生治吸食的主张。但文章没有像一般驳论文那样至此结束，而是又层层设敌，逐一驳斥，从不同方面论证了该主张的正确与有效，使这一主张在批驳中逐步而又水到渠成般地完全确立起来。

试析工业污水处理中机械设备及自动化技术的关碍和解决措施

伴随城市化进程不断加快,工业污水排放已经成为水资源污染的主要原因。现阶段,我国污水处理问题日趋尖锐,大量未经处理或处理不达标的工业污水直接排放至河流中,造成水体污染现象十分严重,水体富营养化与有毒化学品浓度超标,生态平衡受到威胁,对我国进一步发展战略的实施产生阻碍。虽然工业污水包含的生产污水和生产废水在逐年减少排放量,但因其对人体细胞组织的危害性仍然较为明显。鉴于此,本文以机械设备及自动化技术在工业污水处理中的应用为研究对象,分析工业污水处理过程中存在的关碍,寻求相应解决措施,旨在强化机械设备及自动化技术的应用强度,提升工业污水处理能力,节约珍贵资源,推动生态环境可持续发展。

Sphincter of Oddi dysfunction:Psychosocial distress correlates with manometric dyskinesia but not stenosis

AIM:To compare postcholecystectomy patients with Sphincter of Oddi(SO)dyskinesia and those with normal SO motility to determine the psychosocial distress,gender and objective clinical correlates of dyskinesia,and contrast these findings with comparisons between SO stenosis and normal SO motility.METHODS:Within a cohort of seventy-two consecutive postcholecystectomy patients with suspected SO dysfunction,manometric assessment identified subgroups with SO dyskinesia(n=33),SO stenosis(n=18)and normal SO motility(n=21).Each patient was categorized in terms of Milwaukee Type,sociodemographic status and the severity of stress-coping experiences.RESULTS:Logistic regression revealed that in combination certain psychological,sociodemographic and clinical variables significantly differentiated SO dyskinesia,but not SO stenosis,from normal SO function.Levels of psychosocial stress and of coping with this stress(i.e.anger suppressed more frequently and the use of significantly more psychological coping strategies)were highest among patients with SO dyskinesia,especially women.Higher levels of neuroticism(the tendency to stressproneness)further increased the likelihood of SO dyskinesia.CONCLUSION:A motility disturbance related to psychosocial distress may help to explain the finding of SO dyskinesia in some postcholecystectomy patients.

Mothers overcoming remorse to care for self and baby:An emerging concept

Objectives:Mothers with substance use disorder(SUD)experience a range of emotions such as feeling ostracized,diminished,and distressed while watching their baby experience withdrawal from substances.Being fully present in the now moment is to trust self to do what is best by moving beyond perceived boundaries to care for self and baby.The process of concept building arose from nursing practice encounters in a special care nursery(SCN)for babies who experienced withdrawal from substances.Method:Liehr and Smith’s 10-phase concept building approach was used to guide the development of this concept.Concept building began with a practice story.The emerging concept was named,core qualities identified,and supported through a literature review.The middle range theory of uncertainty in illness was chosen to serve as theoretical support for the concept.A model was created to provide clarity on the relationships within the concept.Result:A mini-saga was gathered from a mother in the SCN whose newborn had experienced withdrawal from substances.The minisaga follows:Due to the baby’s discomfort and judging eyes of the staff,she was unable to mother her baby.As the baby recovered,she asked for help,comforted her baby,and gained confidence to move beyond perceived boundaries to become the mother she envisioned.Overcoming perceived boundaries to attend to self and baby is trusting oneself to do what is best in spite of feeling ostracized,diminished,and distressed while watching baby withdraw from substances.Conclusion:This concept provides the perspective of mothers with SUD through intermodernism from experiences in nursing practice.The Uncertainty in Illness theory further allows practitioners to gain an understanding of the role uncertainty plays in this unique situation.

Dynamic obstacles detection of tram based on laser radar

The detection of obstacles in a dynamic environment is a hot and difficult problem.A method of autonomously detecting obstacles based on laser radar is proposed as a safety auxiliary structure of tram.The nearest neighbor method is used for spatial obstacles clustering from laser radar data.By analyzing the characteristics of obstacles,the types of obstacles are determined by time correlation.Experiments were carried out on the developed unmanned aerial vehicle(UAV),and the experimental results verify the effectiveness of the proposed method.

