Objective To investigate the association between two polymorphisms of follicle stimulating hormone receptor （FSHR） gene and polycystic ovary syndrome （PCOS） susceptibility. Methods Case-control studies on relatio...Objective To investigate the association between two polymorphisms of follicle stimulating hormone receptor （FSHR） gene and polycystic ovary syndrome （PCOS） susceptibility. Methods Case-control studies on relationship of Thr307Ala and Asn680Ser polymorphisms in FSHR gene and PCOS susceptibility were searched from PubMed, ISI web of knowledge, EBSCO, and China National Knowledge Infrastructure （CNKI） databases up to March 21, 2013. The pooled odds ratio （OR） and 95% confidence interval （CO were calculated using fixed- or random-effect model based on heterogeneity test in 5 genotype models analyses. Results A total of 11 studies were included in the Meta-analysis. The random-effect analysis showed Asn680Ser was significantly associated with the reduced susceptibility to PCOS with dominant model （Asn/Asn＋Asn/Ser vs. Ser/Ser, OR=0.83, 95% CI： 0.69-1.00）, recessive model （Asn/Asn vs. Asn/Ser＋ Ser/Ser, OR=0.84, 95% CI： 0.72-0.98）, homozygote comparison （Ash/Ash vs. Ser/Ser, 0R=0.79, 95% CI： 0.63-0.98）, and the allele contrast （Asn vs. Ser, OR=0.87, 95% CI： 0.79-0.97） respectively（P=0.02, I2=56.0%）, being protective factors for PCOS. However, no significant associations were found between Thr307Ala and PCOS. Conclusion There might be a significant association between Asn680Ser polymorphism and PCOS.展开更多
Question answering is an important problem that aims to deliver specific answers to questions posed by humans in natural language.How to efficiently identify the exact answer with respect to a given question has becom...Question answering is an important problem that aims to deliver specific answers to questions posed by humans in natural language.How to efficiently identify the exact answer with respect to a given question has become an active line of research.Previous approaches in factoid question answering tasks typically focus on modeling the semantic relevance or syntactic relationship between a given question and its corresponding answer.Most of these models suffer when a question contains very little content that is indicative of the answer.In this paper,we devise an architecture named the temporality-enhanced knowledge memory network(TE-KMN) and apply the model to a factoid question answering dataset from a trivia competition called quiz bowl.Unlike most of the existing approaches,our model encodes not only the content of questions and answers,but also the temporal cues in a sequence of ordered sentences which gradually remark the answer.Moreover,our model collaboratively uses external knowledge for a better understanding of a given question.The experimental results demonstrate that our method achieves better performance than several state-of-the-art methods.展开更多
文摘Objective To investigate the association between two polymorphisms of follicle stimulating hormone receptor （FSHR） gene and polycystic ovary syndrome （PCOS） susceptibility. Methods Case-control studies on relationship of Thr307Ala and Asn680Ser polymorphisms in FSHR gene and PCOS susceptibility were searched from PubMed, ISI web of knowledge, EBSCO, and China National Knowledge Infrastructure （CNKI） databases up to March 21, 2013. The pooled odds ratio （OR） and 95% confidence interval （CO were calculated using fixed- or random-effect model based on heterogeneity test in 5 genotype models analyses. Results A total of 11 studies were included in the Meta-analysis. The random-effect analysis showed Asn680Ser was significantly associated with the reduced susceptibility to PCOS with dominant model （Asn/Asn＋Asn/Ser vs. Ser/Ser, OR=0.83, 95% CI： 0.69-1.00）, recessive model （Asn/Asn vs. Asn/Ser＋ Ser/Ser, OR=0.84, 95% CI： 0.72-0.98）, homozygote comparison （Ash/Ash vs. Ser/Ser, 0R=0.79, 95% CI： 0.63-0.98）, and the allele contrast （Asn vs. Ser, OR=0.87, 95% CI： 0.79-0.97） respectively（P=0.02, I2=56.0%）, being protective factors for PCOS. However, no significant associations were found between Thr307Ala and PCOS. Conclusion There might be a significant association between Asn680Ser polymorphism and PCOS.
基金supported by the National Basic Research Program(973)of China(No.2015CB352302)the National Natural Science Foundation of China(Nos.61625107,U1611461,U1509206,and 61402403)+2 种基金the Key Program of Zhejiang Province,China(No.2015C01027)the Chinese Knowledge Center for Engineering Sciences and Technologythe Fundamental Research Funds for the Central Universities,China
文摘Question answering is an important problem that aims to deliver specific answers to questions posed by humans in natural language.How to efficiently identify the exact answer with respect to a given question has become an active line of research.Previous approaches in factoid question answering tasks typically focus on modeling the semantic relevance or syntactic relationship between a given question and its corresponding answer.Most of these models suffer when a question contains very little content that is indicative of the answer.In this paper,we devise an architecture named the temporality-enhanced knowledge memory network(TE-KMN) and apply the model to a factoid question answering dataset from a trivia competition called quiz bowl.Unlike most of the existing approaches,our model encodes not only the content of questions and answers,but also the temporal cues in a sequence of ordered sentences which gradually remark the answer.Moreover,our model collaboratively uses external knowledge for a better understanding of a given question.The experimental results demonstrate that our method achieves better performance than several state-of-the-art methods.