“Tong Guan Li Qiao” Acupuncture Therapy on Post-Stroke Dysphagia

The differences between the“Tong Guan Li Qiao”acupuncture therapy and the conventional and current other acupuncture methods for poststroke dysphagia are as follows:first,it adheres to the basic idea of "Xing Nao Kai Qiao"acupuncture therapy in selecting and combining acupoints,centers on the brain,and combines the dysphagia symptoms of the mouth,tongue,and throat-related orifices with the root cause of"brain";second,thereare strictand standard requirements intheacupuncture operation,that is,manipulation quantification.In addition to standardized twirling,lifting,and thrusting,the techniques of deep needling on the acupoints in the neck region,blood-letting puncturing at the posterior wallof the pharynx,and theneedling sensation of"like a fishbone getting stuck in the throat"are all unique.

Differences in Values Between Mother and Daughter in Cord

Edna O＇Brien （1930-）, an Irish novelist, poet, and short story writer, is considered as a pioneer for her frank portrayals of women and the most gifted woman writing in English at her time. Her first novel, The Country Girls （1960）, was an immediate success. Her writing is lyrical and intense with passions and aspirations. Set in Britain, the short story Cord describes a story about how the mother and the daughter got along in the short reunion after a long separation. The paper mainly explores different religious values, cultural values, and social values between them which caused irreconcilable conflicts. The present paper concludes that the ＂Cord＂, the blood tie, can never get rid of the spiritual barrier. Only mutual understanding can eliminate the gap and acquire a harmonious relation between parents and children.

Effects of creative expression program on the event-related potential and task reaction time of elderly with mild cognitive impairment

Objectives:This study aimed to evaluate the effects of a 16-week creative expression intervention program(CrExp)on the event-related potential(ERP)and task reaction time in older individuals with mild cognitive impairment(MCI).Methods:This study is a randomized controlled clinical trial conducted in the Memory Center of Fujian Provincial hospital.Thirty-six MCI patients were randomly distributed into two groups.One group underwent a 16-week creative expression program(CrExp,n=18)and the other performed as a control group(CG,n=18)by general social activities.The amplitude and latency of ERP-P300 from the central(Cz),parietal(Pz),frontal(Fz)cortices and task reaction time(RT)were assessed at baseline,postinterventi on,and 24-week follow-up.Results:The CrExp group showed greater differences than CG of P300 latency in Cz(F=4.37,P=0.015),Pz(F=2.78,P=0.009),Fz(F=6.45,P=0.031)brain area after 16 weeks of intervention and in Fz(F=3.23,P=0.028),Cz(F=3.79,P=0.024),and Pz(F=5.60,P=0.036)at 24 weeks follow-up.Also,we analyzed the task reaction time between two groups and found that a shorten reaction time at postintervention(F=4.47,P=0.011)and 24 weeks follow-up(F=3.12,P=0.007)in the CrExp group.However,there was no difference in P300 amplitude in either brain area between the two groups.Conclusion:The electrophysiological results of the creative expression cognitive therapy group were more obvious than those of the general cognitive therapy group,and the latency and task reaction time may be considered as supported parameters in diagnosing the effects during non-drug therapy intervention in clinical practice.

Accessible KnowledgemKnowledge on Accessibility

Although serious efforts are made internationally and nationally, it is a slow process to make our physical environment accessible. In the actual design process, architects play a major role. But what kinds of knowledge, including research-based knowledge, do practicing architects make use of when designing accessible environments？ The answer to the question is crucially important since it affects how knowledge is distributed and how accessibility can be ensured. In order to get first-hand knowledge about the design process and the sources from which they gain knowledge, 11 qualitative interviews were conducted with architects with experience of designing for accessibility. The analysis draws on two theoretical distinctions. The first is research-based knowledge versus knowledge used by architects. The second is context-independent knowledge versus context-dependent knowledge. The practitioners found their primary support in context-dependent knowledge, whereas context-independent knowledge was criticized as being too prescriptive. Further, they tended to ask for assistance from the researcher in person rather than reading research publications. The findings challenge research in two ways--first, to produce context-dependent knowledge to structure the first step of the design process, second, to develop new ways to ensure a knowledge flow between research and practice.

“先生如达”新解

《诗经·大雅·生民》描述后稷降生时用了'先生如达'一语,颇使人产生联想。'先生',或解为'首生',或解为'始生',均无大关碍,关键是在'达'字上有诸多分歧。《毛传》:'达,生也。姜嫄之子先生者也。'把'达'解为'生',使人费解。《郑笺》:'达,羊子也。……生如达之生,言易也。'

Pathways related to mitochondrial dysfunction in cartilage of endemic osteoarthritis patients in China

In this paper, we present the first evidence of differences in the mitochondria-related gene expression profiles of adult articular cartilage derived from patients with Kashin-Beck disease and normal controls. The expression of 705 mitochondria-related genes was analyzed by mitochondria-related gene expression analysis and ingenuity pathways analysis. Mitochondria-related gene expression analysis identified 9 up-regulated genes in Kashin-Beck disease based on their average expression ratio. Three canonical pathways involved in oxidative phosphorylation, apoptosis signaling and pyruvate metabolism were identified, which indicate the involvement of mitochondrial dysfunction in the pathogenesis of Kashin-Beck disease.

Treatment of Temporomandibular Joint Dysfunction Syndrome by Acupuncture,Taiyi Moxa-cigar Plus Tuina

Summary： Fouty-five cases of temporomandibular joint dysfunction syndrome were diagnosed by Xray, excluding the organic diseases. The acupoints Xiaguan （ST 7）, Jiache （ST 6）, Yifeng （TE 17） and Hegu （LI 4） on the affected side were punctured first, after removal of needles, 5-7 layers of cotton cloth was placed on the above acupoints, then moxibustion with moxa-roll made of Chinese medicine was performed. Finally Dian-finger pressing, An-pressing and Rou stationary circular pressing with finger belly of the thumb were applied to the local region around the mandible joint for 3-5 min. After 1-2 courses of treatments, 45 cases all got effect.

Clinical observation of tuina manipulations for tic disorders in kids

Objective:To observe the clinical efficacy of tuina manipulations in treating different types of tic disorders(TD).Methods:Eligible TD patients were classified into three types,transient tic disorders(TTD),chronic multiple tic disorders(CMTD)and Tourette syndrome(TS),according to their disease duration and severity.The three types of children were treated with the same tuina manipulations.Changes in the Yale global tic severity scale(YGTSS)score,effective rate for tic,and cervical spine imaging examination results(including asymmetry of the lateral atlanto-dental interval,broadened anterior atlanto-dental interval,C2 spinous process deviation,occipito-atlanto-axial flexion/extension instability)were observed after 1-month and 3-month treatments respectively.Results:The YGTSS score changed significantly after 1-month and 3-month treatments compared with that before treatment(both P<0.01);the effective rate for TD was 46.6%and 86.7%respectively after 1-month and 3-month treatments;there were significant differences comparing the effective rate for tic between different types of TD after 1-month and 3-month treatments(all P<0.05);comparing the effective rate for tic after 1-month treatment with that after 3-month treatment for the same type,the intra-group differences were statistically significant[TTD group(P<0.01),CMTD group(P<0.01),TS group(P<0.05)];the abnormal parameter rates in neck imaging examination after 3-month treatment were significantly different from those before treatment(all P<0.01).Conclusion:Tuina manipulation is effective for TTD,CMTD and TS.It can correct the abnormal alterations of patients'cervical vertebrae,and its efficacy for TTD is most significant.

Application of P300 in Scalp Acupuncture for Cognitive Disorder Due to Cerebral Infarction

Objective：To observe and compare the therapeutic effect of two different needling methods,liver-soothing and mind-regulating needling method versus conventional needling method,in treating anxiety and depression in tension-type headache.Methods：A total of 120 patients with tension-type headache coupled with anxiety and/or depression were randomized into two groups according to the random number table,a liver-soothing andmind-regulating needling group （group A） and a conventional needling group （group B）,60 patients in each group.The self-rating anxiety scale （SAS） and self-rating depression scale （SDS） were used for evaluation before and after treatment.The therapeutic effects of the two groups were compared after 2-treatment courses.Results：The values of SAS and SDS both significantly dropped in the two groups （P0.01）,and the differences between the two groups after treatment were statistically significant （P0.01,P0.05）.The therapeutic effect in group A was superior to that in group B （P0.01）.The 3-month follow-up study showed that the liver-soothing andmind-regulating needling method had better long-term effect in improving anxiety and depression than the conventional needling method （P0.05）.Conclusion：The liver-soothing andmind-regulating needling method can effectively relieve the anxiety and depression symptoms in patients with tension-type headache,and the long-term effect is also satisfactory.

The effect of electroacupuncture preconditioning on cognitive impairments following knee replacement among elderly:A randomized controlled trial

Objective: To investigate if electroacupuncture(EA) preconditioning can mitigate cognitive impairments and reduce the incidence of postoperative cognitive dysfunction(POCD) following knee replacement and its safety among elderly.Methods: Totally 60 participants met the inclusion criteria were enrolled in a randomized controlled trial a ratio of 1:1, with 30 cases allocated to the treatment group and 30 cases allocated to the control group, respectively. The participants in the treatment group were provided with real-EA therapy whereas participants in control group were provided with placebo-EA therapy(Streitberger Placebo-needle). In both groups, Tou sanshen(头三神)acupoints, including Sìshéncōng(四神聪EX-HN1), Sh6 ntíng(神庭 GV24),and bilateral Běnsh6 n(本神GB13) were adopted as the main acupoints, while Bǎihui(百会GV20), bilateral Hégǔ(合谷Ll4), and bilateral Tàich6 ng(太冲LR3) were adopted as matching acupoints. Interventions were offered 5 days prior to the surgery, once daily, and continued for total 5 days. The global scores of MiniMental State Examination(MMSE), and levels of serum inflammatory cytokines including interleukin 1β(IL-1β) and tumor necrosis factor-α(TNF-α), and S100-β protein were observed at 24 h prior to the surgery, and postoperative 24 and 72 h respectively for assessing the incidence of POCD and the severity of cognitive impairments among patients. Meanwhile, adverse effects were monitored and recorded.Results:(1) Compared with baseline, MMSE global scores in both treatment and control groups markedly decreased at postoperative 24 h. MMSE global scores in treatment group decreased from 29.43 ±0.97 to27.10 ±1.95 while that in control group decreased from 29.27 ± 1.01 to 26.83 ± 2.25(all ?P< 0.05), and this trend continued until postoperative 72 h(at postoperative 72 h, MMSE global scores in treatment group was 26.53 ±2.26 versus 24.79 ±3.03 in control group). Moreover, decline in control group was more significant than that in treatment group at postoperative 72 h(P<0.05).(2) Compared with baseline, levels of serum IL-1β, TNF-α and S100-β in both groups increased markedly at postoperative 24 and 72 h. IL-1β in treatment group increased from 43.13 ±5.51 to 73.13 ±2.32 at postoperative 24 h and reached 83.17 士 5.95 at postoperative 72 h, while IL-1β in control group increased from 44.87 土 5.83 to91.10 ±3.55 at postoperative 24 h and reached 111.93 ±9.18 at postoperative 72 h;TNF-α in treatment group increased from 51.27 士 6.48 to 88.80 ± 3.55 at postoperative 24 h and reached 94.37 ± 5.22 at postoperative 72 h, while TNF-α in control group increased from 52.07 ±7.48 to 116.37 ±3.14 at postoperative24 h and reached 121.40 ±3.68 at postoperative 72 h(both ?P< 0.05), furthermore, increases of IL-1β and TNF-α levels in control group were more significant(P<0.05). Statistical difference in level of S100-β was not observed(P>0.05).(3) There was no statistical difference in POCD incidence at postoperative 24 h and postoperative 72 h between two groups(P> 0.05), though the incidence of POCD in patients receiving real-EA therapy was indeed much lower than that in patients receiving placebo-EA therapy, particularly at postoperative 72 h(POCD incidence rate at postoperative 24 h in treatment group was 26.67%, 30.00%in control group;POCD incidence rate at postoperative 72 h in treatment group was 30.00%, 46.67% in control group).(4) No serious adverse events were reported in this trial. No one dropped out from this trial.Conclusion: EA preconditioning can mitigate cognitive impairments at post-knee replacement surgery 24 and 72 h in elderly through inhibiting expression of inflammation. However, there is insufficient evidence to support that EA pretreatment can reduce the incidence of POCD.

Effect of acupuncture on blood oxygen concentration in brain of rats with post-traumatic stress disorder based on functional near-infrared spectroscopy

Objective: To observe the effect of acupuncture on blood oxygen concentration in the brain of rats with post-traumatic stress disorder (PTSD) based on functional near-infrared spectroscopy (fNIRS), thus to reveal the mechanisms of acupuncture in intervening the brain function of PTSD rats. Methods: Sixty Sprague-Dawley (SD) rats were randomly divided into a blank group, a model group, a grasping group, a paroxetine group and an acupuncture group, with 12 rats in each group. Except the blank group, rats in the other groups all received incarceration plus electric shock for 7 d to prepare the PTSD animal model. One hour before the stress model was established, rats in each group received the desig nated in tervention: rats in the blank group and the model group did not receive any intervention;rats in the grasping group received grasping and fixation;rats in the paroxetine group received paroxetine hydrochloride solution by intragastric administration;and rats in the acupuncture group received acupuncture. Six-day treatme nt was a course, with 2 courses of treatme nt con ducted for a total of 12 d. After the modeli ng, rats in each treatment group received intervention for 5 dz and the fNIRS system was used to collect and record the changes in the concentrations of oxygenated hemoglobin (HbO2), deoxygenated hemoglobin (d-Hb) and total hemoglobin (t-Hb) of the involved rat's brain regions, and also to assess the brain function. Results: Compared with the blank group, the con centrati on of HbO2 was significa ntly in creased, the concen trati on of d-Hb was significa ntly decreased, and the concen tration of t-Hb was sign ifica ntly in creased in the model group and the graspi ng group after the in tervention, and the differ en ces were statistically significant (all P<0.01). Compared with the model group, the concentrations of HbO2, d-Hb and t-Hb in the grasping group did not change significantly (all P>0.05). Compared with the grasping group, the concentration of HbC^was significantly decreased, the concentration of d-Hb was significantly in creased, and the concen trati on of t-Hb was sign ifica ntly decreased in the paroxeti ne group and the acup un cture group, and the differences were statistically sigrdficant (all P<0.05). There were no significant differences in the concentrations of HbO2, d-Hb and t-Hb between the paroxetine group and the acupuncture group (all P>0.05). Con elusion: Acup un cture can regulate the blood oxyge n conce ntrati on in the brain of PTSD model rats, which may be an important mechanism of acupuncture in intervening the brain function in PTSD rats.

Effect of liver-soothing and mind-regulating acupuncture on resting-state electroencephalographic signals in rats with post-traumatic stress disorder

Objective:To observe the effect of liver-soothing and mind-regulating acupuncture method on the resting-state electroencephalography (EEG) in rats with post-traumatic stress disorder (PTSD),and to provide evidence for the effect mechanism study and clinical application of acupuncture intervention for PTSD.Methods:Sixty Sprague-Dawley (SD) rats were randomly divided into a blank control group,a model group,a grasping group,a paroxetine group and an acupuncture group,with 12 rats in each group.Except for rats in the blank control group,rats in the other groups were subjected to preparing the PTSD models using 'incarceration plus electric shock' method.After interventions,changes in rat behavior of each group were observed;changes in resting-state EEG were collected and analyzed with multichannel EEG acquisition and analysis system,and image analysis and statistical processing were performed.Results:Compared with the blank control group,the average escape latency in the model group was significantly longer (P＜0.05),and the times of crossing the platform and the effective areas were all significantly reduced (P＜0.01).Compared with the grasping group,the average escape latencies in the paroxetine group and acupuncture group were significantly shortened (P＜0.05),and the times of crossing the platform and the effective areas were all significantly increased (P＜0.05).There were no significant differences in the average escape latency,the times of crossing the platform and the effective areas between the acupuncture group and paroxetine group (all P＞0.05).Compared with the blank control group,the α-wave power spectrum value in the model group was significantly decreased,and the power spectrum values of β-wave,δ-wave and a-wave were significantly increased (all P＜0.01);compared with the grasping group,α-wave power spectrum values in the paroxetine group and acupuncture group were significantly increased (both P＜0.01),and the power spectrum values of β-wave,δ-wave and a-wave were decreased significantly (all P＜0.01).The power spectrum values of α-wave,β-wave,δ-wave and (e)-wave of rats in the acupuncture group were not significantly different from those in the paroxetine group (all P＞0.05).Conclusion:Liver-soothing and mind-regulating acupuncture method can significantly improve the abnormal EEG activity in PTSD rats,which may be one mechanism of liver-soothing and mind-regulating acupuncture method in effectively affecting the brain function in PTSD rats.

Effects of acupuncture on neuro-electrophysiological activities in hippocampal CAI and CA3 areas of rats with post-traumatic stress disorder

Objective: To observe the effects of acupuncture on the characteristics of neuro-electrophysiological activity in hippocampal CAI and CA3 areas of rats with post-traumatic stress disorder (PTSD). Methods: Fifty Sprague-Dawley (SD) rats were randomly divided into a blank group, a model group, a grasping group, a Western medicine group and an acupuncture group, with 10 rats in each group. Except for the blank group, rats in the other 4 groups all received the combined stress modeling method. Rats in the Western medicine group were intragastrically administrated with paroxetine hydrochloride, those in the acupuncture group received acupuncture intervention, those in the grasping group received grasping fixation, and those in the model group and the blank group did not receive any in terve ntions. After 14 d of in terve ntion, the interspike in terval (ISI) and power spectral den sities (PSD) were an a lyzed and mapped by in vivo multiple channels to record the neuron clusters discharge in the hippocampal CAI and CA3 areas. Results: Compared with the blank group, ISI was proIonged in the CAI and CA3 areas of the model group and the grasping group, and the concentrated PSD distribution area moved down (Pv0.05 or P<0.01). Compared with the grasping group, the ISI of the CAI and CA3 areas in the Western medicine group and the acupuncture group was shortened, and the concentrated PSD distribution area moved up (P<0.05 or P<0.01). The ISI and PSD distributions in the CAI and CA3 areas of the acupuncture group were not statistically different from those in the Western medicine group (both P>0.05). Conclusion: Both acupuncture and paroxetine hydrochloride can significantly regulate the neuro-electrophysiology activity of hippocampal CAI and CA3 areas in PTSD rats, which may be one of the mechanisms of acupuncture intervention to promote PTSD recovery.

The role of microglia in thalamic reticular nucleus in acupuncture regulating cognitive deficits in insomnia rats

Objective:To explore the mechanism of acupuncture in regulating cognitive deficits in insomnia rats by observing the effect of acupuncture on microglia in thalamic reticular nucleus(TRN).Methods:Thirty rats were randomly divided into a control group,a model group and an acupuncture group,with 10 rats in each group.The insomnia model was established by intraperitoneal injection of para-chlorophenylalanine(PCPA)once a day for 2 d.Rats in the control group were intraperitoneally injected with the same amount of normal saline.Rats in the acupuncture group received acupuncture at Neiguan(PC 6)and Zusanli(ST 36)for 5 consecutive days.The CLOCKLAB 2 data acquisition system was used to dynamically observe the sleep of the rats throughout the experiment.The cognition of rats was evaluated by event-related potentials(ERPs).After intervention,brain tissue was extracted.Immunofluorescence was used to test the fluorescence expression in TRN region.The concentrations of interleukin(IL)-1βand tumor necrosis factor(TNF)-αwere detected by enzyme-linked immunosorbent assay.Results:After intraperitoneal injection of PCPA suspension,the spontaneous activity in light period of rats in the model group and acupuncture group increased significantly compared with the control group(both P<0.01).After acupuncture treatment,the rats in the acupuncture group had much less spontaneous activity during the light period than those in the model group(P<0.01),and the results indicated that acupuncture could effectively improve the sleep quality of insomnia rats.Compared with the control group,rats in the model group showed that the P3 latency,the average optical density of microglia,and the concentrations of IL-1βand TNF-αincreased significantly(all P<0.05),and the P3 amplitude decreased significantly(P<0.01).Compared with the model group,rats in the acupuncture group presented that the P3 latency,the average optical density of microglia,and the concentrations of IL-1βand TNF-αwere significantly decreased(all P<0.05),and the amplitude of P3 was significantly increased(P<0.05).Conclusion:Acupuncture possesses an ability to improve the cognitive state in insomnia rats.The mechanism may be related to inhibiting the microglial activation,diminishing the levels of pro-inflammatory mediators like IL-1βand TNF-α,and promoting the recovery of central nervous system function.

Constraints on the Distortion of Area Objects in the Process of Map Objects Displacement

The displacement operator is an important and still a hot topic in map generalization. In the generalization product, symbols must be unambiguous and easily perceived and readily understood, which makes space competition among features an important obstacle in the process of map objects displacement. Space conflict between objects, through propagation process, may be spread and more objects may drift into it. In order to maintain symbols equilibrium and spatial relationship between objects, some unimportant symbols or parts of symbols should be distorted under constraints according to visual graphic resolution thresholds to figure out space competition among map features. Three constraints including position, legibility and characteristics are important for the maintenance of symbols equilibrium and spatial relationship, which are discussed in this paper. The skeleton is introduced to represent area objects figure characteristic, in which an area object can be separated to parts hierarchically according to their importance in the construction. Then, the finite element method is applied to the map objects’ displacement and distortion, in which a strategy for the parameters of finite element method is discussed.